1,948
Views
7
CrossRef citations to date
0
Altmetric
Editorial

Efficacy and safety of dual opioid therapy

Bibliography

  • Gregorian RS, Gasik A, Kwong WJ, et al. Important of side effects in opioid treatment: a trade off analysis with patients and physicians. J Pain 2010;11:1095-108
  • Webster L. Efficacy and safety of dual-opioid therapy in acute pain. Pain Med 2012;13:S12-20
  • Pasternak GW, Pan YX. Mu opioids and their receptors: evolution of a concept. Pharmacol Rev 2013;65:1257-317
  • Davis MP. Evidence from basic research for opioid combinations. Expert Opin Drug Discov 2012;7:165-78
  • Dietis N, Rowbotham DJ, lambert DG. Opioid receptor subtypes: fact or artifact. Br J Anaesth 2011;107:8-18
  • Davis MP. Opioid receptor targeting ligands for pain management: a review and update. Expert Opin Drug Discov 2010;5:1007-22
  • Raehal KM, Schmid CL, Groer CE, Bohn LM. Functional selectivity at the mu-opioid receptor: implications for understanding opioid analgesia and tolerance. Pharmacol Rev 2011;63:1001-19
  • Smith MT. Differences between and combinations of opioid re-visited. Curr Opin Anesthesiol 2008;21:596-601
  • Pasternak GW. Preclinical pharmacology and opioid combination. Pain Med 2012;13:S4-11
  • Bolan EA, Tallarida RJ, Pasternak GW. Synergy between µ opioid ligands: evidence for functional interactions among µ opioid receptor subtypes. J Pharmacol Exp Ther 2002;303:557-62
  • Ross F, Wallis S, Smith MT. Co-administration of sub-nociceptive doses of oxycodone and morphine produces marked antinociceptive synergy with reduced CNS side-effects in rats. Pain 2000;84:421-8
  • Nakamura A, Hasegawa M, Ninami K, et al. Differential activation of the mu-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model. Br J Pharmacol 2013;168:375-88
  • Staahl C, Dimcevsky G, Andersen SD, et al. Different effect of opioids in patients with chronic pancreatitis: an experimental pain study. Scand J Gastroenterol 2007;42:383-90
  • Ladd LA, Kam PC, Williams DB, et al. Ventilatory responses of healthy subjects to intravenous morphine combinations of morphine and oxycodone under imposed hypercapneic and hypoxaemic conditions. Br J Clin Pharmacol 2005;59:524-35
  • Grach M, Massalha W, Pud D, et al. Can coadministration of oxycodone of oxycodone and morphine produce analgesic synergy in humans? An experimental cold pain study. Br J Clin Pharmacol 2004;58:235-42
  • Blumenthal S, Min K, Marquardt M, Borgeat A. Post-operative intravenous morphine consumption, pain scores, and side effects with perioperative oral controlled-release oxycodone after lumbar discectomy. Anesth Analg 2007;105:233-7
  • Webster L, Richards P, Stern W, Kelen R. A double-blind, placebo controlled study of dual-opioid treatment with the combination of morphine plus oxycodone in patients with acute postoperative pain. J Opioid Manage 2010;6:329-40
  • Richards P, Riff D, Kelen R, Stern W. Analgesic and adverse effects of a fixed-ratio morphine-oxycodone combination (MoxDuo) in the treatment of postoperative pain. J Opioid Manage 2011;7:1-12
  • Joppich R, Richards P, Kelen R, et al. Analgesic efficacy and tolerability of intravenous morphine versus combined intravenous morphine and oxycodone in a 2-center, randomized, double-blind, pilot trial of patients with moderate to severe pain after total hip replacement. Clin Ther 2012;34:1751-60
  • Richards P, Gimbel J, Minkowitz HS, et al. Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. Clin Ther 2013;35:498-511
  • Richards P, Riff D, Kelen R, Stern W. A phase 3, randomized, double-blind comparison of analgesic efficacy and tolerability of Q8003 vs oxycodone or morphine for moderate-to-severe postoperative pain following bunionectomy surgery. Pain Med 2013;14:1230-8
  • Di Lorenzo L, Foti C, Forte AM, et al. The addition of tramadol as a second opioid may improve pain relief in severe osteoarthritis: a prospective study. Pain Pract 2010;10:540-7
  • Lauretti GR, Oliveira GM, Pereira NL. Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients. Br J Cancer 2003;89:2027-30
  • Mercadante S, Villari P, Ferrera P, Casuccio A. Addition of a second opioid may improve opioid response in cancer pain. Preliminary data. Support Care Cancer 2004;12:762-6
  • Marinangeli F, Ciccozzi A, Aloisio L, et al. Improved cancer pain treatment using combined fentanyl TTS and tramadol. Pain Pract 2007;7:307-12
  • Mercadante S. Opioid combination: rationale and possible clinical applications. Ann Palliat Med 2013;2:189-96
  • Oderda GM, Said Q, Evans RS, et al. Opioid-related adverse drug events in surgical hospitalization: impact on costs and length of stay. Ann Pharmacother 2007;41:400-6
  • Fallon MT, Laird BJA. A systematic review of combination step III opioid therapy in cancer pain: an EPCRC opioid guideline project. Palliat Med 2010;25:597-603

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.