Non-viral nanovectors for gene delivery: factors that govern successful therapeutics

Bibliography

• Bosch F, Rosich L. The contributions of Paul Ehrlich to pharmacology: a tribute on the occasion of the centenary of his Nobel Prize. Pharmacology 2008;82(3):171-9
   PubMed Web of Science ®Google Scholar
• Brown BD, Gentner B, Cantore A, Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nat Biotechnol 2007;25(12):1457-67
   PubMed Web of Science ®Google Scholar
• Brown BD, Naldini L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nat Rev Genet 2009;10(8):578-85
   PubMed Web of Science ®Google Scholar
• Wooddell CI, Reppen T, Wolff JA, Herweijer H. Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery. J Gene Med 2008;10(5):551-63
   PubMed Web of Science ®Google Scholar
• Sato Y, Roman M, Tighe H, Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996;273(5273):352-4
   PubMed Web of Science ®Google Scholar
• Stenler S, Andersson A, Simonson OE, Gene transfer to mouse heart and skeletal muscles using a minicircle expressing human vascular endothelial growth factor. J Cardiovasc Pharmacol 2009;53(1):18-23
   Google Scholar
• Zhang G, Wooddell CI, Hegge JO, Functional efficacy of dystrophin expression from plasmids delivered to mdx mice by hydrodynamic limb vein injection. Hum Gene Ther 2010;21(2):221-37
   Google Scholar
• DeLong RK, Akhtar U, Sallee M, Characterization and performance of nucleic acid nanoparticles combined with protamine and gold. Biomaterials 2009;30(32):6451-9
   PubMed Web of Science ®Google Scholar
• Lin YC, Yu BY, Lin WC, Tailoring the surface potential of gold nanoparticles with self-assembled monolayers with mixed functional groups. J Colloid Interface Sci 2009;340(1):126-30
   PubMed Web of Science ®Google Scholar
• Jin S, Leach JC, Ye K. Nanoparticle-mediated gene delivery. Methods Mol Biol 2009;544:547-57
   PubMedGoogle Scholar
• Chang CW, Choi D, Kim WJ, Non-ionic amphiphilic biodegradable PEG-PLGA-PEG copolymer enhances gene delivery efficiency in rat skeletal muscle. J Control Release 2007;118(2):245-53
   PubMed Web of Science ®Google Scholar
• Viola JR, Leijonmarck H, Simonson OE, Fatty acid-spermine conjugates as DNA carriers for nonviral in vivo gene delivery. Gene Ther 2009;16(12):1429-40
   PubMed Web of Science ®Google Scholar
• Mae M, Andaloussi SE, Lehto T, Langel U. Chemically modified cell-penetrating peptides for the delivery of nucleic acids. Expert Opin Drug Deliv 2009;6(11):1195-205
   PubMed Web of Science ®Google Scholar
• Midoux P, Pichon C, Yaouanc JJ, Jaffres PA. Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. Br J Pharmacol 2009;157(2):166-78
   PubMed Web of Science ®Google Scholar
• Walker GF, Fella C, Pelisek J, Toward synthetic viruses: endosomal pH-triggered deshielding of targeted polyplexes greatly enhances gene transfer in vitro and in vivo. Mol Ther 2005;11(3):418-25
   PubMed Web of Science ®Google Scholar
• Miller AM, Dean DA. Tissue-specific and transcription factor-mediated nuclear entry of DNA. Adv Drug Deliv Rev 2009;61(7-8):603-13
   PubMed Web of Science ®Google Scholar
• Moreno PM, Wenska M, Lundin KE, A synthetic snRNA m3G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids. Nucleic Acids Res 2009;37(6):1925-35
   PubMed Web of Science ®Google Scholar
• Branden LJ, Mohamed AJ, Smith CI. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA. Nat Biotechnol 1999;17(8):784-7
   PubMed Web of Science ®Google Scholar
• Hillaireau H, Couvreur P. Nanocarriers' entry into the cell: relevance to drug delivery. Cell Mol Life Sci 2009;66(17):2873-96
   PubMed Web of Science ®Google Scholar
• Akita H, Harashima H. Advances in non-viral gene delivery: using multifunctional envelope-type nano-device. Expert Opin Drug Deliv 2008;5(8):847-59
   PubMed Web of Science ®Google Scholar
• Bloomfield VA. DNA condensation. Curr Opin Struct Biol 1996;6(3):334-41
   PubMed Web of Science ®Google Scholar
• Bloomfield VA. DNA condensation by multivalent cations. Biopolymers 1997;44(3):269-82
   PubMed Web of Science ®Google Scholar
• Geall AJ, Blagbrough IS. Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes. Tetrahedron 2000;56(16):2449-60
   Web of Science ®Google Scholar
• Patel MM, Anchordoquy TJ. Contribution of hydrophobicity to thermodynamics of ligand-DNA binding and DNA collapse. Biophys J 2005;88(3):2089-103
   PubMed Web of Science ®Google Scholar
• Lehto T, Abes R, Oskolkov N, Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy. J Control Release 2009;141(1):42-51
   PubMed Web of Science ®Google Scholar
• Mäe M, El Andaloussi S, Lundin P, A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy. J Control Release 2009;134(3):221-7
   PubMed Web of Science ®Google Scholar
• Marshall NB, Oda SK, London CA, Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing. J Immunol Methods 2007;325(1-2):114-26
   PubMed Web of Science ®Google Scholar
• Kabanov A, Zhu J, Alakhov V. Pluronic block copolymers for gene delivery. Adv Genet 2005;53:231-61
   PubMed Web of Science ®Google Scholar
• Santander-Ortega MJ, Jodar-Reyes AB, Csaba N, Colloidal stability of pluronic F68-coated PLGA nanoparticles: a variety of stabilisation mechanisms. J Colloid Interface Sci 2006;302(2):522-9
   PubMed Web of Science ®Google Scholar
• Clover B, Hammouda B. SANS from P85/Water-d under pressure. Langmuir 2010 [Epub ahead of print]
   Google Scholar
• McIlroy D, Barteau B, Cany J, DNA/amphiphilic block copolymer nanospheres promote low-dose DNA vaccination. Mol Ther 2009;17(8):1473-81
   PubMed Web of Science ®Google Scholar
• Batrakova EV, Kabanov AV. Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers. J Control Release 2008;130(2):98-106
   PubMed Web of Science ®Google Scholar
• Roques C, Bouchemal K, Ponchel G, Parameters affecting organization and transfection efficiency of amphiphilic copolymers/DNA carriers. J Control Release 2009;138(1):71-7
   PubMed Web of Science ®Google Scholar
• Braet F, Wisse E, Bomans P, Contribution of high-resolution correlative imaging techniques in the study of the liver sieve in three-dimensions. Microsc Res Tech 2007;70(3):230-42
   PubMed Web of Science ®Google Scholar
• Brissault B, Leborgne C, Guis C, Linear topology confers in vivo gene transfer activity to polyethylenimines. Bioconjug Chem 2006;17(3):759-65
   PubMed Web of Science ®Google Scholar
• Zintchenko A, Susha AS, Concia M, Drug nanocarriers labeled with near-infrared-emitting quantum dots (quantoplexes): imaging fast dynamics of distribution in living animals. Mol Ther 2009;17(11):1849-56
   PubMed Web of Science ®Google Scholar
• Harris TJ, Green JJ, Fung PW, Tissue-specific gene delivery via nanoparticle coating. Biomaterials 2009;31(5):998-1006
   PubMed Web of Science ®Google Scholar
• Malek A, Merkel O, Fink L, In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes. Toxicol Appl Pharmacol 2009;236(1):97-108
   PubMed Web of Science ®Google Scholar
• Hackett PB, Podetz-Petersen KM, Bell JB, Gene expression in lung and liver after intravenous infusion of polyethyleneimine complexes and hydrodynamic delivery of sleeping beauty transposons. Hum Gene Ther 2010;21(2):210-20
   Google Scholar
• Barteau B, Chevre R, Letrou-Bonneval E, Physicochemical parameters of non-viral vectors that govern transfection efficiency. Curr Gene Ther 2008;8(5):313-23
   PubMed Web of Science ®Google Scholar
• Jorgensen L, Hostrup S, Moeller EH, Grohganz H. Recent trends in stabilising peptides and proteins in pharmaceutical formulation–considerations in the choice of excipients. Expert Opin Drug Deliv 2009;6(11):1219-30
   PubMed Web of Science ®Google Scholar
• Merdan T, Kunath K, Petersen H, PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice. Bioconjug Chem 2005;16(4):785-92
   PubMed Web of Science ®Google Scholar
• Merkel OM, Beyerle A, Librizzi D, Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance. Mol Pharm 2009;6(4):1246-60
   PubMed Web of Science ®Google Scholar
• Trubetskoy VS, Wong SC, Subbotin V, Recharging cationic DNA complexes with highly charged polyanions for in vitro and in vivo gene delivery. Gene Ther 2003;10(3):261-71
   PubMed Web of Science ®Google Scholar
• Eliyahu H, Joseph A, Schillemans JP, Characterization and in vivo performance of dextran-spermine polyplexes and DOTAP/cholesterol lipoplexes administered locally and systemically. Biomaterials 2007;28(14):2339-49
   PubMed Web of Science ®Google Scholar
• Zhang W, Tripp RA. RNA interference inhibits respiratory syncytial virus replication and disease pathogenesis without inhibiting priming of the memory immune response. J Virol 2008;82(24):12221-31
   PubMed Web of Science ®Google Scholar
• Zaghloul EM, Viola JR, Zuber G, Formulation and delivery of splice-correction antisense oligonucleotides by amino acid-modified polyethylenimine. Mol Pharm 2010. [Epub ahead of print]
   Google Scholar
• Creusat G, Zuber G. Self-assembling polyethylenimine derivatives mediate efficient siRNA delivery in mammalian cells. Chembiochem 2008;9(17):2787-9
   PubMed Web of Science ®Google Scholar
• Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 2008;5(4):505-15
   PubMedGoogle Scholar
• Liu L, Zern MA, Lizarzaburu ME, Poly(cationic lipid)-mediated in vivo gene delivery to mouse liver. Gene Ther 2003;10(2):180-7
   PubMed Web of Science ®Google Scholar
• Nyunt MT, Dicus CW, Cui YY, Physico-chemical characterization of polylipid nanoparticles for gene delivery to the liver. Bioconjug Chem 2009;20(11):2047-54
   PubMed Web of Science ®Google Scholar
• Wu J, Lizarzaburu ME, Kurth MJ, Cationic lipid polymerization as a novel approach for constructing new DNA delivery agents. Bioconjug Chem 2001;12(2):251-7
   PubMed Web of Science ®Google Scholar
• Klibanov AL, Maruyama K, Torchilin VP, Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett 1990;268(1):235-7
   PubMed Web of Science ®Google Scholar
• Beyerle A, Merkel O, Stoeger T, Kissel T. PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: structure-function relationships. Toxicol Appl Pharmacol 2009;242(2):146-54
   PubMed Web of Science ®Google Scholar
• Kunath K, von Harpe A, Petersen H, The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-kappaB decoy in mice. Pharm Res 2002;19(6):810-7
   PubMed Web of Science ®Google Scholar
• Faure AC, Dufort S, Josserand V, Control of the in vivo biodistribution of hybrid nanoparticles with different poly(ethylene glycol) coatings. Small 2009;5(22):2565-75
   PubMed Web of Science ®Google Scholar
• Kojima C, Regino C, Umeda Y, Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers. Int J Pharm 2010;383(1-2):293-6
   PubMedGoogle Scholar
• Hatakeyama H, Akita H, Kogure K, Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther 2007;14(1):68-77
   PubMed Web of Science ®Google Scholar
• Morille M, Montier T, Legras P, Long-circulating DNA lipid nanocapsules as new vector for passive tumor targeting. Biomaterials 2010;31(2):321-9
   PubMed Web of Science ®Google Scholar
• Kasuya T, Kuroda S. Nanoparticles for human liver-specific drug and gene delivery systems: in vitro and in vivo advances. Expert Opin Drug Deliv 2009;6(1):39-52
   PubMed Web of Science ®Google Scholar
• Oupicky D, Ogris M, Howard KA, Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Mol Ther 2002;5(4):463-72
   PubMed Web of Science ®Google Scholar
• Soutschek J, Akinc A, Bramlage B, Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 2004;432(7014):173-8
   PubMed Web of Science ®Google Scholar
• Akinc A, Goldberg M, Qin J, Development of lipidoid-siRNA formulations for systemic delivery to the liver. Mol Ther 2009;17(5):872-9
   PubMed Web of Science ®Google Scholar
• Fenske DB, Cullis PR. Liposomal nanomedicines. Expert Opin Drug Deliv 2008;5(1):25-44
   PubMed Web of Science ®Google Scholar
• Semple SC, Klimuk SK, Harasym TO, Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochim Biophys Acta 2001;1510(1-2):152-66
   PubMed Web of Science ®Google Scholar
• Krutzfeldt J, Rajewsky N, Braich R, Silencing of microRNAs in vivo with ‘antagomirs’. Nature 2005;438(7068):685-9
   PubMed Web of Science ®Google Scholar
• Thum T, Gross C, Fiedler J, MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008;456(7224):980-4
   PubMed Web of Science ®Google Scholar
• Akinc A, Zumbuehl A, Goldberg M, A combinatorial library of lipid-like materials for delivery of RNAi therapeutics. Nat Biotechnol 2008;26(5):561-9
   PubMed Web of Science ®Google Scholar
• Frank-Kamenetsky M, Grefhorst A, Anderson NN, Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci USA 2008;105(33):11915-20
   PubMed Web of Science ®Google Scholar
• Novobrantseva TI, Akinc A, Borodovsky A, de Fougerolles A. Delivering silence: advancements in developing siRNA therapeutics. Curr Opin Drug Discov Devel 2008;11(2):217-24
   PubMed Web of Science ®Google Scholar
• Lundin P, Johansson H, Guterstam P, Distinct uptake routes of cell-penetrating peptide conjugates. Bioconjug Chem 2008;19(12):2535-42
   PubMed Web of Science ®Google Scholar
• Love K, Mahon KP, Levins CG, Lipid-like materials for low-dose, in vivo gene silencing. PNAS 2010;107(5):1864-9
   Google Scholar
• Brannon-Peppas L, Blanchette JO. Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 2004;56(11):1649-59
   PubMed Web of Science ®Google Scholar
• Chisholm EJ, Vassaux G, Martin-Duque P, Cancer-specific transgene expression mediated by systemic injection of nanoparticles. Cancer Res 2009;69(6):2655-62
   PubMed Web of Science ®Google Scholar
• Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986;46(12 Pt 1):6387-92
   PubMed Web of Science ®Google Scholar
• Ogris M, Wagner E. Tumor-targeted gene transfer with DNA polyplexes. Somat Cell Mol Genet 2002;27(1-6):85-95
   PubMedGoogle Scholar
• Russ V, Frohlich T, Li Y, Improved in vivo gene transfer into tumor tissue by stabilization of pseudodendritic oligoethylenimine-based polyplexes. J Gene Med 2010;12(2):180-193
   PubMed Web of Science ®Google Scholar
• Pike DB, Ghandehari H. HPMA copolymer-cyclic RGD conjugates for tumor targeting. Adv Drug Deliv Rev 2010;62(2):167-83
   Google Scholar
• Li Z, Huang P, Zhang X, RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol Pharm 2010;7(1):94-104
   PubMedGoogle Scholar
• Chen W, Jarzyna PA, van Tilborg GA, RGD peptide functionalized and reconstituted high-density lipoprotein nanoparticles as a versatile and multimodal tumor targeting molecular imaging probe. FASEB J 2010. [Epub ahead of print]
   Google Scholar
• Dhar S, Gu FX, Langer R, Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci USA 2008;105(45):17356-61
   PubMed Web of Science ®Google Scholar
• Dassie JP, Liu XY, Thomas GS, Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol 2009;27(9):839-49
   PubMed Web of Science ®Google Scholar
• Huang R, Han L, Li J, Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles. J Gene Med 2009;11(9):754-63
   PubMed Web of Science ®Google Scholar
• Huang R, Ke W, Han L, Brain-targeting mechanisms of lactoferrin-modified DNA-loaded nanoparticles. J Cereb Blood Flow Metab 2009;29(12):1914-23
   PubMed Web of Science ®Google Scholar
• Huang R, Ke W, Liu Y, Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model. J Neurol Sci 2010;290(1-2):123-30
   Google Scholar
• Huang R-Q, Qu Y-H, Ke W-L, Efficient gene delivery targeted to the brain using a transferrin-conjugated polyehtyleneglycol-modified polyamidoamine dendrimer. FASEB J 2007;21:1117-25
   PubMed Web of Science ®Google Scholar
• Ke W, Shao K, Huang R, Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. Biomaterials 2009;30(36):6976-85
   PubMed Web of Science ®Google Scholar
• Pardridge WM. Drug targeting to the brain. Pharm Res 2007;24(9):1733-44
   PubMed Web of Science ®Google Scholar
• Rip J, Schenk GJ, de Boer AG. Differential receptor-mediated drug targeting to the diseased brain. Expert Opin Drug Deliv 2009;6(3):227-37
   PubMed Web of Science ®Google Scholar
• Kim YI, Chung JW. Selective or targeted gene/drug delivery for liver tumors: advantages and current status of local delivery. Expert Rev Gastroenterol Hepatol 2008;2(6):791-802
   PubMedGoogle Scholar
• Pathak A, Vyas SP, Gupta KC. Nano-vectors for efficient liver specific gene transfer. Int J Nanomedicine 2008;3(1):31-49
   PubMed Web of Science ®Google Scholar
• Wu GY, Wu CH. Receptor-mediated gene delivery and expression in vivo. J Biol Chem 1988;263(29):14621-4
   PubMed Web of Science ®Google Scholar
• Arangoa MA, Duzgunes N, Tros de Ilarduya C. Increased receptor-mediated gene delivery to the liver by protamine-enhanced-asialofetuin-lipoplexes. Gene Ther 2003;10(1):5-14
   PubMed Web of Science ®Google Scholar
• Letrou-Bonneval E, Chevre R, Lambert O, Galactosylated multimodular lipoplexes for specific gene transfer into primary hepatocytes. J Gene Med 2008;10(11):1198-209
   PubMed Web of Science ®Google Scholar
• Diez S, Navarro G, de ICT. In vivo targeted gene delivery by cationic nanoparticles for treatment of hepatocellular carcinoma. J Gene Med 2009;11(1):38-45
   PubMed Web of Science ®Google Scholar
• Sokoloff AV, Wong SC, Ludtke JJ, A new peptide ligand that targets particles and heterologous proteins to hepatocytes in vivo. Mol Ther 2003;8(6):867-72
   PubMed Web of Science ®Google Scholar
• Ludtke JJ, Sokoloff AV, Wong S, Peptide-mediated targeting of hepatocytes via low density lipoprotein receptor-related protein (LRP). Drug Deliv 2009;16(5):268-73
   PubMed Web of Science ®Google Scholar
• Mukthavaram R, Marepally S, Venkata MY, Cationic glycolipids with cyclic and open galactose head groups for the selective targeting of genes to mouse liver. Biomaterials 2009;30(12):2369-84
   PubMed Web of Science ®Google Scholar
• Yan AC, Levy M. Aptamers and aptamer targeted delivery. RNA Biol 2009;6(3):316-20
   PubMed Web of Science ®Google Scholar
• The Eyetech Study Group. Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: phase II study results. Ophthalmology 2003;110(5):979-986
   PubMed Web of Science ®Google Scholar
• Alexander JH, Hafley G, Harrington RA, Efficacy and safety of edifoligide, an E2F transcription factor decoy, for prevention of vein graft failure following coronary artery bypass graft surgery: PREVENT IV: a randomized controlled trial. JAMA 2005;294(19):2446-54
   PubMed Web of Science ®Google Scholar
• Apte RS, Modi M, Masonson H, Pegaptanib 1-year systemic safety results from a safety-pharmacokinetic trial in patients with neovascular age-related macular degeneration. Ophthalmology 2007;114(9):1702-12
   PubMed Web of Science ®Google Scholar
• Chan MY, Cohen MG, Dyke CK, Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease. Circulation 2008;117(22):2865-74
   PubMed Web of Science ®Google Scholar
• Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation 2007;116(23):2678-86
   PubMed Web of Science ®Google Scholar
• Chu TC, Twu KY, Ellington AD, Levy M. Aptamer mediated siRNA delivery. Nucleic Acids Res 2006;34(10):e73
   PubMedGoogle Scholar
• McNamara JO II, Andrechek ER, Wang Y, Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol 2006;24(8):1005-15
   PubMed Web of Science ®Google Scholar
• Shaw BR, Moussa L, Sharaf M, Boranophosphate siRNA-aptamer chimeras for tumor-specific downregulation of cancer receptors and modulators. Nucleic Acids Symp Ser (Oxf) 2008;52(1):655-656
   PubMedGoogle Scholar
• Zhou J, Li H, Li S, Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. Mol Ther 2008;16(8):1481-9
   PubMed Web of Science ®Google Scholar
• Lavigne MD, Yates L, Coxhead P, Gorecki DC. Nuclear-targeted chimeric vector enhancing nonviral gene transfer into skeletal muscle of Fabry mice in vivo. FASEB J 2008;22(6):2097-107
   PubMed Web of Science ®Google Scholar
• Richard P, Pollard H, Lanctin C, Inducible production of erythropoietin using intramuscular injection of block copolymer/DNA formulation. J Gene Med 2005;7(1):80-6
   PubMed Web of Science ®Google Scholar
• Heemskerk H, de Winter CL, van Ommen GJ, Development of antisense-mediated exon skipping as a treatment for duchenne muscular dystrophy. Ann NY Acad Sci 2009;1175:71-9
   PubMed Web of Science ®Google Scholar
• Rodino-Klapac LR, Montgomery CL, Bremer WG, Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery. Mol Ther 2010;18(1):109-17
   Google Scholar
• Richard P, Bossard F, Desigaux L, Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles. Hum Gene Ther 2005;16(11):1318-24
   PubMed Web of Science ®Google Scholar
• Bello-Roufai M, Lambert O, Pitard B. Relationships between the physicochemical properties of an amphiphilic triblock copolymers/DNA complexes and their intramuscular transfection efficiency. Nucleic Acids Res 2007;35(3):728-39
   PubMed Web of Science ®Google Scholar
• Pitard B, Bello-Roufai M, Lambert O, Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer. Nucleic Acids Res 2004;32(20):e159
   PubMedGoogle Scholar
• Pitard B, Pollard H, Agbulut O, A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles. Hum Gene Ther 2002;13(14):1767-75
   PubMed Web of Science ®Google Scholar
• Namgung R, Nam S, Kim SK, An acid-labile temperature-responsive sol-gel reversible polymer for enhanced gene delivery to the myocardium and skeletal muscle cells. Biomaterials 2009;30(28):5225-33
   PubMed Web of Science ®Google Scholar
• Alakhov V, Moskaleva E, Batrakova EV, Kabanov AV. Hypersensitization of multidrug resistant human ovarian carcinoma cells by pluronic P85 block copolymer. Bioconjug Chem 1996;7(2):209-16
   PubMed Web of Science ®Google Scholar
• Yang Z, Sahay G, Sriadibhatla S, Kabanov AV. Amphiphilic block copolymers enhance cellular uptake and nuclear entry of polyplex-delivered DNA. Bioconjug Chem 2008;19(10):1987-94
   PubMed Web of Science ®Google Scholar
• Jeon E, Kim HD, Kim JS. Pluronic-grafted poly-(L)-lysine as a new synthetic gene carrier. J Biomed Mater Res A 2003;66(4):854-9
   PubMedGoogle Scholar
• Ochietti B, Lemieux P, Kabanov AV, Inducing neutrophil recruitment in the liver of ICAM-1-deficient mice using polyethyleneimine grafted with Pluronic P123 as an organ-specific carrier for transgenic ICAM-1. Gene Ther 2002;9(14):939-45
   PubMed Web of Science ®Google Scholar
• Avgoustakis K. Pegylated poly(lactide) and poly(lactide-co-glycolide) nanoparticles: preparation, properties and possible applications in drug delivery. Curr Drug Deliv 2004;1(4):321-33
   PubMedGoogle Scholar
• Park JH, Saravanakumar G, Kim K, Kwon IC. Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv Drug Deliv Rev 2010;62(1):28-41
   Google Scholar
• Jean M, Smaoui F, Lavertu M, Chitosan-plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies. Gene Ther 2009;16(9):1097-110
   PubMed Web of Science ®Google Scholar
• Pringle IA, Hyde SC, Gill DR. Non-viral vectors in cystic fibrosis gene therapy: recent developments and future prospects. Expert Opin Biol Ther 2009;9(8):991-1003
   PubMed Web of Science ®Google Scholar
• Davies LA, McLachlan G, Sumner-Jones SG, Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes. Mol Ther 2008;16(7):1283-90
   PubMed Web of Science ®Google Scholar
• Denk W, Strickler JH, Webb WW. Two-photon laser scanning fluorescence microscopy. Science 1990;248(4951):73-6
   PubMed Web of Science ®Google Scholar
• Holtkamp S, Kreiter S, Selmi A, Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells. Blood 2006;108(13):4009-17
   PubMed Web of Science ®Google Scholar
• Kormann MHG, Aneja M, Nica G, Pulmonary messenger RNA application prevents fatal respiratory distress in surfactant protein B deficient mice [abstract]. Hum Gene Ther 2009;20(11):1409-10
   Web of Science ®Google Scholar
• Weeke-Klimp AH, Bartsch M, Morselt HW, Targeting of stabilized plasmid lipid particles to hepatocytes in vivo by means of coupled lactoferrin. J Drug Target 2007;15(9):585-94
   PubMed Web of Science ®Google Scholar
• Linnemann AK, Platts AE, Doggett N, Genomewide identification of nuclear matrix attachment regions: an analysis of methods. Biochem Soc Trans 2007;35(Pt 3):612-7
   PubMedGoogle Scholar
• Manzini S, Vargiolu A, Stehle IM, Genetically modified pigs produced with a nonviral episomal vector. Proc Natl Acad Sci USA 2006;103(47):17672-7
   PubMed Web of Science ®Google Scholar
• Hyde SC, Pringle IA, Abdullah S, CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression. Nat Biotechnol 2008;26(5):549-51
   PubMed Web of Science ®Google Scholar
• Mercer J, Helenius A. Virus entry by macropinocytosis. Nat Cell Biol 2009;11(5):510-20
   PubMed Web of Science ®Google Scholar