Bibliography
- MCDONALD JC: In search of the Holy Grail (actively acquired immunologic tolerance). Ann. Sorg. (1995) 221:439–445.
- WALDMANN H, COBBOLD SP, FAIRCHILD P, ADAMS E: Therapeutic aspects of tolerance. Corr. Opin. Phannacol (2001) 1:392–397.
- ARTAVANIS-TSAKONAS S, RAND MD, LAKE, RJ: Notch signalling: cell fate control and signal integration in development. Science (1999) 284:770–776.
- ••Definitive review of Notch biology,particularly its role in cell fate determination.
- SAKAGUCHI S, SAKAGUCHI N, SHIMIZU J et al: Immunologic tolerance maintained by CD25' CD4' regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. lannunol Rev (2001) 182:18–32.
- SHE VACH EM, MCHUGH RS, PICCIRILLO CA, THORNTON AM: Control of T-cell activation by CD4' CD25' suppressor T cells. Iminunol. Rev (2001) 182:58–67.
- •Together, these two reviews [4,5] provide definitive coverage of the Treg field.
- ARTAVANIS-TSAKONAS S, DELIDAKIS C, FEHON RG: The Notch locus and the cell biology of neuroblast segregation. Ann. Rev Cell Biol. (1991) 7:427–452.
- FLEMING RJ: Structural conservation of Notch receptors and ligands. &min. Cell Dev. Biol. (1998) 9:599–607.
- LOGEAT F, BESSIA C, BROU C et al: The Notchl receptor is cleaved constitutively by a furin-like convertase. Proc. Natl. Acad. Li. USA (1998) 95:8108–8112.
- REBAY I, FEHON RG, ARTAVANIS-TSAKONAS S: Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell (1993) 74:319–329.
- •The first molecular characterisation of the Notch receptor and associated signalling mutants.
- MUMM JS, SCHROETER EH, SAXENA MT et al.: A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch]. Mol. Cell. (2000) 5:197–206.
- HU Y, YE Y, FORTINI ME: Nicastrin isrequired for gamma-secretase cleavage of the Drosophila Notch receptor. Dev. Cell (2002) 2:69–78.
- LOPEZ-SCHIER H, ST JOHNSTON D: Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev. Cell. (2002) 2:79–89.
- KOPAN R: Notch: a membrane-bound transcription factor. J. Cell. Li. (2002) 115:1095–1097.
- ZHOU S, HAYWARD SD: Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol. Cell. Biol. (2001) 21:6222–6232.
- ESPINOSA L, SANTOS S, INGLES-ESTEVE J, MUNOZ-CANOVES P, BIGAS A: p65-NFkappaB synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR.Sci. (2002) 115:1295–1303.
- HSIEH JJ, ZHOU S, CHEN L, YOUNG DB, HAYWARD SD: CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. Proc. Nati Acad. Sci. USA (1999) 96:23–28.
- KAO HY, ORDENTLICH P, KOYANO-NAKAGAWA N et al.: A histone deacetylase corepressor complex
- •• regulates the Notch signal transduction pathway. Genes Dev. (1998) 12:2269–2277.
- KOVALL RA, HENDRICKSON WA: Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. EMBO J. (2004) 23:3441–451.
- •Recent structural study providing insight Into the mechanism of CBF1 activation by NIC.
- FRYER CJ, LAMAR E, TURBACHOVA I, KINTNER C, JONES KA: Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev. (2002) 16:1397–1411.
- OSWALD F, TAUBER B, DOBNER T et al.: p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol. Cell. Biol. (2001) 21:7761–7774.
- LADERACH D, COMPAGNO D, DANOS O, VAINCHENKER W, GALY A: RNA Interference Shows Critical Requirement for NF-{kappa}B p50 in the Production of IL-12 by Human Dendritic Cells. J. hinnunol (2003) 171:1750–1757.
- HEITZLER P, BOUROUIS M, RUEL L, CARTERET C, SIMPSON P: Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila. Development (1996) 122:161–171.
- MOREL V, SCHWEISGUTH F: Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev. (2000) 14:377–388.
- MARTINEZ ARIAS A, ZECCHINI V, BRENNAN K: CSL-independent Notch signalling: a checkpoint in cell fate decisions during development? Curr. Opin. Genet. Dev. (2002) 12:524–533.
- RAMAIN P, KHECHUMIAN K, SEUGNET L, ARBOGAST N, ACKERMANN C, HEITZLER P: Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr. Biol. (2001) 11:1729–1738.
- •Identifies ground-breaking new Notch mutants which defme the CSL-independent signalling mode.
- MACDONALD HR, WILSON A, RADTKE F: Notch1 and T-cell development: insights from conditional knockout mice. Trends brununol. (2001) 22:155–160.
- RADTKE F, WILSON A, MACDONALD HR: Notch signaling in T- and B-cell development. Curr. Opin. brununol. (2004) 16:174–179.
- KUMANO K, CHIBA S, SHIMIZU K et al.: Notchi inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression. Blood (2001) 98:3283–3289.
- OHISHI K, VARNUM-FINNEY B, BERNSTEIN ID: The notch pathway: modulation of cell fate decisions in hematopoiesis. Int. J. Hernatol (2002) 75:449–459.
- WILSON A, MACDONALD HR, RADTKE F: Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J. Exp. Med. (2001) 194:1003–1012.
- ••Shows that absence of Notchl hasdramatic effect on B/T decision making: mice have striking phenotype of B-cells developing in the thymus.
- HAN H, TANIGAKI K, YAMAMOTO N et al.: Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. brununol. (2002) 14:637–645.
- WOLFER A, WILSON A, NEMIR M, MACDONALD HR, RADTKE F: Inactivation of Notch]. impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. brununio, (2002) 16:869–879.
- TANIGAKI K, TSUJI M, YAMAMOTO N et al.: Regulation of alphabetaigammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. brununio, (2004) 20:611–622.
- HOZUMI K, NEGISHI N, SUZUKI D et al.: Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat. brununol. (2004) 5:638–644.
- SCHMITT TM, ZUNIGA-PFLUCKER JC: Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. brununio, (2002) 17:749–756.
- SCHMITT TM, DE POOTER RE GRONSKI MA, CHO SK, OHASHI PS, ZUNIGA-PFLUCKER JC: Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat. hinnunol (2004) 5:410–417.
- ROBEY E, CHANG D, ITANO A et al: An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell (1996) 87:483–492.
- WOLFER A, BAKKER T, WILSON A et al: Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat. brununol. (2001) 2:235–241.
- ANASTASI E, CAMPESE AF, BELLAVIA D et al: Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes. J. brununol. (2003) 171:4504–4511.
- ••Study showingNotch3-IC transgenic miceare resistant to induced autoimmunity through enhanced Treg functionality.
- SAITO T, CHIBA S, ICHIKAWA M et al: Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. brununio, (2003) 18:675–685.
- MAILLARD I, WENG AP, CARPENTER AC et al.: Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood (2004) 104:1696–1702.
- ABBAS AK, MURPHY KM, SHER A: Functional diversity of helper T lymphocytes. Nature (1996) 383:787–793.
- SHEVACH EM: Suppressor T cells: Rebirth, function and homeostasis. Curr. Biol. (2000) 10:R572–R575.
- BLUESTONE JA: Is CTLA-4 a master switch for peripheral T cell tolerance? brununol. (1997) 158: 1989-1993.
- NAKAMURA K, KITANI A, STROBER W: Cell contact-dependent immunosuppression by CD4*CD25' regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. (2001) 194:629–644.
- MCHUGH RS, WHITTERS MJ, PICCIRILLO CA et al: CD4HCD25I0 immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity (2002) 16:311–323.
- SHIMIZU J, YAMAZAKI S, TAKAHASHI T, ISHIDA Y, SAKAGUCHI S: Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat. Inonunol. (2002) 3:135–142.
- ASANO M, TODA M, SAKAGUCHI N, SAKAGUCHI S: Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. I Exp. Med. (1996) 184:387–396.
- SHIMIZU J, YAMAZAKI S, SAKAGUCHI S: Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. I Immunol (1999) 163:5211–5218.
- UNGER WW, JANSEN W, WOLVERS DA, VAN HALTEREN AG, KRAAL G, SAMSOM JN: Nasal tolerance induces antigen-specific CD4+CD25-regulatory T cells that can transfer their regulatory capacity to naive CD4+ T cells. Int. Immunol. (2003) 15:731–739.
- CHEN C, LEE WH, YUN P, SNOW P, LIU CP: Induction of autoantigen-specific Th2 and Trl regulatory T cells and modulation of autoimmune diabetes. Immunol. (2003) 171:733–744.
- MASSEY EJ, SUNDSTEDT A, DAY MJ, CORFIELD G, ANDERTON S, WRAITH DC: Intranasal peptide-induced peripheral tolerance: the role of IL-10 in regulatory T cell function within the context of experimental autoimmune encephalomyelitis. Vet. Immunol. Immunopathol (2002) 87:357–372.
- HOYNE GE LE ROUX I, CORSIN-JIMENEZ M et al.: Serrate 1-inducednotch signalling regulates the decision between immunity and tolerance made by peripheral CD4O T cells. Int. Immunol. (2000) 12:177–185.
- ••This important study links Notch signalsto peripheral CD4+ Treg activity for the first time.
- WONG KK, CARPENTER MJ, YOUNG LL et al.: Notch ligation by Deltal inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism. Clin. Invest. (2003) 112:1741–1750.
- ••Extending their previous findings, theauthors show that Notch can also regulate CD8+ T-cell responses, blocking transplant rejection.
- YVON ES, VIGOUROUX S, ROUSSEAU RF et al.: Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood (2003) 102:3815–3821.
- VIGOUROUX S, YVON E, WAGNER HJ et al.: Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. Virol. (2003) 77:10872–10880.
- •These two papers {55,56] from the same group describe Notch-dependent generation of Treg cells and show that these cells express enhanced IL-10 and TGF13.
- MAEKAWA Y, TSUKUMO S, CHIBA S et al.: Deltal-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity (2003) 19:549–559.
- AMSEN D, BLANDER JM, LEE GR, TANIGAKI K, HONJO T, FLAVELL RA: Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell (2004) 117:515–526.
- •Important study linking Notch to TH1/ TH2 differentiation, though may overlook dose-dependent effects of Notch ligand-induced signals. Provides strong evidence for Notch regulation of IL-4 production.
- EAGAR TN, TANG Q, WOLFE M, HEY, PEAR WS, BLUESTONE JA: Notch 1 signaling regulates peripheral T cell activation. Immunity (2004) 20:407–415.
- ••Provides the first molecular mode of actionfor Notch function in T-cells, Akt inhibition.
- PALAGA T, MIELE L, GOLDE TE, OSBORNE BA: TCR-mediated notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J. Immunol. (2003) 171:3019–3024.
- ADLER SH, CHIFFOLEAU E, XU L et al: Notch signaling augments T cell responsiveness by enhancing CD25 expression. J. Immunol (2003) 171:2896–2903.
- MCKENZIE GJ, YOUNG LL, BRIEND E, LAMB JR, DALLMAN MJ, CHAMPION BR: Notch signalling in the regulation of peripheral T-cell function. Semin. Cell Dev. Biol. (2003) 14:127–134.
- CHENG P, ZLOBIN A, VOLGINA V et al: Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells. J. Immunol (2001) 167:4458–4467.
- SWIATEK PJ, LINDSELL CE, DEL AMO FE WEINMASTER G, GRIDLEY T: Notchl is essential for postimplantation development in mice. Genes Dev. (1994) 8:707–719.
- TACCHINI-COTTIER F, ALLENBACH C, OTTEN LA, RADTKE F: Notch1 expression on T cells is not required for CD4+ T helper differentiation. Eur. Immunol (2004) 34:1588–1596.
- SCHEID MP, WOODGETT JR: PKB/AKT: functional insights from genetic models. Nat. Rev. Mol. Cell Biol. (2001) 2:760–768.
- KANE LP, ANDRES PG, HOWLAND KC, ABBAS AK, WEISS A: Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat. Immunol. (2001) 2:37–44.
- MACIAN F, GARCIA-COZAR F, IM SH, HORTON HF, BYRNE MC, RAO A: Transcriptional mechanisms underlying lymphocyte tolerance. Cell (2002) 109:719–731.
- •Provides molecular insight into an in vitro tolerance model.
- MACIAN F, IM SH, GARCIA-COZAR FJ, RAO A: T-cell anergy. Curr. Opin. Immunol. (2004) 16:209–216.
- BENSINGER SJ, WALSH PT, ZHANG J et al.: Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. Immunol (2004) 172:5287–5296.
- CHU J, BRESNICK EH: Evidence that C promoter-binding factor 1 binding is required for Notch-l-mediated repression of activator protein-1.j. Biol. Chem. (2004) 279:12337–12345.
- GROUX H, O'GARRA A, BIGLER M et al.: A CDEVT-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 389:737–742.
- •Describes in vitro generation of Treg cells which can cure colitis in vivo.
- LI L, MILNER LA, DENG Y et al: The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity (1998) 8:43–55.
- FAUX CH, TURNLEY AM, EPA R, CAPPAI R, BARTLETT PF: Interactions between fibroblast growth factors and Notch regulate neuronal differentiation. Neurosci. (2001) 21:5587–5596.
- ZLOBIN A, JANG M, MIELE L: Toward the rational design of cell fate modifiers: notch signaling as a target for novel biopharmaceuticals. Curr. Pharm. Biotechnol (2000) 1:83–106.
- CHEN N, GREENWALD I: The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant
- •• secreted and transmembrane DSL proteins. Dev. Cell (2004) 6:183–192.
- HICKS C, LADI E, LINDSELL C et al: A secreted Deltal-Fc fusion protein functions both as an activator and inhibitor of Notchl signaling. J. Neurosci. Res. (2002) 68:655–67.
- SUN X, ARTAVANIS-TSAKONAS S: Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development (1997) 124:3439–3448.
- VARNUM-FINNEY B, WU L, YU M et al.: Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. Cell Sci. (2000) 113\(Pt.23):4313–4318.
- ADA G, RAMSHAW I: DNA vaccination. Expert Opin. Emerg. Drugs (2003) 8:27–35.
- DEAN HJ, FULLER D, OSORIO JE: Powder and particle-mediated approaches for delivery of DNA and protein vaccines into the epidermis. Comp. Immunol Microbial. Infect. Dis. (2003) 26:373–388.
- BOUSSIF O, LEZOUALC'H F, ZANTA MA et al.: A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Nati Acad. Sci.USA (1995) 92:7297–7301.
- WAGNER E, ZENKE M, COTTEN M, BEUG H, BIRNSTIEL ML: Transferrin-polycation conjugates as carriers for DNA uptake into cells. Proc. Natl. Acad. Sci.USA (1990) 87:3410–3414.
- MAPARA MY, SYKES M: Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance. J. Clia Oncol (2004) 22:1136–1151.
- WOO EY, YEH H, CHU CS et al: Cuttingedge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol (2002) 168:4272–4276.
- CURIEL TJ, COUKOS G, ZOU L et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. (2004) 10:942–949.
- ••Together, these two studies [85,86]demonstrate that tumours subvert can T, function to evade immune surveillance; provides key validation for T„-directed therapies in oncology.
- GARCES C, RUIZ-HIDALGO MJ, DE MORA JF et al.: Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J. Biol. Chem. (1997) 272:29729–29734.
- HANNON GJ: RNA interference. Nature (2002) 418:244–251.
- •Excellent all-round review of RNAi biology and therapeutic potential.
- HILL JA, ICHIM TE, KUSZNIERUK KP et al.: Immune Modulation by Silencing IL-12 Production in Dendritic Cells Using Small Interfering RNA. J. Immunol. (2003) 171:691–696.
- MOLONEY DJ, PANIN VM, JOHNSTON SH et al: Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 406:369–375.
- MUNRO S, FREEMAN M: The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Curr. Biol. (2000) 10:813–820.
- RAUSKOLB C, CORREIA T, IRVINE KD: Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing. Nature (1999) 401:476–480.
- OKAJIMA T, IRVINE KD: Regulation of notch signaling by o-linked fucose. Cell (2002) 111:893–904.
- KOCH U, LACOMBE TA, HOLLAND D et al.: Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1. Immunity (2001) 15:225–236.
- BERTOZZI CR, KIESSLING LL: Chemical glycobiology. Science (2001) 291:2357–2364.
- LAI EC: Protein degradation: four E3s forthe notch pathway. Curr. Biol. (2002) 12:R74–R78.
- WU G, LYAPINA S, DAS I et al: SEL-10 isan inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol. Cell. Biol. (2001) 21:7403–7415.
- HUBBARD EJ, WU G, KITAJEWSKI J, GREENWALD I: sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. (1997) 11:3182–3193.
- OBERG C, LI J, PAULEY A, WOLF E, GURNEY M, LENDAHL U: The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J. Biol. Chem. (2001) 276:35847–35853.
- ZHONG W, FEDER JN, JIANG MM, JAN LY, JAN YN: Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis. Neuron (1996) 17:43–53.
- GUO M, JAN LY, JAN YN: Control of daughter cell fates during asymmetric division: interaction of Numb and Notch. Neuron (1996) 17:27–41.
- SPANA EP, DOE CQ: Numb antagonizes Notch signaling to specify sibling neuron cell fates. Neuron (1996) 17:21–26.
- NIE J, MCGILL MA, DERMER M, DHO SE, WOLTING CD, MCGLADE CJ: LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. EMBO J. (2002) 21:93–102.
- QIU L, JOAZEIRO C, FANG N et al: Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. J. Biol. Chem. (2000) 275:35734–35737.
- MCGILL MA, MCGLADE CJ: Mammalian numb proteins promote Notchl receptor ubiquitination and degradation of the Notchl intracellular domain. Biol. Chem. (2003) 278:23196–23203.
- •Fascinating study linking Notch, Numb and Itch; has implications for Notch and anergy.
- HEISSMEYER V, MACIAN F, IM SH et al: Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signalling proteins. Nat. Immunol (2004) 5:255–265.
- PERRY WL, HUSTAD CM, SWING DA, O'SULLIVAN TN, JENKINS NA, COPELAND NG: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in al8H mice. Nat. Genet. (1998) 18:143–146.
- NARAMURA M, JANG IK, KOLE H, HUANG F, HAINES D, GU H: c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation. Nat. Immunol. (2002) 3:1192–1199.
- JEHN BM, DITTERT I, BEYER S, VON DER MARK K, BIELKE W: c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane- associated Notchl. J. Biol. Chem. (2002) 277:8033–8040.
- PAVLOPOULOS E, PITSOULI C, KLUEG KM, MUSKAVITCH MA,
- •• MOSCHONAS NK, DELIDAKIS C: neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis. Dev. Cell (2001) 1:807–816.
- DEBLANDRE GA, LAI EC, KINTNER C: Xenopus neuralized is a ubiquitin ligase that interacts with XDeltal and regulates Notch signaling. Dev. Cell (2001) 1:795–806.
- YEH E, DERMER M, COMMISSO C, ZHOU L, MCGLADE CJ, BOULIANNE GL: Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr. Biol. (2001) 11:1675–1679.
- ITOH M, KIM CH, PALARDY G et al: Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell (2003) 4:67–82.
- •Proposes a novel transendocytosis mechanism for Notch signalling mediated by ubiquitin ligases.
- OVERSTREET E, FITCH E, FISCHER JA: Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells. Development (2004) 131:5355–5366.
- WANG W, STRUHL G: Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. Development (2004) 131:5367–5380.
- TIAN X, HANSEN D, SCHEDL T, SKEATH JB: Epsin potentiates Notch pathway activity in Drosophila and C. elegans. Development (2004) 131:5807–5815.
- ••These three important papers [114-116]provide compelling data which extends the transendocytosis model of Notch signalling by identifying Epsin/Lqf and its regulator Far as a core component of the pathway.
- WENDLAND B: Epsins: adaptors in endocytosis? Nat. Rev Mol. Cell Biol. (2002) 3:971–977.
- SUN Y: Targeting E3 ubiquitin ligases for cancer therapy. Cancer. Biol. Ther. (2003) 2:623–629.
- ROBINSON PA, ARDLEY HC: Ubiquitin-protein ligases-novel therapeutic targets? Curr. Protein Pept. Sci. (2004) 5:163–176.
- ROBEY EA, BLUESTONE JA: Notch signaling in lymphocyte development and function. Curr. Opin. Immunol. (2004) 16:360–366.
- RADTKE F, WILSON A, MANCINI SJ, MACDONALD HR: Notch regulation of lymphocyte development and function. Nat. Immunol. (2004) 5:247-253. Affiliation