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Drug Evaluations

Ondansetron: a review of pharmacokinetics and clinical experience in postoperative nausea and vomiting

& , MD PhD DEAA

Bibliography

  • Gan TJ. Risk factors for postoperative nausea and vomiting. Anesth Analg 2006;102:1884-98
  • Gan TJ. Postoperative nausea and vomiting: can it be eliminated? JAMA 2002;287:1233-6
  • Watcha MF, White PF. Postoperative nausea and vomiting: its etiology, treatment and prevention. Anesthesiology 1992;77:162-84
  • Apfel CC, Krake P, Eberhart LHJ, et al. Comparison of predictive models for postoperative nausea and vomiting. Br J Anaesth 2002;88:234-40
  • Gan TJ, Meyer TA, Apfel CC, et al. Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2007;105:1615-28
  • Grelot L, Miller AD. Vomiting: its ins and outs. News Physiol Sci 1994;9:142-6
  • Fukuda H, Koga T. The Bötzinger complex as the pattern generator for retching and vomiting in the dog. Neurosci Res 1991;12:471-85
  • Hornby PJ. Central neurocircuitry associated with emesis. Am J Med 2001;111:106S-12S
  • Koga T, Fukuda H. Neurons in the nucleus of the solitary tract mediating inputs from vagal afferents and the area postrema to the pattern generator for the emetic act in dogs. Neurosci Res 1992;14:166-79
  • Hesketh PJ. Chemotherapy-induced nausea and vomiting. N Engl J Med 2008;358:2482-94
  • Diemunsch P, Joshi GP, Brichant JF. Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting. Br J Anaesth 2009;103:7-13
  • Ho KY, Gan TJ. Pharmacology, pharmacogenetics, and clinical efficacy of 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Curr Opin Anaesthesiol 2006;19:606-11
  • http://www.gsk.com.au/resources.ashx/prescriptionmedicinesproductschilddataproinfo/95/FileName/B04E66A7A692B605D0A8196CBC881255/PI_Zofran.pdf
  • Tzvetkov MV, Saadatmand AR, Bokelmann K, et al. Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT3 antagonists tropisetron and ondansetron. Pharmacogenomics J 2012;12:22-9
  • Mackinnon JWM, Collin DT. The chemistry of ondansetron. Eur J Cancer Clin Oncol 1989;25(Suppl 1):S61
  • Roila F, Del Favero A. Ondansetron clinical pharmacokinetics. Clin Pharmacokinet 1995;29:95-109
  • Aapro M. 5-HT3-receptor antagonists in the management of nausea and vomiting in cancer and cancer treatment. Oncology 2005;69:97-109
  • Butler A, Hill JM, Ireland SJ, et al. Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors. Br J Pharmacol 1988;94:397-412
  • Bodhankar SL, Thakurdesai PA, Maurya OP. Effects of (RS)-Ondansetron and its enantiomers on QTc interval in Rats. Pharmacologyonline 2006;3:153-8
  • Shinde J, Mandora VP, Joshi PK, Erram SS. Efficacy and safety of R-Ondansetron 4 mg versus racemic Ondansetron 8 mg: results of a randomized, double blind, multicentric clinical trial. Indian Med Gazette 2005;139:444-7
  • Garud KL, Godbole S, Mankar S, Pathak S. Efficacy and safety of R(+) Ondansetron solution in the treatment of nausea and vomiting in children: results of an open-label, non-comparative, prospective clinical study. Indian Med Gazette 2006;140:112-14
  • Boeijinga PH, Galvan M, Baron BM, et al. Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cells. Eur J Pharmacol 1992;219:9-13
  • Yamada Y, Sugiura M, Higo K, et al. Receptor occupancy theory-based analysis of antiemetic effectsand standard doses of 5-HT3 receptor antagonists in cancer patients. Cancer Chemother Pharmacol 2004;54:185-90
  • Ayuhara Y, Takayanagi R, Okuyama K. Receptor occupancy theory-based analysis of interindividual differences in antiemetic effects of 5- HT3 receptor antagonists. Int J Clin Oncol 2009;14:518-24
  • Van Den Berg CM, Kazmil Y, Stewart J, et al. Pharmacokinetics of three formulations of ondansetron hydrochloride in healthy volunteers: 24-mg oral tablet, rectal suppository and i.v. infusion. Am J Health Syst Pharm 2000;57:1046-50
  • Pritchard JF. Ondansetron metabolism and pharmacokinetics. Semin Oncol 1992;19(Suppl 10):95-155
  • Gan TJ. Selective serotonin 5-HT3 receptor antagonists for postoperative nausea and vomiting: are they all the same? CNS Drugs 2005;19:225-38
  • Sphar-Schopfer IA, Lerman J, Sikich N, et al. Pharmacokinetics of intravenous ondansetron in healthy children undergoing ear, nose and throat surgery. Clin Pharmacol Ther 1995;58:361-21
  • Mondick JT, Johnson BM, Haberer LJ, et al. Population pharmacokinetics of intravenous ondansetron in oncology and surgical patients aged 1−48 months. Eur J Clin Pharmacol 2010;66:77-86
  • Figg WD, Dukes GE, Pritchard F, et al. Pharmacokinetics of ondansetron in patients with hepatic insufficiency. J Clin Pharmacol 1996;36:206-25
  • Amantea MA, Yarboro C, Forrest A, et al. Population pharmacokinetics of intravenous and oral ondansetron in patients with systemic lupus erythematosus (SLE). J Clin Pharmacol 1993;33:1004
  • Candiotti KA, Birnbach DJ, Lubarsky DA, et al. The impact of pharmacogenomics on postoperative nausea and vomiting. Do CYP2D6 alleles copy number and polymorphisms affect the success or failure of ondansetron prophylaxis? Anesthesiology 2005;102:543-9
  • Keiser R, Sezer O, Papies A, et al. Patient–tailored antiemetic treatment with 5-hydroxytryptamine type 3 receptor antagonists according to cytochrome P-450 2D6 genotypes. J Clin Oncol 2002;20:2805-11
  • Janicki PK. Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit 2005;11. [Epub ahead of print]
  • Wojnowski L, Kamdem LK. Clinical implications of CYP3A polymorphisms. Expert Opin Drug Metab Toxicol 2006;2:171-82
  • Stamer UM, Lee EH, Rauers NI, et al. CYP2D6- and CYP3A- dependent enantioselective plasma concentrations of ondansetron in postanesthesia care. Anesth Analg 2011;113:48-54
  • Gwak HS, Oh IS, Chun IK. Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers. Drug Dev Ind Pharm 2004;30:187-94
  • Obataa Y, Ashitakaa Y, Kikuchia S, et al. A statistical approach to the development of a transdermal delivery system for ondansetron. Int J Pharm 2010;399:87-93
  • Can AS, Erdal M, Güngör S, Özsoy Y. Optimization and characterization of chitosan films for transdermal delivery of ondansetron. Molecules 2013;18:5455-71
  • Dharani S, Shayeda Formulation and in in vitro evaluation of mucoadhesive buccal patches of ondansetron hydrochloride. Int J Pharm Sci Nanotechnol 2010;3:860-6
  • Park DM, Song YK, Jee JP, et al. Development of chitosan-based ondansetron buccal delivery system for the treatment of emesis. Drug Dev Ind Pharm 2012;38:1077-8
  • Koland M, Charyulu RN, Vijayanarayana K, Prabhu P. In vitro and in vivo evaluation of chitosan buccal films of ondansetron hydrochloride. Int J Pharm Investig 2011;1:164-71
  • Prasanna RI, Anitha P, Chetty CM. Formulation and evaluation of bucco-adhesive tablets of sumatriptan succinate. Int J Pharm Investig 2011;1:182-91
  • Cho E, Gwak H, Chun I. Formulation and evaluation of ondansetron nasal delivery systems. Int J Pharm 2008;349:101-7
  • Gungor S, Okyar A, Erturk-Toker S, et al. Ondansetron-loaded chitosan microspheres for nasal antiemetic drug delivery: an alternative approach to oral and parenteral routes. Drug Dev Ind Pharm 2010;36:806-13
  • Kovac A, McKenzie R, O'Connor T, et al. Prophylactic intravenous ondansetron in female outpatients undergoing gynaecological surgery: a multicentre dose-comparison study. Eur J Anaesthesiol Suppl 1992;9:37-47
  • Du Pen S, Scuderi P, Wetchler B, et al. Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur J Anaesthesiol Suppl 1992;9:55-62
  • Larijani GE, Gratz I, Afshar M, Minassian S. Treatment of postoperative nausea and vomiting with ondansetron: a randomized, double-blind comparison with placebo. Anesth Analg 1991;73:246-9
  • Tramèr MR, Reynolds DJM, Moore RA, et al. Efficacy, dose-response, and safety of ondansetron in prevention of postoperative nausea and vomiting: a qualitative systematic review of randomized placebo-controlled trials. Anesthesiology 1997;87:1277-89
  • Sun R, Klein KW, White PF. The effect of timing of ondansetron administration in outpatients undergoing otolaryngologic surgery. Anesth Analg 1997;84:331-6
  • Tang J, Wang B, White PF, et al. The effect of timing of ondansetron administration on its efficacy, cost-effectiveness, and cost-benefit as a prophylactic antiemetic in the ambulatory setting. Anesth Analg 1998;86:274-82
  • Cruz NI, Portila P, Vela RE. Timing of ondansetron administration to prevent postoperative nausea and vomiting PRHSJ. 2008;27:43-7
  • Kovac AL, O'Connor TA, Pearman MH, et al. Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo- controlled multicenter trial. J Clin Anesth 1999;11:453-9
  • Naguib M, El Bakry AK, Khoshim MHB, et al. Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized double- blind comparison with placebo. Can J Anaesth 1996;43:226-31
  • Jokela J, Koivuranta M, Kangas–Saarela T, et al. Oral ondansetron, tropisetron or metoclopramide to prevent postoperative nausea and vomiting: a comparison in high-risk patients undergoing thyroid or parathyroid surgery. Acta Anaesthesiol Scand 2002;46:519-24
  • Metaxari M, Papaioannou A, Petrou A, et al. Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents. J Anesth 2011;25:356-62
  • Korttila K, Clergue F, Leeser J, et al. Intravenous dolasetron and ondansetron in prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. Acta Anaesthesiol Scand 1997;41:914-22
  • Zarate E, Watcha MF, White PF, et al. Comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg 2000;90:1352-8
  • Meyer TA, Roberson CR, Rajab MH, et al. Dolasetron versus ondansetron for the treatment of postoperative nausea and vomiting. Anesth Analg 2005;100:373-7
  • Moon YE. JooJ, Kim J E, Lee Y. Anti-emetic effect of ondansetron and palonosetron in thyroidectomy: a prospective, randomized, double-blind study. Br J Anaesth 2012;108:417-22
  • Kim YY, Moon SY, Song DU, et al. Comparison of palonosetron with ondansetron in prevention of postoperative nausea and vomiting in patients receiving intravenous patient-controlled analgesia after gynecological laparoscopic surgery. Korean J Anesthesiol 2013;64:122-6
  • Cholwill JM, Wright W, Hobbs GJ, et al. Comparison of ondansetron and cyclizine for prevention of nausea and vomiting after day- case gynaecological laparoscopy. Br J Anaesth 1999;83:611-14
  • Grimsehl K, Whiteside JB, Mackenzie N. Comparison of cyclizine and ondansetron for the prevention of PONV in laparoscopic day –case gynaecological surgery. Anaesthesia 2002;57:61-5
  • Kothari SN, Boyd WC, Bottcher ML, et al. Antiemetic efficacy of prophylactic dimenhydrinate (Dramamine) vs ondansetron (Zofran): a randomized, prospective trial in patients undergoing laparoscopic cholecystectomy. Surg Endosc 2000;14:926-9
  • Ahmed AB, Hobbs GJ, Curran JP. Randomized, placebo-controlled trial of combination antiemetic prophylaxis for day-case gynaecological laparoscopic surgery. Br J Anaesth 2000;85:678-82
  • Sniadach SM, Alberts MS. A comparison of the prophylactic antiemetic effect of ondansetron and droperidol on patients undergoing gynecologic laparoscopy. Anesth Analg 1997;85:797-800
  • Singla NK, Singla SK, Chung F, et al. Phase II study to evaluate the safety and efficacy of the oral neurokinin-1 receptor antagonist casopitant (GW679769) administered with ondansetron for the prevention of postoperative and post discharge nausea and vomiting in high-risk patients. Anesthesiology 2010;113:74-82
  • Apfel CC, Korttila K, Abdalla M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med 2004;350:2441-51
  • Diemunsch P, Gan TJ, Philip BK, et al. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery. Br J Anaesth 2007;99:202-11
  • McQueen KD, Milton JD. Multicenter postmarketing surveillance of ondansetron therapy in pediatric patients. Ann Pharmacother 1994;28:85-92
  • Finn AL. Toxicity and side effects of ondansetron. Semin Oncol 1992;19:53-60
  • Lee CY, Ratnapalan S, Thompson M, et al. Unusual reactions to 5-HT3 receptor antagonists in a child with rhabdomyosarcoma. Can J Clin Pharmacol 2010;17:1-4
  • ZOFRAN® (ondansetron hydrochloride) injection; ZOFRAN®(ondansetron hydrochloride) injection premixed [package insert]. GlaxoSmithKline; Research Triangle Park (NC): 2001
  • Kuryshev Y, Brown AM, Wang L, et al. Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels. J Pharmacol Exp Ther 2000;295:614-20
  • Charbit B, Alvarez JC, Dasque E, et al. Droperidol and ondansetron-induced QT interval prolongation: a clinical drug interaction study. Anesthesiology 2008;109:206-12
  • McKechnie K, Froese A. Ventricular tachycardia after ondansetron administration in a child with undiagnosed long QT syndrome. Can J Anaesth 2010;57:453-7
  • Charbit B, Albaladejo P, Funck-Brentano C, et al. Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. Anesthesiology 2005;102:1094-100
  • Chan MT, Choi KC, Gin T, et al. The additive interactions between ondansetron and droperidol for preventing postoperative nausea and vomiting. Anesth Analg 2006;103:1155-62
  • Siu SSN, Chan MTV, Lau TK. Placental transfer of ondansetron during early human pregnancy. Clin Pharmacokinet 2006;45:419-23
  • Pasternak B, Svanström H. HviidA. Ondansetron in pregnancy and risk of adverse fetal outcomes. N Engl J Med 2013;368:814-23
  • Einarson A, Maltepe C, Navioz Y, et al. The safety of ondansetron for nausea and vomiting of pregnancy: a prospective comparative study. BJOG 2004;111:940-3
  • Anderka M, Mitchell AA, Louik C, et al. National Birth Defects Prevention Study. Medications used to treat nausea and vomiting of pregnancy and the risk of selected birth defects. Birth Defects Res A Clin Mol Teratol 2012;94:22-30
  • Villikka K, Kivistö KT, Neuvonen PJ. The effect of rifampin on the pharmacokinetics of oral and intravenous ondansetron. Clin Pharmacol Ther 1999;65:377-81
  • Johnson B, Adams L, Lu E, et al. Impact of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of ondansetron and dexamethasone. Support Care Cancer 2009;17:1177-85
  • Rauers NI, Stüber F, Lee EH, et al. Antagonistic effects of ondansetron and tramadol? A randomized placebo and active drug controlled study. J Pain 2010;11:1274-8
  • Vale C, Oliveira F, Assunção J, et al. Co-administration of ondansetron decreases the analgesic efficacy of tramadol in humans. Pharmacology 2011;88:182-7
  • Arcioni R, dellaRocca M, Romanò S, et al. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans. Anesth Analg 2002;94:1553-7
  • Broome IJ, Robb HM, Raj N, et al. The use of tramadol following day-case oral surgery. Anaesthesia 1999;54:289-92

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