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Reviews

Sexual dysfunction related to antiepileptic drugs in patients with epilepsy

Yong YangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing400016, China
&
Xuefeng WangDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing400016, ChinaCorrespondence[email protected]
Pages 31-42 | Published online: 11 Nov 2015

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•• A multicenter, double-blind trial to compare the efficacy and safety of carbamazepine, phenytoin, phenobarbital and primidone in the treatment of epilepsy. High incidence of impotence was found for all four AEDs.

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•• A multicenter, double-blind trial to compare the efficacy and safety of carbamazepine valproate in the treatment of epilepsy. High incidence of impotence was found for the two AEDs.

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• A study investigated erection function using the IIEF-5 scale. The result showed both valproate and levetiracetam led to lower scores on questions 1, 2 and 3 of IIEF scale than controls, but did not affect question 4 or 5.

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