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Original Research

Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β

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Bibliography

  • Khalil NTGF-beta: from latent to active. Microbes Infect 1999;1:1255-63
  • Shi M, Zhu J, Wang R, et al. Latent TGF-beta structure and activation. Nature 2011;4):343-9
  • Saharinen J, Hyytiainen M, Taipale J, et al. Latent transforming growth factor-beta binding proteins LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action. Cytokine Growth Factor Rev 1999;10:99-117
  • Saharinen J, Taipale J, Keski-Oja J. Association of the small latent TGF-beta with an eight cysteine repeat of its binding protein LTBP-1. EMBO J 1996;15:245-53
  • Adams G, Vessillier S, Dreja H, et al. Targeting cytokines to inflammation sites. Nat Biotechnol 2003;21:1314-20
  • Vessillier S, Adams G, Montero-Melendez T, et al. Molecular engineering of short half-life small peptides (VIP, alpha-MSH and gamma-MSH) fused to latency-associated peptide results in improved anti-inflammatory therapeutics. Ann Rheum Dis 2012;71:143-9
  • Murphy G, Nagase H. Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair? Nat Clin Pract Rheumatol 2008;4:128-35
  • Mullen L, Adams G, Foster J, et al. A comparative study of matrix metalloproteinase and aggrecanase mediated release of latent cytokines at arthritic joints. Ann. Rheum. Dis 2013; epub ahead of print
  • Yousaf N, Gould DJ, Aganna E, et al. Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor-associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand-independent NF-κb activation. Arthritis Rheum 2005;52:2906-16
  • Chung L, Shimokawa K, Dinakarpandian D, et al. Identification of the (183)rwtnnfrey(191) region as a critical segment of matrix metalloproteinase 1 for the expression of collagenolytic activity. J Biol Chem 2000;275:29610-17
  • Ho SN, Abraham RT, Gillis S, et al. Differential bioassay of interleukin 2 and interleukin 4. J Immunol Methods 1987;98:99-104
  • Schlaak JF, Schmitt E, Huls C, et al. A sensitive and specific bioassay for the detection of human interleukin-10. J Immunol Methods 1994;168:49-54
  • Arenzana-Seisdedos F, Thompson J, Rodriguez MS, et al. Inducible nuclear expression of newly synthesized i kappa b alpha negatively regulates DNA-binding and transcriptional activities of nf-kappa b. Mol Cell Biol 1995;15:2689-96
  • Abe M, Harpel JG, Metz CN, et al. An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 1994;216:276-84
  • Miura Y, Komatsu N, Suda T. Growth and differentiation of two human megakaryoblastic cell lines; CMK and UT-7. Prog Clin Biol Res 1990;259-70
  • Duprez D, Bell EJ, Richardson MK, et al. Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb. Mech Dev 1996;57:145-57
  • Pulverer JE, Rand U, Lienenklaus S, et al. Temporal and spatial resolution of type I and III interferon responses in vivo. J Virol 2010;84:8626-38
  • Croxford JL, Triantaphyllopoulos K, Podhajcer OL, et al. Cytokine gene therapy in experimental allergic encephalomyelitis by injection of plasmid DNA-cationic liposome complex into the central nervous system. J Immunol 1998;160:5181-7
  • Vessillier S, Adams G, Chernajovsky Y. Latent cytokines: Development of novel cleavage sites and kinetic analysis of their differential sensitivity to mmp-1 and mmp-3. Protein Eng Des Sel. 2004;17:829-35
  • Harrison CA, Al-Musawi SL, Walton KL. Prodomains regulate the synthesis, extracellular localisation and activity of TGF-beta superfamily ligands. Growth Factors 2011;29:174-86
  • Walton KL, Makanji Y, Chen J, et al. Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex. J Biol Chem 2010;285:17029-37
  • Mullen LM, Adams G, Chernajovsky Y. Increased disulphide dimer formation of latent associated peptide fusions of TGF-beta by addition of L-cystine. J Biotechnol 2012;161:269-77
  • Lauer-Fields JL, Minond D, Sritharan T, et al. Substrate conformation modulates aggrecanase (adamts-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases chemistry. Biol Chem 2007;282:142-50
  • Nissim A, Gofur Y, Vessillier S, et al. Methods for targeting biological to specific disease sites. Trends Mol Med 2004;10:269-74

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