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Review

Safety profile of platinum-based chemotherapy in the treatment of advanced non-small cell lung cancer in elderly patients

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Pages 1051-1067 | Published online: 28 Oct 2005

Bibliography

  • PARKIN DM, BRAY F, FERLAY J, PISANI P: Estimating the world cancer burden: Globocan 2000. Int. J. Cancer (2001) 94:153–156.
  • COLEMAN MP, GATTA G, VERDECCHIA A et al: EUROCARE-3 summary: cancer survival in Europe at the end of 20th century. Ann. Once]. (2003) 14\(Suppl. 5):128–149.
  • BORRAS JM, FERNANDEZ E, GONZALEZ JR et al: Lung cancer mortality in European regions (1955-1997). Ann. Once]. (2003) 14:159–161.
  • TYCZYNSKI JE, BRAY F, PARKIN DM: Lung cancer in Europe in 2000: epidemiology, prevention, and early detection. Lancet Once]. (2003) 4:45–55.
  • JEMAL A, MURRAY T, SAMUELS A, GHAFOOR A, WARD E, THUN MJ: Cancer statistics, 2003. CA. Cancerj Clin. (2003) 53:5–26.
  • SILVERBERG E, LUBERA JA: Cancer statistics. CA. Cancer (1988) 38:5–22.
  • GRIDELLI C, PERRONE F, MONFARDINI S: Lung cancer in the elderly. Eur. J. Cancer (1997) 33:2313–2314.
  • HAVLIK RJ, YANCIK R, LONG S, RIES L, EDWARDS B: The National Cancer Institute on Aging and the National Cancer Institute SEER. Collaborative study on comorbidity and early diagnosis of cancer in the elderly. Cancer (1994) 74\(Suppl. 7):2101–2106.
  • NON-SMALL CELL LUNG CANCER COLLABORATIVE GROUP: Chemotherapy in non small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Br. Med. J. (1995) 311:899–909.
  • ••First meta-analysis performed about chemotherapy of NSCLC.
  • JANSSEN-HEIJNEN MLG, SCHIPPER RIVI, RAZENBERG PPA, CROMMELIN MA, COEBERG JW: Prevalence of co-morbidity in lung cancer patients and its relationship with treatment: a population-based study. Lung Cancer (1998) 21:105–113.
  • EARLE CC, VENDITTI LN, NEUMANN PJ et al.: Who gets chemotherapy for metastatic lung cancer? Chest (2000) 117:1239–1246.
  • RABY B, PATER J, MACKILLOP W: Does knowledge guide practice? Another look at the management of non-small-cell lung cancer. J. Clin. Once]. (1995) 13:1904–1911.
  • CROOK A, DUFFY A, GIRLING DJ, SOUHAMI RL, PARMAR MK: Survey on the treatment of non-small cell lung cancer (NSCLC) in England and Wales. Eur. Respir: J. (1997) 10:1552–1558.
  • BALDUCCI L: Geriatric oncology: challenges for the new century. Eur J. Cancer (2000) 36:1741–1754.
  • TURNER N, SCARPACE PJ, LOWENTAL DT: Geriatric pharmacology: basic and clinical considerations. Ann. Rev Pharmacol Toxicol (1992) 32:271–302.
  • MAYERSOHN M: Pharmacokinetics in the elderly. Environ. Health Perspect. (1994) 102\(Suppl. 11):119–124.
  • LITCHMAN SM, VILLANI G: Chemotherapy in the elderly: pharmacologic considerations. Cancer Control (2000) 7:548–556.
  • BALDUCCI L, STANTA G: Cancer in the frail patients: a coming epidemic. Hematol. Oncol North. Am. (2000) 14:235–250.
  • BALDUCCI L, EXTERMANN M: Management of the frail person with advanced cancer. Crit. Rev. Oncol Hematol (2000) 33:143–148.
  • EVANS WK: Controversies in the management of elderly patients with small-cell lung cancer. America] Socieg, of Clinical Oncolology, 1997 Educational Book, 33rd Annual Meeting, May 17–20 1997, Denver (CO), pp. 376–381.
  • GOODWIN JS, HUNT WC, HUMBLE CG, KEY CR, SAMET JM: Cancer treatment protocols: who gets chosen. Arch. Intern. Med. (1988) 148:2258–2260.
  • SAMET J, HUNT WC, KEY C, HUMBLE CG, GOODWIN JS: Choice of cancer therapy varies with age of patient. JAMA (1986) 225:3385–3390.
  • GREENBERG ER, CHUTE CG, STUKEL T et al: Social economic factors in the choice of lung cancer treatment. A population-based study in two rural states. N. Engl. J. Med. (1988) 318:612–617.
  • HUTCHINS LF, UNGER JM, CROWLEY JJ, COLTMAN CA JR, ALBAIN KS: Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl. J. Med. (1999) 341:2061–2067.
  • FENTIMAN IS, TIRELLI V, MONFARDINI S et al: Cancer in the elderly: why so badly treated? Lancet (1990) 28:1020–1022.
  • DIXON DO, NEILAN B, JONES SE et al.: Effect of age on therapeutic outcome in advanced diffuse hystiocytic lymphoma: the Southwest Oncology Group experience. Clin. Oncol (1986) 4:295–305.
  • LANGER CJ, MANOLA J, BERNARDO P et al: Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J. Natl. Cancer Inst. (2002) 94:173–181.
  • ROWE JM, ANDERSEN JW, MAZZA JJ et al: A randomized placebo-controlled Phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (>55 to 70 years of age) with acute myelogenus leukemia: a study of the Eastern Cooperative Oncology Group (E1490). Blood (1995) 86:457–462.
  • SARGENT DJ, GOLDBERG RM, JACOBSON SD et al: A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl. J. Med. (2001) 345:1091–1097.
  • YANCIK R, GANZ P, VARRICCHIO CG, CONLEY B: Perspective on comorbidities and cancer in older patients: approaches to expand the knowledge base. J. Clin. Oncol (2001) 19:1147–1151.
  • BALDUCCI L, EXTERMANN M, CARRECA I: Management of breast cancer in the older woman. Cancer Control (2001) 8:431–441.
  • FRIED LP, TANGEN CM, WALSTON J et al.: Frailty in older adults: evidence for a phenotype. J. Cerontol A. Biol. Sri. Med. ScL (2001) 56:M146–M156.
  • SALIBA D, ELLIOTT M, RUBENSTEIN LZ et al: The Vulnerable Elders Survey: a tool for identifying vulnerable older people in the community. J. Am. Ceriatr. Soc. (2001) 49:1691–1699.
  • PERRONE F, GRIDELLI C, CIGOLARI S et al: Baseline assessment of quality of life (QoL) is a strong prognostic factor for survival of elderly patients with advanced non-small cell lung cancer (NSCLC). A secondary analysis of the MILES study. Proceedings of the 38th American Society of Clinical Oncology, Orlando, USA (2002) (abstract 1346) 21:337a.
  • GANZ PA, LEE JJ, SIAU J: Quality of lifeassessment. An independent prognostic variable for survival in lung cancer. Cancer (1991) 67:3131–3135.
  • MONFARDINI S: Prescribing anti-cancer drugs in elderly cancer patients. Ern: Cancer (2002) 38:2341–2346.
  • BERNARD SA, BRUERA E: Drug interactions in palliative care. Clin. Oncol (2000) 18:1780–1799.
  • KALASH GR: Psychotropic drug metabolism in the cancer patient: clinical aspects of management of potential drug interactions. Psychooncology (1998) 7:307–320.
  • BALDUCCI L, HARDY CL, LYMAN GH: Hemopoietic reserve in the older cancer patients: clinical and economic considerations. Cancer Control (2000) 7:539–547.
  • BALDUCCI L: Guidelines for the management of older cancer patients. Cancer Treat. Res. (2005) 124:233–256.
  • ••Benchmark guidelines for the managementof elderly cancer patients.
  • OZER H, ARMITAGE JO, BENNET CL et al: 2000 update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines. American Society of Clinical Oncology Growth Factors Expert Panel. Clin. Oncol (2000) 18:3558–3585.
  • ••Benchmark guidelines for the clinicalpractice use of colony-stimulating growth factors.
  • SCHRIJVERS D, HIGHLEY M, DE BRUYN E, VAN OOSTEROM AT, VERMORKEN JB: Role of red blood cells in pharmacokinetics of chemotherapy agents. Anticancer Drugs (1999) 10:147–153.
  • RIZZO JD, LICHTIN AE, WOOLF SH et al: Use of epoetin in patients with cancer: evidence-based clinical practice guidelines of the American Society of Clinical Oncology and the American Society of Hematology. Blood (2002) 100:2303–2320.
  • ••Benchmark guidelines for the clinicalpractice use of epoetin.
  • BALDUCCI L, EXTERMANN M: Cancer and aging. An evolving panorama. Hematol Oncol Clin. North. Am. (2000) 14:1–16.
  • CRIVELLARI D, BONETTI M, CASTIGLIONE-GERTSCH M et al: Burdens and benefits of adjuvant cyclophosphamide, methotrexate, and fluorouracil and tamoxifen for elderly patients with breast cancer: the International Breast Cancer Study Group Trial VII. J. Clin. Oncol (2000) 18:1412–1422.
  • REPETTO L: Greater risks of chemotherapy toxicity in elderly patients with cancer. .J. Support. Oncol (2003) l\(Suppl. 2):18–24.
  • CVITKOVIC E, SPAULDING J, BETHUNE V, MARTIN J, WHITMORE W: Improvement of cis-dichlorodiammineplatinum (NSC 119875): therapeutic index in an animal model. Cancer (1977) 39:1357–1361.
  • HAYES D, CVITKOVIC E, GOLBEY R, SCHEINER E, HELSON 1, KRAKOFF IH: High dose cis-platinum diammine dichloride: amelioration of renal toxicity by mannitol diuresis. Cancer (1977) 39:1372–1381.
  • O'DWYER P, STEVENSON J, JOHNSON S: Clinical status of cisplatin, carboplatin and other platinum-based antitumor drugs. In: Cisplatin: chemistry and biochemistry of a lea ding Anti-Cancer drug. Lippert B (Ed.), Verlag Helvetica Chimica Acta, Zurich (1999):31–47.
  • JOHNSON SW, STEVENSON JP, O'DWYER PJ: Cisplatin and its analogues. In: Cancer principles and practice of oncology. DeVita VT, Jr., Hellman S, Rosenberg SA (6th Ed.), Lippincot Williams and Wilkins, Philadelphia (2001):376–388.
  • •Detailed discussion of platinum compounds.
  • DESOIZE B, MADOULET C: Particular aspects of platinum compounds used at present in cancer treatment. nit. Rev Oncol Hematol (2002) 42:317–325.
  • •Good summary of main platinum compounds used in clinical practice: cisplatin, carboplatin, oxaliplatin and nedaplatin.
  • HUBBARD K, PAZDUR R, AJANI J et al.: Phase II evaluation of iproplatin in patients with advanced gastric and pancreatic cancer. Am. J. Clin. Oncol (1992) 15:524–527.
  • MURPHY D, LIND M, PRENDIVILLE J et al.: Phase I/II study of intraperitoneal iproplatin in patients with minimal residual disease following platinum-based systemic therapy for epithelial ovarian carcinoma. Eur. J. Cancer (1992) 28A:870–872.
  • SCHILDER R, LACRETA F, PEREZ R et al.: Phase I and pharmacokinetic study of ormaplatin (tetraplatin NSC 363812) administered on a day 1 and day 8 schedule. Cancer Res. (1994) 54:709–717.
  • KELLAND L: The development of orally active platinum drugs. In: Cisplatin: chemistry and biochemistry of a leading Anti-Cancer drug. Lippert B (Ed.), Verlag Helvetica Chimica Acta, Zurich (1999):497–512.
  • FOKKEMA E, GROEN HJ, BAUER J, UGES DR, WEIL C, SMITH IE: Phase II study of oral platinum drug JM216 as first-line treatment in patients with small-cell lung cancer. J. Clin. Oncol (1999) 17:3822–3827.
  • JUDSON I, CERNY T, EPELBAUM R et al: Phase II trial of the oral platinum complex JM216 in non-small-cell lung cancer: an EORTC early clinical studies group investigation. Ann. Oncol (1997) 8:604–606.
  • MANZOTTI C, PRATESI G, MENTA E et al: BBR3464: a novel triplatinum complex, exhibiting a preclinical profile of antitumor efficacy different from cisplatin. Clin. Cancer Res. (2000) 6:2626–2634.
  • GOURLEY C, CASSIDY J, EDWARDS C et al: A Phase I study of the trinuclear platinum compound, BBR3464, In combination with protracted venous infusional 5-fluorouracil in patients with advanced cancer. Cancer Chemother. Pharmacol (2004) 53:95–101.
  • TRIGO J, BEALE P, JUDSON I et al.: Phase I and pharmacokinetic (PK) study of cis-amminedichloro (2-methylpyridine) platinum (II) (ZD0473), a novel sterically hindered platinum complex, in patients (pts) with advanced solid malignancies. Proceedings of the 35th American Society of Clinical Oncology, Atlanta, USA (1999) (abstract 648) 18:169a.
  • GELMON KA, VANDENBERG TA, PANASCI L et al.: A Phase II study of ZD0473 given as a short infusion every 3 weeks to patients with advanced or metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group trial, IND 129. Ann. Oncol (2003) 14:543–548.
  • FLAHERTY KT, STEVENSON JP, REDLINGER M, ALGAZY KM, GIATONIO B, D'WYER PJ: A Phase I, dose escalation of ZD0473, a novel platinum analogue, in combination with gemcitabine. Cancer Chemother. Pharmacol (2004) 53:404–408.
  • TREAT J, SCHILLER J, QUOIX E et al:ZD0473 treatment in lung cancer: an overview of the clinical trial results. Eur. J. Cancer (2002) 38 (Suppl. 8):513–518.
  • PEREZ-SOLER R, KHOKHAR AR, LOPEZ-BERESTEIN G: Treatment and prophylaxis of experimental liver metastases of M5076 reticulosarcoma with cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum encapsulated in multilamellar vesicles. Cancer Res. (1987) 47:6462–6466.
  • PEREZ-SOLER R, FRANCIS K, AL-BAKERS, PILKIEWICZ F, KHOKHAR AR: Preparation and characterization of liposomes containing a lipophilic cisplatin derivative for clinical use. J. Microencapsul (1994) 11:41–54.
  • PEREZ-SOLER R, YANG LY, DREWINKO B, LAUTERZSTAIN J, KHOKHAR AR: Increased cytotoxicity and reversal of resistance to cis-diamminedichloro-platinum(II) with entrapment of cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) in mulitilamellar lipid vesicles. Cancer Res. (1988) 48:4509–4512.
  • PEREZ-SOLER R, LOPEZ-BARESTEIN G, LAUTERSZTAIN J et al: Phase I clinical and pharmacological study of liposome-entrapped cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II). Cancer Res. (1990) 50:4254–4259.
  • ANONYMOUS: Chemotherapy for non-small cell lung cancer: Non-small Cell Lung Cancer Collaborative Group. Cochrane Database Syst. Rev (2000) CD002139.
  • CULLEN MH, BILLINGHAM LJ, WOODROFFE CM et al: Mitomycin, ifosfamide and cisplatin in unresectable non-small-cell lung cancer: Effects on survival and quality of life. J. Clin. Oncol (1999) 17:3188–3194.
  • THONGPRASERT S, SANGUANMITRA P, JUTHAPAN W, CLINCH J: Relationship between quality of life and clinical outcomes in advanced non-small cell lung cancer: Best supportive care (BSC) versus BSC plus chemotherapy. Lung Cancer (1999) 24:17–24.
  • SPIRO SG, RUDD RIVI, SOUHAMI RL et al.: Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life. Thorax (2004) 59:828–836.
  • CRINO L, SCAGLIOTTI GV, RICCI S et al.: Gemcitabine and cisplatin versus mitomycin, ifosfamide, and cisplatin in advanced non-small-cell lung cancer: A randomized Phase III study of the Italian Lung Cancer Project. I Clin. Oncol (1999) 17:3522–3530.
  • GEBBIA V, GALETTA D, RICCARDI R et al.: Vinorelbine plus cisplatin versus cisplatin plus vindesine and mitomycin C in stage IIIB-IV non-small cell lung carcinoma: a prospective randomized study. Lung Cancer (2002) 37:179–187.
  • GIACCONE G, SPLINTER TA, DEBRUYNE C et al.: Randomized study of paclitaxel-cisplatin versus cisplatin-teniposide in patients with advanced non-small-cell lung cancer: The European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. Clin. Oncol (1998) 16:2133–2141.
  • LE CHEVALIER T, BRISGAND D, DOUILLARD JY et al: Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: Results of European multicenter trial including 612 patients.J. Clin. Oncol (1994) 12:360–367.
  • CARDENAL F, LOPEZ-CABRERIZO MP, ANTON A et al: Randomized Phase III study of gemcitabine -cisplatin versus etoposide-cisplatin in the treatment of locally advanced or metastatic non-small-cell lung cancer. J. Clin. Oncol (1999) 17:12–18.
  • BONOMI P, KIM K, FAIRCLOUGH D et al: Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: Results of an Eastern Cooperative Oncology Group trial. Clin. Oncol (2000) 18:623–631.
  • HOTTA K, MATSUO K, UEOKA H, KIURA K, TABATA M, TANIMOTO M: Meta-analysis of randomized clinical trials comparing cisplatin to carboplatin in patients with advanced non-small cell lung cancer. J. Clin. Oncol (2004) 22:3852–3859.
  • ••Detailed meta-analysis of randomisedPhase III trials containing cisplatin-or carboplatin-based regimens.
  • CHAN AM, MAO AJ, WU T et al: Meta-analysis comparing carboplatin and cisplatin-based chemotherapy in advanced non-small cell lung cancer. J. Clin. Oncol (2005) 23(16S):674s (abstract 7218).
  • LE CHEVALIER T, SCAGLIOTTI G, NATALE R et al: Efficacy of gemcitabine plus platinum chemotherapy compared with other platinum containing regimens in advanced non small cell lung cancer: a meta-analysis of survival outcomes. Lung Cancer (2004) 47:69–80.
  • PFISTER DG, JOHNSON DH, AZZOLI CG et al: American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J. Clin. Oncol (2004) 22:330–353.
  • ••Benchmark guidelines for the treatmentof advanced NSCLC.
  • EARLE CC, TSAI JS, GELBER RD, WEINSTEIN MC, NEUMANN PJ, WEEKS JC: Effectiveness of chemotherapy for advanced lung cancer in the elderly: instrumental variable and propensity analysis. J. Clin. Oncol (2001) 19:1064–1070.
  • ELDERLY LUNG CANCER VINORELBINE ITALIAN STUDY (ELVIS) GROUP: Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. Natl. Cancer Inst. (1999) 91:66–72.
  • •A key randomised Phase III trial ever performed in advanced NSCLC elderly patients.
  • FRASCI G, LORUSSO V, PANZA N et al: Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small cell lung cancer. Oncol (2000) 18:2529–2536.
  • GRIDELLI C, PERRONE F, GALLO C et al.: Chemotherapy for elderly patients with advanced non-small-cell lung cancer: the Multicenter Italian Lung Cancer in the Elderly Study (MILES) Phase III randomized trial. J. Natl. Cancer Inst. (2003) 95:362–372.
  • •The largest randomised Phase III trial ever performed in advanced NSCLC elderly patients.
  • DEPIERRE A, CHASTANG Cl, QUOIX E et al: Vinorelbine versus vinorelbine plus cisplatin in advanced non-small cell lung cancer: a randomized trial. Ann. OncoL (1994) 5:37–42.
  • CRAWFORD J, O'ROURKE M, SCHILLER JH et al.: Randomized trial of vinorelbine compared with fluorouracil plus leucovorin in patients with stage IV non-small-cell lung cancer. J. Clin. OncoL (1996) 14:2774–2784.
  • GRIDELLI C, AAPRO M, ARDIZZONI A et al.: Treatment of advanced non-small-cell lung cancer in the elderly: results of an international expert panel. J. Clin. OncoL (2005) 23:3125–3137.
  • ••Benchmark guidelines for the treatmentof advanced NSCLC elderly patients.
  • TAKEDA K, KUDOH S, NAKAGAWA K et al.: Randomized Phase III study of docetaxel (D) versus vinorelbine (V) for elderly patients (pts) with advanced non-small cell lung cancer (NSCLC): Results of a West Japan Thoracic Oncology Group trial (WJTOG9904).OncoL(2005) 23(165):623s (abstract 7009).
  • •First randomised Phase III trial comparing two single-agent in the treatment of advanced non-small cell lung cancer elderly patients.
  • OSHITA F, KURATA T, KASAI et al: Prospective evaluation of the feasibility of cisplatin-based chemotherapy for elderly lung cancer patients with normal organ functions. fpn. J. Cancer Res. (1995) 86:1198–1202.
  • RINALDI M, DE MARINIS F, ARDIZZONI A et al: Correlation between age and prognosis in patients with advanced non small cell lung cancer treated with cisplatin containing chemotherapy: a retrospective multicentre study. Ann. Oncol (1994) 5\(Suppl. 8):58.
  • KUBOTA K, HOSOMURA K, KAKINUMA R et al.: Cisplatin nephrotoxicity in elderly patients with lung cancer. Proceedings of the 34th American Society of Clinical Oncology, Los Angeles, USA (1998) (abstract 1890) 17:491a.
  • LICHTMAN SM, BUCHHOLTZ M, MARINO J et al.: Use of cisplatin for elderly patients. Age Ageing (1992) 21:202–204.
  • •Specific evaluation of cisplatin administration in elderly cancer patients.
  • THYSS A, SAUDES L, OTTO J et al: Renal tolerance of cisplatin in patients more than 80 years old.J. Clin. OncoL (1994) 12:2121–2125.
  • •Specific evaluation of cisplatin administration in elderly cancer patients.
  • CUBILLO A, CORNIDE M, LOPEZ JL eta].: Renal tolerance to cisplatin in patients 70 years and older. Am. J. Clin. OncoL (2001) 24:192–197.
  • •Specific evaluation of cisplatin administration in elderly cancer patients.
  • NGUYEN B, SANDLER A, DENHAM C: The safety and efficacy of gemcitabine plus cisplatin in the elderly chemo-naive NSCLC patients (age 70 years) as compared to those with age 70 years. Proceedings of the 35th American Society of Clinical Oncology, Atlanta, USA (1999) (abstract 1818) 18:471a.
  • KELLY K, GIARRITTA S, AKERLEY W et al: Should older patient (pts) receive combination chemotherapy for advanced stage non-small cell lung cancer (NSCLC)? An analysis of Southwest Oncology Trials 9509 and 9308. Proceedings of the 37th American Society of Clinical Oncology, San Francisco, USA (2001) (abstract 1313) 20:329a.
  • LILENBAUM RC, HERNDON J 2nd, LIST MA et al: Single-agent versus combination chemotherapy in advanced non-small cell lung cancer: the cancer and leukemia group B (study 9730). J. Clia Oncol (2005) 23:190–196.
  • ROCHA LIMA CM, HERNDON JE 2nd, KOSTY M, CLAMON G, GREEN MR: Therapy choices among older patients with lung carcinoma. Cancer (2002) 94:181–187.
  • LANGER CJ, VANGEL J, SCHILLER DP et al: Age-specific subanalysis of ECOG 1594: fit elderly patients (70–80 yrs) with NSCLC do as well as younger patients (70). Proceedings of the 39th American SocitV of Clinical Oncology, Chicago, USA (2003) (abstract 2571) 22:639.
  • FOSSELLA FV, BELANI CP: Phase II study (TAX 326) of docetaxel-cisplatin (DC) and docetaxel-carboplatin (DCb) versus vinorelbine-cisplatin (VC) for the first-line treatment of advanced/metastatic non-small-cell-lung cancer (NSCLC): analysis in elderly patients. Proceedings of the 39th American Society of Clinical Oncology, Chicago, USA (2003) 22:629 (abstract 2528).
  • HENSING TA, PETERMAN AH, SCHELL MJ, LEE JH, SOCINSKI MA: The impact of age on toxicity, response rate, quality of life, and survival in patients with advanced, stage IIIB or IV nonsmall cell lung carcinoma treated with carboplatin and paclitaxel. Cancer (2003) 98:779–88.
  • BELANI C, RAMALINGAM S, PERRY MC et al: Phase III randomized trial comparing weekly versus standard schedules of paclitaxel (P) plus carboplatin (C) for advanced non-small cell lung cancer (NSCLC): Analyses of elderly patients. Lung Cancer (2005) 49\(Suppl. 2):532 (abstract 0–088).
  • SCHILLER JH, HARRINGTON D, BELANI CP et al: Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl. J. Med. (2002) 346:92–98.
  • FOSSELLA F, PEREIRA JR, VON PAWEL J et al.: Randomized, multinational, Phase III study of docetaxel plus platinum combinations versus vinorelbine plus cisplatin for advanced non-small-cell lung cancer: the TAX 326 study." Clin. Oncol (2003) 21:3016–3024.
  • OSHITA F, KURATA T, KASAI T et al: Prospective evaluation of the feasibility of cisplatin-based chemotherapy for elderly lung cancer patients with normal organ function. fpn. Cancer Res. (1995) 86:1198–1202.
  • SOUQUET PJ, BOMBARON P, BRUNEL-CROVA J et al.: Treatment of advanced and disseminated non small cell lung cancer (NSCLC) in elderly patients: results of MIC regimen. Lung Cancer (1997) 18\(Suppl. 1):24.
  • MATTIOLI R, MORESE R, IMPERATORI L et al: Weekly cisplatin (P) and vinorelbine (V) is active, manageable and provides clinical benefit in advanced non-small cell lung cancer (ANSCLC) elderly or poor performance status (PS) patients. Ann. Oncol (2002) 13\(Suppl. 5):104 (abstract 377P).
  • PEREIRA JR, MARTINS SJ, NIKAEDO SM, MARI FK: Chemotherapy with cisplatin and vinorelbine for elderly patients with locally advanced or metastatic non-small-cell lung cancer. B.MC. Cancer (2004) 29:69–73.
  • LIPPE P, SILVA RR, GIULIODORI L et al: Advanced non-small cell lung cancer in the elderly: effective and well tolerated weekly gemcitabine and cisplatin regimen. A pilot study. Minerva Med. (2000) 91:53–57.
  • MOSCETTI L, SALTARELLI R, SIGNORELLI C et al: The combination of gemcitabine (G) and cisplatin (P) in the general population of elderly patients with advanced NSCLC. Lung Cancer (2003) 42\(Suppl. 2):596 (abstract P23).
  • BERARDI R, PORFIRI E, SCARTOZZI M et al: Elderly patients with advanced non-small cell lung cancer. A Phase II study with weekly cisplatin and gemcitabine. Oncology (2003) 65:198–203.
  • FELIU J, MARTIN G, MADRONAL C et al: Combination of low-dose cisplatin and gemcitabine for treatment of elderly patients with advanced non-small cell lung cancer. Cancer Chemother. Pharmacol (2003) 52:247–252.
  • OHE Y, NIHO S, KAKINUMA R et al: A Phase II study of cisplatin and docetaxel administered as three consecutive weekly infusions for advanced non-small-cell lung cancer in elderly patients. Ann. Oncol (2004) 15:45–50.
  • VAN DEN BRANDE, KEYSER EM, SELLESLAG D, DEMEDTS M: Serious myelotoxicity of a carboplatin-etoposide regimen for advanced non small cell lung cancer. Lung Cancer (1991) 7:317–321.
  • ROSTI G, ZUMAGLINI F, GRIDELLI C et al: Carboplatin and oral VP-16 in advanced lung cancer patients aged 70 years. A Phase II trial. Proceedings of 2nd International Conference on Cancer in the Elderly, Genova, Italy (1994) p. 225.
  • THOMAS P, CASTELNAN O, KLEISSSBAUER JP: Carboplatin plus oral etoposide in elderly patients with bronchogenic carcinoma. Preliminary results of a Phase II trial. Proceedings of 2nd International Conference on Cancer in the Elderly, Genova, Italy (1994) p. 226.
  • SHIBATA K, NAKATSUMI Y, KASAHARA K, BANDO T, FUJIMURA M, MATSUDA T: Analysis of thrombocytopenia due to carboplatin combined with etoposide in elderly patients with lung cancer." Cancer Res. Clin. Oncol (1996) 122:437–442.
  • GRIDELLI C, ROSSI A, SCOGNAMIGLIO F et al: Carboplatin plus oral etoposide in elderly patients with advanced non small cell lung cancer. A Phase II study. Anti-Cancer Res. (1998) 17:4755–4758.
  • IMPERATORI L, MATTIOLI R, CASADEI V et al.: Weekly carboplatin + fluorouracil + folinic acid in advanced NSCLC of the elderly: efficacy in symptoms relief. Proceedings of 8th International Congress on Anti-Cancer Treatment, Paris, France (1998) p. 203 (abstract P268).
  • COLLEONI M, VICARIO G, PANCHERI F et al: Weekly carboplatin and vinorelbine in elderly patients with non-small-cell lung cancer (NSCLC). Proceedings 6th International Congress on Anti-Cancer Treatment, Paris, France (1996) p. 194 (abstract 562).
  • SANTOMAGGIO CR, TUCCI E: Chemoterapia con carboplatino (CBDCA) e vinorelbina (V) nell'anziano affetto da carcinoma polmonare con microcitoma, stad avanzati (A-NSCLC). Chemother. (1996) 8(Suppl. 3):104.
  • MAESTU I, GOMEZ-ALDARAVI L, TORREGROSA MD et al: Gemcitabine and low dose carboplatin in the treatment of elderly patients with advanced non-small cell lung cancer. Lung Cancer (2003) 42:345–354.
  • MASTERS GA, NICKOLOV A, HAHN E, HELEN F: Gemcitabine (GEM) and carboplatin (CARB) in elderly patients with advanced non-small cell lung cancer (NSCLC): Subset analysis of a randomized Phase II trial. J. Clin. Oncol. (2005) 23(165):679s (abstract 7236).
  • MOLINIER O, MILLERON B, BRETON JL et al.: Multicenter Phase II trial of carboplatin and weekly paclitaxel as first-line treatment in elderly patients with non-small cell lung cancer: preliminary results. Proceedings of the 39th American Socieg, of Clinical Oncology, Chicago, USA (2003) 22:693 (abstract 2786).
  • JATOI A, STELLA PJ, HILLMAN S et al.: Weekly carbopatin and paclitaxel in elderly non-small-cell lung cancer patients (> or = 65 years of age): a Phase II North Central Cancer Treatment Group study. Am. J. Clin. Oncol. (2003) 26:441–447.
  • CHOI IS, KIM BS, PARK SR et al.: Efficacy of modified regimen with attenuated doses of paclitaxel plus carboplatin combination chemotherapy in elderly and/or weak patients with advanced non-small cell lung cancer. Lung Cancer (2003) 39:99–101.
  • OKAMOTO I, MORIYAMA E, FUJII S et al.: Phase II study of carboplatin-paclitaxel combination chemotherapy in elderly patients with advanced non-small cell lung cancer. fpn.Oncol. (2005) 35:188–194.
  • USUI K, INOUE A, ISHIMOTO 0 et al.: A Phase II trial of weekly paclitaxel and carboplatin for elderly patients with advanced non-small cell lung cancer (NSCLC).Oncol. 23(165):682s(abstract 7248).
  • MARSLAND TA, GARFIELD DH, KHAN MM, LOOK RM, BOEHM KA, ASMAR L: Sequential versus concurrent paclitaxel and carboplatin for the treatment of advanced non-small cell lung cancer in elderly patients and patients with poor performance status: results of two Phase II, multicenter trials. Lung Cancer (2005) 47:111–120.
  • BUOSI R, POLETTI S; CANTELE V et al.: preliminary results of Phase II trial with combination of gemcitabine and oxaliplatin in elderly patients with advanced NSCLC. Proceedings of the 39th American Socieg, of Clinical Oncology, New Orleans, USA (2004) (abstract 7348) 23:700.
  • DOMENECH M, LOSA F, BLANCO R et al.: Phase II study of gemcitabine plus oxaliplatin as first-line treatment in elderly or unfit patients with advanced non-small cell lung cancer (NSCLC). Lung Cancer (2005) 49\(Suppl. 2):S242 (abstract P476).
  • OSHITA F, YAMADA K, SAITO H, NODA K, HAMANAKA M, IKEHARA M: Phase II study of nedaplatin and irinotecan for elderly patients with advanced non-small cell lung cancer. Exp. Thar. Oncol. (2004) 4:343–348.
  • SILVESTRI G, PRITCHARD R, WELCH HG: Preferences for chemotherapy in patients with advanced non-small-cell lung cancer: descriptive study based on scripted interviews. Br. Med. J. (1998) 317:771–775.
  • PERRONE F, GALLO C, GRIDELLI C: Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: Implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J. Nati Cancer Inst. (2002) 94:1029–1030.
  • KLASTERSKY J, SCULIER JP, RAVEZ P et al: A randomized study comparing a high and a standard dose of cisplatin in combination with etoposide and NSCLC. Clin. Oncol. (1986) 4:1780–1786.
  • GANDARA DR, CROWLEY J, LIVINGSTON RB et al.: Evaluation of cisplatin intensity in metastatic NSCLC: a Phase III study of the SWOG. Clin. Oncol. (1993) 11:873–878.
  • EINHORN L: Carboplatin versus cisplatin in lung cancer. Lung Cancer (2005) 49\(Suppl. 3):532–535.
  • MINAMI H, OHE Y, NIHO S et al: Comparison of pharmacokinetics and pharmacodynamics of docetaxel and cisplatin in elderly and non-elderly patients: why is toxicity increased in elderly patients? Clin. Oncol. (2004) 22:2901–2908.

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