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Expert Opinion on Drug Safety Volume 3, 2004 - Issue 4
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Editorial

Gastrointestinal safety of paracetamol: is there any cause for concern?

Bernard Bannwarth Hôpital Pellegrin, Service de Rhumatologie, Hopital Pellegrin, CHU de Bordeaux, 33076 Bordeaux Cedex, France. [email protected]
Pages 269-272 | Published online: 23 Feb 2005

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  • •A study assessing the determinants of paracetamol prescription in clinical practice.
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  • GARCIA RODRIGUEZ LA, HERNANDEZ-DIAZ S: Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs. Epidemiology (2001) 12:570–576.
  • LIPWORTH L, SOREN F, MELLEMKJAER L et al.: A population-based cohort study of mortality among adults prescribed paracetamol in Denmark. J. Clio. Epidemiol. (2003) 56:796–801.
  • ••An illustration of confoundingby indication.
  • LEWIS SC, LANGMAN MJ, LAPORTE JR, MATTHEWS JN, RAWLINS MD, WIHOLM BE: Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious gastrointestinal bleeding: a meta-analysis based on individual patient data. Br. Cl/n. Pharmacol (2002) 54:320–326.
  • ••A clear explanation on how informationabout drug exposure influences the results of case-control studies.
  • LANGMAN MJ, WEIL J, WAINWRIGHT P et al.: Risks of bleeding peptic ulcer associated with non-steroidal anti-inflammatory drugs. Lancet (1994) 343:1075–1078.
  • LANAS A, SERRANO P, BAJADOR E, FUENTES J, SAINZ R: Risk of upper gastrointestinal bleeding associated with non-aspirin cardiovascular drugs, analgesics and nonsteroidal anti-inflammatory drugs. Eurj. Gastroenterol Hepatol. (2003) 15:173–178.
  • ABRAMSON SB: Et tu, acetaminophen? Arthritis Rheum. (2002) 46:2831–2835.
  • ••An evidence-based editorial on GIsafety of paracetamol.
  • CRYER BL: Acetaminophen not associated with gastrointestinal toxicity: comment on the article by Rahme et al. Arthritis Rheum. (2003) 48:2074–2075.
  • BANNWARTH B: Concerns about gastrointestinal safety of acetaminophen: comment on the article by Rahme et al. Arthritis Rheum. (2003) 46:2075.

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