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Expert Opinion on Drug Delivery Volume 13, 2016 - Issue 1
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Reviews

Biomedical applications of microneedles in therapeutics: recent advancements and implications in drug delivery

N. Sanoj RejinoldDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
,
Ju-Hyung ShinDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
,
Hae Yong SeokDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea
&
Yeu-Chun KimDepartment of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of KoreaCorrespondence[email protected]
Pages 109-131 | Published online: 24 Nov 2015

Bibliography

  • Papers of special note have been highlighted as either of interest (•) or of considerable interest (••) to readers.
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•• One of the most cited recent articles on microneedles delivery

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•• Explores macro flux technology

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• This review article focuses on recent and future developments for MN technology, including the latest type of MN design

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• Advanced techniques for penetration enhancement have been discussed here

•• This paper is the first published study on the use of microfabricated microneedles to enhance drug delivery across skin

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• Microfabricated microneedles have been discussed in detail

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• Dermaroller® has been discussed in this paper

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• Report on intradermal influenza vaccine for older adults – Multicenter phase III clinical assessment

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• In vivo insulin delivery using HMNs

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• Inkjet printing of insulin microneedles for transdermal delivery has been discussed

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•• This paper recently published about dissolving microneedle patches that can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage

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