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Development of in vivo drug-induced neurotoxicity models

, Ph D (Professor of Neurobiology (MRC), Docent in Neuroanatomy (UU), Director) , , , , , & show all

Bibliography

  • National Research Council. Enviromental Neurotoxicology. The National Academic Press; Washington DC: 1992
  • Park DH, Eve DJ. Regenerative Medicine: advances in new methods and technologies. Med.Sci Monit 2009;15(11):233-51
  • Schuaumburg HH. Chemicals and the nervous system. The Dana Foundation, New York, USA: 2007
  • Available from: http://bianj.org/Websites/bianj/images/PDFs/2013-Annual-Seminar-Docs/NJ-Neurotox.pdf.html [Accessed on 4 February 2014]
  • Basu N. Neurotoxicity. National library of medicine 2011
  • Sharma HS, Hussain S, Schlager J, et al. Influence of nanoparticles on blood-brain barrier permeability and brain edema formation in rats. Acta. Neurochir Supply 2010;106:359-64
  • Sharma HS, Ali SF, Tian ZR, et al. Chronic treatment with nanoparticles exacerbate hyperthermia induced blood-brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired- antioxidant compound H-290/51. J Nanosci Nanotechnol 2009;9(8):5073-90
  • Sharma HS, Kiyatkin EA. Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy. J Chem Neuroanat 2009;37:18-32
  • Jenner P. A critical role for monoamine oxidase in toxic action for Parkinson’s disease. In: lieberman A, Olanow CW, Youdim MBH, Tipton K, editors. Monoamine oxidase inhibitors in neurological diseases. Marcel Dekker, Inc; USA: 1994, pp 161-5
  • Available from: http://faculty.swosu.edu/scott.long/txcl/cnstox.html [Accessed on 4 February 2014]
  • New York, USA. Available from: http://www.neuroskills.com/brain-injury/anoxia-and-hypoxia.php.html [Accessed on 4 February 2014]
  • Available from: http://www.utexas.edu/research/asrec/drugs.html [Accessed on 4 February 2014]
  • Boulpaep EL, Boron WF. Toxins and drugs affecting synaptic transmission. Medical Physiology, Chapter 8. Elsevier Publications; 2011
  • Angelucci F, Ricci V, Spalletta G, et al. Effects of psychostimulants on neurotrophins implications for psychostimulant- induced neurotoxicity. Int Rev Neurobiol 2009;88:1-24
  • Available from: www.cchr.org/sites/default/files/education/psychostim-booklet.pdf.html [Accessed on 4 February 2014]
  • Available from: www.health.gov.au/internet/publications/publishing.nsf/Content/drugtreat-pubs-modpsy-toc∼drugtreat-pubs-modpsy-2∼drugtreat-pubs-modpsy-2-3∼drugtreat-pubs-modpsy-2-3-psyc.html [Accessed on 4 February 2014]
  • Available from: http://chemistry.about.com/od/medicalhealth/a/crystalmeth.html [Accessed on 4 February 2014]
  • Thrash B, Thiruchelvan K, Ahuja M, et al. Methamphetamine-induced neurotoxicity: the road to Parkinson’s disease. Pharmacol Rep 2009;61:966-77
  • Ramirez SH, Potula R, Fan S, et al. Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells. J Cereb Blood Flow Metab 2009;29:1933-45
  • Volkow ND, Chang L, Wang GJ, et al. Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. J Neurosci 2001;21(23):9414-18
  • Available from: www.pbs.org/wgbh/pages/frontline/meth/body/html [Accessed on 5 February 2014]
  • Available from: www.drugrehab.us/news/cocaine-meth-wreak-havoc-with-the-blood-brain-barrier/html [Accessed on 5 February 2014]
  • Northrop NA, Yamamoto BK. Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier. J Neuroimmune Pharmacol 2012;7(4):951-68
  • Bowyer JF, Ali S. High doses of methamphetamine that causes disruption of blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus. Synapse 2006;60(7):521-32
  • Eisch AJ, Schmued LC, Marshall JF. Characterizing cortical neuron injury with fluoro-jade labeling after a neurotoxic regimen of methamphetamine. Synapse 1998;30(3):329-33
  • Shin EJ, Shin SW, Nguyen TTL, et al. Ginesensoside re rescues methamphetamine-induced oxidative damage, mitochondrial dysfunction, microglial activation and dopaminergic degeneration by inhibiting the protein kinase Cδ gene. In: Bazan NG, editor. Molecular Neurobiology. Springer publishers; USA: 2014
  • Lavoie MJ, Card JP, Hastings TG. Microglial activation precedes dopamine terminal pathology in methamphetamine- induced neurotoxicity. Exp.Neurol 2004;187:47-57
  • Sekine Y, Ouchi Y, Sugihara G, et al. Methamphetamine causes microglial activation in the brains of human abusers. J Neurosci 2008;28(22):5756-61
  • Granado N, Santos SA, Moratalla R. Methamphetamine and Parkinson’s disease. Parkinson’s disease. Hindawi Publishing Corporation, Nasr City, Cairo, Egypt; 2013. 1-10
  • Halpin LE, Collins SA, Yamamoto BK. Neurotoxicity of methamphetamine and 3,4-methylenedioxymethamphetamine. Life Sciences. Elseiver Publications; USA: 2013
  • Available from: http://faculty.washington.edu/chudler/mdma.html [Accessed on 6 February 2014]
  • Murane KS. Neuropharmacology of 3,4- methylenedioxymethamphetamine (MDMA, Ecstasy). 2001
  • Available from: http://methoide.fcm.arizona.edu/infocenter/index.cfm? stid=180.html [Accessed on 6 February 2014]
  • Available from: www.drugabuse.gov/publications/mdma-ecstasy-abuse/what-does-mdma-do-to-brain.html [Accessed on 6th February 2014]
  • Flannagan M. Ecstasy: neurotoxicity and how it can be reduced. Available from: Serendipupdate’s blog [Accessed on 6 February 2014]
  • Sharma HS, Ali SF. Acute administration of 3,4- methylenedioxy methamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation and cell injury. Ann N Y Acad Sci 2008;1139:242-58
  • Hendrick B. Long term ecstasy use may damage the brain. Study shows chronic ecstasy users have reduced volume of hippocampus regions of brain. Mental Health Center. Available from: www.webmd.com/mental-health/addiction/news/20110407/long-term-ecstasy-use-may-damage-the-brain 2011
  • Baggott M, Mendelson J. Does MDMA cause brain damage? In: Holland J, editor. Ecstasy: the complete guide. Park street press publishers; USA: 2001
  • UNODC. “World drug report,” Tech. Rep. E. 12.XI. 1. United Nations publication; 2012
  • Elsevier, Amsterdam, North Holland. Available from: www.drugabuse.gov/drugs-abuse/cocaine.html [Accessed on 6 February 2014]
  • Available from: www.drugabuse.gov/publications/research-reports/cocaine-abuse-addiction/what-cocaine.html [Accessed on 6 February 2014]
  • Available from: www.drugabuse.gov/publications/research-reports/cocaine-abuse-addiction/how-cocaine-abused.html [Accessed on 6 February 2014]
  • Available from: www.drugabuse.gov/publications/research-reports/cocaine-abuse-addiction/what-are-short-term-effects-cocaine-use.html [Accessed on 6 February 2014]
  • Available from: www.drugabuse.gov/publications/research-reports/cocaine-abuse-addiction/what-are-long-term-effects-cocaine-use.html [Accessed on 7 February 2014]
  • Available from: www.drugabuse.gov/publications/research-reports/cocaine-abuse-addiction/how-does-cocaine-produce-its-effects.html [Accessed on 7 February 2014]
  • Kousik SM, Napier TC, Carvey PM. The effects of psychostimulant drugs on blood brain barrier function and Neuroinflammation. Frontiers in pharmacology 2012;3:121
  • Sharma HS, Muresanu DF, Sharma A, Patnaik R. Cocaine induced breakdown of the blood brain barrier and neurotoxicity. Int Rev Neurobiol 2009;88:297-334
  • Nath A, Maragos WF, Avison MJ, et al. Acceleration of HIV dementia with methamphetamine and cocaine. The journal of neurovirology 2001;7:66-71
  • Buch S, Yao H, Guo M, et al. Cocaine and HIV -1 interplay in cellular and molecular mechanisms. Curr HIV Res 2012;10(5):425-8
  • Mastumoto RR, Nguyen L, Kaushal N, et al. Sigma receptors as potential therapeutic targets to mitigate psychostimulant effects. Adv Pharmacol 2014;69:323-86
  • Available from: www.linkinghumansystems.com/drugs/opiates.html [Accessed on 8 February 2014]
  • Available from: www.nlm.nih.gov/medlineplus/ency/article/000949.html [Accessed on 8 February 2014]
  • Available from: http://theweek.com/article/index/244623/8-drugs-that-exist-in-nature [Accessed on 8 February 2014]
  • Available from: www.news-medical.net/health/What-is-Morphine.aspx [Accessed on 8 February 2014]
  • Available from: www.news-medical.net/health/What-is-Morphine.aspx [Accessed on 8 February 2014]
  • Available from: www.mascc.org/assets/documents/pain_Adverse_Effects_Opioids.pdf [Accessed on 9 February 2014]
  • Available from: www.drugabuse.gov/publications/teaching-packets/brain-actions-cocaine-opiates-marijuana/section-iii-introduction-to-drugs-abuse-cocaine-opiat-8 [Accessed on 9 February 2014]
  • Sharma HS, Sjöquist PO, Ali SF. Alterations in blood-brain barrier function and brain pathology by morphine in the rat. Acta Neurochir Suppl 2010;106:61-6
  • Zhang EY, Xiong J, Parker BL, et al. Depletion and recovery of lymphoid subsets following morphine administration. Br J Pharmacol 2011;164(7):1829-44
  • Xie N, Li H, Wei D, et al. Glycogen synthase kinase-3 and p38 mitogen activated protein kinase (MAPK) are required for opioid induced apoptosis. Neuropharmacology 2010;59(6):444-51
  • Zou S, Fitting S, Hahn YK, et al. Morphine potentiates neurodenegerative effects of Human immunodeficiency virus (HIV)-1 Tat through actions at u-opioid receptor-expressing glia. Brain 2011;134(12):3613-28
  • Koodie L, Yuan H, Pumper JA, et al. Morphine inhibits migration of tumor-infiltrating leucocytes and suppresses angiogenesis associated with tumor growth in mice. Am J Pathol 2014
  • Sharma HS, Ali SF. Alterations in blood-brain barrier function by morphine and methamphetamine. Ann N Y Acad Sci 2006;1074:198-224
  • Kiyatkin EA, Brown PL, Sharma HS. Brain edema and breakdown of the blood-brain barrier during methamphetamine intoxication: critical role of brain hyperthermia. Eur J Neurosci 2007;26(5):1242-53
  • Kiyatkin EA, Sharma HS. Acute methamphetamine intoxication: brain hyperthermia, blood-brain barrier, brain edema, and morphological cell abnormalities. Int Rev Neurobiol 2009;88:65-100
  • Sharma HS, Sjöquist PO, Ali SF. Drugs of abuse-induced hyperthermia, blood-brain barrier dysfunction and neurotoxicity: neuroprotective effects of a new antioxidant compound H-290/51. Curr Pharm Des 2007;13(18):1903-23
  • Sharma HS. Blood-brain barrier in StressBHU Press; Banaras Hindu University, Varanasi: 1982. p. 1-85
  • Sharma HS, Westman J. Blood-spinal cord and brain barriers in health & disease. Elsevier Academic Press; San Diego, USA: 2004. p. 1-617
  • Sharma HS. Pathophysiology of blood-brain barrier, brain edema and cell injury following hyperthermia: new role of heat shock protein, nitric oxide and carbon monoxide. An experimental study in the rat using light and electron microscopy. Acta Universitatis Upsaliensis 1999;830:1-94
  • Sharma HS. New Concepts of Psychostimulant Induced Neurotoxicity. Int Rev Neurobiol 2009;88:1-480
  • Sharma HS. New Perspectives of Central Nervous System Injury and Neuroprotection. Int Rev Neurobiol 2012;102:1-415
  • Sharma HS, Westman J. Brain Functions in Hot Environment, Progress in Brain Research 115. Elsevier; Amsterdam: 1998. pp 1-516
  • Rapoport SI. The Blood-brain barrier in Physiology & Medicine. Raven Press; New York, USA: 1976. p. 1-350
  • Sharma HS, Patnaik R, Ray AK, et al. Blood-central nervous system barriers in morphine dependence and withdrawal. In: Sharma HS, Westman J, editors. The blood-spinal cord and brain barriers in health and disease. Elsevier Academic Press; San Diego: 2004. p. 299-328
  • Sharma HS, Westman J, Nyberg F. Pathophysiology of brain edema and cell changes following hyperthermic brain injury. Prog Brain Res 1998;115:351-412. Review
  • Sharma HS, Sharma A. Breakdown of the blood-brain barrier in stress alters cognitive dysfunction and induces brain pathology. New perspective for neuroprotective strategies. In: Ritsner M, editor. “Brain protection in schizophrenia, mood and cognitive disorders”. Springer-Verlag; Berlin, New York: 2010. p. 243-304
  • Sharma HS. Blood–central nervous system barriers: the gateway to neurodegeneration, neuroprotection and neuroregeneration. In: Lajtha A, Banik N, Ray SK, editors. Handbook of neurochemistry and molecular neurobiology: brain and spinal cord trauma. Springer Verlag; Berlin, Heidelberg, New York: 2009. p. 363-457
  • Sharma HS, Westman J, Cervós-Navarro J, et al. Blood-brain barrier in stress: a gateway to various brain diseases. In: Levy A, Grauer E, Ben-Nathan D, de Kloet ER, editors. New frontiers of stress research: modulation of brain function. Harwood Academic Publishers Inc; Amsterdam: 1998. p. 259-76
  • Sharma HS, Westman J. Pathophysiology of hyperthermic brain injury. Current concepts, molecular mechanisms and pharmacological strategies. In: Oehmichen M, editor. Research in legal medicine Vol. 21 hyperthermia, burning and carbon Monoxide. Lübeck Medical University Publications, Schmidt-Römhild Verlag; Lübeck, Germany: 2000. p. 79-120
  • Sharma HS. Early microvascular reactions and blood-spinal cord barrier disruption are instrumental in pathophysiology of spinal cord injury and repair: novel therapeutic strategies including nanowired drug delivery to enhance neuroprotection. J Neural Transm 2011;118(1):155-76
  • Sharma HS, Miclescu A, Wiklund L. Cardiac arrest-induced regional blood-brain barrier breakdown, edema formation and brain pathology: a light and electron microscopic study on a new model for neurodegeneration and neuroprotection in porcine brain. J Neural Transm 2011;118(1):87-114
  • Kiyatkin EA, Sharma HS. Permeability of the blood-brain barrier depends on brain temperature. Neuroscience 2009;161(3):926-39
  • Elliott KA, Jasper H. Measurement of experimentally induced brain swelling and shrinkage. Am J Physiol 1949;157(1):122-9
  • Sharma HS, Ali SF, Patnaik R, et al. Cerebrolysin Attenuates heat shock protein (HSP 72 KD) expression in the rat spinal cord following morphine dependence and withdrawal: possible new therapy for pain management. Curr Neuropharmacol 2011;9(1):223-35
  • Sharma HS, Muresanu DF, Patnaik R, et al. Exacerbation of brain pathology after partial restraint in hypertensive rats following SiO2 nanoparticles exposure at high ambient temperature. Mol Neurobiol 2013;48(2):368-79
  • Sharma A, Muresanu DF, Patnaik R, et al. Size- and age-dependent neurotoxicity of engineered metal nanoparticles in rats. Mol Neurobiol 2013;48(2):386-96
  • Sharma HS, Sharma A. Neurotoxicity of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets 2012;11(1):65-80. Review
  • Sharma HS, Patnaik R, Sharma A, et al. Silicon dioxide nanoparticles (SiO2, 40-50 nm) exacerbate pathophysiology of traumatic spinal cord injury and deteriorate functional outcome in the rat. An experimental study using pharmacological and morphological approaches. J Nanosci Nanotechnol 2009;9(8):4970-80
  • Sharma HS, Muresanu DF, Sharma A, et al. Chapter 9 - Nanoparticles influence pathophysiology of spinal cord injury and repair. Prog Brain Res 2009;180:154-80. Review
  • Kiyatkin EA, Sharma HS. Environmental conditions modulate neurotoxic effects of psychomotor stimulant drugs of abuse. Int Rev Neurobiol 2012;102:147-71
  • Kiyatkin EA, Sharma HS. Expression of heat shock protein (HSP 72 kDa) during acute methamphetamine intoxication depends on brain hyperthermia: neurotoxicity or neuroprotection? J Neural Transm 2011;118(1):47-60
  • Muresanu DF, Sharma HS. Chronic hypertension aggravates heat stress induced cognitive dysfunction and brain pathology: an experimental study in the rat, using growth hormone therapy for possible neuroprotection. Ann N Y Acad Sci 2007;1122:1-22
  • Muresanu DF, Zimmermann-Meinzingen S, Sharma HS. Chronic hypertension aggravates heat stress-induced brain damage: possible neuroprotection by cerebrolysin. Acta Neurochir Suppl 2010;106:327-33
  • Lafuente JV, Sharma A, Patnaik R, et al. Diabetes exacerbates nanoparticles induced brain pathology. CNS Neurol Disord Drug Targets 2012;11(1):26-39 . Review
  • Sharma HS, Sharma A. New perspectives of nanoneuroprotection, nanoneuropharmacology and nanoneurotoxicity: modulatory role of amino acid neurotransmitters, stress, trauma, and co-morbidity factors in nanomedicine. Amino Acids 2013;45(5):1055-71
  • Sharma HS, Sharma A. Nanowired drug delivery for neuroprotection in central nervous system injuries: modulation by environmental temperature, intoxication of nanoparticles, and comorbidity factors. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2012;4(2):184-203
  • Sharma HS, Patnaik R, Sharma A. Diabetes aggravates nanoparticles induced breakdown of the blood-brain barrier permeability, brain edema formation, alterations in cerebral blood flow and neuronal injury. An experimental study using physiological and morphological investigations in the rat. J Nanosci Nanotechnol 2010;10(12):7931-45
  • Muresanu DF, Sharma A, Sharma HS. Diabetes aggravates heat stress-induced blood-brain barrier breakdown, reduction in cerebral blood flow, edema formation, and brain pathology: possible neuroprotection with growth hormone. Ann N Y Acad Sci 2010;1199:15-26
  • Patnaik R, Sharma A, Kiyatkin EA, et al. Nanoparticles exacerbate methamphetamine neurotoxicity in both hot or cold environment. Neuroprotective effects of an antioxidant compound H-290/51 [Abstract 43]. Society for Neuroscience. 43rd Annual Meeting of the Society-for-Neuroscience; 09 - 13 November 2013; San Diego, CA, USA
  • Muresanu DF, Sharma A, Sharma HS. Breakdown of the Blood-Brain Barrier is instrumental in Psychostimulants induced Neurotoxicity. A subject that needs detail awareness and further exploration. 41st Annual Meeting of the Society-for-Neuroscience; 12 - 16 November 2011, Washington, DC, USA
  • Muresanu DF, Vannemreddy P, Sharma HS, et al. Cold and hot environment exacerbates brain pathology following concussive brain injury. Brain Injury 2014;28(5-6):524-5. Meeting Abstract: 0026
  • Patnaik R, Sharma A, Sharma HS. Multimodal animal experiments to simulate clinical situation of disease processes for better therapeutic strategies in neurological disease are the need of the hour. 43rd Annual Meeting of the Society-for-Neuroscience; 09 - 13 November 2013, San Diego, CA, USA
  • Muresanu DF, Sharma A, Patnaik R, et al. Blood-Brain Barrier Breakdown, Edema Formation, Nitric Oxide Synthase Upregulation and Brain Pathology in Diabetic and Hypertensive Rats Following Heat Stroke: Neuroprotective Effects of Titanium Nanowired Cerebrolysin. Cell Transplant 2013;22(5):910-11
  • Müller CP, Homberg JR. The role of serotonin in drug use and addiction. Behav Brain Res 2014; doi: 10.1016/j.bbr.2014.04.007
  • Sharma HS, Olsson Y, Dey PK. Changes in blood-brain barrier and cerebral blood flow following elevation of circulating serotonin level in anesthetized rats. Brain Res 1990;517(1-2):215-23
  • Sharma HS, Patnaik R, Patnaik S, et al. Antibodies to serotonin attenuate closed head injury induced blood brain barrier disruption and brain pathology. Ann N Y Acad Sci 2007;1122:295-312
  • Sharma A, Sharma HS. Monoclonal antibodies as novel neurotherapeutic agents in CNS injury and repair. Int Rev Neurobiol 2012;102:23-45. Review
  • Sharma HS, Westman J, Navarro JC, et al. Probable involvement of serotonin in the increased permeability of the blood-brain barrier by forced swimming. An experimental study using Evans blue and 131I-sodium tracers in the rat. Behav Brain Res 1995;72(1-2):189-96
  • Sharma HS, Dey PK. Influence of long-term acute heat exposure on regional blood-brain barrier permeability, cerebral blood flow and 5-HT level in conscious normotensive young rats. Brain Res 1987;424(1):153-62
  • Sharma HS, Dey PK. Probable involvement of 5-hydroxytryptamine in increased permeability of blood-brain barrier under heat stress in young rats. Neuropharmacology 1986;25(2):161-7
  • Sharma HS, Olsson Y, Dey PK. Early accumulation of serotonin in rat spinal cord subjected to traumatic injury. Relation to edema and blood flow changes. Neuroscience 1990;36(3):725-30
  • Sharma HS, Lundstedt T, Boman A, et al. A potent serotonin-modulating compound AP-267 attenuates morphine withdrawal-induced blood-brain barrier dysfunction in rats. Ann N Y Acad Sci 2006;1074:482-96
  • Pandey AK, Patnaik R, Muresanu DF, et al. Quercetin in hypoxia-induced oxidative stress: novel target for neuroprotection. Int Rev Neurobiol 2012;102:107-46. Review
  • Muresanu DF, Sharma A, Tian ZR, et al. Nanowired drug delivery of antioxidant compound H-290/51 enhances neuroprotection in hyperthermia-induced neurotoxicity. CNS Neurol Disord Drug Targets 2012;11(1):50-64. Review
  • Sharma HS, Gordh T, Wiklund L, et al. Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat. J Neural Transm 2006;113(4):521-36
  • Nikulina EM, Johnston CE, Wang J, et al. Neurotrophins in the ventral tegmental area: role in social stress, mood disorders and drug abuse. Neuroscience 2014; doi: 10.1016/j.neuroscience.2014.05.028
  • Sharma HS. A select combination of neurotrophins enhances neuroprotection and functional recovery following spinal cord injury. Ann N Y Acad Sci 2007;1122:95-111
  • Sharma HS. Neurotrophic factors in combination: a possible new therapeutic strategy to influence pathophysiology of spinal cord injury and repair mechanisms. Curr Pharm Des 2007;13(18):1841-74
  • Sharma HS. New perspectives for the treatment options in spinal cord injury. Expert Opin Pharmacother 2008;9(16):2773-800. Review
  • Sharma HS, Nyberg F, Gordh T, et al. Neurotrophic factors influence upregulation of constitutive isoform of heme oxygenase and cellular stress response in the spinal cord following trauma. An experimental study using immunohistochemistry in the rat. Amino Acids 2000;19(1):351-61
  • Sharma HS, Sharma A, Mössler H, et al. Neuroprotectiveeffects of cerebrolysin, a combination of different active fragments of neurotrophic factors and peptides on the whole body hyperthermia-induced neurotoxicity: modulatory roles of co-morbidity factors and nanoparticle intoxication. Int Rev Neurobiol 2012;102:249-76. Review
  • Menon PK, Muresanu DF, Sharma A, et al. Cerebrolysin, a mixture of neurotrophic factors induces marked neuroprotection in spinal cord injury following intoxication of engineered nanoparticles from metals. CNS Neurol Disord Drug Targets 2012;11(1):40-9. Review
  • Sharma A, Muresanu DF, Mössler H, et al. Superior neuroprotective effects of cerebrolysin in nanoparticle-induced exacerbation of hyperthermia-induced brain pathology. CNS Neurol Disord Drug Targets 2012;11(1):7-25. Review
  • Sharma HS, Ali SF, Tian ZR, et al. Nanowired-drug delivery enhances neuroprotective efficacy of compounds and reduces spinal cord edema formation and improves functional outcome following spinal cord injury in the rat. Acta Neurochir Suppl 2010;106:343-50
  • Sharma HS, Ali S, Tian ZR, et al. Nano-drug delivery and neuroprotection in spinal cord injury. J Nanosci Nanotechnol 2009;9(8):5014-37
  • Sharma HS, Ali SF, Dong W, et al. Drug delivery to the spinal cord tagged with nanowire enhances neuroprotective efficacy and functional recovery following trauma to the rat spinal cord. Ann N Y Acad Sci 2007;1122:197-218
  • Sharma HS, Muresanu DF, Patnaik R, et al. Superior neuroprotective effects of cerebrolysin in heat stroke following chronic intoxication of Cu or Ag engineered nanoparticles. A comparative study with other neuroprotective agents using biochemical and morphological approaches in the rat. J Nanosci Nanotechnol 2011;11(9):7549-69
  • Sharma HS, Menon PK, Lafuente JV, et al. The role of functionalized magnetic iron oxide nanoparticles in the central nervous system injury and repair: new potentials for neuroprotection with cerebrolysin therapy. J Nanosci Nanotechnol 2014;14(1):577-95. Review

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