420
Views
53
CrossRef citations to date
0
Altmetric
Review

Aerosolised antibiotics: a critical appraisal of their use

, &
Pages 71-86 | Published online: 22 Dec 2005

Bibliography

  • NIKOLAIZIK WH, JENNI-GALOVIC V, SCHONI MH: Bronchial constriction after nebulized tobramycin preparations and saline in patients with cystic fibrosis. Eur. J. Pediatr. (1996) 155(7):608-611.
  • COLE PJ: The role of nebulized antibiotics in treating serious respiratory infections. J. Chemother. (2001) 13(4):354-362.
  • ESCHENBACHER WL, BOUSHEY HA, SHEPPARD D: Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am. Rev. Respir. Dis. (1984) 129(2):211-215.
  • LOWRY RH, WOOD AM, HIGENBOTTAM TW: Effects of pH and osmolarity on aerosol-induced cough in normal volunteers. Clin. Sci. (1988) 74(4):373-376.
  • WEBER A, MORLIN G, COHEN M et al.: Effect of nebulizer type and antibiotic concentration on device performance. Pediatr. Pulmonol. (1997) 23(4):249-260.
  • ALOTHMAN GA, ALSAADI MM, HO BL et al.: Evaluation of bronchial constriction in children with cystic fibrosis after inhaling two different preparations of tobramycin. Chest (2002) 122(3):930-934.
  • PROBER CG, WALSON PD, JONES J: Technical report: precautions regarding the use of aerosolized antibiotics. Committee on Infectious Diseases and Committee on Drugs. Pediatrics (2000) 106(6):E89.
  • RAMSEY BW, PEPE MS, QUAN JM et al.: Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N. Engl. J. Med. (1999) 340(1):23-30.
  • BURNS JL, VAN DALFSEN JM, SHAWAR RM et al.: Effect of chronic intermittent administration of inhaled tobramycin on respiratory microbial flora in patients with cystic fibrosis. J. Infect. Dis. (1999) 179(5):1190-1196.
  • HODSON ME, GALLAGHER CG, GOVAN JR: A randomised clinical trial of nebulised tobramycin or colistin in cystic fibrosis. Eur. Respir. J. (2002) 20(3):658-664.
  • BARKER AF, COUCH L, FIEL SB et al.: Tobramycin solution for inhalation reduces sputum Pseudomonas aeruginosa density in bronchiectasis. Am. J. Respir. Crit. Care Med. (2000) 162(2 Pt 1):481-485.
  • COUCH LA: Treatment with tobramycin solution for inhalation in bronchiectasis patients with Pseudomonas aeruginosa. Chest (2001) 120(3 Suppl.):114S-117S.
  • SCHEINBERG P, SHORE E: A pilot study of the safety and efficacy of tobramycin solution for inhalation in patients with severe bronchiectasis. Chest (2005) 127(4):1420-1426.
  • HARDY JG, NEWMAN SP, KNOCH M: Lung deposition from four nebulizers. Respir. Med. (1993) 87(6):461-465.
  • MALLOL J, RATTRAY S, WALKER G, COOK D, ROBERTSON CF: Aerosol deposition in infants with cystic fibrosis. Pediatr. Pulmonol. (1996) 21(5):276-281.
  • ILOWITE JS, GORVOY JD, SMALDONE GC: Quantitative deposition of aerosolized gentamicin in cystic fibrosis. Am Rev Respir Dis (1987) 136(6):1445-1449.
  • CLAY MM, CLARKE SW: Wastage of drug from nebulisers: a review. J. R. Soc. Med. (1987) 80(1):38-39.
  • LIPPMANN M, YEATES DB, ALBERT RE: Deposition, retention, and clearance of inhaled particles. Br. J. Ind. Med. (1980) 37(4):337-362.
  • MATTHEWS LW, DOERSHUK CF: Inhalation therapy and postural drainage for the treatment of cystic fibrosis. Bibl. Paediatr. (1967) 86:297-314.
  • BRAIN JD, VALBERG PA: Deposition of aerosol in the respiratory tract. Am. Rev. Respir. Dis. (1979) 120(6):1325-1373.
  • NEWMAN SP: Aerosol deposition considerations in inhalation therapy. Chest (1985) 88(2 Suppl.):152S-160S.
  • NEWMAN SP, PELLOW PG, CLAY MM, CLARKE SW: Evaluation of jet nebulisers for use with gentamicin solution. Thorax (1985) 40(9):671-676.
  • NERBRINK O, DAHLBACK M, HANSSON HC: Why do medical nebulizers differ in their output and particle size characteristics? J. Aerosol Med. (1994) 7(3):259-276.
  • O’CALLAGHAN C, BARRY PW: The science of nebulised drug delivery. Thorax (1997) 52(Suppl. 2):S31-S44.
  • WOLFF RK, NIVEN RW: Generation of aerosolized drugs. J. Aerosol Med. (1994) 7(1):89-106.
  • DENNIS JH: Drug nebuliser design and performance: breath enhanced jet versus constant output versus ultrasonic. J. Aerosol Med. (1995) 8(3):277-280.
  • EVERARD ML, CLARK AR, MILNER AD: Drug delivery from jet nebulisers. Arch. Dis. Child. (1992) 67(5):586-591.
  • COATES AL, MACNEISH CF, MEISNER D et al.: The choice of jet nebulizer, nebulizing flow, and addition of albuterol affects the output of tobramycin aerosols. Chest (1997) 111(5):1206-1212.
  • LOFFERT DT, IKLE D, NELSON HS: A comparison of commercial jet nebulizers. Chest (1994) 106(6):1788-1792.
  • CHUA HL, COLLIS GG, NEWBURY AM et al.: The influence of age on aerosol deposition in children with cystic fibrosis. Eur. Respir. J. (1994) 7(12):2185-2191.
  • LEUNG K, LOUCA E, COATES AL: Comparison of breath-enhanced to breath-actuated nebulizers for rate, consistency, and efficiency. Chest (2004) 126(5):1619-1627.
  • COATES AL, HO SL: Drug administration by jet nebulization. Pediatr. Pulmonol. (1998) 26(6):412-423.
  • FAURISSON F, DESSANGES JF, GRIMFELD A et al.: Nebulizer performance: AFLM study. Association Francaise de Lutte contre la Mucoviscidose. Respiration (1995) 62(Suppl. 1):13-18.
  • NEWHOUSE MT, HIRST PH, DUDDU SP et al.: Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers. Chest (2003) 124(1):360-366.
  • GELLER DE, ROSENFELD M, WALTZ DA, WILMOTT RW: Efficiency of pulmonary administration of tobramycin solution for inhalation in cystic fibrosis using an improved drug delivery system. Chest (2003) 123(1):28-36.
  • MARTONEN TB, KATZ IM: Deposition patterns of aerosolized drugs within human lungs: effects of ventilatory parameters. Pharm. Res. (1993) 10(6):871-878.
  • SANGWAN S, GURSES BK, SMALDONE GC: Facemasks and facial deposition of aerosols. Pediatr. Pulmonol. (2004) 37(5):447-452.
  • MUKHOPADHYAY S, STADDON GE, EASTMAN C et al.: The quantitative distribution of nebulized antibiotic in the lung in cystic fibrosis. Respir. Med. (1994) 88(3):203-211.
  • GELLER DE, PITLICK WH, NARDELLA PA, TRACEWELL WG, RAMSEY BW: Pharmacokinetics and bioavailability of aerosolized tobramycin in cystic fibrosis. Chest (2002) 122(1):219-226.
  • TOUW DJ, JACOBS FA, BRIMICOMBE RW et al.: Pharmacokinetics of aerosolized tobramycin in adult patients with cystic fibrosis. Antimicrob. Agents Chemother. (1997) 41(1):184-187.
  • COONEY GF, LUM BL, TOMASELLI M, FIEL SB: Absolute bioavailability and absorption characteristics of aerosolized tobramycin in adults with cystic fibrosis. J. Clin. Pharmacol. (1994) 34(3):255-259.
  • VALCKE Y, PAUWELS R, VAN DER STRAETEN M: Pharmacokinetics of antibiotics in the lungs. Eur. Respir. J. (1990) 3(6):715-722.
  • MENDELMAN PM, SMITH AL, LEVY J et al.: Aminoglycoside penetration, inactivation, and efficacy in cystic fibrosis sputum. Am. Rev. Respir. Dis. (1985) 132(4):761-765.
  • LEVY J, SMITH AL, KENNY MA, RAMSEY B, SCHOENKNECHT FD: Bioactivity of gentamicin in purulent sputum from patients with cystic fibrosis or bronchiectasis: comparison with activity in serum. J. Infect. Dis. (1983) 148(6):1069-1076.
  • PENNINGTON JE: Penetration of antibiotics into respiratory secretions. Rev. Infect. Dis. (1981) 3(1):67-73.
  • Cystic Fibrosis Foundation, Patient Registry 2003 Annual Report, Bethesda, Maryland, MD, USA (2003).
  • MOSS RB: Administration of aerosolized antibiotics in cystic fibrosis patients. Chest (2001) 120(3 Suppl.):107S-113S.
  • BARKER AF: Bronchiectasis. N. Engl. J. Med. (2002) 346(18):1383-1393.
  • ANGRILL J, AGUSTI C, DE CELIS R et al.: Bacterial colonisation in patients with bronchiectasis: microbiological pattern and risk factors. Thorax (2002) 57(1):15-19.
  • NICOTRA MB, RIVERA M, DALE AM, SHEPHERD R, CARTER R: Clinical, pathophysiologic, and microbiologic characterization of bronchiectasis in an aging cohort. Chest (1995) 108(4):955-961.
  • WILSON CB, JONES PW, O’LEARY CJ et al.: Effect of sputum bacteriology on the quality of life of patients with bronchiectasis. Eur. Respir. J. (1997) 10(8):1754-1760.
  • DROBNIC ME, SUNE P, MONTORO JB, FERRER A, ORRIOLS R: Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa. Ann. Pharmacother. (2005) 39(1):39-44.
  • RAMSEY BW, DORKIN HL, EISENBERG JD et al.: Efficacy of aerosolized tobramycin in patients with cystic fibrosis. N. Engl. J. Med. (1993) 328(24):1740-1746.
  • Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am. J. Respir. Crit. Care Med. (2005) 171(4):388-416.
  • RELLO J, OLLENDORF DA, OSTER G et al.: Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest (2002) 122(6):2115-2121.
  • COOK DJ, WALTER SD, COOK RJ et al.: Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann. Intern. Med. (1998) 129(6):433-440.
  • CHASTRE J, FAGON JY: Ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. (2002) 165(7):867-903.
  • KLASTERSKY J, HUYSMANS E, WEERTS D, HENSGENS C, DANEAU D: Endotracheally administered gentamicin for the prevention of infections of the respiratory tract in patients with tracheostomy: a double-blind study. Chest (1974) 65(6):650-654.
  • KLICK JM, DU MOULIN GC, HEDLEY-WHYTE J et al.: Prevention of Gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis. II. Effect on the incidence of pneumonia in seriously ill patients. J. Clin. Invest. (1975) 55(3):514-519.
  • FEELEY TW, DU MOULIN GC, HEDLEY-WHYTE J et al.: Aerosol polymyxin and pneumonia in seriously ill patients. N. Engl. J. Med. (1975) 293(10):471-475.
  • WOOD GC, BOUCHER BA, CROCE MA et al.: Aerosolized ceftazidime for prevention of ventilator-associated pneumonia and drug effects on the proinflammatory response in critically ill trauma patients. Pharmacotherapy (2002) 22(8):972-982.
  • MEDURI GU, HEADLEY S, KOHLER G et al.: Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest (1995) 107(4):1062-1073.
  • MEDURI GU, KANANGAT S, STEFAN J, TOLLEY E, SCHABERG D: Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria. Am. J. Respir. Crit. Care Med. (1999) 160(3):961-967.
  • RODRIGUEZ JL, MILLER CG, DEFORGE LE et al.: Local production of interleukin-8 is associated with nosocomial pneumonia. J. Trauma (1992) 33(1):74-81; discussion 81-72.
  • BONTEN MJ, FROON AH, GAILLARD CA et al.: The systemic inflammatory response in the development of ventilator-associated pneumonia. Am. J. Respir. Crit. Care Med. (1997) 156(4 Pt 1):1105-1113.
  • PALMER LB, SMALDONE GC, SIMON SR, O’RIORDAN TG, CUCCIA A: Aerosolized antibiotics in mechanically ventilated patients: delivery and response. Crit. Care Med. (1998) 26(1):31-39.
  • SCHEFFER J, KONIG W: Cephalosporins and inflammatory host reactions. Respiration (1993) 60(Suppl. 1):25-31.
  • NICOD LP, PACHE JC, HOWARTH N: Fungal infections in transplant recipients. Eur. Respir. J. (2001) 17(1):133-140.
  • BEYER J, SCHWARTZ S, HEINEMANN V, SIEGERT W: Strategies in prevention of invasive pulmonary aspergillosis in immunosuppressed or neutropenic patients. Antimicrob. Agents Chemother. (1994) 38(5):911-917.
  • CAHILL BC, HIBBS JR, SAVIK K et al.: Aspergillus airway colonization and invasive disease after lung transplantation. Chest (1997) 112(5):1160-1164.
  • MEHRAD B, PACIOCCO G, MARTINEZ FJ et al.: Spectrum of Aspergillus infection in lung transplant recipients: case series and review of the literature. Chest (2001) 119(1):169-175.
  • SINGH N: Invasive mycoses in organ transplant recipients: controversies in prophylaxis and management. J. Antimicrob. Chemother. (2000) 45(6):749-755.
  • REICHENSPURNER H, GAMBERG P, NITSCHKE M et al.: Significant reduction in the number of fungal infections after lung-, heart-lung, and heart transplantation using aerosolized amphotericin B prophylaxis. Transplant. Proc. (1997) 29(1-2):627-628.
  • CALVO V, BORRO JM, MORALES P et al.: Antifungal prophylaxis during the early postoperative period of lung transplantation. Valencia Lung Transplant Group. Chest (1999) 115(5):1301-1304.
  • SCHWARTZ S, BEHRE G, HEINEMANN V et al.: Aerosolized amphotericin B inhalations as prophylaxis of invasive aspergillus infections during prolonged neutropenia: results of a prospective randomized multicenter trial. Blood (1999) 93(11):3654-3661.
  • DREW RH, DODDS ASHLEY E, BENJAMIN DK JR et al.: Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients. Transplantation (2004) 77(2):232-237.
  • BEYER J, BARZEN G, RISSE G et al.: Aerosol amphotericin B for prevention of invasive pulmonary aspergillosis. Antimicrob. Agents Chemother. (1993) 37(6):1367-1369.
  • PALMER SM, DREW RH, WHITEHOUSE JD et al.: Safety of aerosolized amphotericin B lipid complex in lung transplant recipients. Transplantation (2001) 72(3):545-548.
  • BEHRE GF, SCHWARTZ S, LENZ K et al.: Aerosol amphotericin B inhalations for prevention of invasive pulmonary aspergillosis in neutropenic cancer patients. Ann. Hematol. (1995) 71(6):287-291.
  • HERTENSTEIN B, KERN WV, SCHMEISER T et al.: Low incidence of invasive fungal infections after bone marrow transplantation in patients receiving amphotericin B inhalations during neutropenia. Ann. Hematol. (1994) 68(1):21-26.
  • 2001 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. HIV Clin. Trials (2001) 2(6):493-554.
  • BOZZETTE SA, FINKELSTEIN DM, SPECTOR SA et al.: A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group. N. Engl. J. Med. (1995) 332(11):693-699.
  • SCHNEIDER MM, HOEPELMAN AI, EEFTINCK SCHATTENKERK JK et al.: A controlled trial of aerosolized pentamidine or trimethoprim-sulfamethoxazole as primary prophylaxis against Pneumocystis carinii pneumonia in patients with human immunodeficiency virus infection. The Dutch AIDS Treatment Group. N. Engl. J. Med. (1992) 327(26):1836-1841.
  • LEOUNG GS, FEIGAL DW, JR., MONTGOMERY AB et al.: Aerosolized pentamidine for prophylaxis against Pneumocystis carinii pneumonia. The San Francisco community prophylaxis trial. N. Engl. J. Med. (1990) 323(12):769-775.
  • O’RIORDAN TG, SMALDONE GC: Exposure of health care workers to aerosolized pentamidine. Chest (1992) 101(6):1494-1499.
  • MONTGOMERY AB, CORKERY KJ, BRUNETTE ER et al.: Occupational exposure to aerosolized pentamidine. Chest (1990) 98(2):386-388.
  • Centers for Disease Control and Prevention. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care facilities, 1994. MMWR (1994) 43(No. RR13):35-36.
  • VASSAL S, TAAMMA R, MARTY N et al.: Microbiologic contamination study of nebulizers after aerosol therapy in patients with cystic fibrosis. Am. J. Infect. Control (2000) 28(5):347-351.
  • ROSENFELD M, EMERSON J, ASTLEY S et al.: Home nebulizer use among patients with cystic fibrosis. J. Pediatr. (1998) 132(1):125-131.
  • JENSEN T, PEDERSEN SS, GARNE S et al.: Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. J. Antimicrob. Chemother. (1987) 19(6):831-838.
  • ORRIOLS R, ROIG J, FERRER J et al.: Inhaled antibiotic therapy in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection by Pseudomonas aeruginosa. Respir. Med. (1999) 93(7):476-480.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.