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Review

Carbon nanotubes for the delivery of therapeutic molecules

Pages 57-65 | Published online: 23 Feb 2005

  • ALLEN TM, CULLIS PR: Drug delivery systems: entering the mainstream. Science (2004) 303:1818–1822.
  • LAVAN DA, MCGUIRE T, LANGER R: Small-scale systems for in vivo drug delivery. Nat. Biotechnol (2003) 21:1184–1191.
  • MARTIN CR, KOHLI P: The emerging field of nanotube biotechnology. Nat. Rev Drug Discov. (2003) 2:29–37.
  • •This paper summarises the current efforts toward the development of nanotube structures for biomedical and biotechnological applications.
  • LAVAN DA, LYNN DM, LANGER R: Moving smaller in drug discovery and delivery. Nat. Rev Drug Discov. (2002) 1:77–84.
  • LANGER R: Drug delivery and targeting. Nature (1998) 392(Suppl.):5–10.
  • DUNCAN R: The dawning era of polymer therapeutics. Nat. Rev Drug Discov. (2003) 2:347–360.
  • SAVIC R, LUO L, EISENBERG A, MAYSINGER D: Micellar nanocontainers distribute to defined cytoplasmic organelles. Science (2003) 300:615–618.
  • MURTHY N, XU M, SCHUCK S, KUNISAWA J, SHASTRI N, FRECHET JMJ: A macromolecular delivery vehicle for protein-based vaccines: acid-degradable protein-loaded microgels. Proc. Natl. Acad. Sci. USA (2003) 100:4995–5000.
  • VARDE NK, PACK DW: Microspheres for controlled release drug delivery. Expert Opin. Biol. Ther. (2004) 4:35–51.
  • GREF R, MINAMITAKE Y, PERACCHIA MT, TRUBETSKOY V, TORCHILIN V, LANGER R: Biodegradable long-circulating polymeric nanospheres. Science (1994) 263:1600–1603.
  • BOAS U, HEEGAARD PM: Dendrimm in drug research. Chem. Soc. Rev (2004) 33:43–63.
  • KOSTARELOS K: Rational design and engineering of delivery systems for therapeutics: biomedical exercises in colloid and surface science. Adv. Coll. Inter. Sci. (2003) 106:147–168.
  • Niemeyer CM, Mirkin CA (Eds), Wiley-VCH, Weinheim, Germany (2004).
  • EMERICH DF, THANOS CG: Nanotechnology and medicine. Expert Opin. Biol. Ther. (2003) 3:1–9.
  • BRADBURY J: Beyond pills and jabs. Lancet (2003) 362:1984–1985.
  • BIANCO A, PRATO M: Can carbon nanotubes be considered useful tools for biological applications? Adv. Mater. (2003) 15:1765–1768.
  • BACON R: Growth, structure, and properties of graphite whiskers. I Appl. Phys. (1960) 31:284–290.
  • •This is one of the first reports on the discovery of CNTs.
  • OBERLIN A, ENDO M, KOYAMA T: Filamentous growth of carbon though benzene decomposition. Cryst. Growth (1976) 32:335–349.
  • IIJIMA S: Helical microtubules of graphitic carbon. Nature (1991) 354:56–58.
  • RAO CNR, SATISHKUMAR B, GOVINDARAJ A, NATH M: Nanotubes. Chem. Phys. Chem. (2001) 2:78–105.
  • Special issue on carbon nanotubes. Acc. Chem. Res. (2002) 35:997–1113.
  • •This issue contains a series of excellent articles describing the physicochemical properties of carbon nanotubes and their applications.
  • Dresselhaus MS, Dresselhaus G, Avouris P (Eds), Springer-Velag, Berlin, Germany (2001).
  • LIN Y, TAYLOR S, LI H, FERNANDO KA et al: Advances toward bioapplications of carbon nanotubes. Mater. Chem. (2004) 14:527–541.
  • •This article presents a comprehensive overview of covalent and non-covalent functionalisation of CNTs toward biological applications.
  • O'CONNELL MJ, BOUL P, ERICSON LM et al: Reversible water-solubilization of single-walled carbon nanotubes by polymer wrapping. Chem. Phys. Lett. (2001) 342:265–271.
  • STAR A, STODDARD JF, STEUERMAN D et al.: Preparation and properties of polymer-wrapped single-walled carbon nanotubes. Angew. Chem. Int. Ed. (2001) 40:1721–1725.
  • RICHARD C, BALAVOINE F, SCHULTZ P, EBBESEN TW, MIOSKOWSKI C: Supramolecular self-assembly of lipid derivatives on carbon nanotubes. Science (2003) 300:775–778.
  • KANG Y, TATON TA: Micelle-encapsulated carbon nanotubes: a route to nanotube composites. Am. Chem. Soc. (2003) 125:5650–5651.
  • MCCARTHY B, COLEMAN JN, CZERW R et al.: A microscopic and spectroscopic study of interactions between carbon nanotubes and a conjugated polymer. I Phys. Chem. B(2002) 106:2210–2216.
  • KIM OK, JE J, BALDWIN JW, KOOI S,PEHRSSON PE, BUCKLEY LJ: Solubilization of single-walled carbon nanotubes by supramolecular encapsulation of helical amylose. J. Am. Chem. Soc. (2003) 125:4426–4427.
  • STAR A, STEUERMAN DW, HEATH JR,STODDARD JF: Starched carbon nanotubes. Angew. Chem. Int. Ed. (2002) 41:2508–2512.
  • CHAMBERS G, CARROLL C, FARRELL GF et al: Characterization of the Interaction of gamma cyclodextrin with single-walled carbon nanotubes. Nano Lett. (2003) 3:843–846.
  • DODZIUK H, EJCHART A, ANCZEWSKI W et al.: Water solubilization, determination of the number of different types of single-wall carbon nanotubes and their partial separation with respect to diameters by complexation with h-cyclodextrin. Chem. Commun. (2003):986–987.
  • IN HET PANHUIS M, THIELEMANS W et al: A composite from soy oil and carbon nanotubes. Int. .1. Nanosci. (2003) 2:185–194.
  • ZHENG M, JAGOTA A, SEMKE ED et al.: DNA-assisted dispersion and separation of carbon nanotubes. Nat. Mater. (2003) 2:338–342.
  • ZHENG M, JAGOTA A, STRANO MS et al.: Structure-based carbon nanotube sorting by sequence-dependent DNA assembly. Science (2003) 302:1545–1548.
  • DIECKMANN GR, DALTON AB, JOHNSON PA et al: Controlled assembly of carbon nanotubes by designed amphiphilic peptide helices. I Am. Chem. Soc. (2003) 125:1770–1777.
  • WANG S, HUMPHREYS ES, CHUNG SY et al.: Peptides with selective affinity for carbon nanotubes. Nat. Mater. (2003) 2:196–200.
  • CHEN RJ, ZHANG Y, WANG D, DAI H: Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J. Am. Chem. Soc. (2001) 123:3838–3839.
  • CHEN RJ, BANGSARUNTIP S, DROUVALAKIS KA et al.: Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proc. Natl. Acad. Sci. USA (2003) 100:4984–4989.
  • COLVIN VL: The potential environmental impact of engineered nanomaterials. Nat. Biotech. (2003) 21:1166–1170.
  • •An interesting review that discusses the toxicological and environmental risks of exposure to nanomaterials, focusing particularly on carbon nanostructures.
  • SHVEDOVA AA, CASTRANOVA V, KISIN ER et al.: Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. ToxicoL Environ. Health A. (2003) 66:1909–1926.
  • WARHEIT DB, LAURENCE BR, REED KL, ROACH DH, REYNOLDS GA, WEBB TR: Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxica Se/. (2004) 77:117–125.
  • LAM CW, JAMES JT, MCCLUSKEY R, HUNTER RL: Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxica Se/. (2004) 77:126–134.
  • TASIS D, TAGMATARCHIS N, GEORGAKILAS V, PRATO M: Soluble carbon nanotubes. Chem. Eui: J. (2003) 9:4000–4008.
  • HIRSCH A: Functionalization of single-walled carbon nanotubes. Angew. Chem. Int. Ed. (2002) 41:1853–1859.
  • DYKE CA, TOUR JM: Overcoming the insolubility of carbon nanotubes through high degrees of sidewall functionalization. Chem. Eur. J. (2004) 10:812–817.
  • GEORGAKILAS V, KORDATOS K, PRATO M, GULDI DM, HOLZINGER M, HIRSCH A: Organic functionalization of carbon nanotubes.J. Am. Chem. Soc. (2002) 124:760–761.
  • GEORGAKILAS V, TAGMATARCHIS N, PANTAROTTO D, BIANCO A, BRIAND JP, PRATO M: Amino acid functionalisation of water soluble carbon nanotubes. Chem. Commun. (2002):3050–3051.
  • PANTAROTTO D, HOEBEKE J, GRAFF R et al.: Synthesis, structural characterization and immunological properties of carbon nanotubes functionalized with peptides. I Am. Chem. Soc. (2003) 125:6160–6164.
  • VOSTROWSKY O, HIRSCH A: Molecular peapods as supramolecular carbon allotropes. Angew. Chem. hat Ed (2004) 43:2326–2329.
  • GUO Z, SADLER PJ, TSANG SC: Immobilization and visualization of DNA and proteins on carbon nanotubes. Adv. Mater. (1998) 10:701–703.
  • AJAYAN PM, IJIMA S: Capillarity-induced filling of carbon nanotubes. Nature (1993) 361:333–334.
  • SMITH BW, MONTHIOUX M, LUZZI DE: Encapsulated C60 in carbon nanotubes. Nature (1998) 396:323–324.
  • BRITZ DA, KHLOBYSTOV AN, WANG J et al: Selective host-guest interaction of single-walled carbon nanotubes with functionalized fullerenes. Chem. Commun. (2004) 176–177.
  • TAKENOBU T, TAKANO T, SHIRAISHI M et al.: Stable and controlled amphoteric doping by encapsulation of organic molecules inside carbon nanotubes. Nat. Mater. (2003) 2:683–688.
  • HUMMER G, RASALAH JC, NOWORYTA JP: Water conduction through the hydrophobic channel of a carbon nanotube. Nature (2001) 414:188–190.
  • KALRA A, GARDE S, HUMMER G: Osmotic water transport through carbon nanotube membrane. Proc. Natl. Acad. Sci. (2003) 100:10175–10180.
  • GAO H, KONG Y, CUI D, OZKAN CS:Spontaneous insertion of DNA oligonucleotides into carbon nanotubes. Nano Lett. (2003) 3:471–473.
  • WET C, SRIVASTAVA D: Theory of transport of long polymer molecules through carbon nanotube channels. Phys. Rev. Lett. (2003) 91:235901.
  • ITO T, SUN L, CROOKS RM: Observation of DNA transport through a single carbon nanotube channel using fluorescence microscopy. Chem. Commun. (2003) 7:1482–1483.
  • JOSEPH S, MASHL RJ, JAKOBSSON E, ALURU NR: Electrolytic transport in modified carbon nanotubes. Nano Lett. (2003) 3:1399–1403.
  • QIAO R, ALURU NR: Atypical dependence of electroosmotic transport on surface charge in a single-wall carbon nanotube. Nano Lett. (2003) 3:1013–1017.
  • PARK KH, CHHOWALLA M, IQBAL Z, SESTI F: Single-walled carbon nanotubes are a new class of ion channel blockers. Biol. Chem. (2003) 278:50212–50216.
  • PANTAROTTO D, BRIAND JP, PRATO M, BIANCO A: Translocation of bioactive peptides across cell membrane by carbon nanotubes. Chem. Commun. (2004):16–17.
  • •This article illustrates the first demonstration of the cellular uptake of functionalised CNTs.
  • PANTAROTTO D, SINGH R, MCCARTHY D et al.: Functionalised carbon nanotubes for plasmid DNA gene delivery. Angew. Chem. Int. Ed (2004) 43:5242–5246.
  • LOPEZ CF, NIELSEN SO, MOORE PB, KLEIN ML: Understanding nature's design for a nanosyringe. Proc. Nati Acad. Sci. USA (2004) 101:4431–4434.
  • SHI KAM WN, JESSOP TC, WENDER PA, DAI H: Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into mammalian cells. Am. Chem. Soc. (2004) 126:6850–6851.
  • ZHAO W, SONG C, PEHRSSON PE: Water-soluble and optically pH-sensitive single-walled carbon nanotubes from surface modification. Am. Chem. Soc. (2002) 124:12418–12419.
  • PANTAROTTO D, PARTIDOS CD, HOEBEKE J et al.: Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. Chem. Biol. (2003) 10:961–966.
  • CHEN BX, WILSON SR, DAS M, COUGHLIN DJ, ERLANGER BF: Antigenicity of fullerenes: antibodies specific for fullerenes and their characteristics. Proc. Natl. Acad. Sci. USA (1998) 95:10809–10813.
  • ERLANGER BE CHEN BX, ZHU M, BRUS L: Binding of an anti-fullerene IgG monoclonal antibody to single wall carbon nanotubes. Nano Lett. (2001) 1:465–467.
  • BRIAND JP, BARIN C, VAN REGENMORTEL MH, MULLER S: Application and limitations of the multiple antigen peptide (MAP) system in the production and evaluation of anti-peptide and anti-protein antibodies. Immunol. Methods (1992) 156:255–265.
  • Smyth Templeton N (Ed.), Dekker, New York, USA (2003).
  • NIIDOME T, HUANG L: Gene therapy progress and prospects: nonviral vectors. Gene The]: (2002) 9:1647–1652.
  • LUO D: A new solution for improving gene delivery. Trends Biotech. (2004) 22:101–103.
  • SCHMIDT-WOLF GD, SCHMIDT-WOLF IG: Non-viral and hybrid vectors in human gene therapy: an update. Trends Mol. Med. (2003) 9:67–72.
  • Special issue on non-viral gene delivery systems. Carr: Med. Chem. (2003) 10:1185–1315.
  • DWYER C, GUTHOLD M, FALVO M, WASHBURN S, SUPERFINE R, ERIE D: DNA-functionalized single-walled carbon nanotubes. Nanotechnology (2002) 13:601–604.
  • NGUYEN CV, DELZEIT L, CASSEL AM,LI J, HAN J, MEYYAPPAN M: Preparation of nucleic acid functionalized carbon nanotube arrays. Nano Lett. (2002) 2:1079–1081.
  • BAKER SE, CAI W, LASSETER TL, WEIDKAMP KP, HAMERS RJ: Covalently bonded adducts of deoxyribonucleic acid (DNA) oligonucleotides with single-wall carbon nanotubes: synthesis and hydridization. Nano Lett. (2002) 2:1413–1417.
  • WILLIAMS KA, VEENHUIZEN PTM, DE LA TORRE BG, ERITJIA R, DEKKER C: Carbon nantotubes with DNA recognition. Nature (2002) 420:761.
  • DAAR AS, THORSTEINSDOTTIR H, MARTIN DK, SMITH AC, NAST S, SINGER PA: Top ten biotechnologies for improving health in developing countries. Nat. Genet. (2002) 32:229–232.
  • MCNEELA EA, O' A mucosal vaccine against diphtheria: formulation of cross reacting material (CRIVI197) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery. Vaccine (2000) 19:1188–1198.

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