161
Views
34
CrossRef citations to date
0
Altmetric
Review

Pharmacokinetic drug interactions with non-nucleoside reverse transcriptase inhibitors

, , , , , , & show all
Pages 473-485 | Published online: 29 Sep 2005

Bibliography

  • SMITH PF, DICENZO R, MORSE GD: Clinical pharmacokinetics of nonnucleoside reverse transcriptase inhibitors. Clin. Pharmacokinet. (2001) 40(12):893–905.
  • SAAG MS: Initiation of antiretroviral therapy: implications of recent findings. Top. HIV Med. (2004) 12(3):83–88.
  • MARTINEZ E, ARNAIZ JA, PODZAMCZER D et al. : Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection. N. Engl. J. Med. (2003) 349(11):1036–1046.
  • ALLAVENA C, FERRÉ V, BRUNET-FRANÇOIS C et al.: Efficacy and tolerability of a nucleoside reverse transcriptase inhibitor-sparing combination of lopinavir/ritonavir and efavirenz in HIV-1-infected patients. J. Acquir. Immune Defic. Syndr. (2005) 39(3):300–306.
  • NEGREDO E, MOLTO J, BURGER D et al.: Lopinavir/ritonavir plus nevirapine as a nucleoside-sparing approach in antiretroviral-experienced patients (NEKA study). J. Acquir. Immune Defic. Syndr. (2005) 38(1):47–52.
  • SHELTON MJ, AKBARI B, HEWITT RG, ADAMS JM, MORSE GD: Eradication of Helicobacter pylori is associated with increased exposure to delavirdine in hypochlorhydric HIVpositive patients. J. Acquir. Immune Defic. Syndr. (2000) 24(1):79–82.
  • SHELTON MJ, HEWITT RG, ADAMS JM, COX SR, CHAMBERS JH, MORSE GD: Delavirdine malabsorption in HIV-infected subjects with spontaneous gastric hypoacidity. J. Clin. Pharmacol. (2003) 43(2):171–179.
  • MORSE GD, FISCHL MA, SHELTON MJ et al. : Single-dose pharmacokinetics of delavirdine mesylate and didanosine in patients with human immunodeficiency virus infection. Antimicrob. Agents Chemother. (1997) 41(1):169–174.
  • CHAPUT AJ, D’AMBROSIO R, MORSE GD: In vitro protein-binding characteristics of delavirdine and its N-dealkylated metabolite. Antiviral Res. (1996) 32(2):81–89.
  • SMITH PF, DICENZO R, FORREST A et al.: Population pharmacokinetics of delavirdine and N-delavirdine in HIVinfected individuals. Clin. Pharmacokinet. (2005) 44(1):99–109.
  • DAVEY RT Jr, CHAITT DG, REED GF et al. : Randomized, controlled Phase I/II, trial of combination therapy with delavirdine (U-90152S) and conventional nucleosides in human immunodeficiency virus Type 1-infected patients. Antimicrob. Agents Chemother. (1996) 40(7):1657–1664.
  • STATON BA, JOHNSON MG, FRIIS JM, ADAMS WJ: Simple, rapid and sensitive high-performance liquid chromatographic determination of delavirdine and its N-desisopropyl metabolite in human plasma. J. Chromatogr. B. Biomed. Appl. (1995) 668(1):99–106.
  • VON MOLTKE LL, GREENBLATT DJ, GRANDA BW et al. : Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors. J. Clin. Pharmacol. (2001) 41(1):85–91.
  • TASHIMA KT, CALIENDO AM, AHMAD M et al. : Cerebrospinal fluid human immunodeficiency virus Type 1 (HIV-1) suppression and efavirenz drug concentrations in HIV-1-infected patients receiving combination therapy. J. Infect. Dis. (1999) 180(3):862–864.
  • MARZOLINI C, TELENTI A, DECOSTERD LA, GREUB G, BIOLLAZ J, BUCLIN T: Efavirenz plasma levels can predict treatment failure and central nervous system side effects in HIV-1-infected patients. AIDS (2001) 15(1):71–75.
  • VELDKAMP AI, HARRIS M, MONTANER JS et al. : The steady-state pharmacokinetics of efavirenz and nevirapine when used in combination in human immunodeficiency virus Type 1- infected persons. J. Infect. Dis. (2001) 184(1):37–42.
  • LAMSON MJ, SABO JP, MACGREGOR TR et al. : Single dose pharmacokinetics and bioavailability of nevirapine in healthy volunteers. Biopharm. Drug Dispos. (1999) 20(6):285–291.
  • HAVLIR D, CHEESEMAN SH, MCLAUGHLIN M et al. : High-dose nevirapine: safety, pharmacokinetics, and antiviral effect in patients with human immunodeficiency virus infection. J. Infect. Dis. (1995) 171(3):537–545.
  • VAN HEESWIJK RP, VELDKAMP AI, MULDER JW et al. : The steady-state pharmacokinetics of nevirapine during once daily and twice daily dosing in HIV-1- infected individuals. AIDS (2000) 14(8):F77–F82.
  • GLYNN SL, YAZDANIAN M: In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents. J. Pharm. Sci. (1998) 87(3):306–310.
  • ERICKSON DA, MATHER G, TRAGERWF, LEVY RH, KEIRNS JJ: Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P450. Drug Metab. Dispos. (1999) 27(12):1488–1495.
  • RISKA P, LAMSON M, MACGREGOR T et al. : Disposition and biotransformation of the antiretroviral drug nevirapine in humans. Drug Metab. Dispos. (1999) 27(8):895–901.
  • MURPHY RL: Defining the toxicity profile of nevirapine and other antiretroviral drugs. J. Acquir. Immune Defic. Syndr. (2003) 34(Suppl. 1):S15-S20.
  • WINSTON A, POZNIAK A, SMITH N et al. : Dose escalation or immediate full dose when switching from efavirenz to nevirapine-based highly active antiretroviral therapy in HIV-1-infected individuals? AIDS (2004) 18(3):572–574.
  • CATANZARO LM, SLISH JC, DECENZO R, MORSE GD: Drug interactions with antiretrovirals. Curr. HIV/ AIDS Rep. (2004) 1(2):89–96.
  • TRAN JQ, PETERSEN C, GARRETT M, HEE B, KERR BM: Pharmacokinetic interaction between amprenavir and delavirdine: evidence of induced clearance by amprenavir. Clin. Pharmacol. Ther. (2002) 72(6):615–626.
  • JUSTESEN US, KLITGAARD NA, BROSEN K, PEDERSEN C: Pharmacokinetic interaction between amprenavir and delavirdine after multipledose administration in healthy volunteers. Br. J. Clin. Pharmacol. (2003) 55(1):100–106.
  • JUSTESEN US, KLITGAARD NA, BROSEN K, PEDERSEN C: Dosedependent pharmacokinetics of delavirdine in combination with amprenavir in healthy volunteers. J. Antimicrob. Chemother. (2004) 54(1):206–210.
  • PRESTON S, PILIERO P, O’MARA E et al.: Evaluation of steady-state interaction between atazanavir and efavirenz. 9th Conference on Retroviruses and Opportunistic Infections. Seattle, US (2002):Abstract 443.
  • WINSTON A, BLOCH M, CARR A et al. : The clinical correlations of trough plasma atazanavir levels in a cohort of HIV-1- positive individuals receiving HAART. 12th Conference on Retroviruses and Opportunistic Infections. Boston, US (2005):Abstract 656.
  • PFISTER M, LABBE L, HAMMER SM et al. : Population pharmacokinetics and pharmacodynamics of efavirenz, nelfinavir, and indinavir: Adult AIDS Clinical Trial Group Study 398. Antimicrob. Agents Chemother. (2003) 47(1):130–137.
  • DUVAL X, LE MOING V, LONGUET C et al. : Efavirenz-induced decrease in plasma amprenavir levels in human immunodeficiency virus-infected patients and correction by ritonavir. Antimicrob. Agents Chemother. (2000) 44(9):2593.
  • GOUJARD C, VINCENT I, MEYNARD JL et al. : Steady-state pharmacokinetics of amprenavir coadministered with ritonavir in human immunodeficiency virus Type 1-infected patients. Antimicrob. Agents Chemother. (2003) 47(1):118–123.
  • DEJESUS E, PILIERO P, SUMMERS K et al. : Evaluation of the pharmacokinetic drug interaction between fosamprenavir, fosamprenavir plus ritonavir and nevirapine in HIV-infected patients. 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC, US (2004):Abstract A447.
  • FELLAY J, MARZOLINI C, DECOSTERD L et al. : Variations of CYP3A activity induced by antiretroviral treatment in HIV-1 infected patients. Eur. J. Clin. Pharmacol. (2005) 60(12):865–873.
  • WIRE MB, BALLOW C, PRESTON SL et al. : Pharmacokinetics and safety of GW433908 and ritonavir, with and without efavirenz, in healthy volunteers. AIDS (2004) 18(6):897–907.
  • HSU A, ISAACSON J, BRUN S et al. : Pharmacokinetic-pharmacodynamic analysis of lopinavir-ritonavir in combination with efavirenz and two nucleoside reverse transcriptase inhibitors in extensively pretreated human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. (2003) 47(1):350–359.
  • SOLAS C, POIZOT-MARTIN I, DROGOUL MP et al. : Therapeutic drug monitoring of lopinavir/ritonavir given alone or with a non-nucleoside reverse transcriptase inhibitor. Br. J. Clin. Pharmacol. (2004) 57(4):436–440.
  • DAILLY E, RELIQUET V, RAFFI F, JOLLIET P: A population approach to study the influence of nevirapine administration on lopinavir pharmacokinetics in HIV-1 infected patients. Eur. J. Clin. Pharmacol. (2005) 61(2):153–156.
  • O’MARA E, AGARWALA S, RANDALL D, GERALDES M, STOLTZ R, MUMMANENI V: 9th Conference on Retroviruses and Opportunistic Infections. Seattle, US (2002):Abstract 444.
  • TACKETT D, CHILD M, AGARWALA S et al. : Atazanavir: a summary of two pharmacokinetic drug interaction studies in healthy subjects. 10th Conference on Retroviruses and Opportunistic Infections. Boston, US (2003):Abstract 543.
  • MORSE GD, ROSENKRANZ S, PARA MF et al. : Amprenavir and efavirenz pharmacokinetics before and after the addition of nelfinavir, indinavir, ritonavir, or saquinavir in seronegative individuals. Antimicrob. Agents Chemother. (2005) 49(8):3373–3381.
  • MA Q, FORREST A, OKUSANYA OO et al. : Pharmacokinetic (PK) interaction studies of efavirenz (EFV) and protease inhibitors (PI) in HIV-seronegative volunteers. 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC, US (2004):Abstract A459.
  • KUPER JI, D’APRILE M: Drug-drug interactions of clinical significance in the treatment of patients with Mycobacterium avium complex disease. Clin. Pharmacokinet. (2000) 39(3):203–214.
  • BORIN MT, CHAMBERS JH, CAREL BJ, GAGNON S, FREIMUTH WW: Pharmacokinetic study of the interaction between rifampin and delavirdine mesylate. Clin. Pharmacol. Ther. (1997) 61(5):544–553.
  • BORIN MT, CHAMBERS JH, CAREL BJ, FREIMUTH WW, AKSENTIJEVICH S, PIERGIES AA: Pharmacokinetic study of the interaction between rifabutin and delavirdine mesylate in HIV-1 infected patients. Antiviral Res. (1997) 35(1):53–63.
  • PEDRAL-SAMPAIO DB, ALVES CR, NETTO EM, BRITES C, OLIVEIRA AS, BADARO R: Efficacy and safety of Efavirenz in HIV patients on rifampin for tuberculosis. Braz. J. Infect. Dis. (2004) 8(3):211–216.
  • ROBINSON P, LAMSON M, GIGLIOTTI M, MYERS M: Pharmacokinetic (PK) interaction between nevirapine (NVP) and rifampin (RMP). 12th World AIDS Conference. Geneva, Switzerland (1998):Abstract 60623.
  • OLIVA J, MORENO S, SANZ J et al. : Co-administration of rifampin and nevirapine in HIV-infected patients with tuberculosis. AIDS (2003) 17(4):637–638.
  • RIBERA E, POU L, LOPEZ RM et al. : Pharmacokinetic interaction between nevirapine and rifampicin in HIV-infected patients with tuberculosis. J. Acquir. Immune Defic. Syndr. (2001) 28(5):450–453.
  • MALDONALDO S, LAMSON M, GIGLIOTTI M, PAV JW, ROBINSON P: Pharmacokinetic (PK) interaction between nevirapine (NVP) and rifabutin (RFB). 39th Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, US (1999):Abstract 341.
  • BENEDEK IH, FISKE WD, WHITE SJ, STEVENSON D, JOSEPH JL, KORNHAUSER DM: Pharmacokinetic interaction between multiple doses of efavirenz and rifabutin in healthy volunteers. 36th Annual Meeting of the Infectious Disease Society of America. Denver, US (1998):Abstract 461.
  • EDELSTEIN HE, CUADROS Y: Failure of treatment of tuberculous adenitis due to an unexpected drug interaction with rifabutin and efavirenz. AIDS (2004) 18(12):1748–1749.
  • COX SR, HERMAN BD, BATTS DH, CAREL BJ, CARBERRY PA: Delavirdine and rifabutin: pharmacokinetic evaluation in HIV-1 patients with concentrationtargeting of delavirdine. 5th Conference on Retroviruses and Opportunistic Infections. Chicago, US (1998):Abstract 344.
  • ROBINSON P, GIGLIOTTI M, LAMSON M, AZZAM S, MACGREGOR T: Effect of the reverse transcriptase inhibitor, nevirapine, on the steady-state pharmacokinetics of clarithromycin in HIV-positive patients. 6th Conference on Retroviruses and Opportunistic Infections. Chicago, US (1999):Abstract 374.
  • BENEDEK IH, JOSHI A, FISKE WD et al. : Pharmacokinetic interaction studies in healthy volunteers with efavirenz and the macrolide antibiotics, azithromycin and clarithromycin. 5th Conference on Retroviruses and Opportunistic Infections. Chicago, US (1998):Abstract 347.
  • MICHALETS EL: Update: clinically significant cytochrome P450 drug interactions. Pharmacotherapy (1998) 18(1):84–112.
  • BARRETT JS, JOSHI AS, CHAI M, LUDDEN TM, FISKE WD, PIENIASZEK HJ Jr: Population pharmacokinetic meta-analysis with efavirenz. Int. J. Clin. Pharmacol. Ther. (2002) 40(11):507–519.
  • DE MAAT MM, EKHART GC, HUITEMA AD, KOKS CH, MULDER JW, BEIJNEN JH: Drug interactions between antiretroviral drugs and comedicated agents. Clin. Pharmacokinet. (2003) 42(3):223–282.
  • MARTY F, MYLONAKIS E: Antifungal use in HIV infection. Expert Opin. Pharmacother. (2002) 3(2):91–102.
  • PEARSON MM, ROGERS PD, CLEARY JD, CHAPMAN SW: Voriconazole: a new triazole antifungal agent. Ann. Pharmacother. (2003) 37(3):420–432.
  • DONNELLY JP, DE PAUW BE: Voriconazole-a new therapeutic agent with an extended spectrum of antifungal activity. Clin. Microbiol. Infect. (2004) 10(Suppl. 1):107–117.
  • FERRARI A, COCCIA CP, BERTOLINI A, STERNIERI E: Methadone - metabolism, pharmacokinetics and interactions. Pharmacol. Res. (2004) 50(6):551–559.
  • ALTICE FL, FRIEDLAND GH, COONEY EL: Nevirapine induced opiate withdrawal among injection drug users with HIV infection receiving methadone. AIDS (1999) 13(8):957–962.
  • HEELON MW, MEADE LB: Methadone withdrawal when starting an antiretroviral regimen including nevirapine. Pharmacotherapy (1999) 19(4):471–472.
  • OTERO MJ, FUERTES A, SANCHEZ R, LUNA G: Nevirapine-induced withdrawal symptoms in HIV patients on methadone maintenance programme: an alert. AIDS (1999) 13(8):1004–1005.
  • CLARKE SM, MULCAHY FM, TJIA J et al. : Pharmacokinetic interactions of nevirapine and methadone and guidelines for use of nevirapine to treat injection drug users. Clin. Infect. Dis. (2001) 33(9):1595–1597.
  • STOCKER H, KRUSE G, KRECKEL P et al. : Nevirapine significantly reduces the levels of racemic methadone and (R)- methadone in human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. (2004) 48(11):4148–4153.
  • BOFFITO M, ROSSATI A, REYNOLDS HE, HOGGARD PG, BACK DJ, DI PERRI G: Undefined duration of opiate withdrawal induced by efavirenz in drug users with HIV infection and undergoing chronic methadone treatment. AIDS Res. Hum. Retroviruses (2002) 18(5):341–342.
  • CLARKE SM, MULCAHY FM, TJIA J et al. : The pharmacokinetics of methadone in HIV-positive patients receiving the nonnucleoside reverse transcriptase inhibitor efavirenz. Br. J. Clin. Pharmacol. (2001) 51(3):213–217.
  • BOOKER B, SMITH P, FORREST A et al. : Lack of effect of methadone (MET) on the pharmacokinetics (PK) of delavirdine (DLV) & N-delavirdine. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, US (2001):Abstract A490.
  • JOHNSON RE, CHUTUAPE MA, STRAIN EC, WALSH SL, STITZER ML, BIGELOW GE: A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence. N. Engl. J. Med. (2000) 343(18):1290–1297.
  • MCCANCE-KATZ EF, PADE P, FRIEDLAND G, MORSE G, MOODY D, RAINEY P: Efavirenz decreases buprenorphine exposure, but is not associated with opiate withdrawal in opioid dependent individuals. 12th Conference on Retroviruses and Opportunistic Infections. Boston, US (2005):Abstract 653.
  • LIEDTKE MD, LOCKHART SM, RATHBUN RC: Anticonvulsant and antiretroviral interactions. Ann. Pharmacother. (2004) 38(3):482–489.
  • TSENG AL, FOISY MM: Significant interactions with new antiretrovirals and psychotropic drugs. Ann. Pharmacother. (1999) 33(4):461–473.
  • DICENZO R, PETERSON D, CRUTTENDEN K et al. : Effects of valproic acid coadministration on plasma efavirenz and lopinavir concentrations in human immunodeficiency virus-infected adults. Antimicrob. Agents Chemother. (2004) 48(11):4328–4331.
  • PENZAK SR, CHUCK SK: Management of protease inhibitor-associated hyperlipidemia. Am. J. Cardiovasc. Drugs (2002) 2(2):91–106.
  • FICHTENBAUM CJ, GERBER JG: Interactions between antiretroviral drugs and drugs used for the therapy of the metabolic complications encountered during HIV infection. Clin. Pharmacokinet. (2002) 41(14):1195–1211.
  • CASTRO JG, GUTIERREZ L: Rhabdomyolysis with acute renal failure probably related to the interaction of atorvastatin and delavirdine. Am. J. Med. (2002) 112(6):505.
  • CARR A, WORKMAN C, CAREY D et al. : No effect of rosiglitazone for treatment of HIV-1 lipoatrophy: randomised, double-blind, placebocontrolled trial. Lancet (2004) 363(9407):429–438.
  • MILDVAN D, YARRISH R, MARSHAK A et al. : Pharmacokinetic interaction between nevirapine and ethinyl estradiol/norethindrone when administered concurrently to HIV-infected women. J. Acquir. Immune Defic. Syndr. (2002) 29(5):471–477.
  • COHN SE, WATTS D, LERTORA J, PARK JG, YU S: An open-label, nonrandomized study of the effect of depomedroxyprogesterone acetate on the pharmacokinetics (PK) of selected protease inhibitors and non-nucleoside reverse transcriptase inhibitors therapies among HIV-infected women. 12th Conference on Retroviruses and Opportunistic Infections. Boston, US (2005):Abstract 82.
  • SCOTT LJ, PERRY CM: Delavirdine: a review of its use in HIV infection. Drugs (2000) 60(6):1411–1444.
  • ZAPOR MJ, COZZA KL, WYNN GH, WORTMANN GW, ARMSTRONG SC: Antiretrovirals, Part II: focus on nonprotease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors). Psychosomatics (2004) 45(6):524–535.
  • WYNN GH, COZZA KL, ZAPOR MJ, WORTMANN GW, ARMSTRONG SC: Med-psych drug-drug interactions update. Antiretrovirals, part III: antiretrovirals and drugs of abuse. Psychosomatics (2005) 46(1):79–87.
  • FAIRFIELD KM, EISENBERG DM, DAVIS RB, LIBMAN H, PHILLIPS RS: Patterns of use, expenditures, and perceived efficacy of complementary and alternative therapies in HIV-infected patients. Arch. Intern. Med. (1998) 158(20):2257–2264.
  • PISCITELLI SC, BURSTEIN AH, CHAITT D, ALFARO RM, FALLOON J: Indinavir concentrations and St John’s wort. Lancet (2000) 355(9203):547–548.
  • DE MAAT MM, HUITEMA AD, MULDER JW, MEENHORST PL, VAN GORP EC, BEIJNEN JH: Population pharmacokinetics of nevirapine in an unselected cohort of HIV-1-infected individuals. Br. J. Clin. Pharmacol. (2002) 54(4):378–385.
  • HENNESSY M, KELLEHER D, SPIERS JP et al.: St Johns wort increases expression of P-glycoprotein: implications for drug interactions. Br. J. Clin. Pharmacol. (2002) 53(1):75–82.
  • PISCITELLI SC, BURSTEIN AH, WELDEN N, GALLICANO KD, FALLOON J: The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin. Infect. Dis. (2002) 34(2):234–238.
  • BACK D, GATTI G, FLETCHER C et al. : Therapeutic drug monitoring in HIV infection: current status and future directions. AIDS (2002) 16(Suppl. 1): S5–S37.
  • GERBER JG, ACOSTA EP: Therapeutic drug monitoring in the treatment of HIVinfection. J. Clin. Virol. (2003) 27(2):117–128.
  • FELLAY J, MARZOLINI C, MEADEN ER et al. : Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet (2002) 359(9300):30–36.
  • CSAJKA C, MARZOLINI C, FATTINGER K et al. : Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection. Clin. Pharmacol. Ther. (2003) 73(1):20–30.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.