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Fixed-dose combination and single active ingredient drugs: a comparative cost analysis

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References

  • Orloff DG. Fixed combination drugs for cardiovascular disease risk reduction: regulatory approach. Am J Cardiol 2005;96(9A):28K-33K
  • 21-CFR-300.50: Fixed-combination prescription drugs for humans. Food and Drug Administration (FDA); 1975
  • Guidelines for registration of fixed-dose combination medicinal products. WHO Technical Report Series. World Health Organization (WHO). 2005. Available from: http://apps.who.int/medicinedocs/documents/s19979en/s19979en.pdf [Last accessed 20 April 2014]
  • Gilks CF, Crowley S, Ekpini R, et al. The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings. Lancet 2006;368(9534):505-10
  • Graul AI, Sorbera LA, Bozzo J, et al. The year’s new drugs and biologics--2006. Drug News Perspect 2007;20(1):17-44
  • Bhat VN. Patent term extension strategies in the pharmaceutical industry. Pharmaceuticals Policy and Law 2005;6:109-22
  • The independent review of medical treatment: new drugs from old. Drug Ther Bull 2006;44(10):73-7
  • Hong SH, Shepherd MD, Scoones D, Wan TT. Product-line extensions and pricing strategies of brand-name drugs facing patent expiration. J Manag Care Pharm 2005;11(9):746-54
  • Wadman M. The right combination. Nature 2006;439(26):390-1
  • Prescription drug costs. Kaiser Family Foundation. 2010. Available from: www.kaiseredu.org/Issue-Modules/Prescription-Drug-Costs/Background-Brief.aspx [Last accessed 20 July 2013]
  • Friedman HS, Eid NS, Crespi S, et al. Retrospective claims study of fluticasone propionate/salmeterol fixed-dose combination use as initial asthma controller therapy in children despite guideline recommendations. Clin Ther 2009;31(5):1056-63
  • Brixner DI, Lenhart G, Young DC, Samuelson WM. The effect of fixed combination of fluticasone and salmeterol on asthma drug utilization, asthma drug cost, and episodes of asthma exacerbations. Curr Med Res Opin 2007;23(11):2887-95
  • Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med 2007;120(8):713-19
  • Hong SH, Wang J, Tang J. Dynamic view on affordability of fixed-dose combination antihypertensive drug therapy. Am J Hypertens 2013;26(7):879-87
  • Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003;289(19):2560-72
  • Gish RG, Gholam PM. Monotherapy vs multiple-drug therapy: the experts debate. Cleve Clin J Med 2009;76(3):S20-4
  • Rabbani A, Alexander GC. Out-of-pocket and total costs of fixed-dose combination antihypertensives and their components. Am J Hypertens 2008;21(5):509-13
  • Taylor AA, Shoheiber O. Adherence to antihypertensive therapy with fixed-dose amlodipine besylate/benazepril HCl versus comparable component-based therapy. Congest Heart Fail 2003;9(6):324-32
  • Dickson M, Plauschinat CA. Compliance with antihypertensive therapy in the elderly: a comparison of fixed-dose combination amlodipine/benazepril versus component-based free-combination therapy. Am J Cardiovasc Drugs 2008;8(1):45-50
  • Brixner DI, Jackson KCII, Sheng X, et al. Assessment of adherence, persistence, and costs among valsartan and hydrochlorothiazide retrospective cohorts in free-and fixed-dose combinations. Curr Med Res Opin 2008;24(9):2597-607
  • Balu S, Simko RJ, Quimbo RM, Cziraky MJ. Impact of fixed-dose and multi-pill combination dyslipidemia therapies on medication adherence and the economic burden of sub-optimal adherence. Curr Med Res Opin 2009;25(11):2765-75
  • Malesker MA, Hilleman DE. Comparison of amlodipine/valsartan fixed-dose combination therapy and conventional therapy. Manag Care 2010;19(7):36-42
  • Ferrario CM, Panjabi S, Buzinec P, Swindle JP. Clinical and economic outcomes associated with amlodipine/renin-angiotensin system blocker combinations. Ther Adv Cardiovasc Dis 2013;7(1):27-39
  • Friedman HS, Yawn BP. Resource utilization in asthma: combined fluticasone propionate/salmeterol compared with inhaled corticosteroids. Curr Med Res Opin 2007;23(2):427-34
  • Rascati KL, Akazawa M, Johnsrud M, et al. Comparison of hospitalizations, emergency department visits, and costs in a historical cohort of Texas medicaid patients with chronic obstructive pulmonary disease, by initial medication regimen. Clin Ther 2007;29(6):1203-13
  • Blanchette CM, Akazawa M, Dalal A, Simoni-Wastila L. Risk of hospitalizations/emergency department visits and treatment costs associated with initial maintenance therapy using fluticasone propionate 500 microg/salmeterol 50 microg compared with ipratropium for chronic obstructive pulmonary disease in older adults. Am J Geriatr Pharmacother 2008;6(3):138-46
  • Dalal AA, Roberts MH, Petersen HV, et al. Comparative cost-effectiveness of a fluticasone-propionate/salmeterol combination versus anticholinergics as initial maintenance therapy for chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2011;6:13-22
  • RED BOOK A Comprehensive, Consistent Drug Pricing Resource. Thomson Micomedex’s Red Book 2014. Available from: http://micromedex.com/redbook [Last accessed 20 April 2014]
  • Prescription drug pricing in the private sector. congressional budget office (CBO). 2007. Available from: www.cbo.gov/sites/default/files/cbofiles/ftpdocs/77xx/doc7715/01-03-prescriptiondrug.pdf [Last accessed 20 April 2014]
  • Cheong C, Barner JC, Lawson KA, Johnsrud MT. Patient adherence and reimbursement amount for antidiabetic fixed-dose combination products compared with dual therapy among Texas Medicaid recipients. Clin Ther 2008;30(10):1893-907
  • Barner JC. Adherence to oral antidiabetic agents with pioglitazone and metformin: comparison of fixed-dose combination therapy with monotherapy and loose-dose combination therapy. Clin Ther 2011;33(9):1281-8
  • Kruk ME, Schwalbe N. The relation between intermittent dosing and adherence: preliminary insights. Clin Ther 2006;28(12):1989-95
  • Ramjan R, Calmy A, Vitoria M, et al. Systematic review and meta-analysis: Patient and program impact of fixed-dose combination antiretroviral therapy. Trop Med Int Health 2014;19(5):501-13
  • Hong SH, Wang J, Tang J. Dynamic view on affordability of fixed-dose combination antihypertensive drug therapy. Am J Hypertens 2013;26(7):879-87
  • Dickson M, Plauschinat CA. Compliance with antihypertensive therapy in the elderly: a comparison of fixed-dose combination amlodipine/benazepril versus component-based free-combination therapy. Am J Cardiovasc Drugs 2008;8(1):45-50
  • Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001;23(8):1296-310
  • Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med 2007;120(8):713-19
  • Saini SD, Schoenfeld P, Kaulback K, Dubinsky MC. Effect of medication dosing frequency on adherence in chronic diseases. Am J Manag Care 2009;15(6):e22-33
  • Gupta AK, Arshad S, Poulter NR. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension 2010;55(2):399-407
  • Federal upper limits. Center for Medicare & Medicaid services. 2014. Available from: www.medicaid.gov/Medicaid-CHIP-Program-Information/By-Topics/Benefits/Prescription-Drugs/Federal-Upper-Limits.html [Last accessed 20 April 2014]
  • Liberman JN, Roebuck MC. Prescription drug costs and the generic dispensing ratio. J Manag Care Pharm 2010;16(7):502-6

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