Biochemical mechanisms of nephrotoxicity: application for metabolomics

• PSATY BM, BURKE SP: Protecting the health of the public – institute of medicine recommendations on drug safety. N. Engl. J. Med. (2006) 355:1753-1755.
   PubMed Web of Science ®Google Scholar
• LEEE MY, DORDICK JS: High-throughput human metabolism and toxicity analysis, Curr. Opin. Biotechnol. (2006) 17:619-627.
   PubMed Web of Science ®Google Scholar
• VAIDYA VS, BONVENTRE JV: Mechanistic biomarkers for cytotoxic acute kidney injury. Expert Opin. Drug Metab. Toxicol. (2006) 2:697-713.
   PubMed Web of Science ®Google Scholar
• HEYMAN SN, ROSEN S: Dye-induced nephropathy. Semin. Nephrol. (2003) 23:477-485.
   PubMed Web of Science ®Google Scholar
• LAMEIER NH: Contrast-induced nephropathy – prevention and risk reduction. Nephrol. Dial. Transplant. (2006) 21:11-23.
   Google Scholar
• MARCKMANN P, SKLOV L, ROSSEN K et al.: Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging. J. Am. Soc. Nephrol. (2006) 17:2359-2362.
   PubMed Web of Science ®Google Scholar
• GARSON G, LELEU B, ZERIMECH F et al.: Biologic markers of oxidative stress and nephrotoxicity as studied in biomonitoring of adverse effects of occupational exposure to lead and cadmium. J. Occup. Environ. Med. (2004) 46:1180-1186.
   PubMed Web of Science ®Google Scholar
• CHOUDHURY D, AHMED Z: Drug-associated renal dysfunction and injury. Nat. Clin. Pract. Nephrol. (2006) 2:80-91.
   PubMedGoogle Scholar
• SUN H, FRASSETTO L, BENET LZ: Effects of renal failure on drug transport and metabolism. Pharmacol. Ther. (2006) 109:1-11.
   PubMed Web of Science ®Google Scholar
• HOSTE EA, KELLUM JA: Acute kidney injury: epidemiology and diagnostic criteria. Curr. Opin. Crit. Care (2006) 12:531-537.
   PubMed Web of Science ®Google Scholar
• PERAZELLA MA: Drug-induced nephropathy: an update. Expert Opin. Drug Saf. (2005) 4:689-706.
   PubMed Web of Science ®Google Scholar
• MORI T, COWLEY AW, ITO S: Molecular mechanisms and therapeutic strategies of chronic renal injury: physiological role of angiotensin II-induced oxidative stress in renal medulla. J. Pharmacol. Sci. (2006) 100:2-8.
   PubMed Web of Science ®Google Scholar
• NEUBAUER S: The failing heart – an engine out of fuel. N. Engl. J. Med. (2007) 356:1140-1151.
   PubMed Web of Science ®Google Scholar
• SERKOVA N, CHRISTIANS U, BENET LZ: Biochemical mechanisms of cyclosporine neurotoxicity. Mol. Interv. (2004) 4:97-107.
   PubMed Web of Science ®Google Scholar
• LAISSY JP, IDEE JM, FERNANDEZ P, FLOQUET M, VRTOVSNIK F, SCHOUMAN-CLAEYS E: Magnetic resonance imaging in acute and chronic kidney diseases: present status. Nephron Clin. Pract. (2006) 103:C50-C53.
   PubMed Web of Science ®Google Scholar
• GREGG NJ, COURTAULD EA, BACH PH: Enzyme histochemical changes in an acutely induced renal papillary necrosis. Toxicol. Pathol. (1990) 18:39-46.
   PubMed Web of Science ®Google Scholar
• YOSHIDA I, TAKEDA S, HOMMA S, KUSANO E, ASANO Y: Localization of low-KM cAMP phosphodiesterase in rat nephron segments. Kidney Blood Press Res. (1997) 20:307-311.
   PubMed Web of Science ®Google Scholar
• BURGER-KENTISCHER A, MULLER E, NEUHOFER W, MARZ J, THURAU K, BECK F: Expression of aldose reductase, sorbitol dehydrogenase and Na+/myo-inositol and Na+/Cl-/betaine transporter mRNA in individual cells of the kidney during changes in the diuretic state. Pflugers Arch. (1999) 437:248-254.
   PubMed Web of Science ®Google Scholar
• TIZIANELLO A, DE FERRARI G, GARIBOTTO G, GURRERI G, ROBAUDO C: Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J. Clin. Invest. (1980) 65:1162-1173.
   PubMed Web of Science ®Google Scholar
• UCHIDA S, ENDOU H: Substrate specificity to maintain cellular ATP along the mouse nephron. Am. J. Physiol. (1988) 255:F977-F983.
   PubMed Web of Science ®Google Scholar
• GARROD S, HUMPFER E, SPRAUL M et al.: High-resolution magic angle spinning 1H-NMR spectroscopic studies on intact rat renal cortex and medulla. Magn. Reson. Med. (1999) 41:1108-1118.
   PubMed Web of Science ®Google Scholar
• GARROD S, HUMOHER E, CONNOR SC et al.: High-resolution 1H-NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue. Magn. Reson. Med. (2001) 45:781-790.
   PubMed Web of Science ®Google Scholar
• MEURY L, NOEL J, TEJEDOR A, SENECAL J, GOUGOUX A, VINAY P: Glucose metabolism in dog inner medullary collecting ducts. Ren. Physiol. Biochem. (1994) 17:246-266.
   PubMedGoogle Scholar
• BECK FX, NEUHOFER W: Response of renal medullary cells to osmotic stress. Contrib. Nephrol. (2005) 148:21-34.
   PubMed Web of Science ®Google Scholar
• BECK FX, NEUHOFER W: Cell volume regulation in the renal papilla. Contrib. Nephrol. (2006) 152:181-197.
   PubMed Web of Science ®Google Scholar
• PANTEGINI M, MYERS GL, MILLER WG, GREENBERG N: The importance of metrological traceability on the validity of creatinine measurement as an index of renal function. Clin. Chem. Lab. Med. (2006) 44:1287-1292.
   PubMed Web of Science ®Google Scholar
• RULE AD, BERGSTRALH EJ, SLEZAK JM, BERGERT J, LARSON TS: Glomerular filtration rate estimated by custatin C among different clinical presentations. Kidney Int. (2006) 69:399-405.
   PubMed Web of Science ®Google Scholar
• LINDON JC, HOLMES E, NICHOLSON JK: Metabonomics: system biology in pharmaceutical research and development. Curr. Opin. Mol. Ther. (2004) 6:265-272.
   PubMed Web of Science ®Google Scholar
• GRIFFIN JL, BOLLARD ME: Metabonomics: its potential as a tool in toxicology for safety assessment and data integration. Curr. Drug Metab. (2004) 5:389-398.
   PubMed Web of Science ®Google Scholar
• LINDON JC, HOLMES E, NICHOLSON JK: Metabonomics in pharmaceutical R&D. FEBS J. (2007) 274:1140-1151.
   PubMed Web of Science ®Google Scholar
• ROCHFORT S: Metabolomics reviewed: a new “omics” platform technology for systems biology and implications for natural product research. J. Nat. Prod. (2005) 68:1813-1829.
   PubMed Web of Science ®Google Scholar
• WISHART DS: Metabolomics: the principles and potential applications to transplantation. Am. J. Transplant. (2005) 5:2814-2820.
   PubMed Web of Science ®Google Scholar
• SERKOVA NJ, NIEMANN CU: Pattern recognition and biomarker validation using quantitative 1H-NMR-based metabolomics. Expert Rev. Mol. Diagn. (2006) 6:717-731.
   PubMed Web of Science ®Google Scholar
• WISHART DS: Metabolomics in monitoring kidney transplants. Curr. Opin. Nephrol. Hypertens. (2006) 15:637-642.
   PubMed Web of Science ®Google Scholar
• DUNN WB, BAILEY NJ, JOHNSON HE: Measuring the metabolome: current analytical technologies. Analyst (2005) 130:606-625.
   PubMed Web of Science ®Google Scholar
• WANT EJ, NORDSTROM A, MORITA H, SIUZDAK G: From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics. J. Proteome. Res. (2007) 6:459-468.
   PubMed Web of Science ®Google Scholar
• FOODACRE R, VAIDYANATHAN S, DUNN WB, HARRIGAN GG, KELL DB: Metabolomics by numbers: acquiring and understanding global metabolite data. Trends Biotechnol. (2004) 22:245-252.
   PubMed Web of Science ®Google Scholar
• HOLMES E, LOO RL, CLOAREC O et al.: Detection of urinary metabolites (xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy. Anal. Chem. (2007) 79:2629-2640.
   PubMed Web of Science ®Google Scholar
• KELL DB, BROWN M, DAVEY HM, DUNN WB, SPASIC I, OLIVER SG: Metabolic footprinting and system biology: the medium is the message. Nat. Rev. Microbiol. (2005) 3:557-565.
   PubMed Web of Science ®Google Scholar
• LENZ EM, BRIGHT J, KNIGHT R, WILSON ID, MAJOR H: Cyclosporin A-induced changes in endogenous metabolites is rat urine: a metaonomis investigation using high field 1H-NMR spectroscopy, HPLC-TOF/MS and chemometrics. Pharm. Biomed. Anal. (2004) 35:599-608.
   PubMed Web of Science ®Google Scholar
• KNIGHTS KM, TSOUTSIKOS P, MINERS JO: Novel mechanisms of nonsteroidal anti-inflammatory drug-induced renal toxicity. Expert Opin. Drug Metab. Toxicol. (2005) 1:399-408.
   PubMedGoogle Scholar
• SERKOVA N, FULLER TF, KLAWITTER J, FREISE CE, NIEMANN CU: 1H-NMR-nased metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. Kidney Int. (2005) 67:1142-1151.
   PubMed Web of Science ®Google Scholar
• SERKOVA NJ, ZHANG Y, COATNEY JL et al.: Early detection of graft failure using the blood metabolic profile of a liver recipient. Transplantation (2007) 83:517-521.
   PubMed Web of Science ®Google Scholar
• LINDON JC, KEUN HC, EBBELS TM, PEARCE JM, HOLMES E, NICHOLSON JK: The Consortium for Metabonomics Toxicology (COMET): aims, activities and achievements. Pharmacogenomics (2005) 6:691-699.
   PubMed Web of Science ®Google Scholar
• GRIFFIN JL: Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterization of xenobiotic toxicity and disease diagnosis. Curr. Opin. Chem. Biol. (2003) 7:648-654.
   PubMed Web of Science ®Google Scholar
• HAUET T, BAUMERT H, GIBELIN H et al.: Noninvasive monitoring of citrate, acetate, lactate, and renal medullary osmolyte excretion in urine as biomarkers of exposure to ischemic reperfusion injury. Cryobiology (2000) 41:280-291.
   PubMed Web of Science ®Google Scholar
• GARROD S, BOLLARD ME, NICHOLLS AW et al.: Integrated metabonomic analysis of the multiorgan effects of hydrazine toxicity in the rat. Chem. Res. Toxisol. (2005) 18:115-122.
   PubMed Web of Science ®Google Scholar
• WILLIAMS RE, JACOBSEN M, LOCK EA: 1H-NMR pattern recognition and 31P-NMR studies with D-serine in rat urine and kidney, time- and dose-related metabolic effects. Chem. Res. Toxicol, (2003) 16:1207-1216.
   PubMed Web of Science ®Google Scholar
• GARTLAND KP, BONNER FW, NICHOLSON JK: Investigations into the biochemical effects of region-specific nephrotoxins. Mol. Pharmacol. (1989) 35:242-250.
   PubMed Web of Science ®Google Scholar
• GNANASOUNDARI M, PARI L: Impact of neringerin on oxytetracycline-mediated oxidative damage in kidney of rats. Ren. Fail. (2006) 28:599-605.
   PubMed Web of Science ®Google Scholar
• LENZ EM, BRIGHT J, KNIGHT R et al.: Metabonomics with 1H-NMR spectroscopy and liquid chromatography-mass spectrometry applied to the investigation of metabolic changes caused by gentamicin-induced nephrotoxicity in the rat. Biomarkers (2005) 10:173-187.
   PubMed Web of Science ®Google Scholar
• SAAD SY, NAJJAR TA: Effects of STZ-induced diabetes and its treatment with vanadyl sulphate on cyclosporine A-induced nephrotoxicity in rats. Arch. Toxicol. (2005) 79:493-499.
   PubMed Web of Science ®Google Scholar
• PADI SS, CHOPRA K: Salvage of cyclosporine A-induced oxidative stress and renal dysfunction by carvedilol. Nephron (2002) 92:685-692.
   PubMed Web of Science ®Google Scholar
• SERKOVA NJ, CHRISTIANS U: Biomarkers for toxicodynamic monitoring of immunosuppressants: NMR-based quantitative metabonomics of the blood. Ther. Drug Monitor. (2005) 27:733-737.
   PubMed Web of Science ®Google Scholar
• SERKOVA N, KLAWITTER J, NIEMANN CU: Organ-specific response to inhibition of mitochondrial metabolism by cyclosporine in the rat. Transplant. Int. (2003) 16:748-755.
   PubMed Web of Science ®Google Scholar
• HAN SY, MUN KC, CHOI HJ et al.: Effects of cyclosporine and tacrolimus on the oxidative stress in cultured mesangial cells. Transplant. Proc. (2006) 38:2240-2241.
   PubMed Web of Science ®Google Scholar
• GARLICKI M, CZUBP, LABUS K, EHRLICH MP, RDZANEK H: Conversion from cyclosporine to tacrolimus improves renal function and lipid profile after cardiac transplantation. Ann. Transplant. (2006) 11:24-27.
   PubMedGoogle Scholar
• MCCUNE TR, THACKER LR II, PETERS TG et al.: Effects of tacrolimus on hyperlipidemia after successful renal transplantation: a Southeastern Organ Procurement Foundation Multicenter Clinical Study. Transplantation (1998) 65:87-92.
   PubMed Web of Science ®Google Scholar
• GONWA TA, HRICIK DE, BRINKER K, GRINYO JM, SCHENA FP: Improved renal function in sirolimus-treated renal patients after early cyclosporine elimination. Transplantation (2002) 74:1560-1567.
   PubMed Web of Science ®Google Scholar
• TROTTER JF, WACHS ME, TROUILLOT TE et al.: Dyslipidemia during sirolimus therapy in liver transplant recipients occurs with concomitant cyclosporine but not tacrolimus. Liver Transpl. (2001) 7:401-408.
   PubMed Web of Science ®Google Scholar
• SANTOS NA, CATAO CS, MARTINS NM, CURTI C, BIANCHI ML, SANTOS AC: Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Arch. Toxicol. (2007) 81:495-504.
   PubMed Web of Science ®Google Scholar
• ATESSAHIN A. CERIBASI AO, YUCE A, BULMUS O, CIKIM G: Role of ellagic acid against cisplatin-induced nephrotoxicity and oxidative stress in rats. Basic Clin. Pharmacol. Toxicol. (2007) 100:121-126.
   PubMed Web of Science ®Google Scholar
• SAAD SY, ARAFAH NM, NAJJAR TA: Effects of mycophenolate mofetil on cisplatin-induced renal dysfunction in rats. Cancer Chemother. Pharmacol. (2007) 59:455-460.
   PubMed Web of Science ®Google Scholar
• BUNDY TG, SPURGEON DJ, SVENDSEN C et al.: Environmental metabonomics: applying combination biomarker analysis in earthworms as a metal contaminated site. Ecotoxicology (2004) 13:797-806.
   PubMed Web of Science ®Google Scholar
• AL-NASSER IA: Cadmium hepatotoxicity and alterations of the mitochondrial function. J. Toxicol. Clin. Toxicol. (2000) 38:407-413.
   PubMed Web of Science ®Google Scholar
• LENZ EM, BRIGHT J, KNIGHT R, WILSON ID, MAJOR H: A metabonomic investigation of the biochemical effects of mercuric chloride in the rat using 1H-NMR and HPLC-TOF/MS: time dependent changes in the urinary profile of endogenous metabolites as a result of nephrotoxicity. Analyst (2004) 129:535-541.
   PubMed Web of Science ®Google Scholar
• WANG Y, BOLLARD ME, NICHOLSON JK, HOLMES E: Exploration of the direct metabolic effects of mercury II chloride on the kidney of Sprague–Dawley rats using high-resolution magic angle spinning 1H-NMR spectroscopy of intact tissue and pattern recognition. J. Pharm. Biomed. Anal. (2006) 40:375-381.
   PubMed Web of Science ®Google Scholar
• NOLIN TD, MCMENAMIN ME, HIMMELFARB J: Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: application to studies of oxidative stress. J. Chromatogr. B Abalyt. Technol. Biomed. Life Sci. (2007) 852:554-561.
   PubMed Web of Science ®Google Scholar
• CAUSSE E, PRADELLES A, DIRAT B, NEGRE-SALVAYRE A, SALVAYRE R, COUDERE F: Simultaneous determination of allantoin, hypoxanthine, xanthine, and uric acid in serum/plasma by CE. Electrophoresis (2007) 28:381-387.
   PubMed Web of Science ®Google Scholar
• VAN BIESEN W, VANHOLDER R, VEYS N et al.: The importance of standardization of creatinine in the implementation of guidelines and recommendations for CKD: implications for CKD management programmes. Nephrol. Dial. Transpl. (2006) 21:77-83.
   PubMed Web of Science ®Google Scholar
• CHERTOW GM, BURDICK E, HONOUR M, BONVENTRE JV, BATES DW: Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J. Am. Soc. Nephrol. (2005) 16:3365-3370.
   PubMed Web of Science ®Google Scholar
• NASH K, HAFEEZ A, HOU S: Hospital-acquired renal insufficiency. Am. J. Kidney Dis. (2002) 39:930-936.
   PubMed Web of Science ®Google Scholar
• TOSI MR, RODRIGUEZ-ESTRADA MT, LERCKER G et al.: Magnetic resonance spectroscopy and chromatographic methods identify altered lipid composition in human renal neoplasms. Int. J. Mol. Med. (2004) 14:93-100.
   PubMed Web of Science ®Google Scholar
• PERROUD B, LEE J, VALKOVA N et al.: Pathway analysis of kidney cancer using proteomics and metabolic profiling. Mol. Cancer (2006) 5:64.
   PubMed Web of Science ®Google Scholar
• WISHART DS, TZUR D, KNOX C et al.: HMDB: the human metabolome database. Nucleic Acids Rev. (2007) 35:D521-D526.
   PubMed Web of Science ®Google Scholar

Websites

• http://www.worldkidneyday.org
   Google Scholar
• http://www.hmdb.ca/
   Google Scholar
• http://redpoll.pharmacy.ualberta.ca/drugbank/
   Google Scholar