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Expert Opinion on Drug Delivery Volume 6, 2009 - Issue 8
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Reviews

Vesicular carriers for dermal drug delivery

Chiara Sinico University of Cagliari, Dipartimento Farmaco Chimico Tecnologico, Via Ospedale 72, 09124 Cagliari –Italy +390706758565; +390706758710; [email protected]
&
Anna Maria Fadda University of Cagliari, Dipartimento Farmaco Chimico Tecnologico, Via Ospedale 72, 09124 Cagliari –Italy +390706758565; +390706758710; [email protected]
Pages 813-825 | Published online: 02 Jul 2009

Bibliography

  • Foldvari M. Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharm Sci Technol Today 2000;3(12):417-25
  • Elias PM. Epidermal lipids, barrier function and desquamation. J Invest Dermatol 1983;80:44-9
  • Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Exp Dermatol 2008;17(12):1063-72
  • Knorr F, Lademann J, Patzelt A, et al. Follicular transport route –research progress and future perspectives. Eur J Pharm Biopharm 2009;71:173-80
  • Wartewing S, Neubert RHH. Properties of ceramides and their impact on the stratum corneum structure: a review. Skin Pharmacol Physiol 2007;20:220-29
  • Bouwstra JA, Ponec M. The skin barrier in healthy and diseased state. Biochim Biophys Acta 2006;1758(12):2080-95
  • Elsayed MMA, Abdallah OY, Naggar VF, Khalafallah NM. Lipid vesicles for skin delivery of drugs: Reviewing three decades of research. Int J Pharm 2007;332:1-16
  • Choi MJ, Maibach HI. Liposomes and niosomes as topical drug delivery systems. Skin Pharmacol Physiol 2005;18:209-19
  • Elsayed MMA, Abdallah OY, Naggar VF, Khalafallah NM. Deformable liposomes and ethosomes: mechanism of enhanced skin delivery. Int J Pharm 2006;322:60-6
  • Honeywell-Nguyen PL, Bouwstra JA. Vesicles as a tool for trandermal and dermal delivery. Drug Discov Today 2005;2:67-74
  • Bangham AD. Surrogate cells or trojan horses. The discovery of liposomes. Bioassays 1995;17:1081-8
  • L'Oreal INV, Vanlerberghe G, Handjani-Vila RM. Procédé de fabrication de dispersion aqueuses de spérules lipidiques et nouvelles compositions correspondantes. French 2315991; 1975
  • Cevc G, Blume G. Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim Biophys Acta 1992;1104:226-32
  • van den Bergh BA. Elastic liquid state vesicles as a tool for topical drug delivery. PhD thesis. Leiden University The Netherlands 1999
  • Touitou E, Alkabes M, Dayan N. Ethosomes: novel lipid vesicular system for enhanced delivery. Pharm Res 1997;S14:305-06
  • Verma DD. Invasomes – novel topical carriers for enhanced topical delivery: characterization and skin penetration properties, Marburg/ Lahn 2002, Ph.D. Thesis
  • Dragicevic-Curic N, Scheglmann D, Albrecht V, Fahr A. Temoporfin-loaded invasomes: development, characterization and in vitro skin penetration studies. J Control Release 2008;127:59-69
  • Mezei M, Gulasekharam V. Liposomes – a selective drug delivery system for the topical route of administration. I. Lotion dosage form. Life Sci 1980;26:1473-77
  • Mezei M, Gulasekharam V. Liposomes – a selective drug delivery system for the topical route of administration: gel dosage form. J Pharm Pharmacol 1983;34:473-74
  • Mezei M. Multiphase liposomal drug delivery system. US4761288; 1988
  • Mezei M. In: Gregoriadis G, editor, Liposome Technology, CRC Press, Boca. Raton, FL 1993;3. p. 91-106
  • Patel HM. Liposomes as a controlled release system. Biochem Soc Trans 1985;13:513-16
  • Cosco D, Celia C, Cilurzo F, et al. Colloidal carriers for the enhanced delivery through the skin. Expert Opin Drug Deliv 2008;5:737-55
  • Schmid MH, Korting HC. Therapeutic progress with topical liposome drugs for skin disease. Adv Drug Deliv Rev 1996;18:335-42
  • Gesztes A, Mezei M. Topical anesthesia of the skin by liposome-encapsulated tetracaine. Anesth Analg 1988;67:1079-81
  • Foldvari M, Gesztes A, Mezei M. Dermal drug delivery by liposome encapsulation: clinical and electron microscopic studies. J Microencapsul 1990;7:479-89
  • Foldvari M, Jarvis B, Oguejiofor CJN. Topical dosage form of liposomal tetracaine: effect of additives on the in vitro release and in vivo efficacy. J Control Release 1993;27:193-205
  • Sharma BB, Jain SK, Vyas SP. Topical liposome system bearing local anesthetic lignocaine: preparation and evaluation. J Microencapsul 1994;11:279-86
  • El Ridy MS, Khalil RM. Free versus liposomes-encapsulated lignocaine hydrochloride topical applications. Pharmazie 1999;54:682-84
  • Fisher R, Hung O, Mezei M, Stewart R. Topical anaesthesia of intact skin: liposomeencapsulated tetracaine vs EMLA. Br J Anaest 1998;81:972-73
  • Muller M, Mackeben S, Muller Goymann CC. Physicochemical characterisation of liposomes with encapsulated local anaesthetics. Int J Pharm 2004;274:139-48
  • Mura P, Maestrelli F, González-Rodríguez ML, et al. Development, characterization and in vivo evaluation of benzocaine-loaded liposomes. Eur J Pharm Biopharm 2007;67:86-95
  • Elsaie ML, Baumann LS. Evaluation of liposomal delivery system for topical anaesthesia. Cutis 2008;81:285-89
  • Lasch J, Wohlrab W. Liposome-bound Cortisol: a new approach to cutaneous therapy. Biomed Biochim Acta 1986;10:1295-99
  • Wohlrab W, Lasch J. Penetration kinetics of liposomal hydrocortisone in human skin. Dermatologica 1987;17:418-22
  • Wohlrab W, Lasch J. The effect of liposomal incorporation of topically applied hydrocortisone on its serum concentration and urinary excretion. Dermatol Monatsschr 1989;175:348-52
  • Lasch J, Laub R, Wohlrab W. How deep do intact liposomes penetrate into human skin? J Control Release 1991;18:55-8
  • Fresta M, Puglisi G. Corticosteroid dermal delivery with skin-lipid liposomes. J Control Release 1997;44:141-51
  • Fresta M, Puglisi G. Application of liposomes as potential cutaneous drug delivery systems. In vitro and in vivo investigation with radioactively labelled vesicles. J Drug Target 1996;4:95-101
  • Esposito E, Zanella C, Cortesi R, et al. Note Influence of liposomal formulation parameters on the in vitro absorption of methyl nicotinate. Int J Pharm 1998;172:255-260
  • Du Plessis J, Ramachandran C, Weiner N, Müller DG. The influence of particle size of liposomes on the disposition of drug into the skin. Int J Pharm 1994;103:277-82
  • Verma DD, Verma S, Blume G, Fahr A. Particle size of liposomes influences dermal delivery of substances into skin. Int J Pharm 2003;258:141-51
  • Foong WC, Harsanyi BB, Mezei M. Biodisposition and histological evaluation of topically applied retinoic acid in liposomal, cream and gel dosage forms. In: Hanin I, Pepeu G, editors, Phospholipids, Plenum Press, New York, 1990. p. 139-54
  • Masini V, Bonte F, Meybeck A, Wepierre J. Cutaneous bioavailability in hairless rats of tretinoin in liposomes or gel. J Pharm Sci 1993;82:17-21
  • Schäfer-Korting M, Korting HC, Ponce-Pöschl E. Liposomal tretinoin for uncomplicated acne vulgaris. Clin Invest 1994;72:1086-91
  • Sinico C, Manconi M, Peppi M, et al. Liposomes as carriers for dermal delivery of tretinoin: in vitro evaluation of drug permeation and vesicle–skin interaction. J Control Release 2005;103:123-36
  • Bouwstra JA, Honeywell-Nguyen PL, Gooris GS, Ponec M. Structure of the skin barrier and its modulation by vesicular formulations. Prog Lipid Res 2003;42:1-36
  • Vrhovnik K, Kristl J, Sentjurc M, Smid-Korbar J. Influence of liposome bilayer fluidity on the transport of encapsulated substance into the skin as evaluated by EPR. Pharm Res 1998;15:525-30
  • Abraham W, Downing DT. Interaction between corneocytes and stratum corneum lipid liposomes in vitro. Biochim Biophys Acta 1990;1021:119-25
  • Hofland HE, Bouwstra JA, Bodde HE, et al. Interactions between liposomes and human stratum corneum in vitro: freeze fracture electron microscopical visualization and small angle X-ray scattering studies. Br J Dermatol 1995;132:853-66
  • Junginger HE, Hofland HEJ, Bouwstra JA. Liposomes and niosomes interactions with human skin. Cosmet Toil 1991;106:45-50
  • Handjani-Vila RM, Ribier A, Rondot B, Vanlerberghe G. Dispersion of lamellar phase of non-ionic lipids in cosmetic products. Int J Cosmet Sci 1979;1:303-14
  • Uchegbu IF, Florence AT. Non-ionic surfactant vesicles (niosomes)-physical and pharmaceutical chemistry. Adv Colloid Interf Sci 1995;58:1-55
  • Uchegbu IF, Vyas SP. Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int J Pharm 1998;172:33-70
  • Carafa M, Santucci E, Alhaique F, et al. Preparation and properties of new unilamellar non-ionic/ionic surfactant vesicles. Int J Pharm 1998;160:51-9
  • Manconi M, Valenti D, Sinico C, et al. Niosomes as carriers for tretinoin. I. Preparation and properties. Int J Pharm 2002;234:237-48
  • Gopinath D, Ravi D, Rao BR, et al. 1-O-alkylglycerol vesicles (Algasomes): their formation and characterisation. Int J Pharm 2002;246:187-97
  • Gopinath D, Ravi D, Rao BR, et al. Ascorbyl palmitate vesicles (Aspasomes): formation, characterisation and applications. Int J Pharm 2004;271:95-113
  • Muzzalupo R, Nicoletta FP, Trombino S, et al. A new crown ether as vesicular carrier for 5-fluoruracil: synthesis, characterization and drug delivery evaluation. Colloids Surf Biointerfaces 2007;58:197-202
  • Paolino D, Cosco D, Muzzalupo R, et al. Innovative bolasurfactant niosomes as topical delivery systems of 5-fluorouracil for the treatment of skin cancer. Int J Pharm 2008;353:233-42
  • Paolino D, Muzzalupo R, Ricciardi A, et al. In Vitro and in vivo evaluation of bola-surfactant containing niosomes for transdermal delivery. Biomed Microdevices 2007;9:421-433
  • Hofland HE, van der Geest R, Bodde HE, et al. Estradiol permeation from non-ionic surfactant vesicles through human stratum corneum in vitro. Pharm Res 1994;11:659-64
  • Sinico C, Valenti D, Manconi M, et al. Cutaneous delivery of 8-methoxypsoralen from liposomal and niosomal carriers. J Drug Deliv Sci Tec 2006;16:115-120
  • Mura S, Pirot F, Manconi M, et al. Liposomes and niosomes as potential carrier for dermal delivery of minoxidil. J Drug Target 2007;15:101-08
  • Agarwal R, Katare OP, Vyas SP. Preparation and in vitro evaluation of liposomal/niosomal delivery systems for antipsoriatic drug dithranol. Int J Pharm 2001;228:43-52
  • Manconi M, Sinico C, Valenti D, et al. Niosomes as carriers for tretinoin III. A study into the in vitro cutaneous delivery of vesicle-incorporated tretinoin. Int J Pharm 2006;311:11-9
  • Carafa M, Santucci E, Lucania G. Lidocaine-loaded non-ionic surfactant vesicles: characterization and in vitro permeation studies. Int J Pharm 2002;231:21-32
  • Lieb LM, Ramachandran C, Egbaria K, Weiner N. Topical delivery enhancement with multilamellar liposomes via the pilosebaceous route: I. In vitro evaluation using fluorescent techniques with the hamster ear model. J Invest Dermatol 1992;99:108-13
  • Li L, Margolis LB, Lishko VK, Hoffman RM. Product-delivering liposomes specifically target ear follicles in histocultured intact skin. In vitro Cell Dev Biol 1992;28A:679-81
  • Du Plessis J, Egbaria K, Ramachandran C, Weiner N. Topical delivery of liposomally encapsulated gamma-interferon. Antiviral Res 1992;18:259-65
  • Cevc G. Transfersomes, liposomes and other lipid suspension on the skin: permeation enhancement, vesicle penetration and transdermal drug delivery. Crit Rev Ther Drug Carrier Syst 1996;13:257-388
  • Cevc G, Blume G, Schatzlein A. Transdermal drug carriers: basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptides. J Control Release 1995;36:3-16
  • Cevc G, Gebauer D, Stieber J, et al. Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim Biophys Acta 1998;1368:201-15
  • Cevc G, Blume G. New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochim Biophys Acta 2001;1514:191-205
  • Cevc G, Schatzlein A, Richardsen H. Ultradeformable lipid vesicles can penetrate the skin and other semi-permeable barriers unfragmented. Evidence from double label CLSM experiments and direct size measurements. Biochim Biophys Acta 2002;1564:21-30
  • Schatzlein A, Cevc G. Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high resolution confocal laser scanning microscopy study using highly deformable vesicles (transfersomes). Br J Dermatol 1998;138:583-92
  • El Maghraby GM, Barry BW, Williams AC. Liposomes and skin: from drug delivery to model membranes. Eur J Pharm Sci 2008;34:203-22
  • Bouwstra JA, Honeywell-Nguyen PL. Skin structure and mode of action of vesicles. Adv Drug Deliv Rev 2002;54:S41-55
  • Guo J, Ping Q, Zhang L. Transdermal delivery of insulin in mice by using lecithin vesicles as a carrier. Drug Deliv 2000;7:113-16
  • Choi MJ, Maibach HI. Elastic vesicles as topical/transdermal drug delivery systems. Int J Cosmet Sci 2005;18:209-19
  • Benson HAE. Transfersomes for transdermal drug delivery. Expert Opin Drug Deliv 2006;3:727-37
  • El Maghraby GM, Williams AC, Barry BW. Skin delivery of oestradiol from deformable and traditional liposomes: mechanistic studies. J Pharm Pharmacol 1999;51:1123-34
  • El Maghraby GM, Williams AC, Barry BW. Oestradiol skin delivery from ultradeformable liposomes: renement of surfactant concentration. Int J Pharm 2000;196:63-74
  • El Maghraby GM, Williams AC, Barry BW. Skin delivery of oestradiol from lipid vesicles: importance of liposome structure. Int J Pharm 2000;204:159-69
  • El Maghraby GM, Williams AC, Barry BW. Skin delivery of 5-fluorouracil from ultradeformable and standard liposomes in-vitro. J Pharm Pharmacol 2001;53:1069-77
  • Trotta M, Peira E, Debernardi F, Gallarate M. Elastic liposomes for skin delivery of dipotassium glycyrrhizinate. Int J Pharm 2002;241:319-27
  • Trotta M, Peira E, Carlotti ME, Gallarate M. Deformable liposomes for dermal administration of methotrexate. Int J Pharm 2004;270:119-25
  • Gallarate M, Chirio D, Trotta M, Carlotti ME. Deformable liposomes as topical formulations containing alpha-tocopherol. J Disper Sci Technol 2006;27:703-13
  • Chirio D, Cavalli R, Trotta F, et al. Deformable liposomes containing alkylcarbonates of gamma-cyclodextrins for dermal applications. J Incl Phenom Macrocycl Chem 2007;57:645-49
  • Peira E, Trotta M, Carlotti ME, et al. Elastic positively-charged liposomes for topical administration of acyclovir. J Drug Deliv Sci Technol 2007;17:321-24
  • Kirjavainen M, Urtti A, Jaaskelainen I, et al. Interaction of liposomes with human skin in vitro-the influence of lipid composition and structure. Biochim Biophys Acta 1996;1304:179-89
  • Manconi M, Valenti D, Sinico C, et al. Niosomes as carriers for tretinoin II. influence of vesicular incorporation on tretinoin photostability. Int J Pharm 2003;260:261-72
  • Elsayed MM, Abdallah OY, Naggar VF, Khalafallah NM. Deformable liposomes and ethosomes as carriers for skin delivery of ketotifen. Pharmazie 2007;62:133-37
  • El Maghraby GM, Williams AC, Barry BW. Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes. Int J Pharm 2004;276:143-61
  • Dragicevic-Curic N, Scheglmann D, Albrecht V, Fahr A. Development of different temoporfin-loaded invasomes-novel nanocarriers of temoporfin: characterization, stability and in vitro penetration studies. Colloid Surf B 2009;70:198-206
  • Verma DD, Verma S, McElwee KJ, et al. Treatment of alopecia areata in the DEBR model using Cyclosporin A lipid vesicles. Eur J Dermatol 2004;14:332-38
  • Honeywell-Nguyen PL, de Graaff AM, Groenink HWW, Bouwstra JA. The in vivo interactions of elastic and rigid vesicles with humans kin. Biochim Biophys Acta 2002;1573:130-40
  • van den Bergh BAI, Bouwstra JA, Junginger HE, Wertz PW. Elasticity of vesicles affects hairless mouse skin structure and permeability. J Control Release 1999;62:367-79
  • Honeywell-Nguyen PL, Frederik PM, Bomans PH, et al. Transdermal delivery of pergolide from surfactant-based elastic and rigid vesicles: characterization and in vitro transport studies. Pharm Res 2002;19:991-7
  • Honeywell-Nguyen PL, Van Den Bussche MH, Junginger HE, Bowstra JA. The effect of surfactant-based elastic and rigid vesicles on the penetration of lidocain across human skin. STP Pharm Sci 2002;1:257-62
  • Honeywell-Nguyen PL, Bouwstra JA. The in vitro transport of pergolide from surfactant based elastic vesicles through human skin: a suggested mechanism of action. J Control Release 2003;86:145-56
  • Honeywell-Nguyen PL, Arenja S, Bouwstra JA. Skin penetration and mechanisms of action in the delivery of the D2-agonist rotigotine from surfactant-based elastic vesicle formulations. Pharm Res 2003;20:1619-25
  • Van den Bergh BA, Vroom J, Gerritsen H, et al. Interactions of elastic and rigid vesicles with human skin in vitro: electron microscopy and two-photon excitation microscopy. Biochim Biophys Acta 1999;1461:155-73
  • Honeywell-Nguyen PL, Groenink HWW, Bouwstra JA. Elastic vesicles as a tool for dermal and transdermal delivery. J Liposome Res 2006;16:273-80
  • Honeywell-Nguyen PL, Gooris GS, Bouwstra JA. Quantitative assessment of the transport of elastic and rigid vesicle components and a model drug from these vesicle formulations into human skin in vivo. J Invest Dermatol 2004;123:902-10
  • Touitou E, Dayan N, Bergelson L, et al. Ethosomes – novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 2000;65:403-18
  • Dayan N, Touitou E. Carriers for skin delivery of trihexyphenidyl HCl: ethosomes vs. liposomes. Biomaterials 2000;21:1879-85
  • Godin B, Touitou E. Ethosomes: new prospects in transdermal delivery. Crit Rev Ther Drug Carrier Syst 2003;20:63-102
  • Dkeidek I, Touitou E. Transdermal absoprptio of polypeptides. AAPS Pharm Sci 1999;1:S202
  • Touitou E, Godin B, Weiss C. Enhanced delivery of drugs into and across the skin by ethosomal carriers. Drug Dev Res 2000;50:406-15
  • Touitou E, Godin B, Dayan N, et al. Intracellular delivery mediated by an ethosomal carriern. Biomaterials 2001;22:3053-9
  • Godin B, Touitou E. Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier. J Control Release 2004;94:365-79
  • Godin B, Touitou E. Erythromycin ethosomal systems: physicochemical characterization and enhanced antibacterial activity. Curr Drug Deliv 2005;2:269-75
  • Paolino D, Lucania G, Mardente D, et al. Ethosomes for skin delivery of ammonium glycyrrhizinate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteers. J Control Release 2005;106:99-110
  • Godin B, Touitou E, Rubinstein E, et al. A new approach for treatment of deep skin infections by an ethosomal antibiotic preparation: an in vivo study. J Antimicrob Chemother 2005;55:989-94
  • Dubey V, Mishra D, Dutta T, et al. Dermal and transdermal delivery of an anti-psoriatic agent via ethanolic liposomes. J Control Release 2007;123:148-54

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