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Review

Managing locally advanced bladder cancer

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Pages 656-666 | Published online: 10 Jan 2014

References

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  • Khaled HM, Zaghloul MS, Ghoneim M et al. A randomized Phase III study of neoadjuvant chemotherapy for invasive bladder cancer with gemcitabine and cisplatin. Proc. Am. Soc. (lin. °neat (2002) (Abstract 2421). Leissner J, Hohenfellner R, Thuroff JW, Wolf HK Lymphadenectomy in patients with transitional cell carcinoma of the urinary bladder; significance for staging and prognosis. BJU Int. 85(7), 817–823 (2000). Important paper on the topic of extended versus limited regional lymphnode dissection Loehrer PJ Sr, Einhom LH, Elson PJ et al. A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine and doxorubicin in patients with metastatic urothelial carcinoma: a co-operative group study." (lin. Oncol 10(7), 1066–1073 (1992). Supports the role of MVAC as 'gold standard' during the early 1990s. Logothetis CJ, Dexeus FH, Finn Let al. A prospective randomized trial comparing MVAC and CISCA chemotherapy for patients with metastatic urothelial tumors. J. (lin. Oncol 8(6), 1050–1055 (1990). Supports the role of MVAC as 'gold standard' during the early 1990s. Logothetis CJ, Johnson DE, Chong C et al. Adjuvant cyclophospharnide, doxorubicin and cisplatin chemotherapy for bladder cancer: an update.' (lin. °neat 6(10), 1590–1596 (1988). Malmstrom PU, Rintala E, Wahlqvist R, Hellstrom P, Hellsten S, Hannisdal E. Five-year follow-up of a prospective trial of radical cystectomy and neoadjuvant chemotherapy: Nordic Cystectomy Trial I. The Nordic Co-operative Bladder Cancer Study Group. J. Urol. 155(6), 1903–1906 (1996).
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  • •Supports the role of MVAC as ‘gold Standard’ during the early 1990s.
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  • •Supports the role of MVAC as ‘gold standard’ during the early 1990s.
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  • •The only randomized trial systematically including adjuvant and neoadjuvant adjunctive chemotherapy to cystectomy.
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  • •Most iment Phase III trial supporting neoadjuvant chemotherapy prior to cystectomy (only published as abstract yet, but slide presentation downloadable at www.conference-castcotn/asco/vm 192001/ lectures/ frarne.asp?dir.Natale&slide.018cmax.27)
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  • ••Marks the beginning of effective systemiccombination chemotherapy for urothelial carcinoma and its widespread use.
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