320
Views
6
CrossRef citations to date
0
Altmetric
Reviews

Update on apelin peptides as putative targets for cardiovascular drug discovery

, PhD (Research Associate Professor)
Pages 633-644 | Published online: 24 Mar 2011

Bibliography

  • O'Dowd BF, Heiber M, Chan A, A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene 1993;136:355-60
  • Tatemoto K, Hosoya M, Habata Y, Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998;6:471-6
  • Charles CJ. The apelin peptides as putative targets in cardiovascular drug discovery and development. Exert Opin Drug Discov 2008;3:51-64
  • Habata Y, Fuji R, Hosoya M, Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrums. Biochim Biophys Acta 1999;1452:25-35
  • Kawamata Y, Habata Y, Fukusumi S, Molecular properties of apelin: tissue distribution and receptor binding. Biochim Biophys Acta 2001;1538:162-71
  • Tatemoto K, Takayama K, Zou M, The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Reg Peptides 2001;99:87-92
  • Vickers C, Hales P, Kaushik V, Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. J Biol Chem 2002;277:14838-43
  • El Messari S, Iturrioz X, Fassot C, Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure. J Neurochem 2004;90:1290-301
  • Lee DK, Cheng R, Nguyen T, Characterization of apelin, the ligand for the APJ receptor. J Neurochem 2000;74:34-41
  • Matsumoto M, Hidakaidaka K, Akiho H, Low stringency hybridization study of the dopamine D4 receptor revealed D4-like mRNA distribution of the orphan seven-transmembrane receptor, APJ, in human brain. Neurosci Lett 1996;219:119-22
  • Edinger AL, Hoffman TL, Sharron M, An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a co-receptor for human immunodeficiency virus type 1 and simian immunodeficiency virus. J Virol 1998;72:7934-40
  • Hosoya M, Kawamata S, Fukusumi R, Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem 2000;275:21061-7
  • O'Carroll AM, Don ALJ, Lolait SJ. APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids. J Neuroendocrinology 2003;15:1095-101
  • O'Carroll AM, Lolait SJ. Regulation of rat APJ receptor messenger ribonucleic acid expression in magnocellular neurons of the paraventricular and supraoptic nuclei by osmotic stimuli. J Neuroendocrinology 2003;15:661-6
  • Kleinz MJ, Davenport AP. Immunocytochemical localization of the endogenous vasoactive peptide apelin to human vascular and endocardial endothelial cells. Reg Peptides 2004;118:119-25
  • Kleinz MJ, Skepper JN, Davenport AP. Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Reg Peptides 2005;126:233-40
  • Katugampola SD, MacGuire JJ, Mathewson SR, Davenport AP. [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 2001;132:1255-60
  • Szokodi I, Tavi P, Foldes G, Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res 2002;91:434-40
  • Zhang J, Ren CX, Qi YF, Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sci 2006;79:1153-9
  • Iwanaga Y, Kihara Y, Takenaka H, Kita T. Down-regulation of cardiac apelin system in hypertrophied and failing hearts: Possible role of angiotensin II-angiotensin type 1 receptor system. J Mol Cell Cardiol 2006;41:798-806
  • Ronkainen V-P, Ronkainen JJ, Hanninen SL, Hypoxia inducible factor regulates the cardiac expression and secretion of apelin. FASEB J 2007;21:1821-30
  • Alturi P, Morine KJ, Liao GP, Ischemic heart failure enhances endogenous myocardial apelin and APJ receptor expression. Cell Mol Biol Lett 2007;12:127-38
  • Foldes G, Horkay F, Szokodi I, Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. Biochem Biophys Res Commun 2003;308:480-5
  • Chen MM, Ashley EA, Deng DXF, Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation 2003;108:1432-9
  • Maguire JJ, Kleinz MJ, Pitkin SL, Davenport AP. [Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart. Vasoactive mechanisms and inotropic action in disease. Hypertension 2009;54:598-604
  • Pitkin SL, Maguire JJ, Kuc RE, Davenport AP. Modulation of the apelin/APJ system in heart failure and atherosclerosis in man. Br J Pharmacol 2010;160:1785-95
  • Castan-Laurell I, Boucher J, Dray C, Apelin, a novel adipokine over-produced in obesity: friend or foe? Mol Cell Endocrinol 2005;245:7-9
  • Boucher J, Masri B, Daviaud D, Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 2005;146:1764-71
  • Heinonen MV, Purhonen AK, Miettinen P, Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Reg Peptides 2005;130:7-13
  • Garcia-Diaz D, Campion J, Milagro FI, Martinez JA. Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers. Mol Cell Biochem 2007;305:87-94
  • Higuchi K, Masaki T, Gotoh K, Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice. Endocrinology 2007;148:2690-7
  • Dray C, Knauf C, Daviaud D, Apelin stimulates glucose utilisation in normal and obese insulin-resistant mice. Cell Metab 2008;8:437-45
  • Jia YX, Lu ZF, Zhang J, Apelin activates L-arginine/nitric oxides synthase/nitric oxide pathways in rat aortas. Peptides 2007;28:2023-9
  • Zhong JC, Yu XY, Huang Y, Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice. Cardiovasc Res 2007;74:388-95
  • Hashimoto T, Kihara M, Ishida J, Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2006;26:1267-72
  • Masri B, Morin N, Cornu M, Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J 2004;18:1909-11
  • Masri B, Morin N, Pedebernade L, The apelin receptor is coupled to gi1 or gi2 protein and is differentially desensitized by apelin fragments J Biol Chem 2006;281:18317-26
  • Kasai A, Shintani N, Oda M, Apelin is a novel angiogenic factor in retinal endothelial cells. Biochem Biophys Res Commun 2004;325:395-400
  • Farfasfalvi K, Stagg MA, Coppen SR, Direct effects of apelin on cardiomyocytes contractility and electrophysiology. Biochem Biophys Res Commun 2007;357:889-95
  • Simpkin JC, Yellon DM, Davidson SM, Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia reperfusion injury. Basic Res Cardiol 2007;102:518-28
  • Cheng X, Cheng XS, Pang CCY. Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats. Eur J Pharmacol 2003;470:171-5
  • Kagiyama S, Fukuhara M, Matsumura K, Central and peripheral cardiovascular actions of apelin in conscious rats. Reg Peptides 2005;125:55-9
  • Charles CJ, Rademaker MT, Richards AM. Apelin-13 induces a biphasic haemodynamic response and hormonal activation in normal conscious sheep. J Endocrinol 2006;189:701-10
  • King AJ, Pfeffer JM, Pfeffer MA, Brenner BM. Systemic hemodynamic effects of endothelin in rats. Am J Physiol 1990;258:H787-92
  • Rohmeiss P, Photiadis J, Rohmeiss S, Unger T. Hemodynamic actions of intravenous endothelin in rats: comparison with sodium nitroprusside and methoxamine. Am J Physiol 1990;258:H337-46
  • Gardiner SM, March JE, Kemp PA, Bennet T. Bolus injection of human urotensin II in conscious rats evoke a biphasic haemodynamic response. Br J Pharmacol 2004;143:422-30
  • Lee DK, Saldivia VR, Nguyen T, Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology 2005;146:231-6
  • Graser T, Vanhoute PM. Hypoxic contraction of canine coronary arteries: role of endothelium and cGMP. Am J Physiol 1991;261:H1769-77
  • Rastaldo R, Pagliaro P, Cappello S, Nitric oxide and cardiac function. Life Sci 2007;81:779-93
  • Dai T, Ramirez-Correa G, Gao WD. Apelin increases contractility in failing cardiac muscles. Eur J Pharmacol 2006;553:222-8
  • Berry MF, Pirolli TJ, Jayasankar V, Apelin has in vivo inotropic effects on normal and failing hearts. Circulation 2004;110(suppl II): II-187-93
  • Ashley EA, Powers J, Chen M, The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res 2005;65:73-82
  • Reaux A, De Mota N, Skultetyova I, Physiological role of a novel neuropeptide, apelin, and its receptor in the brain. J Neurochem 2001;77:1085-96
  • De Mota N, Reaux-Le Goazigo A, El Messari S, Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc Nat Acad Sci 2004;101:10464-9
  • Taheri S, Murphy K, Cohen M, The effects of centrally administered apelin-13 on food intake, water intake and pituitary hormone release in rats. Biochem Biophys Res Commun 2002;291:1208-12
  • Jaszeberenyi M, Bujdoso E, Telegdy G. Behavioural, neuroendocrine and thermoregulatory actions of apelin-13. Neuroscience 2004;129:811-16
  • Reaux-Le Goazigo A, Alvear-Perez R, Zizzari P, Cellular localization of apelin and its receptor in the anterior pituitary: evidence for a direct stimulatory action of apelin on ACTH release. Am J Physiol 2007;292:E7-15
  • Hus-Citharel A, Bouby N, Frugiere A, Effect of apelin on glomerular hemodynamic function in the rat kidney. Kidney Int 2008;74:486-94
  • Kuba K, Zhang L, Imai Y, Impaired heart contractility in apelin gene-deficient mice associated with aging and pressure overload. Circ Res 2007;101:e32-42
  • Ishida J, Hashimoto T, Hashimoto Y, Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem 2004;279:26274-9
  • Roberts EM, Newson MJF, Pope GR, Abnormal fluid homeostasis in apelin receptor knockout mice. J Endocrinol 2009;202:453-62
  • Hashimoto T, Kihura M, Imai N, Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis. Am J Pathol 2007;171:1705-12
  • Charo DN, Ho M, Fajardo G, Endogenous regulation of cardiovascular function by apelin-APJ. Am J Physiol 2009;297:H1904-13
  • Kleinz MJ, Baxter GF. Apelin reduces myocardial reperfusion injury independently of PI3K.Akt and P7036 kinase. Reg Peptides 2008;146:271-7
  • Zeng XJ, Zhang LK, Wang HZ, Apelin protects heart against ischemia/reperfusion injury in rat. Peptides 2009;30:1144-52
  • Jia Y-X, Pan C-S, Zhang J, Apelin protects myocardial injury induced by isoproterenol in rats. Reg Peptides 2006;133:147-54
  • Falcao-Pires I, Goncalves N, Henriques-Coelho T, Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension. Am J Physiol 2009;296:H2007-14
  • Foussal C, Lairez O, Calise D, Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy. FEBS Letters 2010;584:2363-70
  • Sonmez A, Celebi G, Erdem G, Plasma apelin and ADMA levels in patients with essential hypertension. Clin Exp Hypertension 2010;32:179-83
  • Ellinor PT, Low AF, MacRae CA. Reduced apelin levels in lone atrial fibrillation. Eur Heart J 2006;27:222-6
  • Li Z, Bai Y, Hu J. Reduced apelin levels in stable angina. Internal Medicine 2008;47:1951-5
  • Kadoglou NPE, Lampropoulos S, Kapelouzou A, Serum levels of apelin and ghrelin in patients with acute coronary syndromes and established coronary artery disease – KOZANI STUDY. Transl Res 2010;155:238-46
  • Weir RAP, Chong KS, Dalzell JR, Plasma apelin concentration is depressed following myocardial infarction in man. Eur J Heart Fail 2009;11:551-8
  • Goetze JP, Rehfeld JF, Carlsen J, Apelin: a new plasma marker of cardiopulmonary disease. Reg Peptides 2006;133:134-8
  • Chong KS, Gardiner RS, Morton JJ, Plasma concentrations of the novel peptide apelin are decreased in patients with chronic heart failure. Eur J Heart Fail 2006;8:355-60
  • Francia P, Salvati A, Balla C, Cardiac resynchronization therapy increases plasma levels of the endogenous inotrope apelin. Eur J Heart Fail 2007;9:306-9
  • Gao LR, Xu RY, Zhang NK, Increased apelin following bone marrow mononuclear cell transplantation contributes to the improvement of cardia function in patients with severe heart failure. Cell Transplant 2009;18:1311-18
  • Van Kimmenade RR, Januzzi JL, Ellinor PT, Utility of amino-terminal pro-brain natriuretic peptide, galectin-3 and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol 2006;48:1217-24
  • Chandrasekaran B, Kalra PR, Donovan J, Myocardial apelin production is reduced in humans with left ventricular systolic dysfunction. J Cardiac Fail 2010;16:556-61
  • Mesmin C, Dubois M, Becher F, Liquid chromatography/tandem mass spectrometry assay for the absolute quantification of the expected circulating apelin peptides in human plasma. Rapid Commun Mass Spectrom 2010;24:2875-84
  • Japp AG, Cruden NL, Amer DAB, Vascular effects of apelin in man. J Am Coll Cardiol 2008;52:908-13
  • Japp AG, Cruden NL, Barnes G, Acute cardiovascular effects of apelin in humans. Potential role in patients with chronic heart failure. Circulation 2010;121:1818-27
  • Zhong JC, Huang Y, Yung LM, The novel peptide apelin regulates intrarenal artery tone in diabetic mice. Reg Peptides 2007;144:109-14
  • Gurzu B, Petrescu BC, Costuleanu M, Interactions between apelin and angiotensin II on rat portal vein. JRAAS 2006;7:212-16
  • Fan X, Zhou N, Zhang X, Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ. Biochemisty 2003;42:10163-8
  • Medhurst AD, Jennings CA, Robbins MJ, Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J Neurochem 2003;84:1162-72
  • Pitkin SL, Maguire JJ, Bonner TI, Davenport AJ. International union of basic and clinical pharmacology. LXXIV. Apelin receptor nomenclature, distribution, pharmacology, and function. Pharmacol Rev 2010;62:331-42
  • Hamada J, Kimura J, Ishida J, Evaluation of novel cyclic analogues of apelin. Int J Molecular Med 2008;22:547-52
  • Iturrioz X, Alvear-Perez R, De Mota N, Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist. FASEB J 2010;24:1506-17

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.