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Review

Extracorporeal methods of blood glutamate scavenging: a novel therapeutic modality

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References

  • Waxweiler RJ, Thurman D, Sniezek J, et al. Monitoring the impact of traumatic brain injury: a review and update. J Neurotrauma 1995;12(4):509-16
  • Baker AJ, Moulton RJ, MacMillan VH, Shedden PM. Excitatory amino acids in cerebrospinal fluid following traumatic brain injury in humans. J Neurosurg 1993;79(3):369-72
  • Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984;43(5):1369-74
  • Davalos A, Castillo J, Serena J, Noya M. Duration of glutamate release after acute ischemic stroke. Stroke 1997;28(4):708-10
  • Palmer AM, Marion DW, Botscheller ML, et al. Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J Neurochem 1993;61(6):2015-24
  • Faden AI, Demediuk P, Panter SS, Vink R. The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 1989;244(4906):798-800
  • Boyko M, Gruenbaum SE, Gruenbaum BF, et al. Brain to blood glutamate scavenging as a novel therapeutic modality: a review. J Neural Transm 2014;121(8):971-9
  • Leibowitz A, Boyko M, Shapira Y, Zlotnik A. Blood glutamate scavenging: insight into neuroprotection. Int J Mol Sci 2012;13(8):10041-66
  • Biegon A, Fry PA, Paden CM, et al. Dynamic changes in N-methyl-D-aspartate receptors after closed head injury in mice: implications for treatment of neurological and cognitive deficits. Proc Natl Acad Sci USA 2004;101(14):5117-22
  • Teichberg VI. GOT to rid the body of excess glutamate. J Cereb Blood Flow Metab 2011;31(6):1376-7
  • Nakanishi S. Molecular diversity of glutamate receptors and implications for brain function. Science 1992;258(5082):597-603
  • Danbolt NC. Glutamate uptake. Prog Neurobiol 2001;65(1):1-105
  • Berger C, Schabitz WR, Wolf M, et al. Hypothermia and brain-derived neurotrophic factor reduce glutamate synergistically in acute stroke. Exp Neurol 2004;185(2):305-12
  • Chakrabarty K, Bhattacharyya S, Christopher R, Khanna S. Glutamatergic dysfunction in OCD. Neuropsychopharmacology 2005;30(9):1735-40
  • Cortese BM, Phan KL. The role of glutamate in anxiety and related disorders. CNS Spectr 2005;10(10):820-30
  • de Groot J, Sontheimer H. Glutamate and the biology of gliomas. Glia 2011;59(8):1181-9
  • Eid T, Williamson A, Lee TS, et al. Glutamate and astrocytes-key players in human mesial temporal lobe epilepsy? Epilepsia 2008;49(Suppl 2):42-52
  • Ferrarese C, Aliprandi A, Tremolizzo L, et al. Increased glutamate in CSF and plasma of patients with HIV dementia. Neurology 2001;57(4):671-5
  • Stobart JL, Anderson CM. Multifunctional role of astrocytes as gatekeepers of neuronal energy supply. Front Cell Neurosci 2013;7:38
  • Grill V, Bjorkman O, Gutniak M, Lindqvist M. Brain uptake and release of amino acids in nondiabetic and insulin-dependent diabetic subjects: important role of glutamine release for nitrogen balance. Metabolism 1992;41(1):28-32
  • Ikonomidou C, Turski L. Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol 2002;1(6):383-6
  • Zlotnik A, Gruenbaum SE, Artru AA, et al. The neuroprotective effects of oxaloacetate in closed head injury in rats is mediated by its blood glutamate scavenging activity: evidence from the use of maleate. J Neurosurg Anesthesiol 2009;21(3):235-41
  • O’Kane RL, Martinez-Lopez I, DeJoseph MR, et al. Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal. J Biol Chem 1999;274(45):31891-5
  • Marliss EB, Aoki TT, Pozefsky T, et al. Muscle and splanchnic glutamine and glutamate metabolism in postabsorptive and starved man. J Clin Invest 1971;50(4):814-17
  • Hosoya K, Sugawara M, Asaba H, Terasaki T. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem 1999;73(3):1206-11
  • Gottlieb M, Wang Y, Teichberg VI. Blood-mediated scavenging of cerebrospinal fluid glutamate. J Neurochem 2003;87(1):119-26
  • Zlotnik A, Gurevich B, Tkachov S, et al. Brain neuroprotection by scavenging blood glutamate. Exp Neurol 2007;203(1):213-20
  • Zlotnik A, Gurevich B, Cherniavsky E, et al. The contribution of the blood glutamate scavenging activity of pyruvate to its neuroprotective properties in a rat model of closed head injury. Neurochem Res 2008;33(6):1044-50
  • Zlotnik A, Sinelnikov I, Gruenbaum BF, et al. Effect of glutamate and blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome and pathohistology of the hippocampus after traumatic brain injury in rats. Anesthesiology 2012;116(1):73-83
  • Boyko M, Zlotnik A, Gruenbaum BF, et al. Pyruvate’s blood glutamate scavenging activity contributes to the spectrum of its neuroprotective mechanisms in a rat model of stroke. Eur J Neurosci 2011;34(9):1432-41
  • Campos F, Sobrino T, Ramos-Cabrer P, et al. Neuroprotection by glutamate oxaloacetate transaminase in ischemic stroke: an experimental study. J Cereb Blood Flow Metab 2011;31(6):1378-86
  • Nagy D, Marosi M, Kis Z, et al. Oxaloacetate decreases the infarct size and attenuates the reduction in evoked responses after photothrombotic focal ischemia in the rat cortex. Cell Mol Neurobiol 2009;29(6-7):827-35
  • Boyko M, Melamed I, Gruenbaum BF, et al. The effect of blood glutamate scavengers oxaloacetate and pyruvate on neurological outcome in a rat model of subarachnoid hemorrhage. Neurotherapeutics 2012;9(3):649-57
  • Carvalho AS, Torres LB, Persike DS, et al. Neuroprotective effect of pyruvate and oxaloacetate during pilocarpine induced status epilepticus in rats. Neurochem Int 2011;58(3):385-90
  • Ruban A, Berkutzki T, Cooper I, et al. Blood glutamate scavengers prolong the survival of rats and mice with brain-implanted gliomas. Invest New Drugs 2012;30(6):2226-35
  • Ruban A, Mohar B, Jona G, Teichberg VI. Blood glutamate scavenging as a novel neuroprotective treatment for paraoxon intoxication. J Cereb Blood Flow Metab 2014;34(2):221-7
  • Zlotnik A, Gruenbaum BF, Mohar B, et al. The effects of estrogen and progesterone on blood glutamate levels: evidence from changes of blood glutamate levels during the menstrual cycle in women. Biol Reprod 2011;84(3):581-6
  • Zlotnik A, Leibowitz A, Gurevich B, et al. Effect of estrogens on blood glutamate levels in relation to neurological outcome after TBI in male rats. Intensive Care Med 2012;38(1):137-44
  • Zlotnik A, Klin Y, Gruenbaum BF, et al. The activation of beta2-adrenergic receptors in naive rats causes a reduction of blood glutamate levels: relevance to stress and neuroprotection. Neurochem Res 2011;36(5):732-8
  • Zlotnik A, Klin Y, Gruenbaum BF, et al. β2 adrenergic-mediated reduction of blood glutamate levels and improved neurological outcome after traumatic brain injury in rats. J Neurosurg Anesthesiol 2012;24(1):30-8
  • Fanne RA, Nassar T, Heyman SN, et al. Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate. Am J Physiol Regul Integr Comp Physiol 2011;301(3):R668-73
  • Zlotnik A, Gruenbaum BF, Klin Y, et al. The effects of insulin, glucagon, glutamate, and glucose infusion on blood glutamate and plasma glucose levels in naive rats. J Neurosurg Anesthesiol 2011;23(4):323-8
  • Rogachev B, Ohayon S, Saad A, et al. The effects of hemodialysis on blood glutamate levels in chronic renal failure: implementation for neuroprotection. J Crit Care 2012;27(6):743.e1-7
  • Rogachev B, Tsesis S, Gruenbaum BF, et al. The effects of peritoneal dialysis on blood glutamate levels: implementation for neuroprotection. J Neurosurg Anesthesiol 2013;25(3):262-6
  • Hu SL, Wang D, Jiang H, et al. Therapeutic effectiveness of sustained low-efficiency hemodialysis plus hemoperfusion and continuous hemofiltration plus hemoperfusion for acute severe organophosphate poisoning. Artif Organs 2014;38(2):121-4
  • Avino P, Capannesi G, Rosada A, et al. Multivariate analysis applied to some elements in human fluids and whole bloods of hemodialysis patients determined by INAA. J Radioanal Nucl Chem 2013;298(3):1957-68
  • Davies S, Lally F, Satchithananda D, et al. Extending the role of peritoneal dialysis: can we win hearts and minds? Nephrol Dial Transplant 2014;29(9):1648-54
  • Himmelfarb J, Ikizler TA. Hemodialysis. N Engl J Med 2010;363(19):1833-45
  • Soupart A, Silver S, Schrooeder B, et al. Rapid (24-hour) reaccumulation of brain organic osmolytes (particularly myo-inositol) in azotemic rats after correction of chronic hyponatremia. J Am Soc Nephrol 2002;13(6):1433-41
  • McLaggan D, Naprstek J, Buurman ET, Epstein W. Interdependence of K+ and glutamate accumulation during osmotic adaptation of Escherichia coli. J Biol Chem 1994;269(3):1911-17
  • Gil HW, Yang JO, Lee EY, et al. The effect of dialysis membrane flux on amino acid loss in hemodialysis patients. J Korean Med Sci 2007;22(4):598-603
  • Godino Mdel C, Romera VG, Sanchez-Tomero JA, et al. Amelioration of ischemic brain damage by peritoneal dialysis. J Clin Invest 2013;123(10):4359-63
  • Friedrich JO, Wald R, Bagshaw SM, et al. Hemofiltration compared to hemodialysis for acute kidney injury: systematic review and meta-analysis. Crit Care 2012;16(4):R146
  • Ronco C, Tetta C, Mariano F, et al. Interpreting the mechanisms of continuous renal replacement therapy in sepsis: the peak concentration hypothesis. Artif Organs 2003;27(9):792-801
  • Patel P, Nandwani V, McCarthy PJ, et al. Continuous renal replacement therapies: a brief primer for the neurointensivist. Neurocrit Care 2010;13(2):286-94

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