293
Views
3
CrossRef citations to date
0
Altmetric
Review

Animal models for anti-emphysema drug discovery

, MSc PhD (Assistant Professor of General Pathology) , , MSc (Research Fellow) & , DVM MSc (Retired)

Bibliography

  • WHO. Projections of mortality and causes of death, 2015 and 2030. Available from: http://www.who.int/entity/healthinfo/global_burden_disease/GHE_DthGlobal_Proj_2015_2030.xls [Cited 14 January 2014]
  • Gardi C, Valacchi G. Cigarette Smoke and Ozone effect on murine inflammatory responses. Ann N Y Acad Sci 2012;1259:104-11
  • Tuder RM, Yoshida T, Arap W, et al. State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective. Proc Am Thorac Soc 2006;3:503-10
  • Chung KF, Adcock IM. Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction. Eur Respir J 2008;31:1334-56
  • Snider GL, Kleinerman J, Thurlbeck WM, Bengali ZH. The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases Workshop. Am Rev Respir Dis 1985;132:182-5
  • Sethi S, Mahler DA, Marcus P, et al. Inflammation in COPD: implications for management. Am J Med 2012;125:1162-70
  • Lόpez-Campos JL, Calero Acuña C. What is the guidelines about the pharmacological treatment of chronic obstructive pulmonary disease? Expert Rev Respir Med 2013;7:43-51
  • Beghè B, Rabe KF, Fabbri LM. Phosphodiesterase-4 inhibitor therapy for lung diseases. Am J Respir Crit Care Med 2013;188:271-8
  • Laurell CB, Eriksson S. The electrophoretic α1-globulin pattern of serum in α1-antitrypsin deficiency. 1963. COPD 2013;10:3-8
  • Gross P, Pfitzer EA, Tolker E, et al. Experimental emphysema with papain in normal and silicotic rats. Arch Environ Health 1965;11:50-8
  • Kleinermann J, Rynbrandt D. Papain-induced emphysema in hamsters: The effect of agents that increase serum α1-antitrypsin. In: Mittmann C, editor. Pulmonary emphysema and proteolysis. Academic Press; New York and London: 1972. p. 421-37
  • Giles RE, Finkel MP, Williams JC, Winbury MM. The therapeutic effect of progesterone in papain-induced emphysema. Proc Soc Exp Biol Med 1974;147:489-93
  • Martorana PA, Richard JW, McKeel NW, Share NN. Inhibition of papain-induced emphysema in the hamster by human alpha1-antitrypsin. Can J Physiol Pharmacol 1974;52:758-9
  • Hayes JA, Korthy A, Snider GL. The pathology of elastase-induced panacinar emphysema in hamsters. J Pathol 1975;117:1-14
  • Snider GL. Emphysema: the first two centuries-and beyond. A historical overview, with suggestions for future research: part 2. Am Rev Respir Dis 1992;146:1615-22
  • Kleinerman J, Ranga V, Rynbrandt D, et al. The effect of the specific elastase inhibitor, alanyl alanyl prolyl alanine chloromethylketone, on elastase-induced emphysema. Am Rev Respir Dis 1980;121:381-7
  • Janoff A, Dearing R. Prevention of elastase-induced experimental emphysema by oral administration of a synthetic elastase inhibitor. Am Rev Respir Dis 1980;121:1025-9
  • Stone PJ, Lucey EC, Calore JD, et al. The moderation of elastase-induced emphysema in the hamster by intratracheal pretreatment or post-treatment with succynil alanyl alanyl prolyl valine chloromethylketone. Am Rev Respir Dis 1981;124:56-9
  • Snider GL, Stone PJ, Lucey EC, et al. Eglin-C, a polypeptide derived from the medicinal leech, prevents human neutrophil elastase-induced emphysema and bronchial secretory cell metaplasia in the hamster. Am Rev Respir Dis 1985;132:1155-61
  • Martorana PA, Lungarella G, Share NN, et al. The effect of furoyl saccharin, a novel non-peptidic acylating protease inhibitor, in various animal models of emphysema. In: Taylor JC, Mittmann C, editors. Pulmonary emphysema and proteolysis. 1986 Academic Press Inc., Orlando, Florida; 1987. p. 57-64
  • Lungarella G, Gardi C, Fonzi L, et al. Effect of the novel synthetic protease inhibitor furoyl saccharin on elastase-induced emphysema in rabbits and hamsters. Exp Lung Res 1986;11:35-47
  • Snider GL, Lucey EC, Stone PJ. Animal models of emphysema. Am Rev Respir Dis 1986;133:149-69
  • Wright JL, Churg A. Cigarette smoke causes physiologic and morphologic changes of emphysema in the guinea pig. Am Rev Respir Dis 1990;142:1422-8
  • Leberl M, Kratzer A, Taraseviciene-Stewart L. Tobacco smoke induced COPD/emphysema in the animal model - are we all on the same page? Front Physiol 2013;4:1-23
  • Brusselle GG, Bracke KR, Maes T, et al. Murine models of COPD. Pulm Pharmacol Ther 2006;19:155-65
  • Martorana PA, Cavarra E, Lucattelli M, et al.et al. COPD involving cigarette smoke. Drug Discov Today 2006;3:225-30
  • Rennard SI. Cigarette smoke in research. Am J Respir Cell Mol Biol 2004;31:479-80
  • Wright JL, Cosio M, Churg A. Animal models of chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol 2008;295:L1-15
  • Martorana PA, McKeel NW, Richard JW, Share NN. Function-structure correlation studies on excised hamster lungs in papain-induced emphysema. Can J Physiol Pharmacol 1973;51(9):635-41
  • Cavarra E, Bartalesi B, Lucattelli M, et al. Effects of cigarette smoke in mice with different levels of proteinase inhibitor and sensitivity to oxidants. Am J Respir Crit Care Med 2001;164:886-90
  • Guerassimov A, Hoshino Y, Takubo Y, et al. The development of emphysema in cigarette-smoke exposed mice is strain-dependent. Am J Respir Crit Care Med 2004;170:974-80
  • Bartalesi B, Cavarra E, Fineschi S, et al. Different lung responses to cigarette smoke in two strains of mice sensitive to oxidants. Eur Respir J 2005;25:15-22
  • Cho HY, Jedlicka AE, Reddy SP, et al. Linkage analysis of susceptibility to hyperoxia. Am J Respir Cell Mol Biol 2002;26:C42-51
  • Vecchio D, Arezzini B, Pecorelli A, et al. Reactivity of mouse alveolar macrophages to cigarette smoke is strain dependent. Am J Physiol Lung Cell Mol Physiol 2010;298:L704-13
  • Gardi C, Cavarra E, Calzoni P, et al. Neutrophil lysosomal dysfunction in mutant C57 Bl/6J mice: interstrain variation in content of lysosomal elastase, cathepsin G and their inhibitors. Biochem J 1994;299:237-45
  • Martorana PA, Beume R, Lucattelli M, et al. Roflumilast fully prevents emphysema in mice chronically exposed to cigarette smoke. Am J Respir Crit Care Med 2005;172:848-53
  • Churg A, Wang X, Wang R, et al. Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages. Am J Respir Cell Mol Biol 2007;37:144-51
  • Hackett TL, Shaheen F, Zhou S, et al. Fibroblast STAT-4 drives cigarette smoke induced airway fibrosis. Am J Respir Cell Mol Biol 2014;51(6):830-9
  • Zhou S, Wright JL, Liu J, et al. Aging does not enhance experimental cigarette smoke-induced COPD in the mouse. PLoS One 2013;8:e71410
  • March TH, Wilder JA, Esparza DC, et al. Modulators of cigarette smoke-induced pulmonary emphysema in A/J mice. Toxicol Sci 2006;92:545-59
  • Machado MN, Figueirôa SF, Mazzoli-Rocha F, et al. Papain-induced experimental pulmonary emphysema in male and female mice. Respir Physiol Neurobiol 2014;200:90-6
  • Sverzellati N, Calabrò E, Randi G, et al. Sex differences in emphysema phenotype in smokers without airflow obstruction. Eur Respir J 2009;33:1320-8
  • Shapiro SD, Goldstein NM, Houghton AM, et al. Neutrophil elastase contributes to cigarette smoke-induced emphysema. Am J Pathol 2003;163:2329-35
  • Van Eijl S, van Oorschot R, Olivier B, et al. Stress and hypothermia in mice in a nose-only cigarette smoke exposure system. Inhal Toxicol 2006;18:911-18
  • Thurlbeck WM. Measurement of pulmonary emphysema. Am Rev Respir Dis 1967;95:752-64
  • Thurlbeck WM. Internal surface area of non emphysematous lungs. Am Rev Respir Dis 1967;95:765-73
  • Eidelman DH, Bellofiore S, Chiche D, et al. Behavior of morphometric indices in pancreatic elastase-induced emphysema in the rats. Lung 1990;168:159-69
  • Gardi C, Arezzini B, Martorana PA. Testing of compounds in models of pulmonary emphysema. Curr Med Chem 2008;15:803-8
  • Churg A, Sin DD, Wright JL. Everything prevents emphysema: are animal models of cigarette smoke-induced chronic obstructive pulmonary disease any use ? Am J Respir Cell Mol Biol 2011;45:1111-15
  • Churg A, Wang RD, Xie C, Wright JL. Alpha1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. Am J Respir Crit Care Med 2003;168:199-207
  • Pemberton PA, Kobayashi D, Wilk BJ, et al. Inhaled recombinant alpha1-antitrypsin ameliorates cigarette smoke-induced emphysema in the mouse. COPD 2006;3:101-8
  • Wright JL, Farmer SG, Churg A. Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs. Am J Respir Crit Care Med 2002;166:954-60
  • Stevens T, Ekholm K, Granse M, et al. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther 2011;339:313-20
  • Pemberton PA, Cantwell JS, Kim KM, et al. An inhaled matrix metalloprotease inhibitor prevents cigarette smoke-induced emphysema in the mouse. COPD 2005;2:303-10
  • Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochim Biophys Acta 2012;1822:714-28
  • Yao H, Arunachalam G, Hwang JW, et al. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci USA 2010;107:15571-6
  • Churg A, Marshall C, Sin DD, et al. Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2012;185:34-43
  • Suzuki M, Betsuyaku T, Ito Y, et al. Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am J Physiol Lung Cell Mol Physiol 2009;296:L614-23
  • Cai S, Chen P, Zhang C, et al. Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats. Respirology 2009;14:354-9
  • Pires KM, Bezerra FS, Machado MN, et al. N-(2-mercaptopropionyl)-glycine but not allopurinol prevented cigarette smoke-induced alveolar enlargement in mouse. Respir Physiol Neurobiol 2011;175:322-30
  • Caramori G, Adcock IM, Di Stefano A, Chung KF. Cytokine inhibition in the treatment of COPD. Int J Chron Obstruct Pulmon Dis 2014;9:397-412
  • Zhang XY, Zhang C, Sun QY, et al. Infliximab protects against pulmonary emphysema in smoking rats. Chin Med J 2011;124:2502-6
  • Martorana PA, Lunghi B, Lucattelli M, et al. Effect of roflumilast on inflammatory cells in the lungs of cigarette smoke-exposed mice. BMC Pulm Med 2008;8:17
  • Mori H, Nose T, Ishitani K, et al. Phosphodiesterase 4 inhibitor GPD-1116 markedly attenuates the development of cigarette smoke-induced emphysema in senescence-accelerated mice P1 strain. Am J Physiol Cell Mol Physiol 2008;294:L196-204
  • Roh GS, Yi CO, Cho YJ, et al. Anti-inflammatory effects of celecoxib in rat lungs with smoke-induced emphysema. Am J Physiol Lung Cell Mol Physiol 2010;299:L184-91
  • Nakanishi Y, Kobayashi D, Asano Y, et al. Clarythromycin prevents smoke-induced emphysema in mice. Am J Respir Crit Care Med 2009;179:271-8
  • Lee JH, Lee DS, Kim EK, et al. Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med 2005;172:987-93
  • Wright JL, Zhou S, Preobrazhenska O, et al. Statin reverses smoke-induced pulmonary hypertension and prevents emphysema but not airway remodeling. Am J Respir Crit Care Med 2011;183:50-8
  • Weissmann N, Lobo B, Pichl A, et al. Stimulation of soluble guanylate cyclase prevents cigarette smoke–induced pulmonary hypertension and emphysema. Am J Respir Crit Care Med 2014;189:1359-73
  • Cantor JO, Cerreta JM, Ochoa M, et al. Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema. Exp Lung Res 2005;31:417-30
  • Cantor JO, Cerreta JM, Ochoa M, et al. Therapeutic effects of hyaluronan on smoke-induced elastic fiber injury: does delayed treatment affect efficacy? Lung 2011;189:51-6
  • Massaro GD, Massaro D. Retinoic acid treatment abrogates elastase-induced emphysema in rats. Nat Med 1997;3:675-7
  • Massaro D, Massaro GD. Retinoids, alveolus formation, and alveolar deficiency: clinical implications. Am J Respir Cell Mol Biol 2003;28:271-4
  • Seimetz M, Parajuli N, Pichl A, et al. Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice. Cell 2011;147:293-305
  • Valenca SS, Bezerra FS, Romana-Souza B, et al. Supplementation with vitamins C and E improves mouse lung repair. J Nutr Biochem 2008;19:604-11
  • Koike K, Ishigami A, Sato Y, et al. Vitamin C prevents cigarette smoke-induced pulmonary emphysema in mice and provides pulmonary restoration. Am J Respir Cell Mol Biol 2014;50:347-57
  • Shan M, You R, Yuan X, et al. Agonistic induction of PPARy reverses cigarette smoke-induced emphysema. J Clin Invest 2014;124:1371-81
  • Pérez-Rial S, Del Puerto-Nevado L, Girόn-Martinez A, et al. Liver growth factor treatment reverses emphysema previously established in a cigarette smoke exposure mouse model. Am J Physiol Lung Cell Mol Physiol 2014;307:L718-26
  • Hatzelmann A, Morcillo EJ, Lungarella G, et al. The preclinical pharmacology of roflumilast - a selective, oral phosphodiesterase-4 inhibitor in development for chronic obstructive pulmonary disease. Pulm Pharmacol Ther 2010;23:235-56
  • Criner GJ, Connett JE, Aaron SD, et al. Simvastatin for the prevention of exarcerbations in moderate-to-severe COPD. N Engl J Med 2014;370:2201-10
  • Ingebrigtsen TS, Marott JL, Nordestgaard BG, et al. Statin use and exacerbations in individuals with chronic obstructive pulmonary disease. Thorax 2015;70(1):33-40
  • Wang MT, Lo YW, Tsai CL, et al. Statin use and risk of COPD exacerbations requiring hospitalization. Am J Med 2013;126:598-606

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.