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Review

Biology and treatment of ductal carcinoma in situ

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Pages 135-145 | Published online: 10 Jan 2014

References

  • Ernster EL, Barclay J, Kerlikowske K, Grady D, Henderson C. Incidence of and treatment for ductal carcinoma in situ of the breast. JAMA275, 913–918 (1996).
  • Burstein HJ, Polyak K, Wong JS, Lester SC, Kaelin CM. Ductal carcinoma in situ of the breast. N. Engl. J. Med.350, 1430–1441 (2004).
  • Broders AC. Carcinoma in situ contrasted with benign proliferating epithelium. JAMA99, 1670–1674 (1932).
  • Bloodgood JC. Comedo carcinoma (or comedo–adenocarcinoma) of the female breast. Presented at: American Association for Cancer Research, Toronto, Canada, 28 March 1934.
  • Eusebi V, Feudale E, Foschini MP et al. Long-term follow-up of in situ carcinoma of the breast. Semin. Diagn. Pathol.11(3), 223–235 (1994).
  • Betsill WL, Rosen PP, Lieberman PH, Robbins GF. Long-term follow-up after treatment by biopsy alone. JAMA239, 1863–1867 (1978).
  • Welch HG, Black WC. Using autopsy series to estimate the disease reservoir for ductal carcinoma in situ of the breast: how much breast cancer can we find? Ann. Intern. Med.127, 1023–1028 (1997).
  • Collins LC, Tamimi RM, Baer HJ, Connolly JL, Colditz GA, Schnitt SJ. Outcome of patient with ductal carcinoma in situ untreated after diagnostic biopsy. Cancer103(9), 1778–1784 (2005).
  • Ashikari R, Huvos A, Snyder R. Prospective study of non-infiltrating carcinoma of the breast. Cancer39, 435–439 (1977).
  • Cataliotti L, Distante V, Ciatto S et al. Intraductal breast cancer: review of 183 consecutive cases. Eur. J. Cancer28A, 917–920 (1992).
  • Gallagher WJ, Koerner FC, Wood WC. Treatment of intraductal carcinoma with limited surgery: long-term follow-up. J. Clin. Oncol.7(3), 376–380 (1989).
  • Longnecker MP, Bernstein L, Paganini-Hill A, Enger SM, Ross RK. Risk factors for in situ breast cancer. Cancer Epidemiol. Biomarkers Prev.5, 961–965 (1996).
  • Claus E, Stowe M, Carter D. Breast carcinoma in situ: risk factors and screening patterns. J. Natl Cancer Inst.93(23), 1811–1817 (2001).
  • Kerlikowske K, Barclay J, Grady D, Sickles EA, Ernster V. Comparison of risk factors for ductal carcinoma in situ and invasive breast cancer. J. Natl Cancer Inst.89(1), 76–82 (1997).
  • Amari M, Moriya T, Ishida T et al. Loss of heterozygosity analysis of asynchronous lesions of ductal carcinoma in situ and invasive ductal carcinoma of the human breast. Jpn. J. Clin. Oncol.33, 556–562 (2003).
  • Hwang ES, DeVries S, Chew KL et al. Patterns of chromosomal alterations in breast ductal carcinoma in situ. Clin. Cancer Res.10, 5160–5167 (2004).
  • Smeds J, Wärnberg F, Norberg T, Nordgren H, Holmberg L, Bergh J. Ductal carcinoma in situ of the breast with different histopathological grades and corresponding new breast tumour events: analysis of loss of heterozygosity. Acta Oncol.44, 41–49 (2005).
  • Claus EB, Petruzella S, Matloff E, Carter D. Prevalence of BRCA1 and BRCA2 mutations in women diagnosed with ductal carcinoma in situ. JAMA293, 964–969 (2005).
  • Bellamy CO, McDonald C, Salter DM, Chetty U, Anderson T. Non-invasive ductal carcinoma of the breast: the relevance of histological categorization. Hum. Pathol.24, 16–23 (1993).
  • Lennington WJ, Jensen RA, Dalton LW, Page DL. Ductal carcinoma in situ of the breast. Cancer73(1), 118–124 (1994).
  • Susnik B, Worth A, Palcic B, Poulin N, LeRiche J. Differences in quantitative nuclear features between ductal carcinoma in situ (DCIS) with and without accompanying invasive carcinoma in the surrounding breast. Anal. Cell. Pathol.8(1), 39–52 (1995).
  • Silverstein MJ, Poller DN, Waisman JR et al. Prognostic classification of ductal carcinoma in situ. Lancet345, 1154–1157 (1995).
  • Lagios MD, Page DL. Radiation therapy for in situ or localized breast cancer, N. Engl. J. Med.328, 1577–1578 (1993).
  • Silverstein MJ, Lagios MD, Craig PH et al. A prognostic index for ductal carcinoma in situ of the breast. Cancer77, 2267–2274 (1996).
  • Silverstein MJ, Buchanan C. Ductal carcinoma in situ: USC/Van Nuys Prognostic Index and the impact of margin status. Breast12, 457–471 (2003).
  • Vicini FA, Recht A. Age at diagnosis and outcome for women with ductal carcinoma in situ of the breast: a critical review of the literature. J. Clin. Oncol.20, 2736–2744 (2002).
  • Douglas-Jones AG, Gupta SK, Attanoos RL, Morgan JM, Mansel RE. A critical appraisal of six modern classifications of ductal carcinoma in situ of the breast (DCIS): correlation with grade of associated invasive carcinoma. Histopathology29, 397–409 (1996).
  • Warnberg F, Nordgren H, Bergh J, Holmberg L. Ductal carcinoma in situ of the breast from a population-defined cohort: an evaluation of new histopathologic classification systems. Eur. J. Cancer35(5), 7140–7120 (1999).
  • Holland R, Peterse JL, Millis RR et al. Ductal carcinoma in situ: a proposal for a new classification. Semin. Diagn. Path.11, 167–180 (1994).
  • AJCC Cancer Staging Manual (5th Edition). Fleming ID (Ed.). Lippincott-Raven, PA, USA (1997).
  • Silverstein MJ, Waisman JB, Gamagami P et al. Intraductal carcinoma of the breast (208 cases): clinical factors influencing treatment choice. Cancer66, 55–65 (1990).
  • De Mascarel I, MacGrogan G, Mathoulin-Pelissier S, Soubeyran I, Picot V, Coindre JM. Breast ductal carcinoma in situ with microinvasion. Cancer94(8), 2134–2142 (2002).
  • Adamovich TL, Simmons RM. Ductal carcinoma in situ with microinvasion. Am. J. Surg.186, 112–116 (2003).
  • Zhao YG, Xiao AZ, Park HI et al. Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion. Cancer Res.64, 590–598 (2004).
  • Hildenbrand R, Arens N. Protein and mRNA expression of uPAR and PAI-1 in myoepithelial cells of early breast cancer lesions and normal breast tissue. Br. J. Cancer91, 564–571 (2004).
  • Yunes MJ, Neuschatz AC, Bornstein LE, Naber SP, Band V, Wazer DE. Loss of expression of the putative tumor suppressor NES1 gene in biopsy-proven ductal carcinoma in situ predicts for invasive carcinoma at definitive surgery. Int. J. Rad. Oncol. Biol. Phys.56(3), 653–657 (2003).
  • Bock N, Meden H, Regenbrecht M, Jubemann B, Wangenin J, Marx P. Expression of the mismatch repair protein hMSH2 in carcinoma in situ and invasive cancer of the breast. AntiCancer Res.20, 119–124 (2000).
  • Teo NB, Shoker BS, Jarvis C, Sloane JP, Holcombe C. Angiogenesis and invasive recurrence in ductal carcinoma in situ of the breast. Eur. J. Cancer39, 38–44 (2003).
  • Guidi AJ, Schnitt SJ, Fischer L et al. Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast. Cancer80(10), 1943–1953 (1997).
  • Rice AJ, Steward MA, Quinn CM. Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast. J. Clin. Pathol.55, 921–925 (2002).
  • Wulfing P, Kersting C, Buerger H et al. Expression patterns of angiogenic and lymphangiogenic factors in ductal breast carcinoma in situ. Br. J. Cancer (92), 1720–1728 (2005).
  • Brown LF, Guidi AJ, Schnitt SJ et al. Vascular stroma formation in carcinoma in situ, invasive carcinoma and metastatic carcinoma of the breast. Clin. Cancer Res.5, 1041–1056 (1999).
  • Mommers EC, van Dienst PJ, Leonhart AM, Meijer CJ, Baak JP. Balance of cell proliferation and apoptosis in breast carcinogenesis. Breast Cancer Res. Treat.58, 163–169 (1999).
  • Gandhi A, Holland PA, Knox WF, Potten CS, Bundred NJ. Evidence of significant apoptosis in poorly differentiated ductal carcinoma in situ of the breast. Br. J. Cancer78(6), 788–794 (1998).
  • Shim JY, An HJ, Lee YH, Kim SK, Lee KP, Lee KS. Overexpression of cyclooxygenase-2 is associated with breast carcinoma and its poor prognostic factors. Mod. Pathol.16(12), 1199–1204 (2003).
  • Shim V, Gauthier ML, Sudilovsky D et al. Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium. Cancer Res.63, 2347–2350 (2003).
  • Barnes N, Haywood P, Flint P, Knox WF, Bundred NJ. Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. Br. J. Cancer94(2), 253–258 (2006).
  • Boland GP, Butt IS, Prasad R, Knox WF, Bundred NJ. COX-2 expression is associated with an aggressive phenotype in ductal carcinoma in situ. Br. J. Cancer90, 423–429 (2004).
  • Hawkins RA, Teasdale A, Ferguson WA, Going JJ. Estrogen receptor activity in intraduct and invasive breast carcinomas. Breast Cancer Res. Treat.9, 129–133 (1987).
  • Bur ME, Zimarowski MJ, Schnitt SJ et al. Estrogen receptor immunohistochemistry in carcinoma in situ of the breast. Cancer69, 1174–1181 (1992).
  • Pallis L, Wilking N, Cedermark B et al. Receptors for estrogen and progesterone in breast carcinoma in situ. AntiCancer Res.12, 2113–2115 (1992).
  • Poller DN, Snead DRJ, Roberts EC et al. Estrogen receptor expression in ductal carcinoma in situ of the breast: relationship to flow cytometric analysis of DNA and expression of c-erbB-2 oncoprotein. Br. J. Cancer68, 156–161 (1993).
  • Zafrani B, Leroyer A, Fourquet A et al. Mammographically-detected ductal in situ carcinoma of the breast analysed with a new classification. A study of 127 cases : correlation with estrogen and progesterone receptors, p53 and c-erbB-2 proteins, and proliferative activity. Semin. Diagn. Pathol.11, 208–214 (1994).
  • Leal CB, Schmitt FC, Bento MJ et al. Ductal carcinoma in situ of the breast. Cancer75, 2213–2231 (1995).
  • Warnberg F, Nordgren H, Bergkvist L, Holmberg L. Tumour markers in breast carcinoma correlate with grade rather than invasiveness. Br. J. Cancer85, 869–874 (2001).
  • Maxhimer JB, Pesce CE, Stewart RA, Gattuso P, Prinz RA, Xu X. Ductal carcinoma in situ of the breast and heparanase-1 expression: molecular explanation for more aggressive subtypes. J. Am. Coll. Surg.200(3), 328–335 (2005).
  • van de Vijver MJ, Petersee JL, Mooi WJ et al. Neu-protein overexpression in breast cancer. N. Engl. J. Med.319, 1239–1245 (1988).
  • Barnes DM, Meyer JS, Gonzalez JG et al. Relationship between c-erbB-2 immunoreactivity and thymidine labelling index. Breast Cancer Res. Treat.18, 11–17 (1991).
  • Hoque A, Sneige N, Sahn AA et al. Her-2/neu gene amplification in ductal carcinoma in situ of the breast. Cancer Epidemiol. Biomarkers Prev.11(6), 587–590 (2002).
  • Bauer RL, Eckhert KH, Nemoto T. Ductal carcinoma in situ-associated nipple discharge: a clinical marker for locally extensive disease. Ann. Surg. Oncol.5, 452–455 (1998).
  • Wang HH, Ducatman BS, Eick D. Comparative features of ductal carcinoma in situ and infiltrating ductal carcinoma of the breast on fine-needle aspiration biopsy. Am. J. Clin. Pathol.92, 736–740 (1989).
  • Reis-Filho JS, Malanezi F, Amendoeira I, Albergarias A, Schmidt FC. P63 staining of myoepithelial cells in breast fine needle aspirates: a study of its role in differentiating in situ from invasive ductal carcinomas of the breast. J. Clin. Pathol.55, 936–939 (2002).
  • Dillon MF, Quinn CM, McDermott EW, O’Doherty A, O’Higgins N, Hill AD. Diagnostic accuracy of core biopsy for ductal carcinoma in situ and its implications for surgical practice. J. Clin. Pathol.59(7), 740–743 (2006).
  • Stomper PC, Connolly JL, Meyer JE, Harris JR. Clinically occult ductal carcinoma in situ detected by mammography: analysis of 100 cases with radiologic-pathologic correlation. Radiology172, 235–241 (1989).
  • Holland R, Hendriks JHCL, Verbeek ALM, Mravunac M, Schuurmans Stekhoven JH. Extent, distribution, and mammographic/histological correlations of breast ductal carcinoma in situ. Lancet335, 519–522 (1990).
  • Drew PJ, Chatterjee S, Turnbull LW et al. Dynamic contrast enhanced magnetic resonance imaging of the breast is superior to triple assessment for the preoperative detection of multifocal breast cancer. Ann. Surg. Oncol.6, 599–603 (1999).
  • Boetes C, Strijk SP, Holland R, Barentsz JO, van der Sluis RT, Ruiss JH. False-negative MR imaging of malignant breast tumors. Eur. Radiol.7(8), 1231–1234 (1997).
  • Neubauer H, Mengxia Li, Kuehne-Heid R, Schneider A, Kaiser WA. High grade and non-high grade ductal carcinoma in situ on dynamic MR mammography: characteristic findings for signal increase and morphological pattern of enhancement. Br. J. Radiol.76, 3–12 (2003).
  • Silverstein MJ, Barth A, Poller DN et al. Ten year results comparing mastectomy to excision and radiation therapy for ductal carcinoma in situ of the breast. Eur. J. Cancer31, 1425–1427 (1995).
  • Veronesi U, Saccozzi R, Del Vecchio et al. Comparing radical mastectomy with quadrantectomy, axillary dissection and radiation therapy in patients with small cancers of the breast. N. Engl. J. Med.305, 6–11 (1981).
  • Fisher B, Anderson S, Redmond CK, Wolmark N, Wickerham DL, Cronin WM. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N. Engl. J. Med.333, 1456–1461 (1995).
  • Mokbel K, Choy C, Leris C et al. Predictors of positive margins after local excision of ductal carcinoma in situ. Am. J. Surg.181, 91–95 (2001).
  • Chan KC, Knox WF, Sinha G et al. Extent of excision margin width required in breast conserving surgery for ductal carcinoma in situ. Cancer91(1), 9–16 (2001).
  • Cheng L, Al-Kaisi NK, Gordon NH, Liu AY, Gebrail F, Shenk RR. Relationship between the size and margin status of ductal carcinoma in situ of the breast and residual disease. J. Natl Cancer Inst.89(18), 1356–1360 (1997).
  • Holland PA, Gandhi A, Knox WF et al. The importance of complete excision in the prevention of local recurrence of ductal carcinoma in situ. Br. J. Cancer77(1), 110–114 (1998).
  • Trisal V, Qian D, Wagman LD. Axillary recurrence in DCIS: is axillary lymphadenectomy warranted? Am. Surg.70(10), 876–880 (2004).
  • Zavagno G, Carcoforo P, Marconato R et al. Role of axillary sentinel lymph node biopsy in patients with pure ductal carcinoma in situ of the breast. BMC Cancer5, 28 (2005).
  • Goyal A, Douglas-Jones A, Monypenny I, Sweetland H, Stevens G, Mansel RE. Is there a role of sentinel lymph node biopsy in ductal carcinoma in situ?: analysis of 587 cases. Breast Cancer Res. Treat.98(3), 311–314 (2006).
  • Lara JF, Young SM, Velilla RE, Santoro EJ, Templeton SF. The relevance of occult axillary micrometastases in ductal carcinoma in situ. A clinicopathologic study with long-term follow-up. Cancer98(10), 2105–2113 (2003).
  • Wong JS, Kaelin CM, Troyan SL et al. Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J. Clin. Oncol.24(7), 1031–1036 (2006).
  • Fisher B, Dignam J, Wolmark N et al. Lumpectomy and radiation therapy for the treatment of intraductal breast cancer: findings from the National Surgical Adjuvant Breast and Bowel Project B-17. J. Clin. Oncol.16(2), 441–452 (1998).
  • Fisher B, Costantino J, Redmond C et al. Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer. N. Engl. J. Med.328(22), 1581–1586 (2003).
  • Julien J-P, Bijker N, Fentiman IS et al. Radiotherapy in breast-conserving treatment for ductal carcinoma in situ: first results of EORTC randomized Phase III trial 10853. Lancet355, 528–533 (2000).
  • Bijker N, Peterse JL, Duchateau L et al. Risk factors for recurrence and metastases after breast-conserving therapy for ductal carcinoma-in situ: analysis of European Organization for Research and Treatment of Cancer Trial 10853. J. Clin. Oncol.19(8), 2263–2271 (2001).
  • Houghton J, George WD, Cuzick J, Duggan C, Fentiman IS, Spittle M. Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia and New Zealand: randomized controlled trial. Lancet362(9378), 95–102 (2003).
  • Emdin SO, Granstrand B, Ringberg A et al. Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening. Acta Oncol.45, 536–543 (2006).
  • Ceilley E, Jagsi R, Goldberg S, Kachnic L, Powell S, Taghian A. The management of ductal carcinoma in situ in North America and Europe. Cancer101(9), 1958–1967 (2004).
  • Fisher B, Costantino J, Redmond C et al. Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomized controlled trial. Lancet353, 1993–2000 (1999).
  • Kestin LL, Goldstein NS, Martinez AA et al. Factors associated with local recurrence of mammographically detected ductal carcinoma in situ in patients given breast-conserving therapy. Cancer88(3), 596–607 (2000).
  • Boland GP, Chan KC, Knox WF, Roberts SA, Bundred NJ. Value of the Van Nuys Prognostic Index in prediction of recurrence of ductal carcinoma in situ after breast conserving surgery. Br. J. Surg.90, 426–432 (2003).
  • Li CI, Malone KE, Saltzman BS, Daling JR. Risk of invasive breast cancer among women diagnosed with ductal carcinoma in situ and lobular carcinoma in situ, 1988–2001. Cancer106(10), 2104–2112 (2006).
  • Fisher E, Dignam J, Tan-Chiu E et al. Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight-year update of Protocol B-17. Cancer86(3), 429–438 (1999).
  • Gupta SK, Douglas-Jones AG, Fenn N, Morgan JM, Mansel RE. The clinical behaviour of breast carcinoma is probably determined at the pre-invasive stage (ductal carcinoma in situ). Cancer80(9), 1740–1745 (1997).
  • Bijker N, Peterse JL, Duchateau L et al. Histological type and marker expression of the primary tumor compared with its local recurrence after breast conserving surgery for ductal carcinoma in situ. Br. J. Cancer84(4), 539–544 (2001).
  • Romero L, Ye W, Holmes D et al. Outcome after invasive recurrence in patients with ductal carcinoma in situ of the breast. Am. J. Surg.188, 371–376 (2004).
  • Habel LA, Dignam JJ, Land SR et al. Mammographic density and breast cancer after ductal carcinoma in situ. J. Natl Cancer Inst.96(19), 1467–1472 (2004).
  • Roka S, Rudas M, Taucher S et al. High nuclear grade and negative estrogen receptor are significant risk factors for recurrence in DCIS. Eur. J. Surg. Oncol.30(3), 243–247 (2004).
  • Cornfield DB, Palazzo JP, Schwartz GF et al. The prognostic significance of multiple morphologic features and biologic markers in ductal carcinoma in situ of the breast. Cancer100(11), 2317–2327 (2004).
  • Kerlikowske K, Molinari A, Cha I et al. Characteristics associated with recurrence among women with ductal carcinoma in situ treated by lumpectomy. J. Natl Cancer Inst.95(22), 1692–1702 (2003).
  • Ringberg A, Idvall I, Ferno M et al. Ipsilateral local recurrence in relation to therapy and morphological characteristics in patients with ductal carcinoma in situ of the breast. Eur. J. Surg. Oncol.26, 444–451 (2000).
  • Baxter NN, Virnig BA, Durham SB, Tuttle TM. Trends in the treatment of ductal carcinoma in situ of the breast. J. Natl Cancer Inst.96(6), 443–448 (2004).
  • Recht A, Rutgers EJ, Fentiman IS, Kurtz JM, Mansel RE, Sloane JP. The Fourth EORTC DCIS Consensus Meeting Conference Report. Eur. J. Cancer34(11), 1664–1669 (1998).
  • Schwartz GF, Solin LJ, Olivotto IA, Ernster VL, Pressman P. The Consensus Conference on the treatment of in situ ductal carcinoma of the breast, 22–15 April 1999. Breast9, 177–186 (2000).
  • Bijker N, Peterse JL, Fentiman IS, Julien JP, Hart AAM, Avril A. Effects of patient selection on the applicability of results from a randomized clinical trial (EORTC 10853) investigating breast-conserving therapy for DCIS. Br. J. Cancer87, 615–620 (2002).
  • White V, Pruden M, Giles G et al. Changes in the management of ductal carcinoma in situ before the release of clinical practice recommendations in Australia: the case in Victoria. ANZ J. Surg.76, 28–34 (2006).
  • Katz SJ, Lantz PM, Janz NK et al. Patterns and correlates of local therapy for women with ductal carcinoma-in-situ. J. Clin. Oncol.23(13), 3001–3007 (2005).
  • Khan SA, Wolfman JA, Segal L et al. Ductal lavage findings in women with known breast cancer undergoing mastectomy. J. Natl Cancer Inst.96(20), 1510–1517 (2004).
  • Al Sarakbi W, Salhab M, Mokbel K. Does mammary ductoscopy have a role in clinical practice? Int. Semin. Surg. Oncol.3, 16 (2006).
  • Matsunanga T, Kawakami Y, Namba K, Fujii M. Intraductal biopsy for diagnosis and treatment of intraductal lesions of the breast. Cancer101(10) 2164–2169 (2004).
  • Giardina C, Guerrieri AM, Ingravallo G et al. The stereotaxic core breast biopsy using the Mammotome: an alternative to intraoperative examination. Pathologica94, 182–189 (2002).
  • Singletary SE, Atkinson EN, Hoque A et al. Phase II clinical trial of N-(4-hydroxyphenyl)retinamide and tamoxifen administration before definitive surgery for breast neoplasia. Clin. Cancer Res.8(9), 2835–2842 (2002).

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