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Editorial

Learning from our failures in blood–brain permeability: what can be done for new drug discovery?

Bibliography

  • Fung LK, Shin M, Tyler B, et al. Chemotherapeutic drug released from polymers: distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat brain. Pharm Res 1996;13(5):671-82
  • Salvatore MF, Ai Y, Fischer B, et al. Point source concentration of GDNF may explain failure of phase II clinical trial. Exp Neurol 2006;202(2):497-505
  • Wu H, Hu K, Jiang X. From node to brain: understanding transport capacity and transport rate of drugs. Expert Opin Drug Deliv 2008;5(10):1159-68
  • Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2005;2(1):3-14
  • Pardridge WM. Drug transport across the blood-brain barrier. J Cerebral Blood Flow & Metabolism 2012;32(11):1959-72
  • Mesiwala AH, Farrell L, Wenzel HJ, et al. High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo. Ultrasound Med Biol 2002;28(3):389-400
  • Jain KK. Nanobiotechnology-based strategies for crossing the blood-brain barrier. Nanomedicine 2012;7(8):1225-33
  • Martel S. Magnetic therapeutic delivery using navigable agents. Therapeutic Delivery 2014;5(2):189-204

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