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Expert Opinion on Drug Metabolism & Toxicology Volume 1, 2005 - Issue 2
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Review

Gene expression profiling for pharmaceutical safety assessment

Russell Huby AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK. [email protected]
&
Jonathan D Tugwood AstraZeneca R&D, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK. [email protected]
Pages 247-260 | Published online: 16 Aug 2005

Bibliography

  • OLSON H, BETTON G, ROBINSON D et al.: Concordance of the toxicity of pharmaceuticals in humans and in animals. Regul. Toxicol. Pharmacol. (2000) 32(1):56–67.
  • NUWAYSIR EF, BITTNER M, TRENT J, BARRETT JC, AFSHARI CA: Microarrays and toxicology: the advent of toxicogenomics. Mol. Carcinog. (1999) 24(3):153–159.
  • LOVETT RA: Toxicogenomics. Toxicologists brace for genomics revolution. Science (2000) 289(5479):536–537.
  • MEDLIN J: Array of hope for gene technology. Environ. Health Perspect. (2001) 109(1):A34–A37.
  • FIELDEN MR, ZACHAREWSKI TR: Challenges and limitations of gene expression profiling in mechanistic and predictive toxicology. Toxicol. Sci. (2001) 60(1):6–10.
  • POGNAN F: Genomics, proteomics and metabonomics in toxicology: hopefully not ’fashionomics’. Pharmacogenomics (2004) 5(7):879–893.
  • ZHAO N, HASHIDA H, TAKAHASHI N, MISUMI Y, SAKAKI Y: High-density cDNA filter analysis: a novel approach for large-scale, quantitative analysis of gene expression. Gene (1995) 156(2):207–213.
  • SCHENA M, SHALON D, DAVIS RW, BROWN PO: Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science (1995) 270(5235):467–470.
  • DERISI J, PENLAND L, BROWN PO et al. : Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nat. Genet. (1996) 14(4):457–460.
  • ALIZADEH AA: Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature (2000) 403(6769):503–511.
  • ‘T VEER LJ, DAI H, VAN DE VIJVER MJ et al. : Gene expression profiling predicts clinical outcome of breast cancer. Nature (2002) 415(6871):530–536.
  • VAN DE VIJVER MJ, HE YD, VAN’T VEER LJ et al.: A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. (2002) 347(25):1999–2009.
  • ALIZADEH AA, STAUDT LM: Genomicscale gene expression profiling of normal and malignant immune cells. Curr. Opin. Immunol. (2000) 12(2):219–225.
  • BURTON GR, GUAN Y, NAGARAJAN R, MCGEHEE RE Jr: Microarray analysis of gene expression during early adipocyte differentiation. Gene (2002) 293(1–2):21–31.
  • HOFFMANN R, MELCHERS F: A genomic view of lymphocyte development. Curr. Opin. Immunol. (2003) 15(3):239–245.
  • PRZYBORSKI SA, SMITH S, WOOD A: Transcriptional profiling of neuronal differentiation by human embryonal carcinoma stem cells in vitro. Stem Cells (2003) 21(4):459–471.
  • FESSLER MB, MALCOLM KC, DUNCAN MW, WORTHEN GS: A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase. J. Biol. Chem. (2002) 277(35):31291–31302.
  • HELLER RA, SCHENA M, CHAI A et al.: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc. Natl Acad. Sci. USA (1997) 94(6):2150–2155.
  • RICCIARDI-CASTAGNOLI P, GRANUCCI F: Opinion: Interpretation of the complexity of innate immune responses by functional genomics. Nat. Rev. Immunol. (2002) 2(11):881–889.
  • HAMALAINEN H, ZHOU H, CHOU W, HASHIZUME H, HELLER R, LAHESMAA R: Distinct gene expression profiles of human Type 1 and Type 2 T helper cells. Genome Biol. (2001) 2(7):RESEARCH0022.
  • GHAEMMAGHAMI S, HUH WK, BOWER K et al.: Global analysis of protein expression in yeast. Nature (2003) 425(6959):737–741.
  • LEE I, DATE SV, ADAI AT, MARCOTTE EM: A probabilistic functional network of yeast genes. Science (2004) 306(5701):1555–1558.
  • HUGHES TR, ROBINSON MD, MITSAKAKIS N, JOHNSTON M: The promise of functional genomics: completing the encyclopedia of a cell. Curr. Opin. Microbiol. (2004) 7(5):546–554.
  • JANSEN R, YU H, GREENBAUM D et al.: A Bayesian networks approach for predicting protein-protein interactions from genomic data. Science (2003) 302(5644):449–453.
  • WATERS MD, FOSTEL JM: Toxicogenomics and systems toxicology: aims and prospects. Nat. Rev. Genet. (2004) 5(12):936–948.
  • HOLDEN PR, JAMES NH, BROOKS AN, ROBERTS RA, KIMBER I, PENNIE WD: Identification of a possible association between carbon tetrachlorideinduced hepatotoxicity and interleukin-8 expression. J. Biochem. Mol. Toxicol. (2000) 14(5):283–290.
  • UEDA A, HAMADEH HK, WEBB HK et al. : Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol. Pharmacol. (2002) 61(1):1–6.
  • HAMADEH HK, BUSHEL PR, JAYADEV S et al.: Gene expression analysis reveals chemical-specific profiles. Toxicol. Sci. (2002) 67(2):219–231.
  • CHEN H, LIU J, MERRICK BA, WAALKES MP: Genetic events associated with arsenic-induced malignant transformation: applications of cDNA microarray technology. Mol. Carcinog. (2001) 30(2):79–87.
  • LU T, LIU J, LECLUYSE EL, ZHOU YS, CHENG ML, WAALKES MP: Application of cDNA microarray to the study of arsenicinduced liver diseases in the population of Guizhou, China. Toxicol. Sci. (2001) 59(1):185–192.
  • YIH LH, PECK K, LEE TC: Changes in gene expression profiles of human fibroblasts in response to sodium arsenite treatment. Carcinogenesis (2002) 23(5):867–876.
  • LOGUINOV AV, ANDERSON LM, CROSBY GJ, YUKHANANOV RY: Gene expression following acute morphine administration. Physiol. Genomics (2001) 6(3):169–181.
  • SATO H, SAGAI M, SUZUKI KT, AOKI Y: Identification, by cDNA microarray, of A-raf and proliferating cell nuclear antigen as genes induced in rat lung by exposure to diesel exhaust. Res. Commun. Mol. Pathol. Pharmacol. (1999) 105(1–2):77–86.
  • BOUTON CM, HOSSAIN MA, FRELIN LP, LATERRA J, PEVSNER J: Microarray analysis of differential gene expression in lead-exposed astrocytes. Toxicol. Appl. Pharmacol. (2001) 176(1):34–53.
  • BULERA SJ, EDDY SM, FERGUSON E et al.: RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology (2001) 33(5):1239–1258.
  • HUANG Q, JIN X, GAILLARD ET et al.: Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants. Mutat. Res. (2004) 549(1–2):147–167.
  • BURCZYNSKI ME, MCMILLIAN M, CIERVO J et al.: Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. Toxicol. Sci. (2000) 58(2):399–415.
  • WARING JF, CIURLIONIS R, JOLLY RA, HEINDEL M, ULRICH RG: Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity. Toxicol. Lett. (2001) 120(1–3):359–368.
  • WARING JF, JOLLY RA, CIURLIONIS R et al.: Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicol Appl. Pharmacol. (2001) 175(1):28–42.
  • AMIN RP, VICKERS AE, SISTARE F et al.: Identification of putative gene based markers of renal toxicity. Environ. Health Perspect. (2004) 112(4):465–479.
  • BARTOSIEWICZ M, PENN S, BUCKPITT A: Applications of gene arrays in environmental toxicology: fingerprints of gene regulation associated with cadmium chloride, benzo(a)pyrene, and trichloroethylene. Environ. Health Perspect. (2001) 109(1):71–74.
  • ELLINGER-ZIEGELBAUER H, STUART B, WAHLE B, BOMANN W, AHR HJ: Characteristic expression profiles induced by genotoxic carcinogens in rat liver. Toxicol. Sci. (2004) 77(1):19–34.
  • AHR HJ: Characteristic expression profiles induced by genotoxic carcinogens in rat liver. Toxicol. Sci. (2004) 77(1):19–34.
  • HAMADEH HK, BUSHEL PR, JAYADEV S et al.: Prediction of compound signature using high density gene expression profiling. Toxicol. Sci. (2002) 67(2):232–240.
  • SLONIM DK: From patterns to pathways: gene expression data analysis comes of age. Nat. Genet. (2002) 32(Suppl.):502–508.
  • MATTES WB, PETTIT SD, SANSONE SA, BUSHEL PR, WATERS MD: Database development in toxicogenomics: issues and efforts. Environ. Health Perspect. (2004) 112(4):495–505.
  • STEINER G, SUTER L, BOESS F et al.: Discriminating different classes of toxicants by transcript profiling. Environ. Health Perspect. (2004) 112(12):1236–1248.
  • SALTER AH, NILSSON KC: Informatics and multivariate analysis of toxicogenomics data. Curr. Opin. Drug Discov. Devel. (2003) 6(1):117–122.
  • PACKEISEN J, KORSCHING E, HERBST H, BOECKER W, BUERGER H: Demystified.tissue microarray technology. Mol Pathol (2003) 56(4):198–204.
  • SIMON R, MIRLACHER M, SAUTER G: Tissue microarrays. Biotechniques (2004) 36(1):98–105.
  • SUTER L, HAIKER M, DE VERA MC, ALBERTINI S: Effect of two 5-HT6 receptor antagonists on the rat liver: a molecular approach. Pharmacogenomics J. (2003) 3(6):320–334.

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