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Review

Animal models for acute radiation syndrome drug discovery

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Bibliography

  • Bushberg JT, Kroger LA, Hartman MB, et al. Nuclear/radiological terrorism: emergency department management of radiation casualties. J Emerg Med 2007;32:71-85
  • Flynn DF, Goans RE. Nuclear terrorism: triage and medical management of radiation and combined-injury casualties. Surg Clin North Am 2006;86:601-36
  • Waselenko JK, MacVittie TJ, Blakely WF, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann Intern Med 2004;140:1037-51
  • DiCarlo AL, Maher C, Hick JL, et al. Radiation injury after a nuclear detonation: medical consequences and the need for scarce resources allocation. Disaster Med Public Health Prep 2011;5(Suppl 1):S32-44
  • Goans RE. Clinical care of the radiation-accident patient: patient presentation, assessment and initial diagnosis. In: Ricks RC, Berger ME, O’Hara FM, editors. The medical basis for victims. Partheon Publishing Group; Boca Raton, FL: 2002. p. 11
  • Dorr H, Meineke V. Acute radiation syndrome caused by accidental radiation exposure - therapeutic principles. BMC Med 2011;9:126
  • Gourmelon P, Benderitter M, Bertho JM, et al. European consensus on the medical management of acute radiation syndrome and analysis of the radiation accidents in Belgium and Senegal. Health Phys 2010;98:825-32
  • Weinstock DM, Case CJr, Bader JL, et al. Radiologic and nuclear events: contingency planning for hematologists/oncologists. Blood 2008;111:5440-5
  • Dainiak N, Gent RN, Carr Z, et al. Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems. Disaster Med Public Health Prep 2011;5:183-201
  • Aebersold P. FDA experience with medical countermeasures under the animal rule. Adv Prev Med 2012;2012:507571
  • Gronvall GK, Trent D, Borio L, et al. The FDA animal efficacy rule and biodefense. Nat Biotechnol 2007;25:1084-7
  • Singh VK, Ducey EJ, Brown DS, Whitnall MH. A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute. Int J Radiat Biol 2012;88:296-310
  • Singh VK, Newman VL, Romaine PL, et al. Radiation countermeasure agents: an update (2011 - 2014). Expert Opin Ther Pat 2014;24:1229-55
  • U.S. Department of Health and Human Services. HHS boosts stockpile of products to treat acute radiation syndrome. 2013. Available from: http://www.hhs.gov/news/press/2013pres/09/20130926a.html [Last accessed 12 February 2014]
  • Singh VK, Newman VL, Seed TM. Colony-stimulating factors for the treatment of the hematopoietic component of the acute radiation syndrome (H-ARS): a review. Cytokine 2015;71:22-37
  • Centers for Disease Control and Prevention. Population monitoring in radiation emergencies: a guide for state and local public health planners. 2007. Available from: http://www.bt.cdc.gov/radiation/pdf/population-monitoring-guide1sted.pdf [Last accessed 20 October 2014]
  • Stone HB, Moulder JE, Coleman CN, et al. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res 2004;162:711-28
  • Singh VK, Beattie LA, Seed TM. Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures. J Radiat Res 2013;54:973-88
  • Weiss JF, Landauer MR. History and development of radiation-protective agents. Int J Radiat Biol 2009;85:539-73
  • Seed TM. Radiation protectants: current status and future prospects. Health Phys 2005;89:531-45
  • Dumont F, Le Roux A, Bischoff P. Radiation countermeasure agents: an update. Expert Opin Ther Pat 2010;20:73-101
  • Moulder JE. 2013; Dade W. Moeller lecture: medical countermeasures against radiological terrorism. Health Phys 2014;107:164-71
  • Singh VK, Romaine PL, Newman VL. Biologics as countermeasures for acute radiation syndrome: where are we now? Expert Opin Biol Ther 2014; In press
  • Farese AM, Cohen MV, Katz BP, et al. Filgrastim improves survival in lethally irradiated nonhuman primates. Radiat Res 2013;179:89-100
  • Herodin F, Roy L, Grenier N, et al. Antiapoptotic cytokines in combination with pegfilgrastim soon after irradiation mitigates myelosuppression in nonhuman primates exposed to high irradiation dose. Exp Hematol 2007;35:1172-81
  • Drouet M, Mourcin F, Grenier N, et al. Single administration of stem cell factor, FLT-3 ligand, megakaryocyte growth and development factor, and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression: long-term follow-up of hematopoiesis. Blood 2004;103:878-85
  • Farese AM, Casey DB, Smith WG, et al. Leridistim, a chimeric dual G-CSF and IL-3 receptor agonist, enhances multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression: effect of schedule, dose, and route of administration. Stem Cells 2001;19:522-33
  • Wagemaker G, Neelis KJ, Hartong SCC, et al. The efficacy of recombinant TPO in murine And nonhuman primate models for myelosuppression and stem cell transplantation. Stem Cells 1998;16(Suppl 2):127-41
  • MacVittie TJ, Farese AM, Patchen ML, Myers LA. Therapeutic efficacy of recombinant interleukin-6 (IL-6) alone and combined with recombinant human IL-3 in a nonhuman primate model of high-dose, sublethal radiation-induced marrow aplasia. Blood 1994;84:2515-22
  • Nightengale SL, Prasher JM, Simonson S. Emergency use authorization (EUA) to enable use of needed products in civilian and military emergencies, United States. Emerging Infect Dis 2002;7:1046-55
  • U.S. Food and Drug Administration. Guidance for Industry: product Developoment Under the Animal Rule. 2014. Available from: http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM399217.pdf [Last accessed 18 July 2014]
  • Hall EJ, Giaccia AJ. Radiobiology for the radiobiologist. 7th edition. Lippincott Williams and Wilkins; Philadelphia, PA: 2012
  • Augustine AD, Gondre-Lewis T, McBride W, et al. Animal models for radiation injury, protection and therapy. Radiat Res 2005;164:100-9
  • Williams JP, Brown SL, Georges GE, et al. Animal models for medical countermeasures to radiation exposure. Radiat Res 2010;173:557-78
  • Sanzari JK, Wan XS, Krigsfeld GS, et al. The effects of gamma and proton radiation exposure on hematopoietic cell counts in the ferret model. Gravit Space Res 2013;1:79-94
  • Krigsfeld GS, Savage AR, Billings PC, et al. Evidence for radiation-induced disseminated intravascular coagulation as a major cause of radiation-induced death in ferrets. Int J Radiat Oncol Biol Phys 2014;88:940-6
  • King GL, Landauer MR. Effects of zacopride and BMY25801 (batanopride) on radiation-induced emesis and locomotor behavior in the ferret. J Pharmacol Exp Ther 1990;253:1026-33
  • Kerekes J, Novak J, Koteles GJ. Micronucleus frequency in peripheral lymphocytes for the differential diagnosis of radiation injuries combined with thermal burns. J Burn Care Rehabil 1988;9:275-8
  • Maleki S, Kamrava SK, Sharifi D, et al. Effect of local irradiation with 630 and 860 nm low-level lasers on tympanic membrane perforation repair in guinea pigs. J Laryngol Otol 2013;127:260-4
  • Su YX, Benedek GA, Sieg P, et al. Radioprotective effect of lidocaine on neurotransmitter agonist-induced secretion in irradiated salivary glands. PLoS ONE 2013;8:e60256
  • Gabka CJ, Benhaim P, Mathes SJ, et al. An experimental model to determine the effect of irradiated tissue on neutrophil function. Plast Reconstr Surg 1995;96:1676-88
  • Gratwohl A, John L, Baldomero H, et al. FLT-3 ligand provides hematopoietic protection from total body irradiation in rabbits. Blood 1998;92:765-9
  • Georgieva S, Popov B, Bonev G. Radioprotective effect of Haberlea rhodopensis (Friv.) leaf extract on gamma-radiation-induced DNA damage, lipid peroxidation and antioxidant levels in rabbit blood. Indian J Exp Biol 2013;51:29-36
  • Albuquerque EX, Pereira EF, Aracava Y, et al. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proc Natl Acad Sci USA 2006;103:13220-5
  • U.S. Food and Drug Administration. FDA approves new antibacterial treatment for plague. 2012. Available from: http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm302220.htm [Last accessed 10 February 2014]
  • U.S. Food and Drug Administration. FDA approves raxibacumab to treat inhalational anthrax. 2012. Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm332341.htm [Last accessed 10 February 2014]
  • U.S. Food and Drug Administration. FDA approves first Botulism Antitoxin for use in neutralizing all seven known botulinum nerve toxin serotypes. 2013. Available from: http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm345128.htm [Last accessed 13 February 2014]
  • McCann DGC. Radiation poisoning: current concepts in the Acute Radiation Syndrome. Am J Clin Med 2006;3:13-21
  • Fliedner TM, Dorr DH, Meineke V. Multi-organ involvement as a pathogenetic principle of the radiation syndromes: a study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effect. Br J Radiol Suppl 2005;27:1-8
  • Hill RP. Radiation effects on the respiratory system. Br J Radiol Suppl 2005;27:75-81
  • Moulder JE, Cohen EP. Radiation-induced multi-organ involvement and failure: the contribution of radiation effects on the renal system. Br J Radiol Suppl 2005;27:82-8
  • Cary LH, Ngudiankama BF, Salber RE, et al. Efficacy of radiation countermeasures depends on radiation quality. Radiat Res 2012;177:663-75
  • Satyamitra M, Lombardini E, Graves JIII, et al. A TPO receptor agonist, ALXN4100TPO, mitigates radiation-induced lethality and stimulates hematopoiesis in CD2F1 mice. Radiat Res 2011;175:746-58
  • Herodin F, Mestries JC, Janodet D, et al. Recombinant glycosylated human interleukin-6 accelerates peripheral blood platelet count recovery in radiation-induced bone marrow depression in baboons. Blood 1992;80:688-95
  • Ledney GD, Elliott TB. Combined injury: factors with potential to impact radiation dose assessments. Health Phys 2010;98:145-52
  • Hanson WR, Fry RJ, Sallese AR, et al. Comparison of intestine and bone marrow radiosensitivity of the BALB/c and the C57BL/6 mouse strains and their B6CF1 offspring. Radiat Res 1987;110:340-52
  • Ciorba MA, Riehl TE, Rao MS, et al. Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner. Gut 2012;61:829-38
  • Duran-Struuck R, Hartigan A, Clouthier SG, et al. Differential susceptibility of C57BL/6NCr and B6.Cg-Ptprca mice to commensal bacteria after whole body irradiation in translational bone marrow transplant studies. J Transl Med 2008;6:10
  • Jackson IL, Vujaskovic Z, Down JD. Revisiting strain-related differences in radiation sensitivity of the mouse lung: recognizing and avoiding the confounding effects of pleural effusions. Radiat Res 2010;173:10-20
  • Jackson IL, Vujaskovic Z, Down JD. A further comparison of pathologies after thoracic irradiation among different mouse strains: finding the best preclinical model for evaluating therapies directed against radiation-induced lung damage. Radiat Res 2011;175:510-18
  • Jackson IL, Xu P, Hadley C, et al. A preclinical rodent model of radiation-induced lung injury for medical countermeasure screening in accordance with the FDA animal rule. Health Phys 2012;103:463-73
  • Booth C, Tudor G, Tudor J, et al. Acute gastrointestinal syndrome in high-dose irradiated mice. Health Phys 2012;103:383-99
  • Strom JS. Health impacts from acute radiation exposure. Office of Security Affairs US Department of Energy under Contract DE-AC06-76RLO 1830. Pacific Northwest National Laboratory; Richland, Washington: 2003
  • International Commission on Radiological Protection. 1990 Recommendations of the International Commission on Radiological Protection. ICRP Publication No. 60 Pergamon Press; New York, NY: 1991
  • National Council on Radiation Protection and Measurements. Induction of Thyroid Cancer by Ionizing Radiation, NCRP Report No. 80. NCRP Publications; Bethesda, MD: 1985
  • Herodin F, Valente M, Abend M. Useful radiation dose biomarkers for early identification of partial-body exposures. Health Phys 2014;106:750-4
  • Reeves G. Overview of use of G-CSF and GM-CSF in the treatment of acute radiation injury. Health Phys 2014;106:699-703
  • Miyamoto K, Watanabe Y, Yukawa M, et al. Reconstruction of two victims’ posturing based on the induced radioactivities in their bones in the criticality accident in Tokai-Mura, Japan. Health Phys 2002;83:19-25
  • Da Silva FC, Hunt JG, Ramalho AT, Crispim VR. Dose reconstruction of a Brazilian industrial gamma radiography partial-body overexposure case. J Radiol Prot 2005;25:289-98
  • Croizat H, Frindel E, Tubiana M. Abscopal effect of irradiation on haemopoietic stem cells of shielded bone marrow–role of migration. Int J Radiat Biol Relat Stud Phys Chem Med 1976;30:347-58
  • Carsten AL, Noonan TR. Hematological effects of partial-body and whole-body X-irradiation in the rat. Radiat Res 1964;22:136-43
  • Scarantino CW, Rubin P, Constine LSIII. The paradoxes in patterns and mechanism of bone marrow regeneration after irradiation. 1. Different volumes and doses. Radiother Oncol 1984;2:215-25
  • Baltschukat K, Nothdurft W. Hematological effects of unilateral and bilateral exposures of dogs to 300-kVp X rays. Radiat Res 1990;123:7-16
  • Baltschukat K, Fliedner TM, Nothdurft W. Hematological effects in dogs after irradiation of the lower part of the body with a single myeloablative dose. Radiother Oncol 1989;14:239-46
  • Nothdurft W, Calvo W, Klinnert V, et al. Acute and long-term alterations in the granulocyte/macrophage progenitor cell (GM-CFC) compartment of dogs after partial-body irradiation: irradiation of the upper body with a single myeloablative dose. Int J Radiat Oncol Biol Phys 1986;12:949-57
  • Monroy RL, Skelly RR, Taylor P, et al. Recovery from severe hematopoietic suppression using recombinant human granulocyte-macrophage colony-stimulating factor. Exp Hematol 1988;16:344-8
  • MacVittie TJ, Farese AM, Bennett A, et al. The acute gastrointestinal subsyndrome of the acute radiation syndrome: a rhesus macaque model. Health Phys 2012;103:411-26
  • Dainiak N. Hematologic consequences of exposure to ionizing radiation. Exp Hematol 2002;30:513-28
  • Goans RE, Holloway EC, Berger ME, Ricks RC. Early dose assessment following severe radiation accidents. Health Phys 1997;72:513-18
  • Inoue T, Hirabayashi Y, Mitsui H, et al. Survival of spleen colony-forming units (CFU-S) of irradiated bone marrow cells in mice: evidence for the existence of a radioresistant subfraction. Exp Hematol 1995;23:1296-300
  • Gianni AM, Bregni M, Siena S, et al. Rapid and complete hemopoietic reconstitution following combined transplantation of autologous blood and bone marrow cells. A changing role for high dose chemo-radiotherapy? Hematol Oncol 1989;7:139-48
  • Laterveer L, Zijlmans JM, Liehl E, et al. Accelerated platelet reconstitution following transplantation of bone marrow cells derived from IL-6-treated donor mice. Ann Hematol 1996;73:239-45
  • Farese AM, Cohen MV, Katz BP, et al. A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management. Health Phys 2012;103:367-82
  • Withers HR, Elkind MM. Dose-survival characteristics of epithelial cells of mouse intestinal mucosa. Radiology 1968;91:998-1000
  • Denham JW, Hauer-Jensen M, Peters LJ. Is it time for a new formalism to categorize normal tissue radiation injury? Int J Radiat Oncol Biol Phys 2001;50:1105-6
  • Ch’ang HJ, Maj JG, Paris F, et al. ATM regulates target switching to escalating doses of radiation in the intestines. Nat Med 2005;11:484-90
  • Geraci JP, Jackson KL, Mariano MS. The intestinal radiation syndrome: sepsis and endotoxin. Radiat Res 1985;101:442-50
  • Carr KE. Effects of radiation damage on intestinal morphology. Int Rev Cytol 2001;208:1-119
  • Mason KA, Withers HR, McBride WH, et al. Comparison of the gastrointestinal syndrome after total-body or total-abdominal irradiation. Radiat Res 1989;117:480-8
  • Krimsky M, Dagan A, Aptekar L, et al. Assessment of intestinal permeability in rats by permeation of inulin-fluorescein. J Basic Clin Physiol Pharmacol 2000;11:143-53
  • Kobayashi T, Ohmori T, Yanai M, et al. The analysis of the defense mechanism against indigenous bacterial translocation in X-irradiated mice. Microbiol Immunol 1991;35:315-24
  • Lutgens LC, Blijlevens NM, Deutz NE, et al. Monitoring myeloablative therapy-induced small bowel toxicity by serum citrulline concentration: a comparison with sugar permeability tests. Cancer 2005;103:191-9
  • Lang IM, Sarna SK, Condon RE. Gastrointestinal motor correlates of vomiting in the dog: quantification and characterization as an independent phenomenon. Gastroenterology 1986;90:40-7
  • Dubois A, Jacobus JP, Grissom MP, et al. Altered gastric emptying and prevention of radiation-induced vomiting in dogs. Gastroenterology 1984;86:444-8
  • Danquechin Dorval E, Mueller GP, Eng RR, et al. Effect of ionizing radiation on gastric secretion and gastric motility in monkeys. Gastroenterology 1985;89:374-80
  • Makrauer FL, Oates E, Becker J, et al. Does local irradiation affect gastric emptying in humans? Am J Med Sci 1999;317:33-7
  • Otterson MF, Sarna SK, Moulder JE. Effects of fractionated doses of ionizing radiation on small intestinal motor activity. Gastroenterology 1988;95:1249-57
  • Otterson MF, Sarna SK, Leming SC, et al. Effects of fractionated doses of ionizing radiation on colonic motor activity. Am J Physiol 1992;263:G518-26
  • Travis EL. Organizational response of normal tissues to irradiation. Semin Radiat Oncol 2001;11:184-96
  • Marks LB, Yu X, Vujaskovic Z, et al. Radiation-induced lung injury. Semin Radiat Oncol 2003;13:333-45
  • Sharplin J, Franko AJ. A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases. Radiat Res 1989;119:15-31
  • Sharplin J, Franko AJ. A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase. Radiat Res 1989;119:1-14
  • McLaughlin RFJr, Tyler WS, Canada RO. Subgross pulmonary anatomy of the rabbit, rat, and guinea pig, with additional notes on the human lung. Am Rev Respir Dis 1966;94:380-7
  • Vujaskovic Z, Marks LB, Anscher MS. The physical parameters and molecular events associated with radiation-induced lung toxicity. Semin Radiat Oncol 2000;10:296-307
  • Haston CK, Zhou X, Gumbiner-Russo L, et al. Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis. Cancer Res 2002;62:3782-8
  • Epperly MW, Carpenter M, Agarwal A, et al. Intraoral manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) radioprotective gene therapy decreases ionizing irradiation-induced murine mucosal cell cycling and apoptosis. In Vivo 2004;18:401-10
  • Carpenter M, Epperly MW, Agarwal A, et al. Inhalation delivery of manganese superoxide dismutase-plasmid/liposomes protects the murine lung from irradiation damage. Gene Ther 2005;12:685-93
  • Chen L, Brizel DM, Rabbani ZN, et al. The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. Int J Radiat Oncol Biol Phys 2004;60:1520-9
  • Travis EL, Tucker SL. The relationship between functional assays of radiation response in the lung and target cell depletion. Br J Cancer Suppl 1986;7:304-19
  • Hopewell JW, Rezvani M, Moustafa HF. The pig as a model for the study of radiation effects on the lung. Int J Radiat Biol 2000;76:447-52
  • Mandel L, Travnicek J, Talafantova M, Zahradnickova M. The LD50/30 and the survival time in whole-body gamma-irradiated conventional and germfree Minnesota miniature piglets. Z Versuchstierkd 1980;22:96-100
  • Slauson DO, Hahn FF, Benjamin SA, et al. Inflammatory sequences in acute pulmonary radiation injury. Am J Pathol 1976;82:549-72
  • Garofalo M, Bennett A, Farese AM, et al. The delayed pulmonary syndrome following acute high-dose irradiation: a rhesus macaque model. Health Phys 2014;106:56-72
  • Adawi A, Zhang Y, Baggs R, et al. Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome. Am J Pathol 1998;152:651-7
  • Adawi A, Zhang Y, Baggs R, et al. Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. Clin Immunol Immunopathol 1998;89:222-30
  • Kaufman J, Sime PJ, Phipps RP. Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis. J Immunol 2004;172:1862-71
  • DiCarlo AL, Jackson IL, Shah JR, et al. Development and licensure of medical countermeasures to treat lung damage resulting from a radiological or nuclear incident. Radiat Res 2012;177:717-21
  • Peter RU. [Cutaneous radiation syndrome after accidental skin exposure to ionizing radiation]. Hautarzt 2013;64:894-903
  • Lataillade JJ, Doucet C, Bey E, et al. New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regen Med 2007;2:785-94
  • Bey E, Prat M, Duhamel P, et al. Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations. Wound Repair Regen 2010;18:50-8
  • Semont A, Francois S, Mouiseddine M, et al. Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury. Adv Exp Med Biol 2006;585:19-30
  • Abdel-Mageed AS, Senagore AJ, Pietryga DW, et al. Intravenous administration of mesenchymal stem cells genetically modified with extracellular superoxide dismutase improves survival in irradiated mice. Blood 2009;113:1201-3
  • Saha S, Bhanja P, Kabarriti R, et al. Bone marrow stromal cell transplantation mitigates radiation-induced gastrointestinal syndrome in mice. PLoS ONE 2011;6:e24072
  • Agay D, Scherthan H, Forcheron F, et al. Multipotent mesenchymal stem cell grafting to treat cutaneous radiation syndrome: development of a new minipig model. Exp Hematol 2010;38:945-56
  • Forcheron F, Agay D, Scherthan H, et al. Autologous adipocyte derived stem cells favour healing in a minipig model of cutaneous radiation syndrome. PLoS ONE 2012;7:e31694
  • Singh VK, Wise SY, Fatanmi OO, et al. Preclinical development of a bridging therapy for radiation casualties: appropriate for high risk personnel. Health Phys 2014;106:689-98
  • Singh VK, Wise SY, Fatanmi OO, et al. Progenitors mobilized by gamma-tocotrienol as an effective radiation countermeasure. PLoS ONE 2014;9:e114078
  • Lopez M, Martin M. Medical management of the acute radiation syndrome. Rep Pract Oncol Radiother 2011;16:138-46
  • Flanders KC, Sullivan CD, Fujii M, et al. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol 2002;160:1057-68
  • Shim S, Jang WS, Lee SJ, et al. Development of a new minipig model to study radiation-induced gastrointestinal syndrome and its application in clinical research. Radiat Res 2014;181:387-95
  • Lippincott SW, Wilson JD, Montour JL. Radiation effects on pig skin. Exposure to different densities of ionization. Arch Pathol 1975;99:105-10
  • Hopewell JW. The skin: its structure and response to ionizing radiation. Int J Radiat Biol 1990;57:751-73
  • King GL. Characterization of radiation-induced emesis in the ferret. Radiat Res 1988;114:599-612
  • Yu ZY, Li M, Han AR, et al. RhG-CSF improves radiation-induced myelosuppression and survival in the canine exposed to fission neutron irradiation. J Radiat Res 2011;52:472-80
  • MacVittie TJ, Monroy RL, Patchen ML, Souza LM. Therapeutic use of recombinant human G-CSF (rhG-CSF) in a canine model of sublethal and lethal whole-body irradiation. Int J Radiat Biol 1990;57:723-36
  • Herrera JL, Vigneulle RM, Gage T, et al. Effect of radiation and radioprotection on small intestinal function in canines. Dig Dis Sci 1995;40:211-18
  • MacVittie TJ, Farese AM, Jackson WIII. Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF. Health Phys 2005;89:546-55
  • Alpen EL. The historical background for large-animal studies with neutrons of various energies. Radiat Res 1991;128:S37-41
  • Summers RW, Flatt AJ, Prihoda MJ, Mitros FA. Effect of irradiation on morphology and motility of canine small intestine. Dig Dis Sci 1987;32:1402-10
  • Sanzari JK, Wan XS, Krigsfeld GS, et al. Effects of solar particle event proton radiation on parameters related to ferret emesis. Radiat Res 2013;180:166-76
  • King GL, Rabin BM, Weatherspoon JK. 5-HT3 receptor antagonists ameliorate emesis in the ferret evoked by neutron or proton radiation. Aviat Space Environ Med 1999;70:485-92
  • Martin C, Roman V, Agay D, Fatome M. Anti-emetic effect of ondansetron and granisetron after exposure to mixed neutron and gamma irradiation. Radiat Res 1998;149:631-6
  • Okayasu R, Suetomi K, Yu Y, et al. A deficiency in DNA repair and DNA-PKcs expression in the radiosensitive BALB/c mouse. Cancer Res 2000;60:4342-5
  • Fan S, Meng Q, Xu J, et al. DIM (3,3’-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proc Natl Acad Sci USA 2013;110:18650-5
  • Soligenix. 2014. Available from: http://www.soligenix.com/prod_def_sgx202.shtml [Last accessed 25 March 2014]
  • Georges GE, Kuver RP, Jordan R, et al. Post-exposure oral 17,21-beclomethasone dipropionate (BDP) improves survival in a canine gastrointestinal acute radiation syndrome (GI-ARS) model. 58th Annual Meeting of the Radiation Research Society. San Juan, PR; September 30 - October 3, 2012
  • Kouvaris JR, Kouloulias VE, Vlahos LJ. Amifostine: the first selective-target and broad-spectrum radioprotector. Oncologist 2007;12:738-47
  • Li M, Yu ZY, Xing S, et al. High dose granulocyte colony-stimulating factor enhances survival and hematopoietic reconstruction in canines irradiated by 2.3 Gy mixed fission neutron and gamma ray. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011;19:991-8
  • Moroni M, Lombardini E, Salber R, et al. Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal models. PLoS ONE 2011;6:e25210
  • Moroni M, Coolbaugh TV, Lombardini E, et al. Hematopoietic radiation syndrome in the Gottingen minipig. Radiat Res 2011;176:89-101
  • Moroni M, Ngudiankama BF, Christensen C, et al. The Gottingen minipig is a model of the hematopoietic acute radiation syndrome: G-colony stimulating factor stimulates hematopoiesis and enhances survival from lethal total-body gamma-irradiation. Int J Radiat Oncol Biol Phys 2013;86:986-92
  • Elliott TB, Deutz NE, Gulani J, et al. Gastrointestinal acute radiation syndrome in gottingen minipigs (Sus scrofa domestica). Comp Med 2014;64:456-63
  • Mahmud N, Pang W, Cobbs C, et al. Studies of the route of administration and role of conditioning with radiation on unrelated allogeneic mismatched mesenchymal stem cell engraftment in a nonhuman primate model. Exp Hematol 2004;32:494-501
  • Norol F, Drouet M, Mathieu J, et al. Ex vivo expanded mobilized peripheral blood CD34+ cells accelerate haematological recovery in a baboon model of autologous transplantation. Br J Haematol 2000;109:162-72
  • Patchen ML, MacVittie TJ, Solberg BD, Souza LM. Therapeutic administration of recombinant human granulocyte colony-stimulating factor accelerates hemopoietic regeneration and enhances survival in a murine model of radiation-induced myelosuppression. Int J Cell Cloning 1990;8:107-22
  • Farese AM, Brown CR, Smith CP, et al. The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent. Health Phys 2014;106:39-47
  • U.S. Food and Drug Administration. FDA Advisory Committee Briefing Document: a Joint Meeting of the Medical Imaging Drugs Advisory Committee and the Oncologic Drugs Advisory Committee. 2013. Available from: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/MedicalImagingDrugsAdvisoryCommittee/UCM350151.pdf [Last accessed 5 February 2014]
  • Farese AM, Cohen MV, Stead RB, et al. Pegfilgrastim administered in an abbreviated schedule, significantly improved neutrophil recovery after high-dose radiation-induced myelosuppression in rhesus macaques. Radiat Res 2012;178:403-13
  • Hankey KG, Farese AM, Gibbs AM, et al. Pegfilgrastim administration significantly improves survival in an LD50/60 model of totalbody irradiation (TBI) in nonhuman primates (NHP). 59th Annual Meeting of the Radiation Research Society; New Orleans, LA; September 14-18, 2013. p. 318
  • Farese AM, Williams DE, Seiler FR, MacVittie TJ. Combination protocols of cytokine therapy with interleukin-3 and granulocyte-macrophage colony-stimulating factor in a primate model of radiation-induced marrow aplasia. Blood 1993;82:3012-18
  • Neelis KJ, Hartong SC, Egeland T, et al. The efficacy of single-dose administration of thrombopoietin with coadministration of either granulocyte/macrophage or granulocyte colony-stimulating factor in myelosuppressed rhesus monkeys. Blood 1997;90:2565-73
  • Cleveland BioLabs, Inc. 2014. Available from: http://www.cbiolabs.com/ [Last accessed 10 September 2014]
  • Krivokrysenko VI, Shakhov AN, Singh VK, et al. Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure. J Pharmacol Exp Ther 2012;343:497-508
  • Gluzman-Poltorak Z, Mendonca SR, Vainstein V, et al. Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation. J Hematol Oncol 2014;7:31
  • Gluzman-Poltorak Z, Vainstein V, Basile LA. Recombinant interleukin-12, but not granulocyte-colony stimulating factor, improves survival in lethally irradiated nonhuman primates in the absence of supportive care: evidence for the development of a frontline radiation medical countermeasure. Am J Hematol 2014;89:868-73
  • Neumedicines. 2014. Available from: http://www.neumedicines.com/ [Last accessed 27 October 2014]
  • Pearlstein RD, Higuchi Y, Moldovan M, et al. Metalloporphyrin antioxidants ameliorate normal tissue radiation damage in rat brain. Int J Radiat Biol 2010;86:145-63
  • Zhang Y, Zhang X, Rabbani ZN, et al. Oxidative stress mediates radiation lung injury by inducing apoptosis. Int J Radiat Oncol Biol Phys 2012;83:740-8
  • Aeolus Pharmaceuticals. 2013. Available from: http://www.aeoluspharma.com/ [Last accessed 30 September 2013]
  • Batinic-Haberle I, Tovmasyan A, Roberts E, et al. SOD therapeutics: latest insights into their structure-activity relationships and impact upon the cellular redox-based pathways. Antioxid Redox Signal 2014;20:2372-415
  • Orrell RW. AEOL-10150 (Aeolus). Curr Opin Investig Drugs 2006;7:70-80
  • Garofalo MC, Ward AA, Farese AM, et al. A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage. Health Phys 2014;106:73-83
  • Stickney DR, Dowding C, Garsd A, et al. 5-androstenediol stimulates multilineage hematopoiesis in rhesus monkeys with radiation-induced myelosuppression. Int Immunopharmacol 2006;6:1706-13
  • Stickney DR, Dowding C, Authier S, et al. 5-androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression. Int Immunopharmacol 2007;7:500-5
  • Geary RS, Swynnerton NF, Miller MA, et al. Intraduodenal administration of ethiofos (WR-2721): dose proportionality study in the rhesus monkey. Res Commun Chem Pathol Pharmacol 1989;65:147-59
  • Davidson DE, Grenan MM, Sweeney TR. Biological Characteristics of some improved radioprotectors. In: Brady LW, editor. Radiation sensitizers, their use in the clinical management of cancer. Masson; New York: 1980. p. 309-20
  • Wasserman TH, Brizel DM. The role of amifostine as a radioprotector. Oncology (Williston Park) 2001;15:1349-54. discussion 57-60
  • MedImmune. 2013. Available from: http://www.medimmune.com/docs/default-source/pdfs/prescribing-information-for-amifostine.pdf [Last accessed 30 September 2013]
  • Seed TM, Inal CE, Singh VK. Radioprotection of hematopoietic progenitors by low dose amifostine prophylaxis. Int J Radiat Biol 2014;90:594-604
  • Culy CR, Spencer CM. Amifostine: an update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome. Drugs 2001;61:641-84
  • U.S. Food and Drug Administration. About the pandemic and all-hazards preparedness reauthorization act of 2013 (PAHPRA), emergency preparedness and response. 2014. Available from: http://www.fda.gov/emergencypreparedness/medicalcountermeasures/ucm346195.htm [Last accessed 15 February 2014]
  • Ahlem CN, White SK, Page TM, Frincke JM. Differential metabolism of androst-5-ene-3beta,17beta-diol between rats, canines, monkeys and humans. Steroids 2011;76:669-74
  • Yan Y, Ran X, Wei S. Changes of immune functions after radiation, burns and combined radiation-burn injury in rats. Chin Med Sci J 1995;10:85-9