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Editorial

Potential of agricultural fungicides for antifungal drug discovery

Bibliography

Papers of special note have been highlighted as either of interest (*) or of considerable interest (**) to readers.

* Important paper focused on utilization of fungal metabolites for drug design

  • Bladt TT, Frisvad JC, Knudsen PB, et al. Anticancer and antifungal compounds from Aspergillus, Penicillium and other filamentous fungi. Molecules. 2013;18:11338–11376.
  • Evidente A, Kornienko A, Cimmino A, et al. Fungal metabolites with anticancer activity. Nat Prod Rep. 2014;31:617–627.
  • Narayanan KB, Sakthivel N. Biological synthesis of metal nanoparticles by microbes. Adv Colloid Interface Sci. 2010;156:1–13.
  • Alghuthaymi MA, Almoammar H, Rai M, et al. Myconanoparticles: synthesis and their role in phytopathogens management. Biotechnol Biotechnol Equip. 2015;29:221–236.
  • De Lucca AJ. Harmful fungi in both agriculture and medicine. Rev Iberoam Micol. 2007;24:3–13.
  • Fisher MC, Henk DA, Briggs CJ, et al. Emerging fungal threats to animal, plant and ecosystem health. Nature. 2012;484:186–194.

* Interesting paper focused on fungal infections in relation to climate change

** Important paper focused on new mycoses

* Important paper focused on mycoses

** Important paper focused on antifungal agents

  • Calderone R, Fonzi W, Gay-Andrieu F, et al. Antifungals and antifungal drug discovery. In: Tegos G, Mylonakis E, editors. Antimicrobial drug discovery: emerging strategies. Oxfordshire (UK): CAB International; 2012. p. 247–264.

* Important chapter in book focused on antifungal drugs and their discovery

  • Antimicrobial resistance: global report on surveillance 2014. Cadman H, Martinez L, editors. Geneva (Switzerland): WHO; 2014.
  • Steinhilber D, Schubert-Zsilavecz M, Roth HJ. Antimykotika. In: Medizinische chemie: targets, arzneistoffe, chemische biologie. Stuttgart (Germany): Deutscher Apotheker Verlag; 2010. p. 574–585.

* Important chapter in book focused on antifungal drugs

** Important paper focused on new potential antifungal agents

* Important paper focused not only on new potential antifungal agents

** Contribution focused on actual classification, modes of actions and structures of agricultural fungicides

** Contribution focused on actual classification and modes of actions of agricultural fungicides

  • Prado-Prado FJ, Borges F, Perez-Montoto LG, et al. Multi-target spectral moment: QSAR for antifungal drugs vs. different fungi species. Eur J Med Chem. 2009;44:4051–4056.
  • Musiol R, Mrozek-Wilczkiewicz A, Polanski J. Synergy against fungal pathogens: working together is better than working alone. Curr Med Chem. 2014;21:870–893.

* Interesting paper focused on drug synergism against fungal pathogens

** Important paper focused on drug-herbicides relationships

  • Swanton CJ, Mashhadi HR, Solomon KR, et al. Similarities between the discovery and regulation of pharmaceuticals and pesticides: in support of a better understanding of the risks and benefits of each. Pest Manag Sci. 2011;67:790–797.
  • Witschel M, Rottmann M, Kaiser M, et al. Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. Plos Neglect Trop Dis. 2012;6:e1805. (10 pages).
  • Myung K, Klittich CJ. Can agricultural fungicides accelerate the discovery of human antifungal drugs? Drug Discov Today. 2015;20:7–10.

** Important paper focused on drug-fungicides relationships

  • Lipinski CA, Lombardo F, Dominy BW, et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 1997;23:3–25.
  • Carr RA, Congreve M, Murray CW, et al. Fragment-based lead discovery: leads by design. Drug Discov Today. 2005;10:987–992.
  • Abad-Zapatero C. Ligand efficiency indices for effective drug discovery. Expert Opin Drug Discov. 2007;2:469–488.

* Important paper focused on innovative drug discovery approaches

  • Walters WP. Going further than Lipinski’s rule in drug design. Expert Opin Drug Discov. 2012;7:99–107.
  • Briggs GG Predicting uptake and movement of agrochemicals from physical properties, Presentation at SCI meeting: Uptake of agrochemicals and pharmaceuticals; 1997 Dec 9; Belgrave Square, London (UK).
  • Tice CM. Selecting the right compounds for screening: does Lipinski’s rule of 5 for pharmaceuticals apply to agrochemicals? Pest Manag Sci. 2001;57:3–16.
  • Clarke ED, Delaney JS. Physical and molecular properties of agrochemicals: an analysis of screen inputs, hits, leads, and products. Chimia. 2003;57:731–734.

* Important paper focused on physicochemical properties of scaffolds of individual agrochemicals

* Important paper focused on properties of individual pesticides

* Important paper focused on quantitative structure-activity relationships of pesticides

* Important paper comparing leadlikeness with druglikeness

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