1,011
Views
168
CrossRef citations to date
0
Altmetric
Reviews

Application of pectin in oral drug delivery

, PhD
Pages 1009-1023 | Published online: 13 May 2011

Bibliography

  • Endress HU, Christensen SH. Pectins. In: Phillips GO, Williams PA, editors Handbook of Hydrocolloids. 2nd edition. Woodhead Publishers Ltd; Cambridge: 2009. p. 274-97
  • Oakenfull DG. The chemistry of high-methoxyl pectins. In: Walter RH, editor The Chemistry and Technology of Pectin. Academic Press; New York: 1991. p. 87-108
  • Rolin C, Nielsen BU, Glahm PE. Pectin. In: Dumitaiu S, editor Polysaccharides: structural diversity and functional versatility. Marcel Dekker; New York: 1998. p. 377-431
  • Chaidedgumjorn A, Sotanaphun U, Kitcharoen N, Pectins from Citrus maxima. Pharm Biol 2009;47:521-6
  • Sriamornsak P. Chemistry of pectin and its pharmaceutical uses: a review. Silpakorn Univ Int J 2003;3:206-28
  • Rinaudo M. Polyelectrolytes derived from natural polysaccharides. In: Belgacem M, Gandini A, editors Monomer, Polymers and Composites from Renewable Resources. Elsevier; Amsterdam: 2008. p. 495-516
  • Grant GT, Morris ER, Rees DA, Biological interactions between polysaccharides and divalent cations: the egg-box model. FEBS Lett 1973;32:195-8
  • Braccini I, Perez S. Molecular basis of Ca2+-induced gelation in alginates and pectins: the egg-box model revisited. Biomacromol 2001;2:1089-96
  • Fang Y, Al-Assaf S, Phillips GO, Binding behavior of calcium to polyuronates: comparison of pectin with alginate. Carbohydr Polym 2008;72:334-41
  • Racape E, Thibault JF, Reitsma JCE, Pilnik W. Properties of amidated pectins: II. Polyelectrolyte behavior and calcium binding of amidated pectins and amidated pectic acid. Biopolym 1989;28:1435-48
  • Slany J, Bronisova D, Chorvatova B, Mandak M. Evaluation of tablets with pectin as a binding agent. Farm Obz 1981;50:491-8
  • Naggar VF, El Khawas M, Ismail FA, Boraie NA. Pectin, a possible matrix for oral sustained-release preparations of water-soluble drugs. STP Pharm Sci 1992;2:227-34
  • Rishabha M, Pranati S, Mayank B, Kumar SP. Formulation and optimization of sustained release matrix tablets of diclofenac sodium using pectin as release modifier. Int J Drug Dev Res 2010;2:330-5
  • Sungthongjeen S, Pitaksuteepong T, Somsiri A, Sriamornsak P. Studies on pectins as potential hydrogel matrices for controlled-release drug delivery. Drug Dev Ind Pharm 1999;25:1271-6
  • Sriamornsak P, Thirawong N, Weerapol Y, Swelling and erosion of pectin matrix tablets and their impact on drug release behavior. Eur J Pharm Biopharm 2007;67:211-19
  • Sungthongjeen S, Sriamornsak P, Pitaksuteepong T, Effect of degree of esterification of pectin and calcium amount on drug release from pectin-based matrix tablets. AAPS PharmSciTech 2004;5:article 9
  • Wei X, Chen Z, Lu Y, Physicochemical characterization of a pectin/calcium matrix containing a large fraction of calcium chloride: implications for sigmoidal release characteristics. J Appl Polym Sci 2009;113:2418-28
  • Kim H, Fassihi R. Application of a binary polymer system in drug release rate modulation. 1. Characterization of release mechanism. J Pharm Sci 1997;86:316-22
  • Kim H, Fassihi R. Application of binary polymer system in drug release rate modulation. 2. Influence of formulation variables and hydrodynamic conditions on release kinetics. J Pharm Sci 1997;86:323-8
  • Wu B, Chen Z, Wei X, Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: I. Characterization and mechanistic study. Eur J Pharm Biopharm 2007;67:707-14
  • Wu B, Deng D, Lu Y, Wu W. Biphasic release of indomethacin from HPMC/pectin/calcium matrix tablet: II. Influencing variables, stability and pharmacokinetics in dogs. Eur J Pharm Biopharm 2008;69:294-302
  • Aydin Z, Akbuga J. Preparation and evaluation of pectin beads. Int J Pharm 1996;137:133-6
  • Sriamornsak P, Nunthanid J. Calcium pectinate gel beads for controlled release drug delivery: I. Preparation and in vitro release studies. Int J Pharm 1998;160:207-12
  • Sriamornsak P, Nunthanid J. Calcium pectinate gel beads for controlled release drug delivery: II. Effect of formulation and processing variables on drug release. J Microencapsul 1999;16:303-13
  • Sriamornsak P, Nunthanid J, Cheewatanakornkool K, Manchun S. Effect of drug loading method on drug content and drug release from calcium pectinate gel beads. AAPS PharmSciTech 2010;11:1315-19
  • Munjeri O, Hodza P, Osim EE, Musabayane CT. An investigation into the suitability of amidated pectin hydrogel beads as a delivery matrix for chloroquine. J Pharm Sci 1998;87:905-8
  • Lee JS, Kim EJ, Chung D, Lee HG. Characteristics and antioxidant activity of catechin-loaded calcium pectinate gel beads prepared by internal gelation. Colloids Surf B Biointerfaces 2009;74:17-22
  • Pillay V, Fassihi R. In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract: II. Physicochemical characterization of calcium-alginate, calcium-pectinate and calcium-alginate-pectinate pellets. J Control Release 1999;59:243-56
  • Sriamornsak P, Burapapadh K, Puttipipatkhachorn S, Nunthanid J. Effect of acidic medium on swelling and release behaviors of chitosan-reinforced calcium pectinate gel beads. Silpakorn Univ Sci Technol J 2008;2:37-44
  • Mennini N, Furlanetto S, Maestrelli F, Response surface methodology in the optimization of chitosan-Ca pectinate bead formulations. Eur J Pharm Sci 2008;35:318-25
  • Nurjaya S, Wong TW. Effects of microwave on drug release properties of matrices of pectin. Carbohydr Polym 2005;62:245-57
  • Wong TW, Nurjaya S. Drug release property of chitosan-pectinate beads and its changes under the influence of microwave. Eur J Pharm Biopharm 2008;69:176-88
  • Sriamornsak P, Prakongpan S, Puttipipatkhachorn S, Kennedy RA. Development of sustained release theophylline pellets coated with calcium pectinate. J Control Release 1997;47:221-32
  • Sriamornsak P, Puttipipatkhachorn S, Prakongpan S. Calcium pectinate gel coated pellets as an alternative carrier to calcium pectinate beads. Int J Pharm 1997;156:189-94
  • Sriamornsak P, Burton MA, Kennedy RA. Development of polysaccharide gel coated pellets for oral administration: 1. Physico-mechanical properties. Int J Pharm 2006;326:80-8
  • Sriamornsak P, Kennedy RA. Development of polysaccharide gel-coated pellets for oral administration: swelling and release behavior of calcium pectinate gel. AAPS PharmSciTech 2007;8:article 79
  • Sriamornsak P, Kennedy RA. A novel gel formation method, microstructure and mechanical properties of calcium polysaccharide gel films. Int J Pharm 2006;323:72-80
  • Sriamornsak P, Kennedy RA. Swelling and diffusion studies of calcium polysaccharide gels intended for film coating. Int J Pharm 2008;358:205-13
  • Sriamornsak P, Kennedy RA. Effect of drug solubility on release behavior of calcium polysaccharide gel-coated pellets. Eur J Pharm Sci 2007;32:231-9
  • Pinto JF. Site-specific drug delivery systems within the gastro-intestinal tract: From the mouth to the colon. Int J Pharm 2010;395:44-52
  • Washington N, Wilson CG, Greaves JL, Danneskiold-Samsoe P. An investigation into the floating behaviour of a pectin-containing anti-reflux formulation (FF5005) by means of gamma scintigraphy. Scand J Gastroenterol 1988;23:920-4
  • Talukder R, Fassihi R. Gastroretentive delivery systems: Hollow beads. Drug Dev Ind Pharm 2004;30:405-12
  • Sriamornsak P, Thirawong N, Puttipipatkhachorn S. Morphology and buoyancy of oil-entrapped calcium pectinate gel beads. AAPS J 2004;6:article 24
  • Sriamornsak P, Thirawong N, Puttipipatkhachorn S. Emulsion gel beads of calcium pectinate capable of floating on the gastric fluid: effect of some additives, hardening agent or coating on release behavior of metronidazole. Eur J Pharm Sci 2005;24:363-73
  • Mishra SK, Pathak K. Formulation and evaluation of oil entrapped gastroretentive floating gel beads of loratadine. Acta Pharm 2008;58:187-97
  • Sriamornsak P, Asavapichayont P, Nunthanid J, Wax-incorporated emulsion gel beads of calcium pectinate for intragastric floating drug delivery. AAPS PharmSciTech 2008;9:571-6
  • Badve SS, Sher P, Korde A, Pawar AP. Development of hollow/porous calcium pectinate beads for floating-pulsatile drug delivery. Eur J Pharm Biopharm 2007;65:85-93
  • Sriamornsak P, Sungthongjeen S, Puttipipatkhachorn S. Use of pectin as a carrier for intragastric floating drug delivery: carbonate salt contained beads. Carbohydr Polym 2007;67:436-45
  • Ashford M, Fell J, Attwood D, An evaluation of pectin as a carrier for drug targeting to the colon. J Control Release 1993;26:213-20
  • Rubinstein A, Radai R, Ezra M, In vitro evaluation of calcium pectinate: A potential colon-specific drug delivery carrier. Pharm Res 1993;10:258-63
  • Cumming JH, Englyst HN. Fermentation in the human large intestine and the available substrates. Am J Clin Nutr 1987;45:1243-55
  • Sandberg AS, Ahderimre R, Andersson H, The effect of citrus pectin on the absorption of nutrients in the small intestine. Hum Nutr Clin Nutr 1983;37C:171-83
  • Liu L, Fishman ML, Kost J, Hicks KB. Pectin-based systems for colon-specific drug delivery via oral route. Biomaterials 2003;24:3333-43
  • Sande SA. Pectin-based oral drug delivery to the colon. Expert Opin Drug Del 2005;2:441-50
  • Ashford M, Fell J, Attwood D, Studies on pectin formulations for colonic drug delivery. J Control Release 1994;30:225-32
  • Rubinstein A, Radai R. In vitro and in vivo analysis of colon specificity of calcium pectinate formulations. Eur J Pharm Biopharm 1995;41:291-5
  • Ugurlu T, Turkoglu M, Gurer US, Akarsu BG. Colonic delivery of compression coated nisin tablets using pectin/HPMC polymer mixture. Eur J Pharm Biopharm 2007;67:202-10
  • Hodges LA, Connolly SM, Band J, Scintigraphic evaluation of colon targeting pectin-HPMC tablets in healthy volunteers. Int J Pharm 2009;370:144-50
  • Munjeri O, Collett JH, Fell JT. Amidated pectin hydrogel beads for colonic drug delivery - an in vitro study. Drug Del 1997;4:207-11
  • Sriamornsak P. Investigation of pectin as a carrier for oral delivery of proteins using calcium pectinate gel beads. Int J Pharm 1998;169:213-20
  • Sriamornsak P. Effect of calcium concentration, hardening agent and drying condition on release characteristics of oral proteins from calcium pectinate gel beads. Eur J Pharm Sci 1999;8:221-7
  • Dupuis G, Chambin O, Genelot C, Colonic drug delivery: Influence of cross-linking agent on pectin beads properties and role of the shell capsule type. Drug Dev Ind Pharm 2006;32:847-55
  • Bourgeois S, Gernet M, Pradeau D, Evaluation of critical formulation parameters influencing the bioactivity of beta-lactamases entrapped in pectin beads. Int J Pharm 2006;324:2-9
  • Liu L, Fishman ML, Hicks KB, Pectin/zein beads for potential colon-specific drug delivery: synthesis and in vitro evaluation. Drug Del 2006;13:417-23
  • Perera G, Barthelmes J, Bernkop-Schnurch A. Novel pectin-4-aminothiophenole conjugate microparticles for colon-specific drug delivery. J Control Release 2010;145:240-6
  • Cheng K, Lim LY. Insulin-loaded calcium pectinate nanoparticles: effects of pectin molecular weight and formulation pH. Drug Dev Ind Pharm 2004;30:359-67
  • Musabayane CT, Munjeri O, Bwititi P, Osim EE. Orally administered, insulin-loaded amidated pectin hydrogel beads sustain plasma concentrations of insulin in streptozotocin-diabetic rats. J Endrocrinol 2000;164:1-6
  • El-Gibaly I. Oral delayed-release system based on Zn-pectinate gel (ZPG) microparticles as an alternative carrier to calcium pectinate beads for colonic drug delivery. Int J Pharm 2002;232:199-211
  • Chambin O, Dupuis G, Champion D, Colon-specific drug delivery: Influence of solution reticulation properties upon pectin beads performance. Int J Pharm 2006;321:86-93
  • Khoder M, Tsapis N, Huguet H, Removal of ciprofloxacin in simulated digestive media by activated charcoal entrapped within zinc-pectinate beads. Int J Pharm 2009;379:251-9
  • Wakerly Z, Fell JT, Attwood D, Parkins D. Studies on drug release from pectin/ethylcellulose film-coated tablets: a potential colonic delivery system. Int J Pharm 1997;153:219-24
  • Macleod GS, Fell JT, Collett JH. Studies on the physical properties of mixed pectin/ethylcellulose films intended for colonic drug delivery. Int J Pharm 1997;157:53-60
  • Semde R, Amighi K, Pierre D, Leaching of pectin from mixed pectin/insoluble polymer films intended for colonic drug delivery. Int J Pharm 1998;174:233-41
  • Wei H, Qing D, De-Ying C, In-vitro and in-vivo studies of pectin/ethylcellulose-film-coated pellets of 5-fluorouracil for colonic targeting. J Pharm Pharmacol 2008;60:35-44
  • Semde R, Amighi K, Devleeschouwer MJ, Moes AJ. Effect of pectinolytic enzymes on the theophylline release from pellets coated with water insoluble polymers containing pectin HM or calcium pectinate. Int J Pharm 2000;197:169-79
  • Semde R, Amighi K, Devleeschouwer MJ, Moes AJ. Studies of pectin HM/Eudragit® RL/Eudragit® NE film-coating formulations intended for colonic drug delivery. Int J Pharm 2000;197:181-92
  • Sriamornsak P, Nunthanid J, Wanchana S, Luangtana-anan M. Composite film-coated tablets intended for colon-specific delivery of 5-aminosalicylic acid using desterified pectin. Pharm Dev Technol 2003;8:311-18
  • Fernandez-Hervas MJ, Fell JT. Pectin/chitosan mixtures as coatings for colon-specific drug delivery: an in vitro evaluation. Int J Pharm 1998;169:115-19
  • Macleod GS, Fell JT, Collett JH, Selective drug delivery to the colon using pectin:chitosan:hydroxypropyl methylcellulose film coated tablets. Int J Pharm 1999;187:251-7
  • Lee JW, Park JH, Robinson JR. Bioadhesive-based dosage forms: the next generation. J Pharm Sci 2000;89:850-65
  • Smart JD, Kellaway IW, Worthington HEC. An in vitro investigation of mucoadhesive materials for use in controlled delivery. J Pharm Pharmacol 1984;36:295-9
  • Lehr CM, Bouwstra JA, Schacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int J Pharm 1992;78:43-8
  • Peppas NA, Buri PA. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release 1985;2:257-75
  • Leung SHS, Robinson JR. Polymer structure features contributing to mucoadhesion. II. J Control Release 1990;12:187-94
  • Schmidgall J, Hensel A. Bioadhesive properties of polygalacturonides against colonic epithelial membranes. Int J Biol Macromol 2002;30:217-25
  • Liu L, Fishman ML, Hicks KB, Kende M. Interaction of various pectin formulations with porcine colonic tissues. Biomaterials 2005;26:5907-16
  • Thirawong N, Nunthanid J, Puttipipatkhachorn S, Sriamornsak P. Mucoadhesive properties of various pectins on gastrointestinal mucosa: an in vitro evaluation using texture analyzer. Eur J Pharm Biopharm 2007;67:132-40
  • Wattanakorn N, Asavapichayont P, Nunthanid J, Pectin-based bioadhesive delivery of carbenoxolone sodium for aphthous ulcers in oral cavity. AAPS PharmSciTech 2010;11:743-51
  • Sriamornsak P, Wattanakorn N, Nunthanid J, Puttipipatkhachorn S. Mucoadhesion of pectin as evidence by wettability and chain interpenetration. Carbohydr Polym 2008;74:458-67
  • Thirawong N, Kennedy RA, Sriamornsak P. Viscometric study of pectin-mucin interaction and its mucoadhesive bond strength. Carbohydr Polym 2008;71:170-9
  • Sriamornsak P, Wattanakorn N. Rheological synergy in aqueous mixtures of pectin and mucin. Carbohydr Polym 2008;74:474-81
  • Sriamornsak P, Wattanakorn N, Takeuchi H. Study on the mucoadhesion mechanism of pectin by atomic force microscopy and mucin-particle method. Carbohydr Polym 2010;79:54-9
  • Sriamornsak P, Thirawong N, Nunthanid J, Atomic force microscopy imaging of novel self-assembling pectin-liposome nanocomplexes. Carbohydr Polym 2008;71:324-9
  • Thirawong N, Thongborisute J, Takeuchi H, Sriamornsak P. Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes. J Control Release 2008;125:236-45
  • Majzoob S, Atyabi F, Dorkoosh F, Pectin-cysteine conjugate: Synthesis and in-vitro evaluation of its potential for drug delivery. J Pharm Pharmacol 2006;58:1601-10
  • Sriamornsak P, Thirawong N, Cheewatanakornkool K, Cryo-scanning electron microscopy (cryo-SEM) as a tool for studying the ultrastructure during bead formation by ionotropic gelation of calcium pectinate. Int J Pharm 2008;352:115-22
  • Liu P, Krishnan TR. Alginate-pectin-poly-L-lysine particulate as a potential controlled release formulation. J Pharm Pharmacol 1999;51:141-9
  • Munjeri O, Collett JH, Fell JT. Hydrogel beads based on amidated pectins for colon-specific drug delivery: the role of chitosan in modifying drug release. J Control Release 1997;46:273-8
  • Bourgeois S, Laham A, Besnard M, In vitro and in vivo evaluation of pectin beads for the colon delivery of beta-lactamases. J Drug Target 2005;13:277-84
  • Macleod GS, Fell JT, Collett JH. An in vitro investigation into the potential for bimodal drug release from pectin/chitosan/HPMC-coated tablets. Int J Pharm 1999;188:11-18

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.