A systematic review of the safety of probiotics

Bibliography

• Lopez-Varela S, Gonzalez-Gross M, Marcos A. Functional foods and the immune system: a review. Eur J Clin Nutr 2002;56:S29-33
   PubMed Web of Science ®Google Scholar
• Lourens-Hattingh A, Viljoen BC. Yogurt as probiotic carrier food. Int Dairy J 2001;11:1-17
   Web of Science ®Google Scholar
• Lavermicocca P, Valerio F, Lonigro SL, et al. Study of adhesion and survival of lactobacilli and bifidobacteria on table olives with the aim of formulating a new probiotic food. Appl Environ Microbiol 2005;71:4233-40
   PubMed Web of Science ®Google Scholar
• Shimakawa Y, Matsubara S, Yuki N, et al. Evaluation of Bifidobacterium breve strain Yakult-fermented soymilk as a probiotic food. Int J Food Microbiol 2003;81:131-6
   PubMed Web of Science ®Google Scholar
• Yuvaraj S, Peppelenbosch MP, Bos NA. Transgenic probiotica as drug delivery systems: the golden bullet? Expert Opin Drug Deliv 2007;4:1-3
   PubMed Web of Science ®Google Scholar
• Sutton A. Product development of probiotics as biological drugs. Clin Infect Dis 2008;46:128-32
   Google Scholar
• Zuccotti GV, Meneghin F, Raimondi C, et al. Probiotics in clinical practice: an overview. J Int Med Res 2008;36:1-53
   PubMed Web of Science ®Google Scholar
• de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 2008;111:1-66
   PubMed Web of Science ®Google Scholar
• Davis CD, Milner JA. Gastrointestinal microflora, food components and colon cancer prevention. J Nutr Biochem 2009;20:743-52
   PubMed Web of Science ®Google Scholar
• Nikfar S, Rahimi R, Rahimi F, et al. Efficacy of probiotics in irritable bowel syndrome: a meta-analysis of randomized, controlled trials. Dis Colon Rectum 2008;51:1775-80
   PubMed Web of Science ®Google Scholar
• Hosseini A, Nikfar S, Abdollahi M. Are probiotics effective in management of irritable bowel syndrome. Arch Med Sci 2012;8:403-5
   PubMed Web of Science ®Google Scholar
• Hosseini A, Nikfar S, Abdollahi M. Probiotics use to treat irritable bowel syndrome. Expert Opin Biol Ther 2012;12:1323-34
   PubMed Web of Science ®Google Scholar
• Rahimi R, Nikfar S, Rahimi F, et al. A meta-analysis on the efficacy of probiotics for maintenance of remission and prevention of clinical and endoscopic relapse in Crohn's disease. Dig Dis Sci 2008;53:2524-31
   PubMed Web of Science ®Google Scholar
• Ghasemi-Niri S, Abdolghaffari A, Fallah-Benakohal S, et al. On the benefit of whey-cultured Lactobacillus casei in murine colitis. J Physiol Pharmacol 2011;62:341-6
   PubMed Web of Science ®Google Scholar
• Ghasemi-Niri SF, Solki S, Didari T, et al. Better efficacy of lactobacillus casei in combination with bifidobacterium bifidum or saccharomyces boulardii in recovery of inflammatory markers of colitis in rat. Asian J Anim Vet Adv 2012;7:1148-56
   Web of Science ®Google Scholar
• Saadatzadeh A, Atyabi F, Fazeli MR, et al. Biochemical and pathological evidences on the benefit of a new biodegradable nanoparticles of probiotic extract in murine colitis. Fundam Clin Pharmacol 2012;26:589-98
   PubMed Web of Science ®Google Scholar
• Gareau MG, Sherman PM, Walker WA. Probiotics and the gut microbiota in intestinal health and disease. Nat Rev Gastroenterol Hepatol 2010;7:503-14
   PubMed Web of Science ®Google Scholar
• Luedtke SA, Yang JT, Wild HE. Probiotics and Necrotizing Enterocolitis: finding the Missing Pieces of the Probiotic Puzzle. J Pediatr Pharmacol Ther 2012;17:308-28
   Google Scholar
• Elahi B, Nikfar S, Derakhshani S, et al. On the benefit of probiotics in the management of pouchitis in patients underwent ileal pouch anal anastomosis: a meta-analysis of controlled clinical trials. Dig Dis Sci 2008;53:1278-84
   PubMed Web of Science ®Google Scholar
• Salari P, Nikfar S, Abdollahi M. A meta-analysis and systematic review on the effect of probiotics in acute diarrhea. Inflamm Allergy Drug Targets 2012;11:3-14
   PubMedGoogle Scholar
• Murdock F, Fields M. B-vitamin content of natural lactic acid fermented cornmeal. J Food Sci 1984;49:373-5
   Web of Science ®Google Scholar
• de Vrese M, Marteau PR. Probiotics and prebiotics: effects on diarrhea. J Nutr 2007;137:803-11
   PubMed Web of Science ®Google Scholar
• Sharp RR, Achkar J-P, Brinich MA, Farrell RM. Helping patients make informed choices about probiotics: a need for research. Am J Gastroenterol 2009;104:809-13
   PubMed Web of Science ®Google Scholar
• Gratz SW, Mykkanen H, El-Nezami HS. Probiotics and gut health: a special focus on liver diseases. World J Gastroenterol 2010;16:403-10
   PubMed Web of Science ®Google Scholar
• Fukuda S, Toh H, Hase K, et al. Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 2011;469:543-7
   PubMed Web of Science ®Google Scholar
• Aureli P, Capurso L, Castellazzi AM, et al. Probiotics and health: an evidence-based review. Pharmacol Res 2011;63:366-76
   PubMed Web of Science ®Google Scholar
• Morishita T, Tamura N, Makino T, Kudo S. Production of menaquinones by lactic acid bacteria. J Dairy Sci 1999;82:1897-903
   PubMed Web of Science ®Google Scholar
• Molinaro F, Paschetta E, Cassader M, et al. Probiotics, prebiotics, energy balance, and obesity: mechanistic insights and therapeutic implications. Gastroenterol Clin North Am 2012;41:843-54
   PubMed Web of Science ®Google Scholar
• Isolauri E, Rautava S, Salminen S. Probiotics in the development and treatment of allergic disease. Gastroenterol Clin North Am 2012;41:747-62
   PubMed Web of Science ®Google Scholar
• Rautava S. Potential uses of probiotics in the neonate. Semin Fetal Neonatal Med 2007;12:45-53
   PubMed Web of Science ®Google Scholar
• Wagner R, Balish E. Potential hazards of probiotic bacteria for immunodeficient patients. Bull de l'Inst Pasteur 1998;96:165-70
   Google Scholar
• Marteau P, Shanahan F. Basic aspects and pharmacology of probiotics: an overview of pharmacokinetics, mechanisms of action and side-effects. Best Pract Res Clin Gastroenterol 2003;17:725-40
   PubMed Web of Science ®Google Scholar
• Taranto MP, Vera JL, Hugenholtz J, et al. Lactobacillus reuteri CRL1098 produces cobalamin. J Bacteriol 2003;185:5643-7
   PubMed Web of Science ®Google Scholar
• Salminen MK, Tynkkynen S, Rautelin H, et al. Lactobacillus bacteremia during a rapid increase in probiotic use of Lactobacillus rhamnosus GG in Finland. Clin Infect Dis 2002;35:1155-60
   PubMed Web of Science ®Google Scholar
• Saxelin M, Chuang N-H, Chassy B, et al. Lactobacilli and bacteremia in southern Finland, 1989–1992. Clin Infect Dis 1996;22:564-6
   PubMed Web of Science ®Google Scholar
• Candy DC, Densham L, Lamont LS, et al. Effect of administration of Lactobacillus casei shirota on sodium balance in an infant with short bowel syndrome. J Pediatr Gastroenterol Nutr 2001;32:506-8
   PubMed Web of Science ®Google Scholar
• Bonsante F, Iacobelli S, Gouyon JB. Routine probiotic use in very preterm infants: retrospective comparison of two cohorts. Am J Perinatol 2013;30:41-6
   PubMed Web of Science ®Google Scholar
• Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM. 17938 for the Management of Infantile Colic in Breastfed Infants: a randomized, double-blind, placebo-controlled trial. J Pediatr 2013;162:257-62
   PubMed Web of Science ®Google Scholar
• Narayanappa D. Randomized double blinded controlled trial to evaluate the efficacy and safety of Bifilac in patients with acute viral diarrhea. Indian J Pediatr 2008;75:709-13
   PubMed Web of Science ®Google Scholar
• Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr 2010;156:679-81
   PubMed Web of Science ®Google Scholar
• Perapoch J, Planes A, Querol A, et al. Fungemia with Saccharomyces cerevisiae in two newborns, only one of whom had been treated with ultra-levura. Eur J Clin Microbiol Infect Dis 2000;19:468-70
   PubMed Web of Science ®Google Scholar
• Alberda C, Gramlich L, Meddings J, et al. Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2007;85:816-23
   PubMed Web of Science ®Google Scholar
• Gionchetti P, Rizzello F, Venturi A, et al. Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterology 2000;119:305-9
   PubMed Web of Science ®Google Scholar
• Besselink M, van Santvoort H, Buskens E, et al. Probiotic prophylaxis in patients with predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Ned Tijdschr Geneeskd 2008;152:685-96
   PubMedGoogle Scholar
• Kukkonen K, Savilahti E, Haahtela T, et al. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial. Pediatrics 2008;122:8-12
   PubMed Web of Science ®Google Scholar
• de Regt MJ, Willems RJ, Hené RJ, et al. Effects of probiotics on acquisition and spread of multiresistant enterococci. Antimicrob Agents Chemother 2010;54:2801-5
   PubMed Web of Science ®Google Scholar
• Laitinen K, Poussa T, Isolauri E. Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. Br J Nutr 2009;101:1679-87
   PubMed Web of Science ®Google Scholar
• Canani RB, Cirillo P, Terrin G, et al. Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations. BMJ 2007;335:340
   PubMed Web of Science ®Google Scholar
• Henker J, Laass M, Blokhin BM, et al. The probiotic Escherichia coli strain Nissle 1917 (EcN) stops acute diarrhoea in infants and toddlers. Eur J Pediatr 2007;166:311-18
   PubMed Web of Science ®Google Scholar
• Salminen MK, Rautelin H, Tynkkynen S, et al. Lactobacillus bacteremia, clinical significance, and patient outcome, with special focus on probiotic L. rhamnosus GG. Clin Infect Dis 2004;38:62-9
   PubMed Web of Science ®Google Scholar
• Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81
   PubMed Web of Science ®Google Scholar
• Cassone M, Serra P, Mondello F, et al. Outbreak of Saccharomyces cerevisiae subtype boulardii fungemia in patients neighboring those treated with a probiotic preparation of the organism. J Clin Microbiol 2003;41:5340-3
   PubMed Web of Science ®Google Scholar
• Zhou J, Shu Q, Rutherfurd K, et al. Safety assessment of potential probiotic lactic acid bacterial strains Lactobacillus rhamnosus HN001, Lb. acidophilus HN017, and Bifidobacterium lactis HN019 in BALB/c mice. Int J Food Microbiol 2000;56:87-96
   PubMed Web of Science ®Google Scholar
• Zhou J, Shu Q, Rutherfurd K, et al. Acute oral toxicity and bacterial translocation studies on potentially probiotic strains of lactic acid bacteria. Food Chem Toxicol 2000;38:153-61
   PubMed Web of Science ®Google Scholar
• Rinkinen M, Jalava K, Westermarck E, et al. Interaction between probiotic lactic acid bacteria and canine enteric pathogens: a risk factor for intestinal Enterococcus faecium colonization? Vet Microbiol 2003;92:111-19
   PubMed Web of Science ®Google Scholar
• Soo I, Madsen KL, Tejpar Q, et al. VSL# 3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation. Can J Gastroenterol 2008;22:237-42
   PubMed Web of Science ®Google Scholar
• Jones ML, Martoni CJ, Tamber S, et al. Evaluation of safety and tolerance of microencapsulated Lactobacillus reuteri NCIMB 30242 in a yogurt formulation: a randomized, placebo-controlled, double-blind study. Food Chem Toxicol 2012;50:2216-23
   PubMed Web of Science ®Google Scholar
• Lorea Baroja M, Kirjavainen P, Hekmat S, Reid G. Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients. Clin Exp Immunol 2007;149:470-9
   PubMed Web of Science ®Google Scholar
• Weichselbaum E. Potential benefits of probiotics-main findings of an in-depth review. Br J Community Nurs 2010;15:110-14
   PubMedGoogle Scholar
• Honeycutt TC, El Khashab M, Wardrop RM III, et al. Probiotic administration and the incidence of nosocomial infection in pediatric intensive care: a randomized placebo-controlled trial. Pediatr Crit Care Med 2007;8:452-8
   PubMed Web of Science ®Google Scholar
• Saarela M, Mogensen G, Fondén R, et al. Probiotic bacteria: safety, functional and technological properties. J Biotechnol 2000;84:197-215
   PubMed Web of Science ®Google Scholar
• Boyle R, Bath-Hextall F, Leonardi-Bee J, et al. Probiotics for the treatment of eczema: a systematic review. Clin Exp Immunol 2009;39:1117-27
   Web of Science ®Google Scholar
• Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics 2010;125:921-30
   PubMed Web of Science ®Google Scholar
• Kataria J, Li N, Wynn JL, Neu J. Probiotic microbes: do they need to be alive to be beneficial? Nutr Rev 2009;67:546-50
   PubMed Web of Science ®Google Scholar
• Marcobal A, Underwood MA, Mills DA. Rapid determination of the bacterialcomposition of commercial probiotic products by terminal restriction fragmentlength polymorphism analysis. J Pediatr Gastroenterol Nutr 2008;46:608-11
   PubMed Web of Science ®Google Scholar
• Salminen S, Isolauri E. Intestinal colonization, microbiota, and probiotics. J Pediatr 2006;149:115-20
   Web of Science ®Google Scholar
• Eckburg PB, Bik EM, Bernstein CN, et al. Diversity of the human intestinal microbial flora. Science 2005;308:1635-8
   PubMed Web of Science ®Google Scholar
• Franz CM, Huch M, Abriouel H, et al. Enterococci as probiotics and their implications in food safety. Int J Food Microbiol 2011;151:125-40
   PubMed Web of Science ®Google Scholar
• Forestier C, Guelon D, Cluytens V, et al. Oral probiotic and prevention of Pseudomonas aeruginosa infections: a randomized, double-blind, placebo-controlled pilot study in intensive care unit patients. Crit Care 2008;12:R69
   PubMed Web of Science ®Google Scholar
• Klarin B, Wullt M, Palmquist I, et al. Lactobacillus plantarum 299v reduces colonisation of Clostridium difficile in critically ill patients treated with antibiotics. Acta Anaesthesiol Scand 2008;52:1096-102
   PubMed Web of Science ®Google Scholar
• Manzoni P, Mostert M, Leonessa M, et al. Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clin Infect Dis 2006;42:1735-42
   PubMed Web of Science ®Google Scholar
• Rayes N, Hansen S, Seehofer D, et al. Early enteral supply of fiber and Lactobacilli versus conventional nutrition: a controlled trial in patients with major abdominal surgery. Nutrition 2002;18:609-15
   PubMed Web of Science ®Google Scholar
• Rayes N, Seehofer D, Hansen S, et al. Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation 2002;74:123-8
   PubMed Web of Science ®Google Scholar
• Qin H, Zheng J, Tong D, et al. Effect of Lactobacillus plantarum enteral feeding on the gut permeability and septic complications in the patients with acute pancreatitis. Eur J Clin Nutr 2007;62:923-30
   PubMed Web of Science ®Google Scholar
• Fukushima Y, Miyaguchi S, Yamano T, et al. Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533). Br J Nutr 2007;98:969-77
   PubMed Web of Science ®Google Scholar
• Millar M, Bacon C, Smith S, et al. Enteral feeding of premature infants with Lactobacillus GG. Arch Dis Child 1993;69:483-7
   PubMed Web of Science ®Google Scholar
• Srinivasan R, Meyer R, Padmanabhan R, Britto J. Clinical safety of Lactobacillus casei shirota as a probiotic in critically ill children. J Pediatr Gastroenterol Nutr 2006;42:171-3
   PubMed Web of Science ®Google Scholar
• Klarin B, Johansson M-L, Molin G, et al. Adhesion of the probiotic bacterium Lactobacillus plantarum 299v onto the gut mucosa in critically ill patients: a randomised open trial. Crit Care 2005;9:R285
   PubMed Web of Science ®Google Scholar
• Kunz AN, Noel JM, Fairchok MP. Two cases of Lactobacillus bacteremia during probiotic treatment of short gut syndrome. J Pediatr Gastroenterol Nutr 2004;38:457-8
   PubMed Web of Science ®Google Scholar
• De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80
   PubMed Web of Science ®Google Scholar
• Kitajima H, Sumida Y, Tanaka R, et al. Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 1997;76:101-7
   PubMed Web of Science ®Google Scholar
• Li Y, Shimizu T, Hosaka A, et al. Effects of Bifidobacterium breve supplementation on intestinal flora of low birth weight infants. Pediatr Int 2004;46:509-15
   PubMed Web of Science ®Google Scholar
• Wang C, Shoji H, Sato H, et al. Effects of oral administration of Bifidobacterium breve on fecal lactic acid and short-chain fatty acids in low birth weight infants. J Pediatr Gastroenterol Nutr 2007;44:252-7
   PubMed Web of Science ®Google Scholar
• Mihatsch WA, Vossbeck S, Franz AR, Kron M. Effect of enteral administration of a probiotic strain of bifidobacteria on the incidence of nosocomial infections in preterm infants. Pediatr Res 2004;55:448
   Google Scholar
• Whorwell PJ, Altringer L, Morel J, et al. Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome. Am J Gastroenterol 2006;101:1581-90
   PubMed Web of Science ®Google Scholar
• Samanta M, Sarkar M, Ghosh P, et al. Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns. J Trop Pediatr 2009;55:128-31
   PubMed Web of Science ®Google Scholar
• Rougé C, Piloquet H, Butel M-J, et al. Oral supplementation with probiotics in very-low-birth-weight preterm infants: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2009;89:1828-35
   PubMed Web of Science ®Google Scholar
• Underwood MA, Salzman NH, Bennett SH, et al. A Randomized placebo-controlled comparison of two prebiotic/probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short chain fatty acids. J Pediatr Gastroenterol Nutr 2009;48:216-25
   PubMed Web of Science ®Google Scholar
• Lin H-C, Su B-H, Chen A-C, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics 2005;115:1-4
   PubMed Web of Science ®Google Scholar
• Lin H-C, Hsu C-H, Chen H-L, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics 2008;122:693-700
   PubMed Web of Science ®Google Scholar
• Sugawara G, Nagino M, Nishio H, et al. Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial. Ann Surg 2006;244:706-14
   PubMed Web of Science ®Google Scholar
• Hoyos AB. Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis 1999;3:197-202
   PubMedGoogle Scholar
• Shimizu K, Ogura H, Goto M, et al. Synbiotics decrease the incidence of septic complications in patients with severe SIRS: a preliminary report. Dig Dis Sci 2009;54:1071-8
   PubMed Web of Science ®Google Scholar
• Costalos C, Skouteri V, Gounaris A, et al. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum Dev 2003;74:89-96
   PubMed Web of Science ®Google Scholar
• Bleichner G, Blehaut H, Mentec H, Moyse D. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. Intensive Care Med 1997;23:517-23
   PubMed Web of Science ®Google Scholar
• Schneider SM, Girard-Pipau F, Filippi J, et al. Effects of Saccharomyces boulardii on fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition. World J Gastroenterol 2005;11:6165-9
   PubMed Web of Science ®Google Scholar
• McFarland LV, Surawicz CM, Greenberg RN, et al. A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA 1994;271:1913-18
   PubMed Web of Science ®Google Scholar
• Lungarotti M, Mezzetti D, Radicioni M. Methaemoglobinaemia with concurrent blood isolation of Saccharomyces and Candida. Arch Dis Child Fetal Neonatal Ed 2003;88:F446
   PubMed Web of Science ®Google Scholar
• Lolis N, Veldekis D, Moraitou H, et al. Saccharomyces boulardii fungaemia in an intensive care unit patient treated with caspofungin. Crit Care 2008;12:414
   PubMed Web of Science ®Google Scholar
• Pletincx M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-15
   PubMed Web of Science ®Google Scholar
• Viggiano M, Badetti C, Bernini V, et al. Saccharomyces boulardii fungemia in a patient with severe burns. Ann Fr Anesth Reanim 1995;14:356-8
   PubMed Web of Science ®Google Scholar
• Burkhardt O, Köhnlein T, Pletz MW, Welte T. Saccharomyces boulardii induced sepsis: successful therapy with voriconazole after treatment failure with fluconazole. Scand J Infect Dis 2005;37:69-72
   PubMed Web of Science ®Google Scholar
• Zunic P, Lacotte J, Pegoix M, et al. Saccharomyces boulardii fungemia. Apropos of a case. Therapie 1991;46:498-9
   PubMed Web of Science ®Google Scholar
• Lestin F, Pertschy A, Rimek D. Fungemia after oral treatment with Saccharomyces boulardii in a patient with multiple comorbidities. Dtsch Med Wochenschr 2003;128:2531-3
   PubMed Web of Science ®Google Scholar
• Fredenucci I, Chomarat M, Boucaud C, Flandrois J. Saccharomyces boulardii fungemia in a patient receiving Ultra-levure therapy. Clin Infect Dis 1998;27:222-3
   PubMed Web of Science ®Google Scholar
• Hennequin C, Kauffmann-Lacroix C, Jobert A, et al. Possible role of catheters in Saccharomyces boulardii fungemia. Eur J Clin Microbiol Infect Dis 2000;19:16-20
   PubMed Web of Science ®Google Scholar
• Lherm T, Monet C, Nougière B, et al. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28:797-801
   PubMed Web of Science ®Google Scholar
• Henry S, D'Hondt L, Andre M, et al. Saccharomyces cerevisiae fungemia in a head and neck cancer patient: a case report and review of the literature. Acta Clin Belg 2004;59:220-2
   PubMed Web of Science ®Google Scholar
• Muñoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34
   PubMed Web of Science ®Google Scholar
• Rijnders B, Van Wijngaerden E, Verwaest C, Peetermans W. Saccharomyces fungemia complicating Saccharomyces boulardii treatment in a non-immunocompromised host. Intensive Care Med 2000;26:825
   PubMed Web of Science ®Google Scholar
• Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930
   PubMed Web of Science ®Google Scholar
• Cherifi S, Robberecht J, Miendje Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg 2004;59:223-4
   PubMed Web of Science ®Google Scholar
• Bin-Nun A, Bromiker R, Wilschanski M, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr 2005;147:192-6
   PubMed Web of Science ®Google Scholar
• Giamarellos-Bourboulis EJ, Bengmark S, Kanellakopoulou K, Kotzampassi K. Pro-and synbiotics to control inflammation and infection in patients with multiple injuries. J Trauma 2009;67:815-21
   PubMed Web of Science ®Google Scholar
• Knight DJ, Gardiner D, Banks A, et al. Effect of synbiotic therapy on the incidence of ventilator associated pneumonia in critically ill patients: a randomised, double-blind, placebo-controlled trial. Intensive Care Med 2009;35:854-61
   PubMed Web of Science ®Google Scholar
• Waitzberg DL, Logullo LC, Bittencourt AF, et al. Effect of synbiotic in constipated adult women–a randomized, double-blind, placebo-controlled study of clinical response. Clin Nutr 2012;32:27-33
   PubMed Web of Science ®Google Scholar