The effect of grapefruit juice on drug disposition

Bibliography

• Bailey DG, Spence JD, Edgar B, Ethanol enhances the hemodynamic effects of felodipine. Clin Invest Med 1989;12(6):357-62
   PubMed Web of Science ®Google Scholar
• Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol 1998;46(2):101-10
   PubMed Web of Science ®Google Scholar
• Paine MF, Oberlies NH. Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions. Expert Opin Drug Metab Toxicol 2007;3(1):67-80
   PubMed Web of Science ®Google Scholar
• Mertens-Talcott SU, Zadezensky I, De Castro WV, Grapefruit-drug interactions: can interactions with drugs be avoided? J Clin Pharmacol 2006;46(12):1390-416
   PubMed Web of Science ®Google Scholar
• Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4(4):381-93
   PubMed Web of Science ®Google Scholar
• Greenblatt DJ. Update on drug interactions with grapefruit juice: an evidence-based review. Pharm Times 2010;76:95-104
   Google Scholar
• Paine MF, Widmer WW, Hart HL, A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction. Am J Clin Nutr 2006;83(5):1097-105
   PubMed Web of Science ®Google Scholar
• Paine MF, Widmer WW, Pusek SN, Further characterization of a furanocoumarin-free grapefruit juice on drug disposition: studies with cyclosporine. Am J Clin Nutr 2008;87(4):863-71
   PubMed Web of Science ®Google Scholar
• Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49(12):1403-7
   PubMed Web of Science ®Google Scholar
• Bailey DG, Dresser GK, Leake BF, Kim RB. Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice. Clin Pharmacol Ther 2007;81(4):495-502
   PubMed Web of Science ®Google Scholar
• De Castro WV, Mertens-Talcott S, Rubner A, Variation of flavonoids and furanocoumarins in grapefruit juices: a potential source of variability in grapefruit juice-drug interaction studies. J Agric Food Chem 2006;54(1):249-55
   PubMed Web of Science ®Google Scholar
• Ho PC, Saville DJ, Coville PF, Wanwimolruk S. Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products. Pharm Acta Helv 2000;74(4):379-85
   PubMedGoogle Scholar
• Bailey DG, Arnold JM, Strong HA, Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics. Clin Pharmacol Ther 1993;54(6):589-94
   PubMed Web of Science ®Google Scholar
• Bailey DG, Arnold JM, Munoz C, Spence JD. Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin. Clin Pharmacol Ther 1993;53(6):637-42
   PubMed Web of Science ®Google Scholar
• Rashid J, McKinstry C, Renwick AG, Quercetin, an in vitro inhibitor of CYP3A, does not contribute to the interaction between nifedipine and grapefruit juice. Br J Clin Pharmacol 1993;36(5):460-3
   PubMed Web of Science ®Google Scholar
• Lin HL, Kent UM, Hollenberg PF. The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5. J Pharmacol Exp Ther 2005;313(1):154-64
   PubMed Web of Science ®Google Scholar
• Schmiedlin-Ren P, Edwards DJ, Fitzsimmons ME, Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins. Drug Metab Dispos 1997;25(11):1228-33
   PubMed Web of Science ®Google Scholar
• Guo LQ, Fukuda K, Ohta T, Yamazoe Y. Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity. Drug Metab Dispos 2000;28(7):766-71
   PubMed Web of Science ®Google Scholar
• Ohta T, Maruyama T, Nagahashi M, Paradisin C: a new CYP3A4 inhibitor from grapefruit juice. Tetrahedron 2002;58:6631-5
   Web of Science ®Google Scholar
• Girennavar B, Poulose SM, Jayaprakasha GK, Furocoumarins from grapefruit juice and their effect on human CYP 3A4 and CYP 1B1 isoenzymes. Bioorg Med Chem 2006;14(8):2606-12
   PubMed Web of Science ®Google Scholar
• Tassaneeyakul W, Guo LQ, Fukuda K, Inhibition selectivity of grapefruit juice components on human cytochromes P450. Arch Biochem Biophys 2000;378(2):356-63
   PubMed Web of Science ®Google Scholar
• Uesawa Y, Mohri K. UV-irradiated grapefruit juice loses pharmacokinetic interaction with nifedipine in rats. Biol Pharm Bull 2006;29(6):1286-9
   PubMed Web of Science ®Google Scholar
• Uesawa Y, Mohri K. The use of heat treatment to eliminate drug interactions due to grapefruit juice. Biol Pharm Bull 2006;29(11):2274-8
   PubMed Web of Science ®Google Scholar
• Zhang L, Reynolds KS, Zhao P, Huang SM. Drug interactions evaluation: an integrated part of risk assessment of therapeutics. Toxicol Appl Pharmacol 2010;243(2):134-45
   PubMed Web of Science ®Google Scholar
• Greenblatt DJ, He P, von Moltke LL, Court MH. The CYP3 family. In: Ioannides C, editor, Cytochrome P450: role in the metabolism and toxicology of drugs and other xenobiotics. Royal Society of Chemistry, Cambridge, United Kingdom; 2008. p. 354-83
   Google Scholar
• Guo LQ, Yamazoe Y. Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines. Acta Pharmacol Sin 2004;25(2):129-36
   PubMed Web of Science ®Google Scholar
• Paine MF, Criss AB, Watkins PB. Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties. Drug Metab Dispos 2004;32(10):1146-53
   PubMed Web of Science ®Google Scholar
• Paine MF, Criss AB, Watkins PB. Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition. J Pharmacol Exp Ther 2005;312(3):1151-60
   PubMed Web of Science ®Google Scholar
• Greenblatt DJ, von Moltke LL, Harmatz JS, Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice. Clin Pharmacol Ther 2003;74(2):121-9
   PubMed Web of Science ®Google Scholar
• Ohnishi A, Matsuo H, Yamada S, Effect of furanocoumarin derivatives in grapefruit juice on the uptake of vinblastine by Caco-2 cells and on the activity of cytochrome P450 3A4. Br J Pharmacol 2000;130(6):1369-77
   PubMed Web of Science ®Google Scholar
• Eagling VA, Profit L, Back DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol 1999;48(4):543-52
   PubMed Web of Science ®Google Scholar
• Fukuda K, Ohta T, Yamazoe Y. Grapefruit component interacting with rat and human P450 CYP3A: possible involvement of non-flavonoid components in drug interaction. Biol Pharm Bull 1997;20(5):560-4
   PubMed Web of Science ®Google Scholar
• Edwards DJ, Bellevue FH III, Woster PM. Identification of 6′,7′-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metab Dispos 1996;24(12):1287-90
   PubMed Web of Science ®Google Scholar
• Schwarz UI, Johnston PE, Bailey DG, Impact of citrus soft drinks relative to grapefruit juice on ciclosporin disposition. Br J Clin Pharmacol 2006;62(4):485-91
   PubMed Web of Science ®Google Scholar
• Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin Pharmacol Ther 2003;73(6):529-37
   PubMed Web of Science ®Google Scholar
• Goosen TC, Cillie D, Bailey DG, Bergamottin contribution to the grapefruit juice-felodipine interaction and disposition in humans. Clin Pharmacol Ther 2004;76(6):607-17
   PubMed Web of Science ®Google Scholar
• Lown KS, Bailey DG, Fontana RJ, Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression. J Clin Invest 1997;99(10):2545-53
   PubMed Web of Science ®Google Scholar
• Glaeser H, Bailey DG, Dresser GK, Intestinal drug transporter expression and the impact of grapefruit juice in humans. Clin Pharmacol Ther 2007;81(3):362-70
   PubMed Web of Science ®Google Scholar
• Edwards DJ, Fitzsimmons ME, Schuetz EG, 6′,7′-Dihydroxybergamottin in grapefruit juice and seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther 1999;65(3):237-44
   PubMed Web of Science ®Google Scholar
• Culm-Merdek KE, von Moltke LL, Gan L, Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir. Clin Pharmacol Ther 2006;79(3):243-54
   PubMed Web of Science ®Google Scholar
• Takanaga H, Ohnishi A, Murakami H, Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. Clin Pharmacol Ther 2000;67(3):201-14
   PubMed Web of Science ®Google Scholar
• Lundahl J, Regardh CG, Edgar B, Johnsson G. Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects. Eur J Clin Pharmacol 1995;49(1-2):61-7
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Kivisto KT, Neuvonen PJ. Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin. Clin Pharmacol Ther 2000;68(4):384-90
   PubMed Web of Science ®Google Scholar
• Wang X, Wolkoff AW, Morris ME. Flavonoids as a novel class of human organic anion-transporting polypeptide OATP1B1 (OATP-C) modulators. Drug Metab Dispos 2005;33(11):1666-72
   PubMed Web of Science ®Google Scholar
• Satoh H, Yamashita F, Tsujimoto M, Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos 2005;33(4):518-23
   PubMed Web of Science ®Google Scholar
• Dresser GK, Bailey DG, Leake BF, Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 2002;71(1):11-20
   PubMed Web of Science ®Google Scholar
• Shirasaka Y, Kuraoka E, Spahn-Langguth H, Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat. J Pharmacol Exp Ther 2010;332(1):181-9
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75(3):184-90
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Niemi M, Fredrikson H, Neuvonen PJ. Effects of clarithromycin and grapefruit juice on the pharmacokinetics of glibenclamide. Br J Clin Pharmacol 2007;63(6):732-40
   PubMed Web of Science ®Google Scholar
• Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995;13(3):129-34
   PubMed Web of Science ®Google Scholar
• Takanaga H, Ohnishi A, Matsuo H, Sawada Y. Inhibition of vinblastine efflux mediated by P-glycoprotein by grapefruit juice components in Caco-2 cells. Biol Pharm Bull 1998;21(10):1062-6
   PubMed Web of Science ®Google Scholar
• Soldner A, Christians U, Susanto M, Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res 1999;16(4):478-85
   PubMed Web of Science ®Google Scholar
• Spahn-Langguth H, Langguth P. Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol. Eur J Pharm Sci 2001;12(4):361-7
   PubMed Web of Science ®Google Scholar
• Ofer M, Wolffram S, Koggel A, Modulation of drug transport by selected flavonoids: Involvement of P-gp and OCT? Eur J Pharm Sci 2005;25(2-3):263-71
   PubMed Web of Science ®Google Scholar
• Lim SL, Lim LY. Effects of citrus fruit juices on cytotoxicity and drug transport pathways of Caco-2 cell monolayers. Int J Pharm 2006;307(1):42-50
   PubMedGoogle Scholar
• Dahan A, Amidon GL. Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein. Pharm Res 2009;26(4):883-92
   PubMed Web of Science ®Google Scholar
• de Castro WV, Mertens-Talcott S, Derendorf H, Butterweck V. Grapefruit juice-drug interactions: grapefruit juice and its components inhibit P-glycoprotein (ABCB1) mediated transport of talinolol in Caco-2 cells. J Pharm Sci 2007;96(10):2808-17
   PubMed Web of Science ®Google Scholar
• Tourniaire F, Hassan M, Andre M, Molecular mechanisms of the naringin low uptake by intestinal Caco-2 cells. Mol Nutr Food Res 2005;49(10):957-62
   PubMed Web of Science ®Google Scholar
• Schwarz UI, Seemann D, Oertel R, Grapefruit juice ingestion significantly reduces talinolol bioavailability. Clin Pharmacol Ther 2005;77(4):291-301
   PubMed Web of Science ®Google Scholar
• Lown KS, Mayo RR, Leichtman AB, Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clin Pharmacol Ther 1997;62(3):248-60
   PubMed Web of Science ®Google Scholar
• Becquemont L, Verstuyft C, Kerb R, Effect of grapefruit juice on digoxin pharmacokinetics in humans. Clin Pharmacol Ther 2001;70(4):311-16
   PubMed Web of Science ®Google Scholar
• Parker RB, Yates CR, Soberman JE, Laizure SC. Effects of grapefruit juice on intestinal P-glycoprotein: evaluation using digoxin in humans. Pharmacotherapy 2003;23(8):979-87
   PubMed Web of Science ®Google Scholar
• Li P, Callery PS, Gan LS, Balani SK. Esterase inhibition attribute of grapefruit juice leading to a new drug interaction. Drug Metab Dispos 2007;35(7):1023-31
   PubMed Web of Science ®Google Scholar
• Li P, Callery PS, Gan LS, Balani SK. Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction. Drug Metab Dispos 2007;35(7):1203-8
   PubMed Web of Science ®Google Scholar
• Nishimuta H, Tsujimoto M, Ogura K, Inhibitory effects of various beverages on ritodrine sulfation by recombinant human sulfotransferase isoforms SULT1A1 and SULT1A3. Pharm Res 2005;22(8):1406-10
   PubMed Web of Science ®Google Scholar
• Nishimuta H, Ohtani H, Tsujimoto M, Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. Biopharm Drug Dispos 2007;28(9):491-500
   PubMed Web of Science ®Google Scholar
• Walle T, Eaton EA, Walle UK. Quercetin, a potent and specific inhibitor of the human P-form phenosulfotransferase. Biochem Pharmacol 1995;50(5):731-4
   PubMed Web of Science ®Google Scholar
• Yasui N, Kondo T, Furukori H, Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam. Psychopharmacology (Berl) 2000;150(2):185-90
   PubMed Web of Science ®Google Scholar
• Ozdemir M, Aktan Y, Boydag BS, Interaction between grapefruit juice and diazepam in humans. Eur J Drug Metab Pharmacokinet 1998;23(1):55-9
   PubMed Web of Science ®Google Scholar
• Farkas D, Oleson LE, Zhao Y, Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47(3):286-94
   PubMed Web of Science ®Google Scholar
• Kupferschmidt HH, Ha HR, Ziegler WH, Interaction between grapefruit juice and midazolam in humans. Clin Pharmacol Ther 1995;58(1):20-8
   PubMed Web of Science ®Google Scholar
• Andersen V, Pedersen N, Larsen NE, Intestinal first pass metabolism of midazolam in liver cirrhosis –effect of grapefruit juice. Br J Clin Pharmacol 2002;54(2):120-4
   PubMed Web of Science ®Google Scholar
• Veronese ML, Gillen LP, Burke JP, Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice. J Clin Pharmacol 2003;43(8):831-9
   PubMed Web of Science ®Google Scholar
• Rogers JD, Zhao J, Liu L, Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Clin Pharmacol Ther 1999;66(4):358-66
   PubMed Web of Science ®Google Scholar
• van Erp NP, Baker SD, Zandvliet AS, Marginal increase of sunitinib exposure by grapefruit juice. Cancer Chemother Pharmacol 29 May 2010. [Epub ahead of print] PMID: 20512335
   Google Scholar
• Kharasch ED, Walker A, Hoffer C, Sheffels P. Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis. Clin Pharmacol Ther 2004;76(5):452-66
   PubMed Web of Science ®Google Scholar
• Vanakoski J, Mattila MJ, Seppala T. Grapefruit juice does not enhance the effects of midazolam and triazolam in man. Eur J Clin Pharmacol 1996;50(6):501-8
   PubMed Web of Science ®Google Scholar
• Sugimoto K, Araki N, Ohmori M, Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam. Eur J Clin Pharmacol 2006;62(3):209-15
   PubMed Web of Science ®Google Scholar
• Hukkinen SK, Varhe A, Olkkola KT, Neuvonen PJ. Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice. Clin Pharmacol Ther 1995;58(2):127-31
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Kivisto KT, Backman JT, Neuvonen PJ. Effect of grapefruit juice dose on grapefruit juice-triazolam interaction: repeated consumption prolongs triazolam half-life. Eur J Clin Pharmacol 2000;56(5):411-15
   PubMed Web of Science ®Google Scholar
• Garg SK, Kumar N, Bhargava VK, Prabhakar SK. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharmacol Ther 1998;64(3):286-8
   PubMed Web of Science ®Google Scholar
• Kumar N, Garg SK, Prabhakar S. Lack of pharmacokinetic interaction between grapefruit juice and phenytoin in healthy male volunteers and epileptic patients. Methods Find Exp Clin Pharmacol 1999;21(9):629-32
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Kivisto KT, Backman JT, Grapefruit juice substantially increases plasma concentrations of buspirone. Clin Pharmacol Ther 1998;64(6):655-60
   PubMed Web of Science ®Google Scholar
• Vandel S, Netillard C, Perault MC, Bel AM. Plasma levels of clozapine and desmethylclozapine are unaffected by concomitant ingestion of grapefruit juice. Eur J Clin Pharmacol 2000;56(4):347-8
   PubMed Web of Science ®Google Scholar
• Lane HY, Jann MW, Chang YC, Repeated ingestion of grapefruit juice does not alter clozapine's steady-state plasma levels, effectiveness, and tolerability. J Clin Psychiatry 2001;62(10):812-7
   PubMed Web of Science ®Google Scholar
• Lane HY, Chiu CC, Kazmi Y, Lack of CYP3A4 inhibition by grapefruit juice and ketoconazole upon clozapine administration in vivo. Drug Metabol Drug Interact 2001;18(3-4):263-78
   PubMedGoogle Scholar
• Hori H, Yoshimura R, Ueda N, Grapefruit juice-fluvoxamine interaction–is it risky or not? J Clin Psychopharmacol 2003;23(4):422-4
   PubMed Web of Science ®Google Scholar
• Yasui N, Kondo T, Suzuki A, Lack of significant pharmacokinetic interaction between haloperidol and grapefruit juice. Int Clin Psychopharmacol 1999;14(2):113-8
   PubMed Web of Science ®Google Scholar
• Lee AJ, Chan WK, Harralson AF, The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study. Clin Ther 1999;21(11):1890-9
   PubMed Web of Science ®Google Scholar
• Ueda N, Yoshimura R, Umene-Nakano W, Grapefruit juice alters plasma sertraline levels after single ingestion of sertraline in healthy volunteers. World J Biol Psychiatry 2009;10(4 Pt 3):832-5
   PubMed Web of Science ®Google Scholar
• Kharasch ED, Whittington D, Hoffer C. Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate. Anesthesiology 2004;101(3):729-37
   PubMed Web of Science ®Google Scholar
• Kharasch ED, Hoffer C, Whittington D, Sheffels P. Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. Clin Pharmacol Ther 2004;76(3):250-69
   PubMed Web of Science ®Google Scholar
• Benmebarek M, Devaud C, Gex-Fabry M, Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone. Clin Pharmacol Ther 2004;76(1):55-63
   PubMed Web of Science ®Google Scholar
• Nieminen TH, Hagelberg NM, Saari TI, Grapefruit juice enhances the exposure to oral oxycodone. Basic Clin Pharmacol Toxicol 2010;107(4):782-8
   PubMed Web of Science ®Google Scholar
• Cheng KL, Nafziger AN, Peloquin CA, Amsden GW. Effect of grapefruit juice on clarithromycin pharmacokinetics. Antimicrob Agents Chemother 1998;42(4):927-9
   PubMed Web of Science ®Google Scholar
• Kanazawa S, Ohkubo T, Sugawara K. The effects of grapefruit juice on the pharmacokinetics of erythromycin. Eur J Clin Pharmacol 2001;56(11):799-803
   PubMed Web of Science ®Google Scholar
• Shi J, Montay G, Leroy B, Bhargava VO. Effects of itraconazole or grapefruit juice on the pharmacokinetics of telithromycin. Pharmacotherapy 2005;25(1):42-51
   PubMed Web of Science ®Google Scholar
• van Agtmael MA, Gupta V, van der Wosten TH, Grapefruit juice increases the bioavailability of artemether. Eur J Clin Pharmacol 1999;55(5):405-10
   PubMed Web of Science ®Google Scholar
• van Agtmael MA, Gupta V, van der Graaf CA, van Boxtel CJ. The effect of grapefruit juice on the time-dependent decline of artemether plasma levels in healthy subjects. Clin Pharmacol Ther 1999;66(4):408-14
   PubMed Web of Science ®Google Scholar
• Charbit B, Becquemont L, Lepere B, Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine. Clin Pharmacol Ther 2002;72(5):514-23
   PubMed Web of Science ®Google Scholar
• Ho PC, Chalcroft SC, Coville PF, Wanwimolruk S. Grapefruit juice has no effect on quinine pharmacokinetics. Eur J Clin Pharmacol 1999;55(5):393-8
   PubMed Web of Science ®Google Scholar
• Cuong BT, Binh VQ, Dai B, Does gender, food or grapefruit juice alter the pharmacokinetics of primaquine in healthy subjects? Br J Clin Pharmacol 2006;61(6):682-9
   PubMed Web of Science ®Google Scholar
• Nagy J, Schipper HG, Koopmans RP, Effect of grapefruit juice or cimetidine coadministration on albendazole bioavailability. Am J Trop Med Hyg 2002;66(3):260-3
   PubMed Web of Science ®Google Scholar
• Castro N, Jung H, Medina R, Interaction between grapefruit juice and praziquantel in humans. Antimicrob Agents Chemother 2002;46(5):1614-16
   PubMed Web of Science ®Google Scholar
• Demarles D, Gillotin C, Bonaventure-Paci S, Single-dose pharmacokinetics of amprenavir coadministered with grapefruit juice. Antimicrob Agents Chemother 2002;46(5):1589-90
   PubMed Web of Science ®Google Scholar
• Shelton MJ, Wynn HE, Hewitt RG, DiFrancesco R. Effects of grapefruit juice on pharmacokinetic exposure to indinavir in HIV-positive subjects. J Clin Pharmacol 2001;41(4):435-42
   PubMed Web of Science ®Google Scholar
• Penzak SR, Acosta EP, Turner M, Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics. J Clin Pharmacol 2002;42(10):1165-70
   PubMed Web of Science ®Google Scholar
• Kupferschmidt HH, Fattinger KE, Ha HR, Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man. Br J Clin Pharmacol 1998;45(4):355-9
   PubMed Web of Science ®Google Scholar
• Kawakami M, Suzuki K, Ishizuka T, Effect of grapefruit juice on pharmacokinetics of itraconazole in healthy subjects. Int J Clin Pharmacol Ther 1998;36(6):306-8
   PubMed Web of Science ®Google Scholar
• Penzak SR, Gubbins PO, Gurley BJ, Grapefruit juice decreases the systemic availability of itraconazole capsules in healthy volunteers. Ther Drug Monit 1999;21(3):304-9
   PubMed Web of Science ®Google Scholar
• Gubbins PO, McConnell SA, Gurley BJ, Influence of grapefruit juice on the systemic availability of itraconazole oral solution in healthy adult volunteers. Pharmacotherapy 2004;24(4):460-7
   PubMed Web of Science ®Google Scholar
• Gubbins PO, Gurley BJ, Williams DK, Examining sex-related differences in enteric itraconazole metabolism in healthy adults using grapefruit juice. Eur J Clin Pharmacol 2008;64(3):293-301
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Raaska K, Neuvonen PJ. Effects of grapefruit juice on the pharmacokinetics of acebutolol. Br J Clin Pharmacol 2005;60(6):659-63
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Backman JT, Laitila J, Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol. Clin Pharmacol Ther 2003;73(3):192-8
   PubMed Web of Science ®Google Scholar
• Josefsson M, Zackrisson AL, Ahlner J. Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers. Eur J Clin Pharmacol 1996;51(2):189-93
   PubMed Web of Science ®Google Scholar
• Vincent J, Harris SI, Foulds G, Lack of effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of amlodipine. Br J Clin Pharmacol 2000;50(5):455-63
   PubMed Web of Science ®Google Scholar
• Hirashima H, Uchida N, Fukazawa I, Effect of a single glass of grapefruit juice on the apparent oral bioavailability of the dihydropyridine calcium channel antagonist, azelnidipine, in healthy Japanese volunteers. Jpn J Clin Pharmacol Ther 2006;37(3):127-33
   Google Scholar
• Sigusch H, Henschel L, Kraul H, Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects. Pharmazie 1994;49(9):675-9
   PubMed Web of Science ®Google Scholar
• Christensen H, Asberg A, Holmboe AB, Berg KJ. Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers. Eur J Clin Pharmacol 2002;58(8):515-20
   PubMed Web of Science ®Google Scholar
• Bailey DG, Spence JD, Munoz C, Arnold JM. Interaction of citrus juices with felodipine and nifedipine. Lancet 1991;337(8736):268-9
   PubMed Web of Science ®Google Scholar
• Lundahl J, Regardh CG, Edgar B, Johnsson G. Effects of grapefruit juice ingestion–pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men. Eur J Clin Pharmacol 1997;52(2):139-45
   PubMed Web of Science ®Google Scholar
• Lundahl JU, Regardh CG, Edgar B, Johnsson G. The interaction effect of grapefruit juice is maximal after the first glass. Eur J Clin Pharmacol 1998;54(1):75-81
   PubMed Web of Science ®Google Scholar
• Bailey DG, Kreeft JH, Munoz C, Grapefruit juice-felodipine interaction: effect of naringin and 6′,7′-dihydroxybergamottin in humans. Clin Pharmacol Ther 1998;64(3):248-56
   PubMed Web of Science ®Google Scholar
• Bailey DG, Dresser GK, Kreeft JH, Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients. Clin Pharmacol Ther 2000;68(5):468-77
   PubMed Web of Science ®Google Scholar
• Dresser GK, Bailey DG, Carruthers SG. Grapefruit juice–felodipine interaction in the elderly. Clin Pharmacol Ther 2000;68(1):28-34
   PubMed Web of Science ®Google Scholar
• Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther 2001;69(1):14-23
   PubMed Web of Science ®Google Scholar
• Kakar SM, Paine MF, Stewart PW, Watkins PB. 6′7′-Dihydroxybergamottin contributes to the grapefruit juice effect. Clin Pharmacol Ther 2004;75(6):569-79
   PubMed Web of Science ®Google Scholar
• Bailey DG, Arnold JM, Bend JR, Grapefruit juice-felodipine interaction: reproducibility and characterization with the extended release drug formulation. Br J Clin Pharmacol 1995;40(2):135-40
   PubMed Web of Science ®Google Scholar
• Bailey DG, Bend JR, Arnold JM, Erythromycin-felodipine interaction: magnitude, mechanism, and comparison with grapefruit juice. Clin Pharmacol Ther 1996;60(1):25-33
   PubMed Web of Science ®Google Scholar
• Edgar B, Bailey D, Bergstrand R, Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance. Eur J Clin Pharmacol 1992;42(3):313-17
   PubMed Web of Science ®Google Scholar
• Uno T, Ohkubo T, Motomura S, Sugawara K. Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects. Br J Clin Pharmacol 2006;61(5):533-7
   PubMed Web of Science ®Google Scholar
• Uno T, Ohkubo T, Sugawara K, Effects of grapefruit juice on the stereoselective disposition of nicardipine in humans: evidence for dominant presystemic elimination at the gut site. Eur J Clin Pharmacol 2000;56(9-10):643-9
   PubMed Web of Science ®Google Scholar
• Sigusch H, Hippius M, Henschel L, Influence of grapefruit juice on the pharmacokinetics of a slow release nifedipine formulation. Pharmazie 1994;49(7):522-4
   PubMed Web of Science ®Google Scholar
• Rashid TJ, Martin U, Clarke H, Factors affecting the absolute bioavailability of nifedipine. Br J Clin Pharmacol 1995;40(1):51-8
   PubMed Web of Science ®Google Scholar
• Odou P, Ferrari N, Barthelemy C, Grapefruit juice-nifedipine interaction: possible involvement of several mechanisms. J Clin Pharm Ther 2005;30(2):153-8
   PubMed Web of Science ®Google Scholar
• Fuhr U, Maier-Bruggemann A, Blume H, Grapefruit juice increases oral nimodipine bioavailability. Int J Clin Pharmacol Ther 1998;36(3):126-32
   PubMed Web of Science ®Google Scholar
• Soons PA, Vogels BA, Roosemalen MC, Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans. Clin Pharmacol Ther 1991;50(4):394-403
   PubMed Web of Science ®Google Scholar
• Hashimoto K, Shirafuji T, Sekino H, Interaction of citrus juices with pranidipine, a new 1,4-dihydropyridine calcium antagonist, in healthy subjects. Eur J Clin Pharmacol 1998;54(9-10):753-60
   PubMed Web of Science ®Google Scholar
• Zaidenstein R, Dishi V, Gips M, The effect of grapefruit juice on the pharmacokinetics of orally administered verapamil. Eur J Clin Pharmacol 1998;54(4):337-40
   PubMed Web of Science ®Google Scholar
• Ho PC, Ghose K, Saville D, Wanwimolruk S. Effect of grapefruit juice on pharmacokinetics and pharmacodynamics of verapamil enantiomers in healthy volunteers. Eur J Clin Pharmacol 2000;56(9-10):693-8
   PubMed Web of Science ®Google Scholar
• Fuhr U, Muller-Peltzer H, Kern R, Effects of grapefruit juice and smoking on verapamil concentrations in steady state. Eur J Clin Pharmacol 2002;58(1):45-53
   PubMed Web of Science ®Google Scholar
• Libersa CC, Brique SA, Motte KB, Dramatic inhibition of amiodarone metabolism induced by grapefruit juice. Br J Clin Pharmacol 2000;49(4):373-8
   PubMed Web of Science ®Google Scholar
• Min DI, Ku YM, Geraets DR, Lee H. Effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of quinidine in healthy volunteers. J Clin Pharmacol 1996;36(5):469-76
   PubMed Web of Science ®Google Scholar
• Damkier P, Hansen LL, Brosen K. Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. Br J Clin Pharmacol 1999;48(6):829-38
   PubMed Web of Science ®Google Scholar
• Ando H, Tsuruoka S, Yanagihara H, Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin. Br J Clin Pharmacol 2005;60(5):494-7
   PubMed Web of Science ®Google Scholar
• Fukazawa I, Uchida N, Uchida E, Yasuhara H. Effects of grapefruit juice on pharmacokinetics of atorvastatin and pravastatin in Japanese. Br J Clin Pharmacol 2004;57(4):448-55
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Clin Pharmacol Ther 1999;66(2):118-27
   PubMed Web of Science ®Google Scholar
• Kantola T, Kivisto KT, Neuvonen PJ. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther 1998;63(4):397-402
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors. Clin Pharmacol Ther 1998;64(5):477-83
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Neuvonen M, Neuvonen PJ. Effects of regular consumption of grapefruit juice on the pharmacokinetics of simvastatin. Br J Clin Pharmacol 2004;58(1):56-60
   PubMed Web of Science ®Google Scholar
• Tapaninen T, Neuvonen PJ, Niemi M. Grapefruit juice greatly reduces the plasma concentrations of the OATP2B1 and CYP3A4 substrate aliskiren. Clin Pharmacol Ther 2010;88(3):339-42
   PubMed Web of Science ®Google Scholar
• Zaidenstein R, Soback S, Gips M, Effect of grapefruit juice on the pharmacokinetics of losartan and its active metabolite E3174 in healthy volunteers. Ther Drug Monit 2001;23(4):369-73
   PubMed Web of Science ®Google Scholar
• Sullivan DM, Ford MA, Boyden TW. Grapefruit juice and the response to warfarin. Am J Health Syst Pharm 1998;55(15):1581-3
   PubMed Web of Science ®Google Scholar
• Uno T, Yasui-Furukori N, Takahata T, Lack of significant effect of grapefruit juice on the pharmacokinetics of lansoprazole and its metabolites in subjects with different CYP2C19 genotypes. J Clin Pharmacol 2005;45(6):690-4
   PubMed Web of Science ®Google Scholar
• Miura M, Kagaya H, Tada H, Intestinal CYP3A4 is not involved in the enantioselective disposition of lansoprazole. Xenobiotica 2006;36(1):95-102
   PubMed Web of Science ®Google Scholar
• Tassaneeyakul W, Vannaprasaht S, Yamazoe Y. Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice. Br J Clin Pharmacol 2000;49(2):139-44
   PubMed Web of Science ®Google Scholar
• Hermann M, Asberg A, Reubsaet JL, Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients. Int J Clin Pharmacol Ther 2002;40(10):451-6
   PubMed Web of Science ®Google Scholar
• Bistrup C, Nielsen FT, Jeppesen UE, Dieperink H. Effect of grapefruit juice on Sandimmun Neoral absorption among stable renal allograft recipients. Nephrol Dial Transplant 2001;16(2):373-7
   PubMed Web of Science ®Google Scholar
• Lee M, Min DI, Ku YM, Flanigan M. Effect of grapefruit juice on pharmacokinetics of microemulsion cyclosporine in African American subjects compared with Caucasian subjects: does ethnic difference matter? J Clin Pharmacol 2001;41(3):317-23
   PubMed Web of Science ®Google Scholar
• Ducharme MP, Warbasse LH, Edwards DJ. Disposition of intravenous and oral cyclosporine after administration with grapefruit juice. Clin Pharmacol Ther 1995;57(5):485-91
   PubMed Web of Science ®Google Scholar
• Ku YM, Min DI, Flanigan M. Effect of grapefruit juice on the pharmacokinetics of microemulsion cyclosporine and its metabolite in healthy volunteers: does the formulation difference matter? J Clin Pharmacol 1998;38(10):959-65
   PubMed Web of Science ®Google Scholar
• Min DI, Ku YM, Perry PJ, Effect of grapefruit juice on cyclosporine pharmacokinetics in renal transplant patients. Transplantation 1996;62(1):123-5
   PubMed Web of Science ®Google Scholar
• Hollander AA, van Rooij J, Lentjes GW, The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients. Clin Pharmacol Ther 1995;57(3):318-24
   PubMed Web of Science ®Google Scholar
• Yee GC, Stanley DL, Pessa LJ, Effect of grapefruit juice on blood cyclosporin concentration. Lancet 1995;345(8955):955-6
   PubMed Web of Science ®Google Scholar
• Brunner LJ, Pai KS, Munar MY, Effect of grapefruit juice on cyclosporin A pharmacokinetics in pediatric renal transplant patients. Pediatr Transplant 2000;4(4):313-21
   PubMedGoogle Scholar
• Ioannides-Demos LL, Christophidis N, Ryan P, Dosing implications of a clinical interaction between grapefruit juice and cyclosporine and metabolite concentrations in patients with autoimmune diseases. J Rheumatol 1997;24(1):49-54
   PubMed Web of Science ®Google Scholar
• Ducharme MP, Provenzano R, Dehoorne-Smith M, Edwards DJ. Trough concentrations of cyclosporine in blood following administration with grapefruit juice. Br J Clin Pharmacol 1993;36(5):457-9
   PubMed Web of Science ®Google Scholar
• Brunner LJ, Munar MY, Vallian J, Interaction between cyclosporine and grapefruit juice requires long-term ingestion in stable renal transplant recipients. Pharmacotherapy 1998;18(1):23-9
   PubMed Web of Science ®Google Scholar
• Liu C, Shang YF, Zhang XF, Co-administration of grapefruit juice increases bioavailability of tacrolimus in liver transplant patients: a prospective study. Eur J Clin Pharmacol 2009;65(9):881-5
   PubMed Web of Science ®Google Scholar
• Bidstrup TB, Damkier P, Olsen AK, The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide. Br J Clin Pharmacol 2006;61(1):49-57
   PubMed Web of Science ®Google Scholar
• Reif S, Nicolson MC, Bisset D, Effect of grapefruit juice intake on etoposide bioavailability. Eur J Clin Pharmacol 2002;58(7):491-4
   PubMed Web of Science ®Google Scholar
• Yin OQ, Gallagher N, Li A, Effect of grapefruit juice on the pharmacokinetics of nilotinib in healthy participants. J Clin Pharmacol 2010;50(2):188-94
   PubMed Web of Science ®Google Scholar
• Seidegard J, Randvall G, Nyberg L, Borga O. Grapefruit juice interaction with oral budesonide: equal effect on immediate-release and delayed-release formulations. Pharmazie 2009;64(7):461-5
   PubMed Web of Science ®Google Scholar
• Schubert W, Cullberg G, Edgar B, Hedner T. Inhibition of 17 beta-estradiol metabolism by grapefruit juice in ovariectomized women. Maturitas 1994;20(2-3):155-63
   PubMed Web of Science ®Google Scholar
• Weber A, Jager R, Borner A, Can grapefruit juice influence ethinylestradiol bioavailability? Contraception 1996;53(1):41-7
   PubMed Web of Science ®Google Scholar
• Lilja JJ, Laitinen K, Neuvonen PJ. Effects of grapefruit juice on the absorption of levothyroxine. Br J Clin Pharmacol 2005;60(3):337-41
   PubMed Web of Science ®Google Scholar
• Varis T, Kivisto KT, Neuvonen PJ. Grapefruit juice can increase the plasma concentrations of oral methylprednisolone. Eur J Clin Pharmacol 2000;56(6-7):489-93
   PubMed Web of Science ®Google Scholar
• Banfield C, Gupta S, Marino M, Grapefruit juice reduces the oral bioavailability of fexofenadine but not desloratadine. Clin Pharmacokinet 2002;41(4):311-18
   PubMed Web of Science ®Google Scholar
• Dresser GK, Kim RB, Bailey DG. Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides. Clin Pharmacol Ther 2005;77(3):170-7
   PubMed Web of Science ®Google Scholar
• Clifford CP, Adams DA, Murray S, The cardiac effects of terfenadine after inhibition of its metabolism by grapefruit juice. Eur J Clin Pharmacol 1997;52(4):311-15
   PubMed Web of Science ®Google Scholar
• Honig PK, Wortham DC, Lazarev A, Cantilena LR. Grapefruit juice alters the systemic bioavailability and cardiac repolarization of terfenadine in poor metabolizers of terfenadine. J Clin Pharmacol 1996;36(4):345-51
   PubMed Web of Science ®Google Scholar
• Benton RE, Honig PK, Zamani K, Grapefruit juice alters terfenadine pharmacokinetics, resulting in prolongation of repolarization on the electrocardiogram. Clin Pharmacol Ther 1996;59(4):383-8
   PubMed Web of Science ®Google Scholar
• Rau SE, Bend JR, Arnold MO, Grapefruit juice-terfenadine single-dose interaction: magnitude, mechanism, and relevance. Clin Pharmacol Ther 1997;61(4):401-9
   PubMed Web of Science ®Google Scholar
• Fuhr U, Klittich K, Staib AH. Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man. Br J Clin Pharmacol 1993;35(4):431-6
   PubMed Web of Science ®Google Scholar
• Maish WA, Hampton EM, Whitsett TL, Influence of grapefruit juice on caffeine pharmacokinetics and pharmacodynamics. Pharmacotherapy 1996;16(6):1046-52
   PubMed Web of Science ®Google Scholar
• Lucas D, Ferrara R, Gonzalez E, Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans. Pharmacogenetics 1999;9(3):377-88
   PubMedGoogle Scholar
• Gross AS, Goh YD, Addison RS, Shenfield GM. Influence of grapefruit juice on cisapride pharmacokinetics. Clin Pharmacol Ther 1999;65(4):395-401
   PubMed Web of Science ®Google Scholar
• Kivisto KT, Lilja JJ, Backman JT, Neuvonen PJ. Repeated consumption of grapefruit juice considerably increases plasma concentrations of cisapride. Clin Pharmacol Ther 1999;66(5):448-53
   PubMed Web of Science ®Google Scholar
• Offman EM, Freeman DJ, Dresser GK, Red wine-cisapride interaction: comparison with grapefruit juice. Clin Pharmacol Ther 2001;70(1):17-23
   PubMed Web of Science ®Google Scholar
• Desta Z, Kivisto KT, Lilja JJ, Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice. Br J Clin Pharmacol 2001;52(4):399-407
   PubMed Web of Science ®Google Scholar
• Di Marco MP, Edwards DJ, Wainer IW, Ducharme MP. The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. Life Sci 2002;71(10):1149-60
   PubMed Web of Science ®Google Scholar
• Strauch K, Lutz U, Bittner N, Lutz WK. Dose-response relationship for the pharmacokinetic interaction of grapefruit juice with dextromethorphan investigated by human urinary metabolite profiles. Food Chem Toxicol 2009;47(8):1928-35
   PubMed Web of Science ®Google Scholar
• Mougey EB, Lang JE, Wen X, Lima JJ. Effect of citrus juice and SLCO2B1 genotype on the pharmacokinetics of montelukast. J Clin Pharmacol 25 Oct 2010. [Epub ahead of print] PMID: 20974993
   Google Scholar
• Ebert U, Oertel R, Kirch W. Influence of grapefruit juice on scopolamine pharmacokinetics and pharmacodynamics in healthy male and female subjects. Int J Clin Pharmacol Ther 2000;38(11):523-31
   PubMed Web of Science ®Google Scholar
• Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, Effects of grapefruit juice on the pharmacokinetics of sildenafil. Clin Pharmacol Ther 2002;71(1):21-9
   PubMed Web of Science ®Google Scholar
• Fuhr U, Maier A, Keller A, Lacking effect of grapefruit juice on theophylline pharmacokinetics. Int J Clin Pharmacol Ther 1995;33(6):311-14
   PubMed Web of Science ®Google Scholar
• Hanley MJ, Cerundolo R, Radwanski N, Court MH. Grapefruit juice, lyophilized grapefruit juice, and powdered whole grapefruit inhibit cytochrome P450-mediated triazolam hydroxylation by beagle dog liver microsomes. J Vet Pharmacol Ther 2010;33(2):189-95
   PubMed Web of Science ®Google Scholar