- ALLEN TM, CULLIS PR: Drug delivery systems: entering the mainstream. Science (2004) 303:1818–1822.
- LAVAN DA, MCGUIRE T, LANGER R: Small-scale systems for in vivo drug delivery. Nat. Biotechnol (2003) 21:1184–1191.
- MARTIN CR, KOHLI P: The emerging field of nanotube biotechnology. Nat. Rev Drug Discov. (2003) 2:29–37.
- •This paper summarises the current efforts toward the development of nanotube structures for biomedical and biotechnological applications.
- LAVAN DA, LYNN DM, LANGER R: Moving smaller in drug discovery and delivery. Nat. Rev Drug Discov. (2002) 1:77–84.
- LANGER R: Drug delivery and targeting. Nature (1998) 392(Suppl.):5–10.
- DUNCAN R: The dawning era of polymer therapeutics. Nat. Rev Drug Discov. (2003) 2:347–360.
- SAVIC R, LUO L, EISENBERG A, MAYSINGER D: Micellar nanocontainers distribute to defined cytoplasmic organelles. Science (2003) 300:615–618.
- MURTHY N, XU M, SCHUCK S, KUNISAWA J, SHASTRI N, FRECHET JMJ: A macromolecular delivery vehicle for protein-based vaccines: acid-degradable protein-loaded microgels. Proc. Natl. Acad. Sci. USA (2003) 100:4995–5000.
- VARDE NK, PACK DW: Microspheres for controlled release drug delivery. Expert Opin. Biol. Ther. (2004) 4:35–51.
- GREF R, MINAMITAKE Y, PERACCHIA MT, TRUBETSKOY V, TORCHILIN V, LANGER R: Biodegradable long-circulating polymeric nanospheres. Science (1994) 263:1600–1603.
- BOAS U, HEEGAARD PM: Dendrimm in drug research. Chem. Soc. Rev (2004) 33:43–63.
- KOSTARELOS K: Rational design and engineering of delivery systems for therapeutics: biomedical exercises in colloid and surface science. Adv. Coll. Inter. Sci. (2003) 106:147–168.
- Niemeyer CM, Mirkin CA (Eds), Wiley-VCH, Weinheim, Germany (2004).
- EMERICH DF, THANOS CG: Nanotechnology and medicine. Expert Opin. Biol. Ther. (2003) 3:1–9.
- BRADBURY J: Beyond pills and jabs. Lancet (2003) 362:1984–1985.
- BIANCO A, PRATO M: Can carbon nanotubes be considered useful tools for biological applications? Adv. Mater. (2003) 15:1765–1768.
- BACON R: Growth, structure, and properties of graphite whiskers. I Appl. Phys. (1960) 31:284–290.
- •This is one of the first reports on the discovery of CNTs.
- OBERLIN A, ENDO M, KOYAMA T: Filamentous growth of carbon though benzene decomposition. Cryst. Growth (1976) 32:335–349.
- IIJIMA S: Helical microtubules of graphitic carbon. Nature (1991) 354:56–58.
- RAO CNR, SATISHKUMAR B, GOVINDARAJ A, NATH M: Nanotubes. Chem. Phys. Chem. (2001) 2:78–105.
- Special issue on carbon nanotubes. Acc. Chem. Res. (2002) 35:997–1113.
- •This issue contains a series of excellent articles describing the physicochemical properties of carbon nanotubes and their applications.
- Dresselhaus MS, Dresselhaus G, Avouris P (Eds), Springer-Velag, Berlin, Germany (2001).
- LIN Y, TAYLOR S, LI H, FERNANDO KA et al: Advances toward bioapplications of carbon nanotubes. Mater. Chem. (2004) 14:527–541.
- •This article presents a comprehensive overview of covalent and non-covalent functionalisation of CNTs toward biological applications.
- O'CONNELL MJ, BOUL P, ERICSON LM et al: Reversible water-solubilization of single-walled carbon nanotubes by polymer wrapping. Chem. Phys. Lett. (2001) 342:265–271.
- STAR A, STODDARD JF, STEUERMAN D et al.: Preparation and properties of polymer-wrapped single-walled carbon nanotubes. Angew. Chem. Int. Ed. (2001) 40:1721–1725.
- RICHARD C, BALAVOINE F, SCHULTZ P, EBBESEN TW, MIOSKOWSKI C: Supramolecular self-assembly of lipid derivatives on carbon nanotubes. Science (2003) 300:775–778.
- KANG Y, TATON TA: Micelle-encapsulated carbon nanotubes: a route to nanotube composites. Am. Chem. Soc. (2003) 125:5650–5651.
- MCCARTHY B, COLEMAN JN, CZERW R et al.: A microscopic and spectroscopic study of interactions between carbon nanotubes and a conjugated polymer. I Phys. Chem. B(2002) 106:2210–2216.
- KIM OK, JE J, BALDWIN JW, KOOI S,PEHRSSON PE, BUCKLEY LJ: Solubilization of single-walled carbon nanotubes by supramolecular encapsulation of helical amylose. J. Am. Chem. Soc. (2003) 125:4426–4427.
- STAR A, STEUERMAN DW, HEATH JR,STODDARD JF: Starched carbon nanotubes. Angew. Chem. Int. Ed. (2002) 41:2508–2512.
- CHAMBERS G, CARROLL C, FARRELL GF et al: Characterization of the Interaction of gamma cyclodextrin with single-walled carbon nanotubes. Nano Lett. (2003) 3:843–846.
- DODZIUK H, EJCHART A, ANCZEWSKI W et al.: Water solubilization, determination of the number of different types of single-wall carbon nanotubes and their partial separation with respect to diameters by complexation with h-cyclodextrin. Chem. Commun. (2003):986–987.
- IN HET PANHUIS M, THIELEMANS W et al: A composite from soy oil and carbon nanotubes. Int. .1. Nanosci. (2003) 2:185–194.
- ZHENG M, JAGOTA A, SEMKE ED et al.: DNA-assisted dispersion and separation of carbon nanotubes. Nat. Mater. (2003) 2:338–342.
- ZHENG M, JAGOTA A, STRANO MS et al.: Structure-based carbon nanotube sorting by sequence-dependent DNA assembly. Science (2003) 302:1545–1548.
- DIECKMANN GR, DALTON AB, JOHNSON PA et al: Controlled assembly of carbon nanotubes by designed amphiphilic peptide helices. I Am. Chem. Soc. (2003) 125:1770–1777.
- WANG S, HUMPHREYS ES, CHUNG SY et al.: Peptides with selective affinity for carbon nanotubes. Nat. Mater. (2003) 2:196–200.
- CHEN RJ, ZHANG Y, WANG D, DAI H: Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J. Am. Chem. Soc. (2001) 123:3838–3839.
- CHEN RJ, BANGSARUNTIP S, DROUVALAKIS KA et al.: Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proc. Natl. Acad. Sci. USA (2003) 100:4984–4989.
- COLVIN VL: The potential environmental impact of engineered nanomaterials. Nat. Biotech. (2003) 21:1166–1170.
- •An interesting review that discusses the toxicological and environmental risks of exposure to nanomaterials, focusing particularly on carbon nanostructures.
- SHVEDOVA AA, CASTRANOVA V, KISIN ER et al.: Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. ToxicoL Environ. Health A. (2003) 66:1909–1926.
- WARHEIT DB, LAURENCE BR, REED KL, ROACH DH, REYNOLDS GA, WEBB TR: Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxica Se/. (2004) 77:117–125.
- LAM CW, JAMES JT, MCCLUSKEY R, HUNTER RL: Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxica Se/. (2004) 77:126–134.
- TASIS D, TAGMATARCHIS N, GEORGAKILAS V, PRATO M: Soluble carbon nanotubes. Chem. Eui: J. (2003) 9:4000–4008.
- HIRSCH A: Functionalization of single-walled carbon nanotubes. Angew. Chem. Int. Ed. (2002) 41:1853–1859.
- DYKE CA, TOUR JM: Overcoming the insolubility of carbon nanotubes through high degrees of sidewall functionalization. Chem. Eur. J. (2004) 10:812–817.
- GEORGAKILAS V, KORDATOS K, PRATO M, GULDI DM, HOLZINGER M, HIRSCH A: Organic functionalization of carbon nanotubes.J. Am. Chem. Soc. (2002) 124:760–761.
- GEORGAKILAS V, TAGMATARCHIS N, PANTAROTTO D, BIANCO A, BRIAND JP, PRATO M: Amino acid functionalisation of water soluble carbon nanotubes. Chem. Commun. (2002):3050–3051.
- PANTAROTTO D, HOEBEKE J, GRAFF R et al.: Synthesis, structural characterization and immunological properties of carbon nanotubes functionalized with peptides. I Am. Chem. Soc. (2003) 125:6160–6164.
- VOSTROWSKY O, HIRSCH A: Molecular peapods as supramolecular carbon allotropes. Angew. Chem. hat Ed (2004) 43:2326–2329.
- GUO Z, SADLER PJ, TSANG SC: Immobilization and visualization of DNA and proteins on carbon nanotubes. Adv. Mater. (1998) 10:701–703.
- AJAYAN PM, IJIMA S: Capillarity-induced filling of carbon nanotubes. Nature (1993) 361:333–334.
- SMITH BW, MONTHIOUX M, LUZZI DE: Encapsulated C60 in carbon nanotubes. Nature (1998) 396:323–324.
- BRITZ DA, KHLOBYSTOV AN, WANG J et al: Selective host-guest interaction of single-walled carbon nanotubes with functionalized fullerenes. Chem. Commun. (2004) 176–177.
- TAKENOBU T, TAKANO T, SHIRAISHI M et al.: Stable and controlled amphoteric doping by encapsulation of organic molecules inside carbon nanotubes. Nat. Mater. (2003) 2:683–688.
- HUMMER G, RASALAH JC, NOWORYTA JP: Water conduction through the hydrophobic channel of a carbon nanotube. Nature (2001) 414:188–190.
- KALRA A, GARDE S, HUMMER G: Osmotic water transport through carbon nanotube membrane. Proc. Natl. Acad. Sci. (2003) 100:10175–10180.
- GAO H, KONG Y, CUI D, OZKAN CS:Spontaneous insertion of DNA oligonucleotides into carbon nanotubes. Nano Lett. (2003) 3:471–473.
- WET C, SRIVASTAVA D: Theory of transport of long polymer molecules through carbon nanotube channels. Phys. Rev. Lett. (2003) 91:235901.
- ITO T, SUN L, CROOKS RM: Observation of DNA transport through a single carbon nanotube channel using fluorescence microscopy. Chem. Commun. (2003) 7:1482–1483.
- JOSEPH S, MASHL RJ, JAKOBSSON E, ALURU NR: Electrolytic transport in modified carbon nanotubes. Nano Lett. (2003) 3:1399–1403.
- QIAO R, ALURU NR: Atypical dependence of electroosmotic transport on surface charge in a single-wall carbon nanotube. Nano Lett. (2003) 3:1013–1017.
- PARK KH, CHHOWALLA M, IQBAL Z, SESTI F: Single-walled carbon nanotubes are a new class of ion channel blockers. Biol. Chem. (2003) 278:50212–50216.
- PANTAROTTO D, BRIAND JP, PRATO M, BIANCO A: Translocation of bioactive peptides across cell membrane by carbon nanotubes. Chem. Commun. (2004):16–17.
- •This article illustrates the first demonstration of the cellular uptake of functionalised CNTs.
- PANTAROTTO D, SINGH R, MCCARTHY D et al.: Functionalised carbon nanotubes for plasmid DNA gene delivery. Angew. Chem. Int. Ed (2004) 43:5242–5246.
- LOPEZ CF, NIELSEN SO, MOORE PB, KLEIN ML: Understanding nature's design for a nanosyringe. Proc. Nati Acad. Sci. USA (2004) 101:4431–4434.
- SHI KAM WN, JESSOP TC, WENDER PA, DAI H: Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into mammalian cells. Am. Chem. Soc. (2004) 126:6850–6851.
- ZHAO W, SONG C, PEHRSSON PE: Water-soluble and optically pH-sensitive single-walled carbon nanotubes from surface modification. Am. Chem. Soc. (2002) 124:12418–12419.
- PANTAROTTO D, PARTIDOS CD, HOEBEKE J et al.: Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. Chem. Biol. (2003) 10:961–966.
- CHEN BX, WILSON SR, DAS M, COUGHLIN DJ, ERLANGER BF: Antigenicity of fullerenes: antibodies specific for fullerenes and their characteristics. Proc. Natl. Acad. Sci. USA (1998) 95:10809–10813.
- ERLANGER BE CHEN BX, ZHU M, BRUS L: Binding of an anti-fullerene IgG monoclonal antibody to single wall carbon nanotubes. Nano Lett. (2001) 1:465–467.
- BRIAND JP, BARIN C, VAN REGENMORTEL MH, MULLER S: Application and limitations of the multiple antigen peptide (MAP) system in the production and evaluation of anti-peptide and anti-protein antibodies. Immunol. Methods (1992) 156:255–265.
- Smyth Templeton N (Ed.), Dekker, New York, USA (2003).
- NIIDOME T, HUANG L: Gene therapy progress and prospects: nonviral vectors. Gene The]: (2002) 9:1647–1652.
- LUO D: A new solution for improving gene delivery. Trends Biotech. (2004) 22:101–103.
- SCHMIDT-WOLF GD, SCHMIDT-WOLF IG: Non-viral and hybrid vectors in human gene therapy: an update. Trends Mol. Med. (2003) 9:67–72.
- Special issue on non-viral gene delivery systems. Carr: Med. Chem. (2003) 10:1185–1315.
- DWYER C, GUTHOLD M, FALVO M, WASHBURN S, SUPERFINE R, ERIE D: DNA-functionalized single-walled carbon nanotubes. Nanotechnology (2002) 13:601–604.
- NGUYEN CV, DELZEIT L, CASSEL AM,LI J, HAN J, MEYYAPPAN M: Preparation of nucleic acid functionalized carbon nanotube arrays. Nano Lett. (2002) 2:1079–1081.
- BAKER SE, CAI W, LASSETER TL, WEIDKAMP KP, HAMERS RJ: Covalently bonded adducts of deoxyribonucleic acid (DNA) oligonucleotides with single-wall carbon nanotubes: synthesis and hydridization. Nano Lett. (2002) 2:1413–1417.
- WILLIAMS KA, VEENHUIZEN PTM, DE LA TORRE BG, ERITJIA R, DEKKER C: Carbon nantotubes with DNA recognition. Nature (2002) 420:761.
- DAAR AS, THORSTEINSDOTTIR H, MARTIN DK, SMITH AC, NAST S, SINGER PA: Top ten biotechnologies for improving health in developing countries. Nat. Genet. (2002) 32:229–232.
- MCNEELA EA, O' A mucosal vaccine against diphtheria: formulation of cross reacting material (CRIVI197) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery. Vaccine (2000) 19:1188–1198.
Carbon nanotubes for the delivery of therapeutic molecules
Reprints and Corporate Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
To request a reprint or corporate permissions for this article, please click on the relevant link below:
Academic Permissions
Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?
Obtain permissions instantly via Rightslink by clicking on the button below:
If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.
Related research
People also read lists articles that other readers of this article have read.
Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.
Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.