148
Views
42
CrossRef citations to date
0
Altmetric
Drug Profile

Bevacizumab in the management of solid tumors

&
Pages 433-445 | Published online: 10 Jan 2014

References

  • Risau W, Lemmon V. Changes in the vascular extracellular matrix during embryonic vasculogenesis and angiogenesis. Dev. Biol.125(2), 441–450 (1988).
  • Risau W, Sariola H, Zerwes HG et al. Vasculogenesis and angiogenesis in embryonic-stem-cell-derived embryoid bodies. Development102(3), 471–478 (1988).
  • Ferrara N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am. J. Physiol. Cell Physiol.280(6), C1358–C1366 (2001).
  • Shweiki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature359, 843–845 (1992).
  • Banai S, Shweiki D, Pinson A, Chandra M, Lazarovici G, Keshet E. Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis. Cardiovasc. Res.28, 1176–1179 (1994).
  • Taylor P. VEGF and imaging of vessels in rheumatoid arthritis. Arthritis Res.4(Suppl. 3), S99–S107 (2002).
  • Paleolog E. Angiogenesis in rheumatoid arthritis. Arthritis Res.4(Suppl. 3), S81–S90 (2002).
  • Witmer AN, Vrensen GFJM, Van Noorden CJF, Schlingemann RO. Vascular endothelial growth factors and angiogenesis in eye disease. Prog. Retinal Eye Res.22(1), 1–29 (2003).
  • Folkman J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med.285, 1182–1186 (1971).
  • Folkman J, Klagsbrun M. Angiogenic factors. Science235, 442–447 (1987).
  • Folkman J. What is the evidence that tumors are angiogenesis dependent? J. Natl Cancer Inst.82, 4–6 (1991).
  • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr. Rev.18, 4–25 (1997).
  • Folkman J, Shing Y. Angiogenesis. J. Biol. Chem.267, 10931–10934 (1992).
  • Klagsbrun M, D’Amore PA. Regulators of angiogenesis. Ann. Rev. Physiol.53, 217–239 (1991).
  • Choong PF, Nadesapillai AP. Urokinase plasminogen activator system: a multifunctional role in tumor progression and metastasis. Clin. Orthop. (Suppl. 415), S46–S58 (2003).
  • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol.20, 4368–4380 (2002).
  • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol.23, 1011–1027 (2005).
  • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science246, 1306–1309 (1989).
  • Keck PJ, Sauser SD, Krivi G et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science246, 1309–1312 (1989).
  • Alon T, Hemo I, Itin A et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat. Med.1, 1024–1028 (1995).
  • Shweiki D, Itin A, Soffer D et al. Vascular endothelial cell growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature359, 843–845 (1992).
  • Neufeld G, Cohen T, Gengrinovitch S et al. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J.13, 9–22 (1999).
  • Poon RT, Fan ST, Wong J. Clinical implications of circulating angiogenic factors in cancer patients. J. Clin. Oncol.19, 1207–1225 (2001).
  • Tsai JC, Goldman CK, Gillespie GY. Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J. Neurosurg.82, 864–873 (1995).
  • Akagi Y, Liu W, Xie K et al. Regulation of vascular endothelial growth factor expression in human colon cancer by interleukin-1β. Br. J. Cancer80, 1506–1511 (1999).
  • Potapova O, Fakhrai H, Baird S et al. Platelet-derived growth factor-B/v-sis confers a tumorigenic and metastatic phenotype to human T98G glioblastoma cells. Cancer Res.56, 280–286 (1996).
  • Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol.5, 1806–1814 (1991).
  • Tischer E, Mitchell R, Hartman T et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem.266, 11947–11954 (1991).
  • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev.25, 581–611 (2004).
  • Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem.267, 26031–26037 (1992).
  • Park JE, Keller GA, Ferrara N. The vascular endothelial growth factor isoforms (VEGF): differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell4, 1317–1326 (1993).
  • Park JE, Chen HH, Winer J, Houck KA, Ferrara N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem.269, 25646–25654 (1994).
  • Weidner N, Semple JP, Welch WR et al. Tumor angiogenesis and metastasis – correlation in invasive breast carcinoma. N. Engl. J. Med.324, 1–8 (1991).
  • Gabrilovich D, Ishida T, Oyama T et al. vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo. Blood92, 4150–4166 (1998).
  • Mechtcheriakova D, Schabbauer G, Lucerna M et al. Specificity, diversity, and convergence in VEGF and TNF-α signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells. FASEB J.15, 230–242 (2001).
  • Barleon B, Sozzani S, Zhou D et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood87, 3336–3343 (1996).
  • Pekala P, Marlow M, Heuvelman D et al. Regulation of hexose transport in aortic endothelial cells by vascular permeability factor and tumor necrosis factor-α, but not by insulin. J. Biol. Chem.265, 18051–18054 (1990).
  • Roberts WG, Palade GE. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J. Cell Sci.108, 2369–2379 (1995).
  • Margolin K, Gordon MS, Holmgren E et al. Phase Ib trial of recombinant humanized monoclonal antibody to vascular endothelial growth factor in combination with chemotherapy in patients with advanced cancer: pharmacologic and long-term safety data. J. Clin. Oncol.19, 851–856 (2001).
  • Borgstrom P, Gold DP, Hillan KJ et al. Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res.19, 4203–4214 (1999).
  • Kendall RL, Wang G, Thomas KA. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem. Biophys. Res. Commun.226, 324–328 (1996).
  • Lin P, Sankar S, Shan S et al. Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ.9, 49–58 (1998).
  • Fairbrother WJ, Christinger HW, Cochran AG et al. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site. Biochemistry37, 17754–17764 (1998).
  • Laird AD, Vajkoczy P, Shawver LK et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res.60, 4152–4160 (2000).
  • Mendel DB, Laird AD, Smolich BD et al. Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anticancer Drug Des.15, 29–41 (2000).
  • Fong TA, Shawyer LK, Sun L et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res.59, 99–106 (1999).
  • Vajkoczy P, Menger MD, Vollmar B et al. Inhibition of tumor growth, angiogenesis, and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy. Neoplasia1, 31–41 (1999).
  • Wedge SR, Ogilvie DJ, Dukes M et al. ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad spectrum antitumor efficacy. Cancer Res.60, 970–975 (2000).
  • Presta LG, Chen H, O’Connor SJ et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res.57, 4593–4599 (1997).
  • Lin YS, Nguyen C, Mendoza JL et al. Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor. J. Pharmacol. Exp. Ther.288, 371–378 (1999).
  • Data on file. South San Francisco, CA, Genentech Inc. (2002).
  • Gordon MS, Margolin K, Talpaz M et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J. Clin. Oncol.19, 843 (2001).
  • Avastin®, package insert. Genentech Inc., CA, USA (2006).
  • Yang JC, Haworth L, Sherry RM et al. A randomized trial of bevacizumab, an anti–vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl. J. Med.349, 427–434 (2003).
  • Johnson DH, Fehrenbacher L, Novotny WF et al. Randomized Phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J. Clin. Oncol.22(11), 2184–2191 (2004).
  • Tong RT, Boucher Y, Kozin SV et al. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res.64, 3731–3736 (2004).
  • Cobleigh MA, Langmuir VK, Sledge GW et al. A Phase I/II dose-escalation trial of bevacizumab in previously treated metastatic breast cancer. Semin. Oncol.30(Suppl. 16), 117–124 (2003).
  • Bergsland E, Dickler M. Maximizing the potential of bevacizumab in cancer treatment. Oncologist9(Suppl. 1), 36–42 (2004).
  • Kabbinavar F, Hurwitz H, Fehrenbacher L et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J. Clin. Oncol.21, 60–65 (2003).
  • Kabbinavar F, Schulz J, McCleod M et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized Phase II Trial. J. Clin. Oncol.23, 3697–3705 (2005).
  • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med.350, 2335–2342 (2004).
  • Giantonio BJ, Catalano PJ, Meropol NJ et al. High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: results from the Eastern Cooperative Oncology Group (ECOG) study E3200. J. Clin. Oncol.23(Suppl. Pt 1), S16 (2005).
  • Gordon MS, Cunningham D. Managing patients treated with bevacizumab combination therapy. Oncology69(Suppl. 3), 25–33 (2005).
  • Skillings RJ, Johnson HD, Miller K et al. Arterial thromboembolic events (ATEs) in a pooled analysis of 5 randomized, controlled trials (RCTs) of bevacizumab (BV) with chemotherapy. Proc. Am. Soc. Clin. Oncol. (2005) (Abstract 3019).
  • Ellis LM, Curley SA, Grothey A. Surgical resection after downsizing of colorectal liver metastasis in the era of bevacizumab. J. Clin. Oncol.23, 4853–4855 (2005).
  • Cannistra SA, Matulonis U, Penson R et al. Bevacizumab in patients with advanced platinum-resistant ovarian cancer. J. Clin. Oncol.24(Suppl. Pt 1) S18 (2006).
  • Allen JA, Adlakha A, Bergethon PR. Reversible posterior leukoencephalopathy syndrome after bevacizumab/FOLFIRI regimen for metastatic colon cancer. Arch. Neurol.63, 1475–1478 (2006).
  • Glusker P, Recht L, Lane B. Reversible posterior leukoencephalopathy syndrome and bevacizumab. N. Engl. J. Med.354, 980 (2006).
  • Fakih MG, Lombardo JC. Bevacizumab-induced nasal septum perforation. Oncologist11, 85–86 (2006).
  • Traina TA, Norton L, Drucker K, Singh B. Nasal septum perforation in a bevacizumab-treated patient with metastatic breast cancer. Oncologist11, 1070–1071 (2006).
  • Cassidy J, Clarke S, Diaz-Rubio E et al. First efficacy and safety results from XELOX-1/NO16966, a randomized 2 x 2 factorial Phase III trial of XELOX vs. FOLFOX4 + bevacizumab or placebo in first-line metastatic colorectal cancer (MCRC). Ann. Oncol.17(Suppl. 9), LBA3 (2006).
  • Miller KD, Chap LI, Holmes FA et al. Randomized Phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J. Clin. Oncol.23, 792–799 (2005).
  • Ramaswamy B, Elias AD, Kelbick NT et al. Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients. Clin. Cancer Res.12(10), 3124–3129 (2006).
  • Brahmer JR, Gray R, Schiller JH, Perry M, Sandler A, Johnson D. ECOG 4599 Phase III trial of carboplatin and paclitaxel ±bevacizumab: subset analysis of survival by gender. J. Clin. Oncol.24(Suppl. 18), 7036 (2006).
  • Sandler A, Gray R, Perry MC et al. Paclitaxel–carboplatin alone or with bevacizumab for non-small-cell lung cancer. N. Engl. J. Med.355, 2542–2550 (2006).
  • Miller KD, Wang M, Gralow J et al. A randomized Phase III trial of paclitaxel versus paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer: a trial conducted by the Eastern Cooperative Oncology Group (E2100). Presented at: San Antonio Breast Cancer Symposium. San Antonio, TX, USA (2005).
  • Burger RA, Sill M, Monk BJ, Greer B, Sorosky J. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer (EOC) or primary peritoneal cancer (PPC): a Gynecologic Oncology Group (GOG) study. J. Clin. Oncol.23(Suppl. Pt 1), S16 (2005).
  • Garcia AA, Oza AM, Hirte H et al. Interim report of a Phase II clinical trial of bevacizumab (Bev) and low dose metronomic oral cyclophosphamide (mCTX) in recurrent ovarian (OC) and primary peritoneal carcinoma: a California Cancer Consortium Trial. J. Clin. Oncol.23(Suppl. Pt 1), S16 (2005).
  • Bocci G, Francia G, Man S, Lawler J, Kerbel RS. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc. Natl Acad. Sci.100(22), 12917–12922 (2003).
  • Hamano Y, Sugimoto H, Soubasakos MA et al. Thrombospondin-1 associated with tumor microenvironment contributes to low-dose cyclophosphamide-mediated endothelial cell apoptosis and tumor growth suppression. Cancer Res.64, 1570–1574 (2004).
  • Hainsworth JD, Sosman JA, Spigel DR et al. Phase II trial of bevacizumab and erlotinib in patients with metastatic renal carcinoma (RCC). J. Clin. Oncol.23 (2004) (Abstract 4502).
  • Ning YM, Arlen P, Gulley J et al. A Phase II trial of docetaxel, thalidomide, bevacizumab, and prednisone in patients (pts) with metastatic androgen-independent prostate cancer (AIPC). J. Clin. Oncol.24(Suppl. 18), 13037 (2006).
  • Rini BI, Weinberg V, Fong L, Conry S, Hershberg RM, Small EJ. Combination immunotherapy with prostatic acid phosphatase pulsed antigen-presenting cells (provenge) plus bevacizumab in patients with serologic progression of prostate cancer after definitive local therapy. Cancer107, 67–74 (2006).
  • Vredenburgh JJ, Desjardins A, Herndon JE et al. Bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and irinotecan for treatment of malignant gliomas. J. Clin. Oncol.24(Suppl. 18), 1506 (2006).
  • Kirkpatrick J, Desjardins A, Vredenburgh JJ et al. Combination of bevacizumab, a monoclonal antibody to vascular endothelial growth factor (VEGF), and temozolomide: study of cases. J. Clin. Oncol.24(Suppl. 18), 11522 (2006).
  • Welch S, Kocha W, Rumble RB, Spithoff K, Maroun J; and the Gastrointestinal Cancer Disease Site Group. The role of bevacizumab (Avastin) combined with chemotherapy in the treatment of patients with advanced colorectal cancer. Cancer Care Ontario23, 2–25 (2005).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.