492
Views
82
CrossRef citations to date
0
Altmetric
Review

Utilization of nanoemulsions to enhance bioactivity of pharmaceuticals, supplements, and nutraceuticals: Nanoemulsion delivery systems and nanoemulsion excipient systems

, , &
Pages 1327-1336 | Received 24 Dec 2015, Accepted 01 Mar 2016, Published online: 21 Mar 2016

References

  • Williams HD, Trevaskis NL, Yeap YY, et al. Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway. Pharm Res. 2013;30:2976–2992.
  • Williams HD, Trevaskis NL, Charman SA, et al. Strategies to address low drug solubility in discovery and development. Pharmacol Rev. 2013;65:315–499.
  • McClements DJ, Li F, Xiao H. The nutraceutical bioavailability classification scheme: classifying nutraceuticals according to factors limiting their oral bioavailability. Annu Rev Food Sci Technol. 2015;6(6):299–327.
  • Wang G, Wang J, Wu W, et al. Advances in lipid-based drug delivery: enhancing efficiency for hydrophobic drugs. Expert Opin Drug Deliv. 2015;12:1475–1499.
  • Yadollahi R, Vasilev K, Simovic S. Nanosuspension technologies for delivery of poorly soluble drugs. J Nanomater. 2015;2015:1–13.
  • Kesisoglou F, Mitra A. Crystalline nanosuspensions as potential toxicology and clinical oral formulations for BCS II/IV compounds. AAPS J. 2012;14:677–687.
  • Kumar S, Bhargava D, Thakkar A, et al. Drug carrier systems for solubility enhancement of BCS class II drugs: a critical review. Crit Rev Ther Drug Carrier Syst. 2013;30:217–256.
  • Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech. 2015;5:123–127.
  • Gutierrez JM, Gonzalez C, Maestro A, et al. Nano-emulsions: new applications and optimization of their preparation. Curr Opin Colloid Interface Sci. 2008;13:245–251.
  • McClements DJ, Rao J. Food-grade nanoemulsions: formulation, fabrication, properties, performance, biological fate, and potential toxicity. Crit Rev Food Sci Nutr. 2011;51:285–330.
  • Oehlke K, Adamiuk M, Behsnilian D, et al. Potential bioavailability enhancement of bioactive compounds using food-grade engineered nanomaterials: a review of the existing evidence. Food Funct. 2014;5:1341–1359.
  • McClements DJ. Nanoscale nutrient delivery systems for food applications: improving bioactive dispersibility, stability, and bioavailability. J Food Sci. 2015;80:N1602–N1611.
  • McClements DJ, Xiao H. Potential biological fate of ingested nanoemulsions: influence of particle characteristics. Food Funct. 2012;3:202–220.
  • McClements DJ. Utilizing food effects to overcome challenges in delivery of lipophilic bioactives: structural design of medical and functional foods. Expert Opin Drug Deliv. 2013;10:1621–1632.
  • Kawabata Y, Wada K, Nakatani M, et al. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm. 2011;420:1–10.
  • McClements DJ. Emulsion design to improve the delivery of functional lipophilic components. In: Doyle MP, Klaenhammer TR, editors. Annual review of food science and technology. Vol. 1. Washington (DC): Annual Reviews; 2010. pp. 241–269.
  • Pathak K, Raghuvanshi S. Oral bioavailability: issues and solutions via nanoformulations. Clin Pharmacokinet. 2015;54:325–357.
  • Zhang XW, Wu BJ. Submicron lipid emulsions: a versatile platform for drug delivery. Curr Drug Metab. 2015;16:211–220.
  • McClements DJ. Edible nanoemulsions: fabrication, properties, and functional performance. Soft Matter. 2011;7:2297–2316.
  • McClements DJ. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter. 2012;8:1719–1729.
  • Anton N, Vandamme TF. Nano-emulsions and micro-emulsions: clarifications of the critical differences. Pharm Res. 2011;28:978–985.
  • Koroleva MY, Yurtov EV. Nanoemulsions: the properties, methods of preparation and promising applications. Russian Chem Rev. 2012;81:21–43.
  • Singh B, Bandopadhyay S, Kapil R, et al. Self-emulsifying drug delivery systems (sedds): formulation development, characterization, and applications. Crit Rev Ther Drug Carrier Syst. 2009;26:427–521.
  • Cerpnjak K, Zvonar A, Gasperlin M, et al. Lipid-based systems as a promising approach for enhancing the bioavailability of poorly water-soluble drugs. Acta Pharm. 2013;63:427–445.
  • Abbas S, Hayat K, Karangwa E, et al. An overview of ultrasound-assisted food-grade nanoemulsions. Food Eng Rev. 2013;5:139–157.
  • Dumay E, Chevalier-Lucia D, Picart-Palmade L, et al. Technological aspects and potential applications of (ultra) high-pressure homogenisation. Trends Food Sci Technol. 2013;31:13–26.
  • Solans C, Sole I. Nano-emulsions: formation by low-energy methods. Curr Opin Colloid Interface Sci. 2012;17:246–254.
  • Perazzo A, Preziosi V, Guido S. Phase inversion emulsification: current understanding and applications. Adv Colloid Interface Sci. 2015;222:581–599.
  • Lee HS, Morrison ED, Frethem CD, et al. Cryogenic electron microscopy study of nanoemulsion formation from microemulsions. Langmuir. 2014;30:10826–10833.
  • Donsi F, Sessa M, Mediouni H, et al. Encapsulation of bioactive compounds in nanoemulsion-based delivery systems. In: Saravacos G, Taoukis P, Krokida M, et al., editors. 11th international congress on engineering and food. Vol. 1. 2011; Athens. New York: Springer Science; p. 1666–1671.
  • Kotta S, Khan AW, Pramod K, et al. Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv. 2012;9:585–598.
  • Ganta S, Talekar M, Singh A, et al. Nanoemulsions in translational research-opportunities and challenges in targeted cancer therapy. AAPS PharmSciTech. 2014;15:694–708.
  • Zou L, Liu W, Liu C, et al. Utilizing food matrix effects to enhance nutraceutical bioavailability: increase of curcumin bioaccessibility using excipient emulsions. J Agric Food Chem. 2015;63:2052–2062.
  • Zou L, Zheng B, Liu W, et al. Enhancing nutraceutical bioavailability using excipient emulsions: influence of lipid droplet size on solubility and bioaccessibility of powdered curcumin. J Funct Foods. 2015;15:72–83.
  • Livney YD. Nanostructured delivery systems in food: latest developments and potential future directions. Curr Opin Food Sci. 2015;3:125–135.
  • Chen H, Khemtong C, Yang X, et al. Nanonization strategies for poorly water-soluble drugs. Drug Discov Today. 2011;16:354–360.
  • Shegokar R, Mueller RH. Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives. Int J Pharm. 2010;399:129–139.
  • McClements DJ. Edible lipid nanoparticles: digestion, absorption, and potential toxicity. Prog Lipid Res. 2013;52:409–423.
  • Porter CJH, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov. 2007;6:231–248.
  • Ozturk B, Argin S, Ozilgen M, et al. Nanoemulsion delivery systems for oil-soluble vitamins: influence of carrier oil type on lipid digestion and vitamin d-3 bioaccessibility. Food Chem. 2015;187:499–506.
  • Davidov-Pardo G, McClements DJ. Nutraceutical delivery systems: resveratrol encapsulation in grape seed oil nanoemulsions formed by spontaneous emulsification. Food Chem. 2015;167:205–212.
  • Qian C, Decker EA, Xiao H, et al. Nanoemulsion delivery systems: influence of carrier oil on β-carotene bioaccessibility. Food Chem. 2012;135:1440–1447.
  • Salvia-Trujillo L, Qian C, Martin-Belloso O, et al. Modulating β-carotene bioaccessibility by controlling oil composition and concentration in edible nanoemulsions. Food Chem. 2013;139:878–884.
  • Yang Y, McClements DJ. Vitamin E bioaccessibility: influence of carrier oil type on digestion and release of emulsified α-tocopherol acetate. Food Chem. 2013;141:473–481.
  • Salvia-Trujillo L, Sun Q, Um BH, et al. In vitro and in vivo study of fucoxanthin bioavailability from nanoemulsion-based delivery systems: impact of lipid carrier type. J Funct Foods. 2015;17:293–304.
  • Sun Y, Xia ZY, Zheng JK, et al. Nanoemulsion-based delivery systems for nutraceuticals: influence of carrier oil type on bioavailability of pterostilbene. J Funct Foods. 2015;13:61–70.
  • Calligaris S, Comuzzo P, Bot F, et al. Nanoemulsions as delivery systems of hydrophobic silybin from silymarin extract: effect of oil type on silybin solubility, in vitro bioaccessibility and stability. Lwt-Food Sci Technol. 2015;63:77–84.
  • Zhang RJ, Zhang ZP, Zhang H, et al. Influence of lipid type on gastrointestinal fate of oil-in-water emulsions: in vitro digestion study. Food Res Int. 2015;75:71–78.
  • Cho HT, Salvia-Trujillo L, Kim J, et al. Droplet size and composition of nutraceutical nanoemulsions influences bioavailability of long chain fatty acids and coenzyme q10. Food Chem. 2014;156:117–122.
  • Rao JJ, Decker EA, Xiao H, et al. Nutraceutical nanoemulsions: influence of carrier oil composition (digestible versus indigestible oil) on β-carotene bioavailability. J Sci Food Agric. 2013;93:3175–3183.
  • Pinheiro AC, Coimbra MA, Vicente AA. In vitro behaviour of curcumin nanoemulsions stabilized by biopolymer emulsifiers - effect of interfacial composition. Food Hydrocoll. 2016;52:460–467.
  • Hou ZQ, Liu YW, Lei F, et al. Investigation into the in vitro release properties of β-carotene in emulsions stabilized by different emulsifiers. Lwt-Food Sci Technol. 2014;59:867–873.
  • Zhang RJ, Zhang ZP, Zhang H, et al. Influence of emulsifier type on gastrointestinal fate of oil-in-water emulsions containing anionic dietary fiber (pectin). Food Hydrocoll. 2015;45:175–185.
  • Mun S, Kim YR, Shin M, et al. Control of lipid digestion and nutraceutical bioaccessibility using starch-based filled hydrogels: influence of starch and surfactant type. Food Hydrocoll. 2015;44:380–389.
  • Golding M, Wooster TJ, Day L, et al. Impact of gastric structuring on the lipolysis of emulsified lipids. Soft Matter. 2011;7:3513–3523.
  • Wooster TJ, Day L, Xu M, et al. Impact of different biopolymer networks on the digestion of gastric structured emulsions. Food Hydrocoll. 2014;36:102–114.
  • Gulseren I, Guri A, Corredig M. Effect of interfacial composition on uptake of curcumin-piperine mixtures in oil in water emulsions by caco-2 cells. Food Funct. 2014;5:1218–1223.
  • Pinheiro AC, Lad M, Silva HD, et al. Unravelling the behaviour of curcumin nanoemulsions during in vitro digestion: effect of the surface charge. Soft Matter. 2013;9:3147–3154.
  • Troncoso E, Aguilera JM, McClements DJ. Fabrication, characterization and lipase digestibility of food-grade nanoemulsions. Food Hydrocoll. 2012;27:355–363.
  • Qiu CY, Zhao MM, Decker EA, et al. Influence of protein type on oxidation and digestibility of fish oil-in-water emulsions: gliadin, caseinate, and whey protein. Food Chem. 2015;175:249–257.
  • Zeeb B, Weiss J, McClements DJ. Electrostatic modulation and enzymatic cross-linking of interfacial layers impacts gastrointestinal fate of multilayer emulsions. Food Chem. 2015;180:257–264.
  • Hu B, Zhang LY, Liang R, et al. Cross-linking of interfacial casein layer with genipin prevented ph-induced structural instability and lipase digestibility of the fat droplets. J Agric Food Chem. 2015;63:2033–2040.
  • Nik AM, Langmaid S, Wright AJ. Digestibility and β-carotene release from lipid nanodispersions depend on dispersed phase crystallinity and interfacial properties. Food Funct. 2012;3:234–245.
  • Michalski MC, Genot C, Gayet C, et al. Multiscale structures of lipids in foods as parameters affecting fatty acid bioavailability and lipid metabolism. Prog Lipid Res. 2013;52:354–373.
  • Bonnaire L, Sandra S, Helgason T, et al. Influence of lipid physical state on the in vitro digestibility of emulsified lipids. J Agric Food Chem. 2008;56:3791–3797.
  • Danielsen EM, Hansen GH, Rasmussen K, et al. Permeabilization of enterocytes induced by absorption of dietary fat. Mol Membr Biol. 2013;30:261–272.
  • Aungst BJ. Intestinal permeation enhancers. J Pharm Sci. 2000;89:429–442.
  • Qian C, Decker EA, Xiao H, et al. Inhibition of β-carotene degradation in oil-in-water nanoemulsions: influence of oil-soluble and water-soluble antioxidants. Food Chem. 2012;135:1036–1043.
  • Tiwari SB, Amiji MM. Improved oral delivery of paclitaxel following administration in nanoemulsion formulations. J Nanosci Nanotechnol. 2006;6:3215–3221.
  • Laxmi M, Bhardwaj A, Mehta S, et al. Development and characterization of nanoemulsion as carrier for the enhancement of bioavailability of artemether. Artif Cells Nanomed Biotechnol. 2015;43:334–344.
  • Thakkar HP, Khunt A, Dhande RD, et al. Formulation and evaluation of itraconazole nanoemulsion for enhanced oral bioavailability. J Microencapsul. 2015;32:559–569.
  • Hatanaka J, Chikamori H, Sato H, et al. Physicochemical and pharmacological characterization of alpha-tocopherol-loaded nano-emulsion system. Int J Pharm. 2010;396:188–193.
  • Nielsen FS, Petersen KB, Mullertz A. Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state. Eur J Pharm Biopharm. 2008;69:553–562.
  • Shafiq S, Shakeel F, Talegaonkar S, et al. Design and development of oral oil in water ramipril nanoemulsion formulation: in vitro and in vivo assessment. J Biomed Nanotechnol. 2007;3:28–44.
  • Singh B, Singh R, Bandyopadhyay S, et al. Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol. Colloids Surf B Biointerfaces. 2013;101:465–474.
  • Ghai D, Sinha VR. Nanoemulsions as self-emulsified drug delivery carriers for enhanced permeability of the poorly water-soluble selective β1-adrenoreceptor blocker Talinolol. Nanomedicine. 2012;8:618–626.
  • Tran TH, Guo Y, Song DH, et al. Quercetin-containing self-nanoemulsifying drug delivery system for improving oral bioavailability. J Pharm Sci. 2014;103:840–852.
  • Kuo F, Subramanian B, Kotyla T, et al. Nanoemulsions of an anti-oxidant synergy formulation containing gamma tocopherol have enhanced bioavailability and anti-inflammatory properties. Int J Pharm. 2008;363:206–213.
  • Zheng ZL, Sun YH, Liu ZL, et al. The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug Des Dev Ther. 2015;9:4931–4942.
  • Sun DQ, Wei XB, Xue X, et al. Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions. Int J Nanomed. 2014;9:3413–3423.
  • Li Y, Song CK, Kim MK, et al. Nanomemulsion of megestrol acetate for improved oral bioavailability and reduced food effect. Arch Pharm Res. 2015;38:1850–1856.
  • Guan YG, Wu J, Zhong QX. Eugenol improves physical and chemical stabilities of nanoemulsions loaded with β-carotene. Food Chem. 2016;194:787–796.
  • Baspinar Y, Gundogdu E, Koksal C, et al. Pitavastatin-containing nanoemulsions: preparation, characterization and in vitro cytotoxicity. J Drug Deliv Sci Technol. 2015;29:117–124.
  • Inugala S, Eedara BB, Sunkavalli S, et al. Solid self-nanoemulsifying drug delivery system (s-snedds) of darunavir for improved dissolution and oral bioavailability: in vitro and in vivo evaluation. Eur J Pharm Sci. 2015;74:1–10.
  • Shi YB, Li HL, Li JC, et al. Development, optimization and evaluation of emodin loaded nanoemulsion prepared by ultrasonic emulsification. J Drug Deliv Sci Technol. 2015;27:46–55.
  • Sessa M, Balestrieri ML, Ferrari G, et al. Bioavailability of encapsulated resveratrol into nanoemulsion-based delivery systems. Food Chem. 2014;147:42–50.
  • Shakeel F, Haq N, El-Badry M, et al. Ultra fine super self-nanoemulsifying drug delivery system (snedds) enhanced solubility and dissolution of indomethacin. J Mol Liq. 2013;180:89–94.
  • Bandyopadhyay S, Katare OP, Singh B. Optimized self nano-emulsifying systems of ezetimibe with enhanced bioavailability potential using long chain and medium chain triglycerides. Colloids Surf B Biointerfaces. 2012;100:50–61.
  • Chen HL, An YP, Yan XX, et al. Designing self-nanoemulsifying delivery systems to enhance bioaccessibility of hydrophobic bioactives (nobiletin): influence of hydroxypropyl methylcellulose and thermal processing. Food Hydrocoll. 2015;51:395–404.
  • Zou LQ, Liu W, Liu CM, et al. Designing excipient emulsions to increase nutraceutical bioavailability: emulsifier type influences curcumin stability and bioaccessibility by altering gastrointestinal fate. Food Funct. 2015;6:2475–2486.
  • Liu X, Bi JF, Xiao H, et al. Increasing carotenoid bioaccessibility from yellow peppers using excipient emulsions: impact of lipid type and thermal processing. J Agric Food Chem. 2015;63:8534–8543.
  • McClements DJ, Xiao H. Excipient foods: designing food matrices that improve the oral bioavailability of pharmaceuticals and nutraceuticals. Food Funct. 2014;5:1320–1333.
  • Zhang R, Zhang Z, Zou L, et al. Enhancing nutraceutical bioavailability from raw and cooked vegetables using excipient emulsions: influence of lipid type on carotenoid bioaccessibility from carrots. J Agric Food Chem. 2015;63:10508–10517.
  • McClements DJ. Nanoparticle- and microparticle-based delivery systems: encapsulation, protection, and release of active components. Boca Raton (FL): CRC Press; 2014.
  • Guzey D, McClements DJ. Formation, stability and properties of multilayer emulsions for application in the food industry. Adv Colloid Interface Sci. 2006;128–130:227–248.
  • McClements DJ. Design of nano-laminated coatings to control bioavailability of lipophilic food components. J Food Sci. 2010;75:R30–R42.
  • Dima S, Dima C, Iordachescu G. Encapsulation of functional lipophilic food and drug biocomponents. Food Eng Rev. 2015;7:417–438.
  • Anton N, Benoit J-P, Saulnier P. Design and production of nanoparticles formulated from nano-emulsion templates - a review. J Control Release. 2008;128:185–199.
  • Das S, Chaudhury A. Recent advances in lipid nanoparticle formulations with solid matrix for oral drug delivery. Aaps Pharmscitech. 2011;12:62–76.
  • Wong HL, Bendayan R, Rauth AM, et al. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev. 2007;59:491–504.
  • McClements DJ. Advances in fabrication of emulsions with enhanced functionality using structural design principles. Curr Opin Colloid Interface Sci. 2012;17:235–245.
  • Joye IJ, McClements DJ. Biopolymer-based nanoparticles and microparticles: fabrication, characterization, and application. Curr Opin Colloid Interface Sci. 2014;19:417–427.
  • Shewan HM, Stokes JR. Review of techniques to manufacture micro-hydrogel particles for the food industry and their applications. J Food Eng. 2013;119:781–792.
  • Matalanis A, Decker EA, McClements DJ. Inhibition of lipid oxidation by encapsulation of emulsion droplets within hydrogel microspheres. Food Chem. 2012;132:766–772.
  • Zhang Z, Decker EA, McClements DJ. Encapsulation, protection, and release of polyunsaturated lipids using biopolymer-based hydrogel particles. Food Res Int. 2014;64:520–526.
  • Zhang ZP, Zhang RJ, Chen L, et al. Designing hydrogel particles for controlled or targeted release of lipophilic bioactive agents in the gastrointestinal tract. Eur Polym J. 2015;72:698–716.
  • Mun S, Decker EA, Park Y, et al. Influence of interfacial composition on in vitro digestibility of emulsified lipids: potential mechanism for chitosan’s ability to inhibit fat digestion. Food Biophys. 2006;1:21–29.
  • Xiang N, Lyu Y, Narsimhan G. Characterization of fish oil in water emulsion produced by layer by layer deposition of soy β-conglycinin and high methoxyl pectin. Food Hydrocoll. 2016;52:678–689.
  • Mao Y, Dubot M, Xiao H, et al. Interfacial engineering using mixed protein systems: emulsion-based delivery systems for encapsulation and stabilization of β-carotene. J Agric Food Chem. 2013;61:5163–5169.
  • Helgason T, Awad TS, Kristbergsson K, et al. Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles. J Agric Food Chem. 2009;57:8033–8040.
  • Shangguan MZ, Lu Y, Qi JP, et al. Binary lipids-based nanostructured lipid carriers for improved oral bioavailability of silymarin. J Biomater Appl. 2014;28:887–896.
  • Sookkasem A, Chatpun S, Yuenyongsawad S, et al. Alginate beads for colon specific delivery of self-emulsifying curcumin. J Drug Deliv Sci Technol. 2015;29:159–166.
  • Li Y, Hu M, Du Y, et al. Control of lipase digestibility of emulsified lipids by encapsulation within calcium alginate beads. Food Hydrocoll. 2011;25:122–130.
  • Tokle T, Mao Y, McClements DJ. Potential biological fate of emulsion-based delivery systems: lipid particles nanolaminated with lactoferrin and β-lactoglobulin coatings. Pharm Res. 2013;30:3200–3213.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.