Pregnane X receptor and drug-induced liver injury

Bibliography

• Navarro VJ, Senior JR. Drug-related hepatotoxicity. N Engl J Med 2006;354:731-9
   PubMed Web of Science ®Google Scholar
• Lee WM. Acute liver failure in the United States. Semin Liver Dis 2003;23:217-26
   PubMed Web of Science ®Google Scholar
• Chalasani N, Fontana RJ, Bonkovsky HL, et al. Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology 2008;135:1924-34
   PubMed Web of Science ®Google Scholar
• Sgro C, Clinard F, Ouazir K, et al. Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology 2002;36:451-5
   PubMed Web of Science ®Google Scholar
• Larrey D. Epidemiology and individual susceptibility to adverse drug reactions affecting the liver. Semin Liver Dis 2002;22:145-55
   PubMed Web of Science ®Google Scholar
• Stine JG, Lewis JH. Drug-induced liver injury: a summary of recent advances. Expert Opin Drug Metab Toxicol 2011;7:875-90
   PubMed Web of Science ®Google Scholar
• Temple R. Hy’s law: predicting serious hepatotoxicity. Pharmacoepidemiol Drug Saf 2006;15:241-3
   PubMed Web of Science ®Google Scholar
• Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov 2005;4:489-99
   PubMed Web of Science ®Google Scholar
• Garcia-Cortes M, Stephens C, Lucena MI, et al. Causality assessment methods in drug induced liver injury: strengths and weaknesses. J Hepatol 2011;55:683-91
   PubMed Web of Science ®Google Scholar
• Corsini A, Bortolini M. Drug-induced liver injury: the role of drug metabolism and transport. J Clin Pharmacol 2013;53:463-74
   PubMed Web of Science ®Google Scholar
• Guengerich FP. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol 2001;14:611-50
   PubMed Web of Science ®Google Scholar
• Nebert DW, Gonzalez FJ. P450 genes: structure, evolution, and regulation. Annu Rev Biochem 1987;56:945-93
   PubMed Web of Science ®Google Scholar
• Willson TM, Kliewer SA. PXR, CAR and drug metabolism. Nat Rev Drug Discov 2002;1:259-66
   PubMed Web of Science ®Google Scholar
• McCarver DG, Hines RN. The ontogeny of human drug-metabolizing enzymes: phase II conjugation enzymes and regulatory mechanisms. J Pharmacol Exp Ther 2002;300:361-6
   PubMed Web of Science ®Google Scholar
• Ayrton A, Morgan P. Role of transport proteins in drug discovery and development: a pharmaceutical perspective. Xenobiotica 2008;38:676-708
   PubMed Web of Science ®Google Scholar
• El-Sheikh AA, Masereeuw R, Russel FG. Mechanisms of renal anionic drug transport. Eur J Pharmacol 2008;585:245-55
   PubMed Web of Science ®Google Scholar
• Tolson AH, Wang H. Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. Adv Drug Deliv Rev 2010;62:1238-49
   PubMed Web of Science ®Google Scholar
• Wang YM, Lin W, Chai SC, et al. Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. Toxicol Appl Pharmacol 2013;272:96-107
   PubMed Web of Science ®Google Scholar
• Wang YM, Ong SS, Chai SC, et al. Role of CAR and PXR in xenobiotic sensing and metabolism. Expert Opin Drug Metab Toxicol 2012;8:803-17
   PubMed Web of Science ®Google Scholar
• Ong SS, Wang Y-M, Chai SC, Chen T. Pregnane X receptor in drug development. In: Rundfeldt C, editor. Drug development - a case study based insight into modern strategies. InTech, Croatia; 2011
   Google Scholar
• Yuan L, Kaplowitz N. Mechanisms of drug-induced liver injury. Clin Liver Dis 2013;17:507-18; vii
   PubMed Web of Science ®Google Scholar
• Han D, Dara L, Win S, et al. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci 2013;34:243-53
   PubMed Web of Science ®Google Scholar
• Wagner M, Zollner G, Trauner M. Nuclear receptors in liver disease. Hepatology 2011;53:1023-34
   PubMed Web of Science ®Google Scholar
• Roberts RA, Ganey PE, Ju C, et al. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicol Sci 2007;96:2-15
   PubMed Web of Science ®Google Scholar
• Lammert C, Bjornsson E, Niklasson A, et al. Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events. Hepatology 2010;51:615-20
   PubMed Web of Science ®Google Scholar
• Ma X, Idle JR, Gonzalez FJ. The pregnane X receptor: from bench to bedside. Expert Opin Drug Metab Toxicol 2008;4:895-908
   PubMed Web of Science ®Google Scholar
• Sinz MW. Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development. Drug Metab Rev 2013;45:3-14
   PubMed Web of Science ®Google Scholar
• Zhang X, Ouyang J, Thung SN. Histopathologic manifestations of drug-induced hepatotoxicity. Clin Liver Dis 2013;17:547-64
   PubMed Web of Science ®Google Scholar
• Zimmerman HJ. Drug-induced liver disease. Clin Liver Dis 2000;4:73-96, vi
   PubMedGoogle Scholar
• Marschall HU, Wagner M, Zollner G, et al. Clinical hepatotoxicity. Regulation and treatment with inducers of transport and cofactors. Mol Pharm 2007;4:895-910
   PubMedGoogle Scholar
• Tujios S, Fontana RJ. Mechanisms of drug-induced liver injury: from bedside to bench. Nat Rev Gastroenterol Hepatol 2011;8:202-11
   PubMed Web of Science ®Google Scholar
• Uetrecht J. Immunoallergic drug-induced liver injury in humans. Semin Liver Dis 2009;29:383-92
   PubMed Web of Science ®Google Scholar
• Meier Y, Pauli-Magnus C, Zanger UM, et al. Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver. Hepatology 2006;44:62-74
   PubMed Web of Science ®Google Scholar
• Jemnitz K, Veres Z, Vereczkey L. Contribution of high basolateral bile salt efflux to the lack of hepatotoxicity in rat in response to drugs inducing cholestasis in human. Toxicol Sci 2010;115:80-8
   PubMed Web of Science ®Google Scholar
• Yew WW, Leung CC. Antituberculosis drugs and hepatotoxicity. Respirology 2006;11:699-707
   PubMed Web of Science ®Google Scholar
• Li F, Lu J, Cheng J, et al. Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med 2013;19:418
   PubMed Web of Science ®Google Scholar
• Fraser DJ, Zumsteg A, Meyer UA. Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. J Biol Chem 2003;278:39392-401
   PubMed Web of Science ®Google Scholar
• Lee WM. Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology 2004;40:6-9
   PubMed Web of Science ®Google Scholar
• James LP, Mayeux PR, Hinson JA. Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 2003;31:1499-506
   PubMed Web of Science ®Google Scholar
• Kalhorn TF, Lee CA, Slattery JT, et al. Effect of methylxanthines on acetaminophen hepatotoxicity in various induction states. J Pharmacol Exp Ther 1990;252:112-16
   PubMed Web of Science ®Google Scholar
• Madhu C, Maziasz T, Klaassen CD. Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice. Toxicol Appl Pharmacol 1992;115:191-8
   PubMed Web of Science ®Google Scholar
• Guo GL, Moffit JS, Nicol CJ, et al. Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicol Sci 2004;82:374-80
   PubMed Web of Science ®Google Scholar
• Wolf KK, Wood SG, Hunt JA, et al. Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity. Drug Metab Dispos 2005;33:1827-36
   PubMed Web of Science ®Google Scholar
• Cheng J, Ma X, Krausz KW, et al. Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos 2009;37:1611-21
   PubMed Web of Science ®Google Scholar
• Huwyler J, Wright MB, Gutmann H, et al. Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin. Curr Drug Metab 2006;7:119-26
   PubMed Web of Science ®Google Scholar
• Andrews E, Armstrong M, Tugwood J, et al. A role for the pregnane X receptor in flucloxacillin-induced liver injury. Hepatology 2010;51:1656-64
   PubMed Web of Science ®Google Scholar
• Lakehal F, Dansette PM, Becquemont L, et al. Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes. Chem Res Toxicol 2001;14:694-701
   PubMed Web of Science ®Google Scholar
• Carey MA, van Pelt FN. Immunochemical detection of flucloxacillin adduct formation in livers of treated rats. Toxicology 2005;216:41-8
   PubMed Web of Science ®Google Scholar
• Jaeschke H. Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury? Toxicol Sci 2007;97:1-3
   PubMed Web of Science ®Google Scholar
• He K, Talaat RE, Pool WF, et al. Metabolic activation of troglitazone: identification of a reactive metabolite and mechanisms involved. Drug Metab Dispos 2004;32:639-46
   PubMed Web of Science ®Google Scholar
• Hartley DP, Dai X, Yabut J, et al. Identification of potential pharmacological and toxicological targets differentiating structural analogs by a combination of transcriptional profiling and promoter analysis in LS-180 and Caco-2 adenocarcinoma cell lines. Pharmacogenet Genomics 2006;16:579-99
   PubMed Web of Science ®Google Scholar
• Ekins S, Erickson JA. A pharmacophore for human pregnane X receptor ligands. Drug Metab Dispos 2002;30:96-9
   PubMed Web of Science ®Google Scholar
• Trubetskoy O, Marks B, Zielinski T, et al. A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. AAPS J 2005;7:E6-13
   Google Scholar
• Devarbhavi H, Andrade RJ. Drug-induced liver injury due to antimicrobials, central nervous system agents, and nonsteroidal anti-inflammatory drugs. Semin Liver Dis 2014;34:145-61
   PubMed Web of Science ®Google Scholar
• Eghbal MA, Taziki S, Sattari MR. Mechanisms of phenytoin-induced toxicity in freshly isolated rat hepatocytes and the protective effects of taurine and/or melatonin. J Biochem Mol Toxicol 2014;28:111-18
   PubMed Web of Science ®Google Scholar
• Sasaki E, Matsuo K, Iida A, et al. A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism. Toxicol Sci 2013;136:250-63
   PubMed Web of Science ®Google Scholar
• Chen Y, Ferguson SS, Negishi M, et al. Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther 2004;308:495-501
   PubMed Web of Science ®Google Scholar
• Al-Dosari MS, Knapp JE, Liu D. Activation of human CYP2C9 promoter and regulation by CAR and PXR in mouse liver. Mol Pharm 2006;3:322-8
   PubMedGoogle Scholar
• Chaudhry AS, Urban TJ, Lamba JK, et al. CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. J Pharmacol Exp Ther 2010;332:599-611
   PubMed Web of Science ®Google Scholar
• Luo G, Cunningham M, Kim S, et al. CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes. Drug Metab Dispos 2002;30:795-804
   PubMed Web of Science ®Google Scholar
• Raucy JL. Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products. Drug Metab Dispos 2003;31:533-9
   PubMed Web of Science ®Google Scholar
• Raucy JL, Lasker JM. Cell-based systems to assess nuclear receptor activation and their use in drug development. Drug Metab Rev 2013;45:101-9
   PubMed Web of Science ®Google Scholar
• Godoy P, Hewitt NJ, Albrecht U, et al. Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch Toxicol 2013;87:1315-530
   PubMed Web of Science ®Google Scholar
• LeCluyse EL. Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur J Pharm Sci 2001;13:343-68
   PubMed Web of Science ®Google Scholar
• Gomez-Lechon MJ, Lahoz A, Gombau L, et al. In vitro evaluation of potential hepatotoxicity induced by drugs. Curr Pharm Des 2010;16:1963-77
   PubMed Web of Science ®Google Scholar
• Garside H, Marcoe KF, Chesnut-Speelman J, et al. Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes. Toxicol In Vitro 2014;28:171-81
   PubMed Web of Science ®Google Scholar
• Xu JJ, Henstock PV, Dunn MC, et al. Cellular imaging predictions of clinical drug-induced liver injury. Toxicol Sci 2008;105:97-105
   PubMed Web of Science ®Google Scholar
• Moeller TA, Shukla SJ, Xia M. Assessment of compound hepatotoxicity using human plateable cryopreserved hepatocytes in a 1536-well-plate format. Assay Drug Dev Technol 2012;10:78-87
   PubMed Web of Science ®Google Scholar
• Gunness P, Mueller D, Shevchenko V, et al. 3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies. Toxicol Sci 2013;133:67-78
   PubMed Web of Science ®Google Scholar
• Takayama K, Kawabata K, Nagamoto Y, et al. 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing. Biomaterials 2013;34:1781-9
   PubMed Web of Science ®Google Scholar
• Kostadinova R, Boess F, Applegate D, et al. A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity. Toxicol Appl Pharmacol 2013;268:1-16
   PubMed Web of Science ®Google Scholar
• Ekins S, Mirny L, Schuetz EG. A ligand-based approach to understanding selectivity of nuclear hormone receptors PXR, CAR, FXR, LXRalpha, and LXRbeta. Pharm Res 2002;19:1788-800
   PubMed Web of Science ®Google Scholar
• Kliewer SA, Moore JT, Wade L, et al. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 1998;92:73-82
   PubMed Web of Science ®Google Scholar
• Xie W, Barwick JL, Downes M, et al. Humanized xenobiotic response in mice expressing nuclear receptor SXR. Nature 2000;406:435-9
   PubMed Web of Science ®Google Scholar
• Gong H, Singh SV, Singh SP, et al. Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells. Mol Endocrinol 2006;20:279-90
   PubMed Web of Science ®Google Scholar
• Ma X, Shah Y, Cheung C, et al. The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A. Drug Metab Dispos 2007;35:194-200
   PubMed Web of Science ®Google Scholar
• Ma X, Cheung C, Krausz KW, et al. A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug Metab Dispos 2008;36:2506-12
   PubMed Web of Science ®Google Scholar
• Scheer N, Ross J, Rode A, et al. A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest 2008;118:3228-39
   PubMed Web of Science ®Google Scholar
• Backman TWH, Cao YQ, Girke T. ChemMine tools: an online service for analyzing and clustering small molecules. Nucleic Acids Res 2011;39:W486-91
   PubMed Web of Science ®Google Scholar
• Letunic I, Bork P. Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy. Nucleic Acids Res 2011;39:W475-8
   PubMed Web of Science ®Google Scholar
• Synold TW, Dussault I, Forman BM. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med 2001;7:584-90
   PubMed Web of Science ®Google Scholar
• van Kesteren C, de Vooght MM, Lopez-Lazaro L, et al. Yondelis (R) (trabectedin, ET-743): the development of an anticancer agent of marine origin. Anticancer Drugs 2003;14:487-502
   PubMed Web of Science ®Google Scholar
• Mani S, Dou W, Redinbo MR. PXR antagonists and implication in drug metabolism. Drug Metab Rev 2013;45:60-72
   PubMed Web of Science ®Google Scholar
• Huang H, Wang H, Sinz M, et al. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene 2007;26:258-68
   PubMed Web of Science ®Google Scholar
• Das BC, Madhukumar AV, Anguiano J, et al. Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). Bioorg Med Chem Lett 2008;18:3974-7
   PubMed Web of Science ®Google Scholar
• Venkatesh M, Wang HW, Cayer J, et al. In Vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation. Mol Pharmacol 2011;80:124-35
   PubMed Web of Science ®Google Scholar
• Tabb MM, Kholodovych V, Grun F, et al. Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR). Environ Health Perspect 2004;112:163-9
   PubMed Web of Science ®Google Scholar
• Ekins S, Chang C, Mani S, et al. Human pregnane X receptor antagonists and Agonists define molecular requirements for different binding sites. Mol Pharmacol 2007;72:592-603
   PubMed Web of Science ®Google Scholar
• Ekins S, Kholodovych V, Ai N, et al. Computational discovery of novel low micromolar human pregnane X receptor antagonists. Mol Pharmacol 2008;74:662-72
   PubMed Web of Science ®Google Scholar
• Krausova L, Stejskaova L, Wang HW, et al. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene. Biochem Pharmacol 2011;82:1771-80
   PubMed Web of Science ®Google Scholar
• Healan-Greenberg C, Waring JF, Kempf DJ, et al. A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane x receptor. Drug Metab Dispos 2008;36:500-7
   PubMed Web of Science ®Google Scholar
• Zhou CC, Poulton EJ, Grun F, et al. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol 2007;71:220-9
   PubMed Web of Science ®Google Scholar
• Morimitsu Y, Nakagawa Y, Hayashi K, et al. A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. J Biol Chem 2002;277:3456-63
   PubMed Web of Science ®Google Scholar
• Poulton EJ, Levy L, Lampe JW, et al. Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. Toxicol Appl Pharmacol 2013;266:122-31
   PubMed Web of Science ®Google Scholar
• Wang HW, Li H, Moore LB, et al. The phytoestrogen Coumestrol is a naturally occurring antagonist of the human pregnane x receptor. Mol Endocrinol 2008;22:838-57
   PubMed Web of Science ®Google Scholar
• Blumberg B, Sabbagh W, Juguilon H, et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 1998;12:3195-205
   PubMed Web of Science ®Google Scholar
• Lim YP, Ma CY, Liu CL, et al. Sesamin: a naturally occurring lignan inhibits CYP3A4 by antagonizing the pregnane X receptor activation. Evid Based Complement Alternat Med 2012;2012:242810
   PubMed Web of Science ®Google Scholar
• Wall ME, Wani MC, Cook CE, et al. Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from camptotheca acuminata1, 2. J Am Chem Soc 1966;88:3888-90
   Web of Science ®Google Scholar
• Huang QQ, Wang L, Lu W. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem 2013;63:746-57
   PubMed Web of Science ®Google Scholar
• Chen YK, Tang Y, Robbins GT, et al. Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor. J Pharmacol Exp Ther 2010;334:999-1008
   PubMed Web of Science ®Google Scholar
• Schuetz E, Lan LB, Yasuda K, et al. Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents. Mol Pharmacol 2002;62:439-45
   PubMed Web of Science ®Google Scholar
• Xue Y, Chao E, Zuercher WJ, et al. Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorg Med Chem 2007;15:2156-66
   PubMed Web of Science ®Google Scholar
• Watkins RE, Wisely GB, Moore LB, et al. The human nuclear xenobiotic receptor PXR: Structural determinants of directed promiscuity. Science 2001;292:2329-33
   PubMed Web of Science ®Google Scholar
• Watkins RE, Davis-Searles PR, Lambert MH, et al. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J Mol Biol 2003;331:815-28
   PubMed Web of Science ®Google Scholar
• Smutny T, Mani S, Pavek P. Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily. Curr Drug Metab 2013;14:1059-69
   PubMed Web of Science ®Google Scholar
• Tian Y. Epigenetic regulation of pregnane X receptor activity. Drug Metab Rev 2013;45:166-72
   PubMed Web of Science ®Google Scholar
• Tirona RG, Lee W, Leake BF, et al. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. Nat Med 2003;9:220-4
   PubMed Web of Science ®Google Scholar
• Shi D, Yang D, Yan B. Dexamethasone transcriptionally increases the expression of the pregnane X receptor and synergistically enhances pyrethroid esfenvalerate in the induction of cytochrome P450 3A23. Biochem Pharmacol 2010;80:1274-83
   PubMed Web of Science ®Google Scholar
• Jung D, Mangelsdorf DJ, Meyer UA. Pregnane X receptor is a target of farnesoid X receptor. J Biol Chem 2006;281:19081-91
   PubMed Web of Science ®Google Scholar
• Misawa A, Inoue J, Sugino Y, et al. Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification. Cancer Res 2005;65:10233-42
   PubMed Web of Science ®Google Scholar
• Habano W, Gamo T, Terashima J, et al. Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells. BMC Cancer 2011;11:81
   PubMed Web of Science ®Google Scholar
• Takagi S, Nakajima M, Mohri T, et al. Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4. J Biol Chem 2008;283:9674-80
   PubMed Web of Science ®Google Scholar
• Wang K, Zhang S, Marzolf B, et al. Circulating microRNAs, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci USA 2009;106:4402-7
   PubMed Web of Science ®Google Scholar
• Lin W, Wu J, Dong H, et al. Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. J Biol Chem 2008;283:30650-7
   PubMed Web of Science ®Google Scholar
• Lichti-Kaiser K, Brobst D, Xu C, et al. A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein. J Pharmacol Exp Ther 2009;331:65-76
   PubMed Web of Science ®Google Scholar
• Pondugula SR, Brimer-Cline C, Wu J, et al. A phosphomimetic mutation at threonine-57 abolishes transactivation activity and alters nuclear localization pattern of human pregnane x receptor. Drug Metab Dispos 2009;37:719-30
   PubMed Web of Science ®Google Scholar
• Elias A, High AA, Mishra A, et al. Identification and characterization of phosphorylation sites within the pregnane X receptor protein. Biochem Pharmacol 2014;87:360-70
   PubMed Web of Science ®Google Scholar
• Ong SS, Goktug AN, Elias A, et al. Stability of the human pregnane X receptor is regulated by E3 ligase UBR5 and serine/threonine kinase DYRK2. Biochem J 2014;459:193-203
   PubMed Web of Science ®Google Scholar
• Rana R, Coulter S, Kinyamu H, et al. RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor. Drug Metab Dispos 2013;41:398-405
   PubMed Web of Science ®Google Scholar
• Staudinger JL, Xu C, Biswas A, et al. Post-translational modification of pregnane x receptor. Pharmacol Res 2011;64:4-10
   PubMed Web of Science ®Google Scholar
• Biswas A, Pasquel D, Tyagi RK, et al. Acetylation of pregnane X receptor protein determines selective function independent of ligand activation. Biochem Biophys Res Commun 2011;406:371-6
   PubMed Web of Science ®Google Scholar
• Castano G, Burgueno A, Fernandez GT, et al. The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy. Aliment Pharmacol Ther 2010;31:583-92
   PubMed Web of Science ®Google Scholar
• Sookoian S, Castano GO, Burgueno AL, et al. The nuclear receptor PXR gene variants are associated with liver injury in nonalcoholic fatty liver disease. Pharmacogenet Genomics 2010;20:1-8
   PubMed Web of Science ®Google Scholar
• Li T, Yu RT, Atkins AR, et al. Targeting the pregnane X receptor in liver injury. Expert Opin Ther Targets 2012;16:1075-83
   PubMed Web of Science ®Google Scholar
• Zhang B, Xie W, Krasowski MD. PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics. Pharmacogenomics 2008;9:1695-709
   PubMed Web of Science ®Google Scholar
• Kotta-Loizou I, Patsouris E, Theocharis S. Pregnane X receptor polymorphisms associated with human diseases. Expert Opin Ther Targets 2013;17:1167-77
   PubMed Web of Science ®Google Scholar