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Review

Resected gastric cancer with D2 dissection: advances in adjuvant chemoradiotherapy and radiotherapy techniques

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References

  • Brenner H, Rothenbacher D, Arndt V. Epidemiology of stomach cancer. Methods Mol Biol 2009;472:467-77
  • Sung CM, Hsu CM, Hsu JT, et al. Predictive factors for lymph node metastasis in early gastric cancer. World J Gastroenterol 2010;16(41):5252-6
  • Gunderson LL, Sosin H. Adenocarcinoma of the stomach: areas of failure in a re-operation series (Second or symptomatic look) clinicopathoIogic correlation and implications for adjuvant therapy. Int J Radiat Oncol Biol Phys 1982;8(1):1-11
  • Landry J, Teooer JE, Wood WC, et al. Patterns of failure following curative resection of gastric carcinoma. Int J Radiat Oncol Biol Phys 1990;19(6):1357-62
  • Wisbeck WM, Becher EM, Russell AH. Adenocarcinoma of the stomach: autopsy observations with therapeutic implications for the radiation oncologist. Radiother Oncol 1986;7(1):13-18
  • Macdonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001;345(10):725-30
  • Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 2006;355(1):11-20
  • Songun I, Putter H, Kranenbarg EM, et al. Surgical treatment of gastric cancer: 15–year follow–up results of the randomised nationwide Dutch D1D2 trial. Lancet Oncol 2010;11(5):439-49
  • Degiuli M, Sasako M, Ponti A. Morbidity and mortality in the Italian Gastric Cancer Study Group randomized clinical trial of D1 versus D2 resection for gastric cancer. Br J Surg 2010;97(5):643-9
  • Wu CW, Hsiung CA, Lo SS, et al. Nodal dissection for patients with gastric cancer: a randomised controlled trial. Lancet Oncol 2006;7(4):309-15
  • Sakuramoto S, Sasako M, Yamaguchi T, et al. Adjuvant chemotherapy for gastric cancer with S–1, an oral fluoropyrimidine. N Engl J Med 2007;357(18):1810-20
  • Bang YJ, Kim YW, Yang HK, et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open–label, randomised controlled trial. Lancet 2012;379:315-21
  • Moertel CG, Childs DSJr, Reitemeier RJ, et al. Combined 5–fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet 1969;2:865-7
  • Dent DM, Werner ID, Novis B, et al. Prospective randomized trial of combined oncological therapy for gastric carcinoma. Cancer 1979;44(2):385-91
  • Moertel CG, Childs DS, O’Fallon JR, et al. Combined 5–fluorouracil and radiation therapy as a surgical adjuvant for poor prognosis gastric carcinoma. J Clin Oncol 1984;2(11):1249-54
  • Bleiberg H, Goffin JC, Dalesio O, et al. Adjuvant radiotherapy and chemotherapy in resectable gastric cancer. A randomized trial of the gastro-intestinal tract cancer cooperative group of the EORTC. Eur J Surg Oncol 1989;15(6):535-43
  • Smalley SR, Benedetti JK, Haller DG, et al. Updated analysis of SWOG–directed intergroup study 0116: a phase III trial of adjuvant radiochemotherapy versus observation after curative gastric cancer resection. J Clin Oncol 2012;30(19):2327-33
  • Kim S, Lim DH, Lee J, et al. An observational study suggesting clinical benefit for adjuvant postoperative chemoradiation in a population of over 500 cases after gastric resection with D2 nodal dissection for adenocarcinoma of the stomach. Int J Radiat Oncol Biol Phys 2005;63(5):1279-85
  • Chang JS, Lim JS, Noh SH, et al. Patterns of regional recurrence after curative D2 resection for stage III (N3) gastric cancer: implications for postoperative radiotherapy. Radiother Oncol 2012;104(3):367-73
  • Lim DH, Kim DY, Kang MK, et al. Patterns of failure in gastric carcinoma after D2 gastrectomy and chemoradiotherapy: a radiation oncologist’s view. Br J Cancer 2004;91(1):11-17
  • Li Q, Li G, Wang Y, et al. Lymph node status as predictive factor for selective adjuvant chemoradiation in patients with locally advanced gastric cancer with D2 dissection. Int J Radiat Oncol Biol Phys 2013;87(2):S299
  • Kwon HC, Kim MC, Kim KH, et al. Adjuvant chemoradiation versus chemotherapy in completely resected advanced gastric cancer with D2 nodal dissection. Asia–Pac J Clin Oncol 2010;6(4):278-85
  • Lee J, Lim do H, Kim S, et al. Phase III trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial. J Clin Oncol 2012;30(3):268-73
  • Zhu WG, Xua DF, Pu J, et al. A randomized, controlled, multicenter study comparing intensity–modulated radiotherapy plus concurrent chemotherapy with chemotherapy alone in gastric cancer patients with D2 resection. Radiother Oncol 2012;104(3):361-6
  • Kim TH, Park SR, Ryu KW, et al. Phase 3 trial of postoperative chemotherapy alone versus chemoradiation therapy in stage III–IV gastric cancer treated with R0 gastrectomy and D2 lymph node dissection. Int J Radiat Oncol Biol Phys 2012;84(5):e585-92
  • Yu C, Yu R, Zhu W, et al. Intensity-modulated radiotherapy combined with chemotherapy for the treatment of gastric cancer patients after standard D1/D2 surgery. J Cancer Res Clin Oncol 2012;138(2):255-9
  • Ychou M, Boige V, Pignon JP, et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. J Clin Oncol 2011;29(13):1715-21
  • Dikken JL, Jansen EP, Cats A, et al. Impact of the extent of surgery and postoperative chemoradiotherapy on recurrence patterns in gastric cancer. J Clin Oncol 2010;28(14):2430-6
  • Markelis R, Endzinas Z, Kiudelis M, et al. Adjuvant therapy after curative resection with D2 lymphadenectomy for gastric cancer: results of a prospective clinical trial. Medicina (Kaunas) 2009;45(6):460-8
  • Kilic L, Ordu C, Ekenel M, et al. Comparison of two different adjuvant treatment modalities for pN3 gastric cancer patients after D2 lymph node dissection: can we avoid radiotherapy in a subgroup of patients? Med Oncol 2013;30(3):660
  • Randomized Phase III Trial of Adjuvant Chemotherapy or Chemoradiotherapy in Resectable Gastric Cancer (CRITICS). Available from: https://clinicaltrials.gov/ct2/show/NCT00407186
  • Dikken JL, van Sandick JW, Maurits Swellengrebel HA, et al. Neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy for patients with resectable gastric cancer (CRITICS). BMC Cancer 2011;11:329
  • Smalley SR, Gunderson L, Tepper J, et al. Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implementation. Int J Radiat Oncol Biol Phys 2002;52(2):283-93
  • Chung HT, Shakespeare TP, Wynne CJ, et al. Evaluation of a radiotherapy protocol based on INT0116 for completely resected gastric adenocarcinoma. Int J Radiat Oncol Biol Phys 2004;59(5):1446-53
  • Baker GR. Localization: conventional and CT simulation. Br J Radiol 2006;79:S36-49
  • Verhey LJ. Comparison of three-dimensional conformal radiation therapy and intensity-modulated radiation therapy systems. Semin Radiat Oncol 1999;9(1):78-98
  • Leong T, Willis D, Joon DL, et al. 3D conformal radiotherapy for gastric cancer—results of a comparative planning study. Radiother Oncol 2005;74(3):301-6
  • Marcenaro M, Foppiano F, Durzu S, et al. Kidney–sparing radiotherapy by multiple-field three-dimensional technique in the postoperative management of patients with gastric cancer: comparison with standard two-field conformal technique. Tumori 2006;92(1):34-40
  • Soyfer V, Corn BW, Melamud A, et al. Three–dimensional non–coplanar conformal radiotherapy yields better results than traditional beam arrangements for adjuvant treatment of gastric cancer. Int J Radiat Oncol Biol Phys 2007;69(2):364-9
  • El-Hossiny HA, Diab NA, El-Taher MM. A comparative dosimetric study of adjuvant 3D conformal radiotherapy for operable stomach cancer versus AP-PA conventional radiotherapy in NCI-Cairo. J Egypt Natl Canc Inst 2009;21(3):197-202
  • Lohr F, Dobler B, Mai S, et al. Optimization of dose distributions for adjuvant locoregional radiotherapy of gastric cancer by IMRT. Strahlenther Onkol 2003;179(8):557-63
  • Wieland P, Dobler B, Mai S, et al. IMRT for postoperative treatment of gastric cancer: covering large target volumes in the upper abdomen: a comparison of a step–and–shoot and an arc therapy approach. Int J Radiat Oncol Biol Phys 2004;59(4):1236-44
  • Ringash J, Perkins G, Brierley J, et al. IMRT for adjuvant radiation in gastric cancer: a preferred plan? Int J Radiat Oncol Biol Phys 2005;63(3):732-8
  • Dahele M, Skinner M, Schultz B, et al. Adjuvant radiotherapy for gastric cancer: A dosimetric comparison of 3–dimensional conformal radiotherapy, tomotherapy and conventional intensity modulated radiotherapy treatment plans. Med Dosim 2010;35(2):115-21
  • Zhang Y, Zhu WG, Han JH, et al. Application of simplified intensity modulated radiation therapy in gastric cancer after operation. Zhong Hua Wei Chang Wai Ke Za Zhi 2013;16(3):268-72
  • Tang H, Luo JD, Lu XJ, et al. Dosimetry analysis of three kinds of radiation technique for postoperative gastric cancer. Adv Mater Res 2013; 641-642: 725–731
  • Ma H, Han J, Zhang T, Ke Y. Comparison of dosiology between three dimensional conformal and intensity–modulated radiotherapies (5 and 7 fields) in gastric cancer post–surgery. J Huazhong Univ Sci Technolog Med Sci 2013;33(5):759-64
  • Chung HT, Lee B, Park E, et al. Can all centers plan intensity–modulated radiotherapy (IMRT) effectively? An external audit of dosimetric comparisons between three–dimensional conformal radiotherapy and IMRT for adjuvant chemoradiation for gastric cancer. Int J Radiat Oncol Biol Phys 2008;71(4):1167-74
  • Bortfeld T. IMRT: a review and preview. Phys Med Biol 2006;51(13):R363-79
  • Wang JZ, Li XA, D’Souza WD, Stewart RD. Impact of prolonged fraction delivery times on tumor control: a note of caution for intensity–modulated radiation therapy (IMRT). Int J Radiat Oncol Biol Phys 2003;57(2):543-52
  • Teoh M, Clark CH, Wood K, et al. Volumetric modulated arc therapy: a review of current literature and clinical use in practice. Br J Radiol 2011;84:967-96
  • Palma DA, Verbakel WF, Otto K, Senan S. New developments in arc radiation therapy: a review. Cancer Treat Rev 2010;36(5):393-9
  • Fenwick JD, Tome WA, Soisson ET, et al. Tomotherapy and other innovative IMRT delivery systems. Semin Radiat Oncol 2006;16:199-208
  • Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys 2008;35:310-17
  • Wang X, Li G, Zhang Y, et al. Single–arc volumetric–modulated arc therapy (sVMAT) as adjuvant treatment for gastric cancer: Dosimetric comparisons with three–dimensional conformal radiotherapy (3D–CRT) and intensity–modulated radiotherapy (IMRT). Med Dosim 2013;38(4):395-400
  • Holt A, van Vliet-Vroegindeweij C, Mans A, et al. Volumetric–modulated arc therapy for stereotactic body radiotherapy of lung tumors: a comparison with intensity–modulated radiotherapy techniques. Int J Radiat Oncol Biol Phys 2011;81(5):1560-7
  • Guckenberger M, Richter A, Krieger T, et al. Is a single arc sufficient in volumetric–modulated arc therapy (VMAT) for complex–shaped target volumes? Radiother Oncol 2009;93(2):259-65
  • Bertelsen A, Hansen CR, Johansen J, Brink C. Single arc volumetric modulated arc therapy of head and neck cancer. Radiother Oncol 2010;95(2):142-8
  • Watanabe M, Isobe K, Takisima H, et al. Intrafractional gastric motion and interfractional stomach deformity during radiation therapy. Radiother Oncol 2008;87(3):425-31
  • Wysocka B, Kassam Z, Lockwood G, et al. Interfraction and respiratory organ motion during conformal radiotherapy in gastric cancer. Int J Radiat Oncol Biol Phys 2010;77(1):53-9
  • Watanabe M, Isobe K, Uno T, et al. Intrafractional gastric motion and interfractional stomach deformity using CT images. J Radiat Res 2011;52(5):660-5
  • Yamashita H, Okuma K, Takahashi W, et al. Four–dimensional measurement of the displacement of metal clips or postoperative surgical staples during 320–multislice computed tomography scanning of gastric cancer. Radiat Oncol 2012;7:137
  • Hu W, Ye J, Wang J, et al. Incorporating breath holding and image guidance in the adjuvant gastric cancer radiotherapy: a dosimetric study. Radiat Oncol 2012;7:98
  • Fukada J, Shigematsu N, Hanada T, et al. Inter–and intrafraction gastric motion study – impact of breathing and stomach filling. Int J Radiat Oncol Biol Phys 2012;84(3):S318
  • Fuss M, Salter BJ, Cavanaugh SX, et al. Daily ultrasound–based image–guided targeting for radiotherapy of upper abdominal malignancies. Int J Radiat Oncol Biol Phys 2004;59(4):1245-56
  • Boda–Heggemann J, Mennemeyer P, Wertz H, et al. Accuracy of ultrasound–based image guidance for daily positioning of the upper abdomen: an online comparison with cone beam CT. Int J Radiat Oncol Biol Phys 2009;74(3):892-7
  • van der Geld YG, Senan S, van Sörnsen de Koste JR, et al. A four–dimensional CT–based evaluation of techniques for gastric irradiation. Int J Radiat Oncol Biol Phys 2007;69(3):903-9
  • Hu W, Ye J, Wang J, et al. Implement of passive breath gating equipment for cone beam CT guided volumetric modulated radiation therapy in gastric cancer treatment: preliminary results. Int J Radiat Oncol Biol Phys 2012;84(3):S858
  • Ringash J, Khaksart SJ, Oza A, et al. Post–operative radiochemotherapy for gastric cancer: adoption and adaptation. Clin Oncol (R Coll Radiol) 2005;17(2):91-5
  • Ren H, Jin J, Li Y, et al. Preliminary results of ongoing Phase II study of postoperative intensity modulated radiation therapy (IMRT) combined with capecitabine for high–risk gastric cancer patients. Int J Radiat Oncol Biol Phys 2012;84(3):S315
  • Boda–Heggemann J, Hofheinz RD, Weiss C, et al. Combined adjuvant radiochemotherapy with IMRT/XELOX improves outcome with low renal toxicity in gastric cancer. Int J Radiat Oncol Biol Phys 2009;75(4):1187-95
  • Boda–Heggemann J, Weiss C, Schneider V, et al. Adjuvant IMRT/XELOX radiochemotherapy improves long–term overall– and disease–free survival in advanced gastric cancer. Strahlenther Onkol 2013;189(5):417-23
  • Minn AY, Hsu A, La T, et al. Comparison of intensity–modulated radiotherapy and 3–dimensional conformal radiotherapy as adjuvant therapy for gastric cancer. Cancer 2010;116(16):3943-52
  • Gordon MA, Gundacker HM, Benedetti J, et al. Assessment of HER2 gene amplification in adenocarcinomas of the stomach or gastroesophageal junction in the INT–0116/SWOG9008 clinical trial. Ann Oncol 2013;24(7):1754-61
  • Bell LA, Ryan KM. Life and death decisions by E2F–1. Cell Death Differ 2004;11(2):137-42
  • LaThangue NB. The yin and yang of E2F–1: balancing life and death. Nat Cell Biol 2003;5(7):587-9
  • Lee J, Park CK, Park JO, et al. Impact of E2F–1 expression on clinical outcome of gastric adenocarcinoma patients with adjuvant chemoradiation therapy. Clin Cancer Res 2008;14(1):82-8

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