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Review

Emerging safety issues regarding long-term usage of H1-receptor antagonists

Pages 225-235 | Published online: 23 Feb 2005

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  • ••An important molecular-based studydemonstrating that cardiotoxicity by antihistamines via blockade of K± channels is not a property common to all second generation drugs.
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  • •A very nice review comparing desloratadine with the parent compound loratadine.
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  • •A very good overview of the anti-allergic and anti-inflammatory effects of desloratadine.
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  • •This study shows that desloratadine can relieve nasal congestion in allergic rhinitis.
  • Data on file, Schering-Plough, Kenilworth, NJ, USA.
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  • SYMPSON K, JARVIS B: Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria. Dugs (2000) 59:301–321.
  • •Comprehensive review on fexofenadine.
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  • •This study demonstrates the positive effects of fexofenadine on nasal blockade in allergic rhinitis.
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  • HINDMARCH I, SHAMSI Z, STANLEY N, FAIRWEATHER DB: A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function. Br. j Clin. Pharmacol. (1999) 48(2)200–206.
  • NICHOLSON AN, STONE BM, TURNER C, MILLS SL: Antihistamines and aircrew: usefulness of fexofenadine. Aviat. Space Environ. Med. (2000) 71:2–6.
  • HINDMARCH I, SHAMSI Z, KIMBER S: An evaluation of the effects of high dose fexofenadine on the rental nervous system: a
  • •• double-blind, placebo controlled study in healthy volunteers. Clin. Exp. Allergy (2002) 32:133–139.
  • •A well-performed study on the CNS effects of high doses of fexofenadine given to healthy volunteers.
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  • •Demonstrates fexofenadine to be safe and efficacious in children with seasonal allergic rhinitis.
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  • •Comprehesive study comparing levocetirizine with the parent compound cetirizine for their effects on histamine-induced nasal response.
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