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Review

Targeting epigenetic regulatory mechanisms in cancer chemoprevention

, &
Pages 315-328 | Published online: 22 Apr 2005

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  • ••Interesting discussion of possiblealternative mechanism of action of HDAC inhibitors.
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  • •First demonstration of synergy between DNMT and HDAC inhibitors.
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  • •DNA hypomethylation linked to tumour enhancement in animal model.
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  • TING AH, JAIR K-W, SUZUKI H, YEN R-WC, BAYLIN SB, SCHUEBEL KE: CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1. Nat. Genet. (2004) 36:582–584.
  • LAIRD PW: The power and the promise of DNA methylation markers. Nat. Rev Cancer (2003) 3:253–266.
  • ••Excellent review of the potential uses ofDNA methylation markers in clinical settings.

Websites

  • hdp://www.cancengovklinicaltrials. US National Cancer Institute, National Institutes of Health. Links to clinical trials (2004).

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