Animal models in tuberculosis research – where is the beef?

Bibliography

• World Health Organization. Global tuberculosis report 2014. 2014. Available from: http://www.who.int/tb/publications/global_report/en/
   Google Scholar
• Riley RL. Airborne pulmonary tuberculosis. Bacteriol Rev 1961;25:243-8
   PubMedGoogle Scholar
• Jones-Lopez EC, Namugga O, Mumbowa F, et al. Cough aerosols of Mycobacterium tuberculosis predict new infection: A household contact study. Am J Respir Crit Care Med 2013;187:1007-15
   PubMed Web of Science ®Google Scholar
• O’Garra A, Redford PS, McNab FW, et al. The immune response in tuberculosis. Annu Rev Immunol 2013;31:475-527
   PubMed Web of Science ®Google Scholar
• Dara M, Acosta CD, Rusovich V, et al. Bacille calmette-guerin vaccination: The current situation in europe. Eur Respir J 2014;43:24-35
   PubMed Web of Science ®Google Scholar
• Roy A, Eisenhut M, Harris RJ, et al. Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis. BMJ 2014;349:g4643
   PubMed Web of Science ®Google Scholar
• Arbues A, Aguilo JI, Gonzalo-Asensio J, et al. Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials. Vaccine 2013;31:4867-73
   PubMed Web of Science ®Google Scholar
• Kaufmann SH, Cotton MF, Eisele B, et al. The BCG replacement vaccine VPM1002: From drawing board to clinical trial. Expert Rev Vaccines 2014;13:619-30
   PubMed Web of Science ®Google Scholar
• Reither K, Katsoulis L, Beattie T, et al. Safety and immunogenicity of H1/IC31(R), an adjuvanted TB subunit vaccine, in HIV-infected adults with CD4+ lymphocyte counts greater than 350 cells/mm3: A phase II, multi-centre, double-blind, randomized, placebo-controlled trial. PLoS ONE 2014;9:e114602
   PubMed Web of Science ®Google Scholar
• Kagina BM, Abel B, Scriba TJ, et al. Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus calmette-guerin vaccination of newborns. Am J Respir Crit Care Med 2010;182:1073-9
   PubMed Web of Science ®Google Scholar
• Andersen P, Kaufmann SH. Novel vaccination strategies against tuberculosis. Cold Spring Harb Perspect Med 2014;4. doi:10.1101/cshperspect.a018523
   Web of Science ®Google Scholar
• Kanesa-thasan N, Shaw A, Stoddard JJ, Vernon TM. Ensuring the optimal safety of licensed vaccines: A perspective of the vaccine research, development, and manufacturing companies. Pediatrics 2011;127(Suppl 1):S16-22
   PubMed Web of Science ®Google Scholar
• Esmail H, Barry CEIII, Young DB, Wilkinson RJ. The ongoing challenge of latent tuberculosis. Philos Trans R Soc Lond B Biol Sci 2014;369:20130437
   PubMed Web of Science ®Google Scholar
• Barry CEIII, Boshoff HI, Dartois V, et al. The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies. Nat Rev Microbiol 2009;7:845-55
   PubMed Web of Science ®Google Scholar
• Ramakrishnan L. Revisiting the role of the granuloma in tuberculosis. Nat Rev Immunol 2012;12:352-66
   PubMed Web of Science ®Google Scholar
• Philips JA, Ernst JD. Tuberculosis pathogenesis and immunity. Annu Rev Pathol 2012;7:353-84
   PubMed Web of Science ®Google Scholar
• Armstrong JA, Hart PD. Response of cultured macrophages to Mycobacterium tuberculosis, with observations on fusion of lysosomes with phagosomes. J Exp Med 1971;134:713-40
   PubMed Web of Science ®Google Scholar
• Divangahi M, Desjardins D, Nunes-Alves C, et al. Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis. Nat Immunol 2010;11:751-8
   PubMed Web of Science ®Google Scholar
• Martin CJ, Booty MG, Rosebrock TR, et al. Efferocytosis is an innate antibacterial mechanism. Cell Host Microbe 2012;12:289-300
   PubMed Web of Science ®Google Scholar
• Khan N, Vidyarthi A, Pahari S, Agrewala JN. Distinct strategies employed by dendritic cells and macrophages in restricting Mycobacterium tuberculosis infection: Different philosophies but same desire. Int Rev Immunol 2015. [Epub ahead of print]
   PubMedGoogle Scholar
• Cooper AM, Dalton DK, Stewart TA, et al. Disseminated tuberculosis in interferon gamma gene-disrupted mice. J Exp Med 1993;178:2243-7
   PubMed Web of Science ®Google Scholar
• Flynn JL, Chan J, Triebold KJ, et al. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection. J Exp Med 1993;178:2249-54
   PubMed Web of Science ®Google Scholar
• Chackerian AA, Perera TV, Behar SM. Gamma interferon-producing CD4+ T lymphocytes in the lung correlate with resistance to infection with Mycobacterium tuberculosis. Infect Immun 2001;69:2666-74
   PubMed Web of Science ®Google Scholar
• Sakai S, Mayer-Barber KD, Barber DL. Defining features of protective CD4 T cell responses to Mycobacterium tuberculosis. Curr Opin Immunol 2014;29:137-42
   PubMed Web of Science ®Google Scholar
• Derrick SC, Yabe IM, Yang A, Morris SL. Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells. Vaccine 2011;29:2902-9
   PubMed Web of Science ®Google Scholar
• Jasenosky LD, Scriba TJ, Hanekom WA, Goldfeld AE. T cells and adaptive immunity to Mycobacterium tuberculosis in humans. Immunol Rev 2015;264:74-87
   PubMed Web of Science ®Google Scholar
• Tameris MD, Hatherill M, Landry BS, et al. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: A randomised, placebo-controlled phase 2b trial. Lancet 2013;381:1021-8
   PubMed Web of Science ®Google Scholar
• Via LE, Lin PL, Ray SM, et al. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun 2008;76:2333-40
   PubMed Web of Science ®Google Scholar
• Tsai MC, Chakravarty S, Zhu G, et al. Characterization of the tuberculous granuloma in murine and human lungs: Cellular composition and relative tissue oxygen tension. Cell Microbiol 2006;8:218-32
   PubMed Web of Science ®Google Scholar
• Dharmadhikari AS, Nardell EA. What animal models teach humans about tuberculosis. Am J Respir Cell Mol Biol 2008;39:503-8
   PubMed Web of Science ®Google Scholar
• Kelly BP, Furney SK, Jessen MT, Orme IM. Low-dose aerosol infection model for testing drugs for efficacy against Mycobacterium tuberculosis. Antimicrob Agents Chemother 1996;40:2809-12
   PubMed Web of Science ®Google Scholar
• Bai X, Kim SH, Azam T, et al. IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages. J Immunol 2010;184:3830-40
   PubMed Web of Science ®Google Scholar
• Bai X, Shang S, Henao-Tamayo M, et al. Human IL-32 expression protects mice against a hypervirulent strain of Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2015;112:5111-16
   PubMed Web of Science ®Google Scholar
• Rhoades ER, Frank AA, Orme IM. Progression of chronic pulmonary tuberculosis in mice aerogenically infected with virulent Mycobacterium tuberculosis. Tuber Lung Dis 1997;78:57-66
   PubMedGoogle Scholar
• Orme IM, Basaraba RJ. The formation of the granuloma in tuberculosis infection. Semin Immunol 2014;26:601-9
   PubMed Web of Science ®Google Scholar
• McCune RMJr, Tompsett R. Fate of Mycobacterium tuberculosis in mouse tissues as determined by the microbial enumeration technique. I. the persistence of drug-susceptible tubercle bacilli in the tissues despite prolonged antimicrobial therapy. J Exp Med 1956;104:737-62
   PubMed Web of Science ®Google Scholar
• Pan H, Yan BS, Rojas M, et al. Ipr1 gene mediates innate immunity to tuberculosis. Nature 2005;434:767-72
   PubMed Web of Science ®Google Scholar
• Dutta NK, Illei PB, Jain SK, Karakousis PC. Characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice. Am J Pathol 2014;184:2045-55
   PubMed Web of Science ®Google Scholar
• Calderon VE, Valbuena G, Goez Y, et al. A humanized mouse model of tuberculosis. PLoS ONE 2013;8:e63331
   PubMed Web of Science ®Google Scholar
• Acosta A, Norazmi MN, Hernandez-Pando R, et al. The importance of animal models in tuberculosis vaccine development. Malays J Med Sci 2011;18:5-12
   PubMedGoogle Scholar
• Orme IM. Mouse and guinea pig models for testing new tuberculosis vaccines. Tuberculosis (Edinb) 2005;85:13-17
   PubMed Web of Science ®Google Scholar
• Franzblau SG, DeGroote MA, Cho SH, et al. Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis. Tuberculosis (Edinb) 2012;92:453-88
   PubMed Web of Science ®Google Scholar
• Young D. Animal models of tuberculosis. Eur J Immunol 2009;39:2011-14
   PubMed Web of Science ®Google Scholar
• Kaufmann SH. Koch’s dilemma revisited. Scand J Infect Dis 2001;33:5-8
   PubMed Web of Science ®Google Scholar
• Padilla-Carlin DJ, McMurray DN, Hickey AJ. The guinea pig as a model of infectious diseases. Comp Med 2008;58:324-40
   PubMed Web of Science ®Google Scholar
• Smith DW, McMurray DN, Wiegeshaus EH, et al. Host-parasite relationships in experimental airborne tuberculosis. IV. early events in the course of infection in vaccinated and nonvaccinated guinea pigs. Am Rev Respir Dis 1970;102:937-49
   PubMed Web of Science ®Google Scholar
• Dharmadhikari AS, Basaraba RJ, Van Der Walt ML, et al. Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis. Tuberculosis (Edinb) 2011;91:329-38
   PubMed Web of Science ®Google Scholar
• Tree JA, Smith S, Baker N, et al. Method for assessing IFN-gamma responses in guinea pigs during TB vaccine trials. Lett Appl Microbiol 2012;55:295-300
   PubMed Web of Science ®Google Scholar
• Baldwin SL, D’Souza C, Roberts AD, et al. Evaluation of new vaccines in the mouse and guinea pig model of tuberculosis. Infect Immun 1998;66:2951-9
   PubMed Web of Science ®Google Scholar
• Ordway DJ, Shanley CA, Caraway ML, et al. Evaluation of standard chemotherapy in the guinea pig model of tuberculosis. Antimicrob Agents Chemother 2010;54:1820-33
   PubMed Web of Science ®Google Scholar
• Shang S, Shanley CA, Caraway ML, et al. Drug treatment combined with BCG vaccination reduces disease reactivation in guinea pigs infected with Mycobacterium tuberculosis. Vaccine 2012;30:1572-82
   PubMed Web of Science ®Google Scholar
• Williams A, Goonetilleke NP, McShane H, et al. Boosting with poxviruses enhances mycobacterium bovis BCG efficacy against tuberculosis in guinea pigs. Infect Immun 2005;73:3814-16
   PubMed Web of Science ®Google Scholar
• Dirisala VR, Jeevan A, Ly LH, McMurray DN. Prokaryotic expression and in vitro functional analysis of IL-1beta and MCP-1 from guinea pig. Mol Biotechnol 2013;54:312-19
   PubMed Web of Science ®Google Scholar
• Lurie MB. The fate of human and bovine tubercle bacilli in various organs of the rabbit. J Exp Med 1928;48:155-82
   PubMedGoogle Scholar
• Manabe YC, Dannenberg AMJr, Tyagi SK, et al. Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis. Infect Immun 2003;71:6004-11
   PubMed Web of Science ®Google Scholar
• Mendez S, Hatem CL, Kesavan AK, et al. Susceptibility to tuberculosis: Composition of tuberculous granulomas in thorbecke and outbred new zealand white rabbits. Vet Immunol Immunopathol 2008;122:167-74
   PubMed Web of Science ®Google Scholar
• Dannenberg AMJr. Perspectives on clinical and preclinical testing of new tuberculosis vaccines. Clin Microbiol Rev 2010;23:781-94
   PubMed Web of Science ®Google Scholar
• Subbian S, Tsenova L, O’Brien P, et al. Spontaneous latency in a rabbit model of pulmonary tuberculosis. Am J Pathol 2012;181:1711-24
   PubMed Web of Science ®Google Scholar
• Lurie MB, Abramson S, Heppleston AG. On the response of genetically resistant and susceptible rabbits to the quantitative inhalation of human type tubercle bacilli and the nature of resistance to tuberculosis. J Exp Med 1952;95:119-34
   PubMed Web of Science ®Google Scholar
• Dorman SE, Hatem CL, Tyagi S, et al. Susceptibility to tuberculosis: Clues from studies with inbred and outbred new zealand white rabbits. Infect Immun 2004;72:1700-5
   PubMed Web of Science ®Google Scholar
• Subbian S, Bandyopadhyay N, Tsenova L, et al. Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits. Cell Commun Signal 2013;11:60
   PubMed Web of Science ®Google Scholar
• Liu X, Jia W, Wang H, et al. Establishment of a rabbit model of spinal tuberculosis using Mycobacterium tuberculosis strain H37Rv. Jpn J Infect Dis 2015;68:89-97
   PubMed Web of Science ®Google Scholar
• Gertz EM, Schaffer AA, Agarwala R, et al. Accuracy and coverage assessment of oryctolagus cuniculus (rabbit) genes encoding immunoglobulins in the whole genome sequence assembly (OryCun2.0) and localization of the IGH locus to chromosome 20. Immunogenetics 2013;65:749-62
   PubMed Web of Science ®Google Scholar
• Lerche NW, Yee JL, Capuano SV, Flynn JL. New approaches to tuberculosis surveillance in nonhuman primates. ILAR J 2008;49:170-8
   PubMed Web of Science ®Google Scholar
• Capuano SVIII, Croix DA, Pawar S, et al. Experimental Mycobacterium tuberculosis infection of cynomolgus macaques closely resembles the various manifestations of human M. tuberculosis infection. Infect Immun 2003;71:5831-44
   PubMed Web of Science ®Google Scholar
• Lin PL, Pawar S, Myers A, et al. Early events in Mycobacterium tuberculosis infection in cynomolgus macaques. Infect Immun 2006;74:3790-803
   PubMed Web of Science ®Google Scholar
• Lin PL, Rodgers M, Smith L, et al. Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infect Immun 2009;77:4631-42
   PubMed Web of Science ®Google Scholar
• Lin PL, Myers A, Smith L, et al. Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model. Arthritis Rheum 2010;62:340-50
   PubMed Web of Science ®Google Scholar
• McShane H, Williams A. A review of preclinical animal models utilised for TB vaccine evaluation in the context of recent human efficacy data. Tuberculosis (Edinb) 2014;94:105-10
   PubMed Web of Science ®Google Scholar
• Sharpe SA, McShane H, Dennis MJ, et al. Establishment of an aerosol challenge model of tuberculosis in rhesus macaques and an evaluation of endpoints for vaccine testing. Clin Vaccine Immunol 2010;17:1170-82
   PubMed Web of Science ®Google Scholar
• Via LE, Weiner DM, Schimel D, et al. Differential virulence and disease progression following Mycobacterium tuberculosis complex infection of the common marmoset (callithrix jacchus). Infect Immun 2013;81:2909-19
   PubMed Web of Science ®Google Scholar
• Palmer MV. Mycobacterium bovis: characteristics of wildlife reservoir hosts. Transbound Emerg Dis 2013;60(Suppl 1):1-13
   PubMed Web of Science ®Google Scholar
• Pesciaroli M, Alvarez J, Boniotti MB, et al. Tuberculosis in domestic animal species. Res Vet Sci 2014;97(Suppl):S78-85
   PubMed Web of Science ®Google Scholar
• Cassidy JP. The pathogenesis and pathology of bovine tuberculosis with insights from studies of tuberculosis in humans and laboratory animal models. Vet Microbiol 2006;112:151-61
   PubMed Web of Science ®Google Scholar
• Nol P, Palmer MV, Waters WR, et al. Efficacy of oral and parenteral routes of mycobacterium bovis bacille calmette-guerin vaccination against experimental bovine tuberculosis in white-tailed deer (odocoileus virginianus): A feasibility study. J Wildl Dis 2008;44:247-59
   PubMed Web of Science ®Google Scholar
• Corner LA, Buddle BM. Conjunctival vaccination of the brushtail possum (trichosurus vulpecula) with bacille calmette-guerin. N Z Vet J 2005;53:133-6
   PubMed Web of Science ®Google Scholar
• Pym AS, Brodin P, Brosch R, et al. Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines mycobacterium bovis BCG and mycobacterium microti. Mol Microbiol 2002;46:709-17
   PubMed Web of Science ®Google Scholar
• Thom ML, McAulay M, Vordermeier HM, et al. Duration of immunity against mycobacterium bovis following neonatal vaccination with bacillus calmette-guerin danish: Significant protection against infection at 12, but not 24, months. Clin Vaccine Immunol 2012;19:1254-60
   PubMed Web of Science ®Google Scholar
• Rizzi C, Bianco MV, Blanco FC, et al. Vaccination with a BCG strain overexpressing Ag85B protects cattle against mycobacterium bovis challenge. PLoS One 2012;7:e51396
   PubMed Web of Science ®Google Scholar
• Blanco FC, Bianco MV, Garbaccio S, et al. Mycobacterium bovis Deltamce2 double deletion mutant protects cattle against challenge with virulent M. bovis. Tuberculosis (Edinb) 2013;93:363-72
   PubMed Web of Science ®Google Scholar
• Gonzalez-Juarrero M, Bosco-Lauth A, Podell B, et al. Experimental aerosol mycobacterium bovis model of infection in goats. Tuberculosis (Edinb) 2013;93:558-64
   PubMed Web of Science ®Google Scholar
• Sanchez J, Tomas L, Ortega N, et al. Microscopical and immunological features of tuberculoid granulomata and cavitary pulmonary tuberculosis in naturally infected goats. J Comp Pathol 2011;145:107-17
   PubMed Web of Science ®Google Scholar
• Perez de Val B, Villarreal-Ramos B, Nofrarias M, et al. Goats primed with mycobacterium bovis BCG and boosted with a recombinant adenovirus expressing Ag85A show enhanced protection against tuberculosis. Clin Vaccine Immunol 2012;19:1339-47
   PubMed Web of Science ®Google Scholar
• Solomon JM, Leung GS, Isberg RR. Intracellular replication of mycobacterium marinum within dictyostelium discoideum: Efficient replication in the absence of host coronin. Infect Immun 2003;71:3578-86
   PubMed Web of Science ®Google Scholar
• Peracino B, Wagner C, Balest A, et al. Function and mechanism of action of dictyostelium Nramp1 (Slc11a1) in bacterial infection. Traffic 2006;7:22-38
   PubMed Web of Science ®Google Scholar
• Dionne MS, Ghori N, Schneider DS. Drosophila melanogaster is a genetically tractable model host for mycobacterium marinum. Infect Immun 2003;71:3540-50
   PubMed Web of Science ®Google Scholar
• Pozos TC, Ramakrishnan L. New models for the study of mycobacterium-host interactions. Curr Opin Immunol 2004;16:499-505
   PubMed Web of Science ®Google Scholar
• Stinear TP, Seemann T, Harrison PF, et al. Insights from the complete genome sequence of mycobacterium marinum on the evolution of Mycobacterium tuberculosis. Genome Res 2008;18:729-41
   PubMed Web of Science ®Google Scholar
• Swaim LE, Connolly LE, Volkman HE, et al. Mycobacterium marinum infection of adult zebrafish causes caseating granulomatous tuberculosis and is moderated by adaptive immunity. Infect Immun 2006;74:6108-17
   PubMed Web of Science ®Google Scholar
• Dionne MS, Pham LN, Shirasu-Hiza M, Schneider DS. Akt and FOXO dysregulation contribute to infection-induced wasting in drosophila. Curr Biol 2006;16:1977-85
   PubMed Web of Science ®Google Scholar
• Hagedorn M, Soldati T. Flotillin and RacH modulate the intracellular immunity of dictyostelium to mycobacterium marinum infection. Cell Microbiol 2007;9:2716-33
   PubMed Web of Science ®Google Scholar
• Hagedorn M, Rohde KH, Russell DG, Soldati T. Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts. Science 2009;323:1729-33
   Google Scholar
• Ramet M. The fruit fly drosophila melanogaster unfolds the secrets of innate immunity. Acta Paediatr 2012;101:900-5
   PubMed Web of Science ®Google Scholar
• Manzanillo PS, Ayres JS, Watson RO, et al. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature 2013;501:512-16
   PubMed Web of Science ®Google Scholar
• Lohi O, Parikka M, Ramet M. The zebrafish as a model for paediatric diseases. Acta Paediatr 2013;102:104-10
   PubMed Web of Science ®Google Scholar
• Meijer AH, Spaink HP. Host-pathogen interactions made transparent with the zebrafish model. Curr Drug Targets 2011;12:1000-17
   PubMed Web of Science ®Google Scholar
• Parikka M, Hammaren MM, Harjula SK, et al. Mycobacterium marinum causes a latent infection that can be reactivated by gamma irradiation in adult zebrafish. PLoS Pathog 2012;8:e1002944
   PubMed Web of Science ®Google Scholar
• Oksanen KE, Halfpenny NJ, Sherwood E, et al. An adult zebrafish model for preclinical tuberculosis vaccine development. Vaccine 2013;31:5202-9
   PubMed Web of Science ®Google Scholar
• Clay H, Davis JM, Beery D, et al. Dichotomous role of the macrophage in early mycobacterium marinum infection of the zebrafish. Cell Host Microbe 2007;2:29-39
   PubMed Web of Science ®Google Scholar
• Cambier CJ, Takaki KK, Larson RP, et al. Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. Nature 2014;505:218-22
   PubMed Web of Science ®Google Scholar
• Clay H, Volkman HE, Ramakrishnan L. Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Immunity 2008;29:283-94
   PubMed Web of Science ®Google Scholar
• Roca FJ, Ramakrishnan L. TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell 2013;153:521-34
   PubMed Web of Science ®Google Scholar
• Yang CT, Cambier CJ, Davis JM, et al. Neutrophils exert protection in the early tuberculous granuloma by oxidative killing of mycobacteria phagocytosed from infected macrophages. Cell Host Microbe 2012;12:301-12
   PubMed Web of Science ®Google Scholar
• Davis JM, Clay H, Lewis JL, et al. Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. Immunity 2002;17:693-702
   PubMed Web of Science ®Google Scholar
• Cosma CL, Humbert O, Ramakrishnan L. Superinfecting mycobacteria home to established tuberculous granulomas. Nat Immunol 2004;5:828-35
   PubMed Web of Science ®Google Scholar
• Davis JM, Ramakrishnan L. The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell 2009;136:37-49
   PubMed Web of Science ®Google Scholar
• Hammaren MM, Oksanen KE, Nisula HM, et al. Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog 2014;10:e1004190
   PubMed Web of Science ®Google Scholar
• van Meijgaarden KE, Haks MC, Caccamo N, et al. Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, mtb inhibitory phenotype and represent a novel human T-cell subset. PLoS Pathog 2015;11:e1004671
   PubMed Web of Science ®Google Scholar
• Adams KN, Takaki K, Connolly LE, et al. Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism. Cell 2011;145:39-53
   PubMed Web of Science ®Google Scholar
• Fitzgerald LE, Abendano N, Juste RA, Alonso-Hearn M. Three-dimensional in vitro models of granuloma to study bacteria-host interactions, drug-susceptibility, and resuscitation of dormant mycobacteria. Biomed Res Int 2014;2014:623856
   Web of Science ®Google Scholar
• Goonetilleke NP, McShane H, Hannan CM, et al. Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille calmette-guerin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus ankara. J Immunol 2003;171:1602-9
   PubMed Web of Science ®Google Scholar
• Sweeney KA, Dao DN, Goldberg MF, et al. A recombinant mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nat Med 2011;17:1261-8
   PubMed Web of Science ®Google Scholar
• Dutt AK, Moers D, Stead WW. Smear- and culture-negative pulmonary tuberculosis: Four-month short-course chemotherapy. Am Rev Respir Dis 1989;139:867-70
   PubMed Web of Science ®Google Scholar
• Adams KN, Szumowski JD, Ramakrishnan L. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis 2014;210:456-66
   PubMed Web of Science ®Google Scholar