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Expert Opinion on Drug Safety Volume 6, 2007 - Issue 4
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Review

Safety of sildenafil in the treatment of erectile dysfunction in patients with obstructive sleep apnoea

Petros Perimenis University Hospital of Patras, Department of Urology, Medical School, 26500 Patras, Greece [email protected]
&
Konstantinos Giannitsas University Hospital of Patras, Department of Urology, Medical School, 26500 Patras, Greece [email protected]
Pages 423-430 | Published online: 09 Aug 2007

Bibliography

  • NO AUTHORS LISTED: Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The Report of the American Academy of Sleep Medicine Task Force. Sleep (1999) 22(5):667-689.
  • YOUNG T, PALTA M, DEMPSEY J, SKATRUD J, BADR S: The occurrence of sleep-disordered breathing among middle-aged adults. N. Engl. J. Med. (1993) 328(17):1230-1235.
  • LAVIE P: Incidence of sleep apnoea in a presumably healthy working population: significant relationship with excessive day time sleepiness. Sleep (1983) 6(4):312-318.
  • LACASSE Y, GODBOUT C, SERIES F: Health-related quality of life in obstructive sleep apnoea. Eur. Respir. J. (2002) 19(3):499-503.
  • PANKOW W, NABE B, LIES A et al.: Influence of sleep apnoea on 24-hour blood pressure. Chest (1997) 112(5):1253-1258.
  • NIETO FJ, YOUNG TB, LIND BK et al.: Association of sleep disordered breathing, sleep apnoea and hypertension in a large community-based study. Sleep Heart Health Study. JAMA (2000) 283(14):1829-1836.
  • SHAHAR E, WHITNEY CW, REDLINE S et al.: Sleep-disordered breathing and cardiovascular disease: cross-sectional results the Sleep Heart Health Study. Am. J. Respir. Crit. Care Med. (2001) 163(1):19-25.
  • DYKEN ME, SOMERS VK, YAMADA T, REN ZY, ZIMMERMAN MB: Investigating the relationship between stroke and obstructive sleep apnoea. Stroke (1996) 27(3):401-407.
  • TISHLER PV, LARKIN EK, SCHLUCHTER MD, REDLINE S: Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing. JAMA (2003) 289(17):2230-2237.
  • STRADLING JR, CROSBY JH: Predictors and prevalence of obstructive sleep apnoea and snoring in 1001 middle aged men. Thorax (1991) 46(2):85-90.
  • BIXLER EO, VGONTZAS AN, TEN HAVE T, TYSON K, KALES A: Effects of age on sleep apnoea in men: I. Prevalence and severity. Am. J. Respir. Crit. Care Med. (1998) 157(1):144-148.
  • NO AUTHORS LISTED: NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA (1993) 270(1):83-90.
  • ROSEN RC, FISHER WA, EARDLEY I, NIEDERBERGER C, NADEL A, SAND M: The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr. Med. Res. Opin. (2004) 20(5):607-617.
  • FELDMAN HA, GOLDSTEIN I, HATZICHRISTOU DG, KRANE RJ, MCKINLAY JB: Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J. Urol. (1994) 151(1):54-61.
  • ALTHOF SE: Quality of life and erectile dysfunction. Urology (2002) 59(6):803-810.
  • CARSON CC, LUE TF: Phosphodiesterase 5 inhibitors for erectile dysfunction. BJU Int. (2005) 96(3):257-280.
  • PRESSMAN MR, DIPHILLIPO MA, KENDRICK JI, CONROY K, FRY JM: Problems in the interpretation of nocturnal penile tumescence studies: disruption of sleep by occult sleep disorders. J. Urol. (1986) 136(3):595-598.
  • HIRSHKOWITZ M, KARACAN I, ARCASOY MO, ACIK G, NARTER EM, WILLIAMS RL: Prevalence of sleep apnoea in men with erectile dysfunction. Urology (1990) 36(3):232-234.
  • SCHIAVI RC, MANDELI J, SCHREINER ENGEL P, CHAMBERS A: Aging, sleep disorders, and male sexual function. Biol. Psychiatry (1991) 30(1):15-24.
  • SEFTAL AD, STROHL KP, LOYE TL, BAYARD D, KRESS J, NETZER NC: Erectile dysfunction and symptoms of sleep disorders. Sleep (2000) 25(6):643-647.
  • HERUTI R, SHOCHAT T, TEKES-MANOVA D, ASHKENAZI I, JUSTO D: Association between erectile dysfunction and sleep disorders measured by self-assessment questionnaires in adult men. J. Sex. Med. (2005) 2(4):543-550.
  • MARGEL D, COHEN M, LIVNE PM, PILLAR G: Severe, but not mild, obstructive sleep apnoea syndrome is associated with erectile dysfunction. Urology (2004) 63(3):545-549.
  • TELOKEN PE, SMITH E, LODOWSKY C, FREEDOM T, MULHALL JP: Defining association between sleep apnoea syndrome and erectile dysfunction. Urology (2006) 67(5):1033-1037.
  • GONCALVES MA, GUILLEMINAULT C, RAMOS E, PALHA A, PAIVA T: Erectile dysfunction, obstructive sleep apnoea syndrome and nasal CPAP treatment. Sleep Med. (2005) 6(4):333-339.
  • KARACAN I, KARATAS M: Erectile dysfunction in sleep apnoea and response to CPAP. J. Sex. Marital Ther. (1995) 21(4):239-247.
  • PERIMENIS P, KARKOULIAS K, KONSTANTINOPOULOS A et al.: The impact of long-term conventional treatment for overlap syndrome (obstructive sleep apnoea and chronic obstructive pulmonary disease) on concurrent erectile dysfunction. Respir. Med. (2007) 101(2):210-216.
  • FANFULLA F, MALAGUTI S, MONTAGA T et al.: Erectile dysfunction in men with obstructive sleep apnoea: an early sign of nerve involvement. Sleep (2000) 23(6):775-781.
  • MC COWEN KC, MALHOTRA A: The correlation between obstructive sleep apnoea and low gonadotropin secretion in men. Sleep Med. (2003) 4(1):83-84.
  • RAJFER J, ARONSON WJ, BUSH PA, DOREY FJ, IGNARRO J: Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med. (1992) 326(2):90-94.
  • IP MS, LAM B, CHAN LY et al.: Circulating nitric oxide is suppressed in obstructive sleep apnoea and is reversed by nasal continuous positive airway pressure. Am. J. Respir. Crit. Care (2000) 162(6):2166-2171.
  • KATO M, ROBERTS-THOMSON P, PHILLIPS BG et al.: Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnoea. Circulation (2000) 102(21):2607-2610.
  • WHITE DP: Pathogenesis of obstructive and central sleep apnoea. Am. J. Respir. Crit. Care Med. (2005) 172(11):1363-1370.
  • FOGEL RB, TRINDER J, MALHOTRA A et al.: Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state. J. Physiol. (2003) 550(3):899-910.
  • BALLARD SA, GINGELL CJ, TANG K, TURNER LA, PRICE ME, NAYLOR AM: Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities cyclic nucleotide phosphodiesterase isozymes. J. Urol. (1998) 159(6):2164-2171.
  • BOOLELL M, ALLEN MJ, BALLARD SA et al.: Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int. J. Impot. Res. (1996) 8(2):47-52.
  • LIN CS, LIN G, XIN ZC, LUE TF: Expression, distribution and regulation of phosphodiesterase 5. Curr. Pharm. Des. (2006) 12(27):3439-3457.
  • MOTAMED M, SANDHU D, MURTY GE: Sildenafil and nasal obstruction. J. Otolaryngol. (2003) 32(4):259-261.
  • KIROGLU AF, BAYRAKLI H, YUCA K, CANKAYA H, KIRIS M: Nasal obstruction as a common side-effect of sildenafil citrate. Tohoku. J. Exp. Med. (2006) 208(3):251-254.
  • STAMLER JS, MEISSNER G: Physiology of nitric oxide in skeletal muscle. Physiol. Rev. (2001) 81(1):209-237.
  • KOBZIK L, REID MB, BREDT DS, STAMLER JS: Nitric oxide in skeletal muscle. Nature (1994) 372(6506):546-548.
  • MURAD F: The 1996 Albert Lasker Medical Research Awards. Signal transduction using nitric oxide and cyclic guanosine monophosphate. JAMA (1996) 276(14):1189-1192.
  • KING-VANVLACK CE, CURTIS SE, MEWBURN JD, CAIN SM, CHAPLER CK: Role of endothelial factors in active hyperemic responses in contracting canine muscle. J. Appl. Physiol. (1995) 79(1):107-112.
  • MURRANT CS, WOODLEY NE, BARCLAY JK: Effect of nitroprusside and endothelium-derived products on slow-twitch skeletal muscle function in vitro. Can. J. Physiol. Pharmacol. (1994) 72(9):1089-1093.
  • WHARTON J, STRANGE JW, MOLLER GM et al.: Anti-proliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells. Am. J. Respir. Crit. Care Med. (2005) 172(1):105-113.
  • ZHU B, STRADA S, STEVENS T: Cyclic GMP-specific phosphodiesterase 5 regulates growth and apoptosis in pulmonary endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. (2005) 289(2):196-206.
  • GALIE N, GHOFRANI HA, TORBICKI A et al.: Sildenafil citrate therapy for pulmonary arterial hypertension. N. Engl. J. Med. (2005) 353(20):2148-2157.
  • ZHAO L, MASON NA, MORRELL NW et al.: Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation (2001) 104(4):424-428.
  • RICHALET JP, GRATADOUR P, ROBACH P et al.: Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am. J. Respir. Crit. Care Med. (2005) 171(3): 275-281.
  • GHOFRANI HA, REICHENBERGER F, KOHSTALL MG et al.: Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann. Intern. Med. (2004) 141(3):169-177.
  • KLEINSASSER A, LOECKINGER A, HOERMANN C et al.: Sildenafil modulates hemodynamics and pulmonary gas exchange. Am. J. Respir. Crit. Care Med. (2001) 163(2):339-343.
  • RICART A, MARISTANY J, FORT N, LEAL C, PAGES T, VISCOR G: Effects of sildenafil on the human response to acute hypoxia and exercise. High Alt. Med. Biol. (2005) 6(1):43-49.
  • ROIZENBLATT S, GUILLEMINAULT C, POYARES D, CINTRA F, KAUATI A, TUFIK S: A double-blind, placebo-controlled, crossover study of sildenafil in obstructive sleep apnoea. Arch. Intern. Med. (2006) 166(16):1763-1767.
  • PERIMENIS P, KARKOULIAS K, MARKOU S et al.: Erectile dysfunction in men with obstructive sleep apnoea syndrome: a randomized study of the efficacy of sildenafil and continuous positive airway pressure. Int. J. Impot. Res. (2004) 16(3):256-260.
  • PERIMENIS P, KARKOULIAS K, KONSTANTINOPOULOS A et al.: Sildenafil versus continuous positive airway pressure for erectile dysfunction in men with obstructive sleep apnea: a comparative study of their efficacy and safety and the patient's satisfaction with treatment. Asian J. Androl. (In Press).
  • PERIMENIS P, KONSTANTINOPOULOS A, KARKOULIAS K, MARKOU S, PERIMENI P, SPYROPOULOS K: Sildenafil combined with continuous positive airway pressure for treatment of erectile dysfunction in men with obstructive sleep apnea. Int. Urol. Nephrol. (In Press).
  • MORALES A, GINGELL C, COLLINS M, WICKER PA, OSTERLOH IH: Clinical safety of oral sildenafil citrate (VIAGRA) in the treatment of erectile dysfunction. Int. J. Impot. Res. (1998) 10(2):69-74.

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