Levetiracetam for the treatment of status epilepticus

References

• Csilla G, Vera J, Reka H, et al. [Status epilepticus and its treatment–update 2013]. Ideggyogy Sz 2013;66(11-12):372-82
   PubMedGoogle Scholar
• Hocker S, Tatum WO, LaRoche S, Freeman WD. Refractory and super-refractory status epilepticus-an update. Curr Neurol Neurosci Rep 2014;14(6):452
   PubMed Web of Science ®Google Scholar
• Meierkord H, Holtkamp M. Non-convulsive status epilepticus in adults: clinical forms and treatment. Lancet Neurol 2007;6(4):329-39
   PubMed Web of Science ®Google Scholar
• Neligan A, Shorvon SD. Frequency and prognosis of convulsive status epilepticus of different causes: a systematic review. Arch of neurol 2010;67(8):931-40
   PubMed Web of Science ®Google Scholar
• Shorvon S. The historical evolution of, and the paradigms shifts in, the therapy of convulsive status epilepticus over the past 150 years. Epilepsia 2013;54(Suppl 6):64-7
   PubMedGoogle Scholar
• Manno EM. Status epilepticus: current treatment strategies. Neurohospitalist 2011;1(1):23-31
   Google Scholar
• Rosche J, Pohley I, Rantsch K, et al. [Experience with levetiracetam in the treatment of status epilepticus]. Fortschr Neurol Psychiatr 2013;81(1):21-7
   PubMed Web of Science ®Google Scholar
• Kellinghaus C, Stogbauer F. Treatment of status epilepticus in a large community hospital. Epilep behav 2012;23(3):235-40
   PubMed Web of Science ®Google Scholar
• Zona C, Niespodziany I, Marchetti C, et al. Levetiracetam does not modulate neuronal voltage-gated Na+ and T-type Ca2+ currents. Seizure 2001;10(4):279-86
   PubMed Web of Science ®Google Scholar
• Eue S, Grumbt M, Muller M, Schulze A. Two years of experience in the treatment of status epilepticus with intravenous levetiracetam. Epilep behav 2009;15(4):467-9
   PubMed Web of Science ®Google Scholar
• Loscher W, Honack D, Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J Pharmacol Exp Ther 1998;284(2):474-9
   PubMed Web of Science ®Google Scholar
• Klitgaard H, Matagne A, Gobert J, Wulfert E. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur J pharmacol 1998;353(2-3):191-206
   PubMed Web of Science ®Google Scholar
• Holtkamp M. Treatment strategies for refractory status epilepticus. Curr Opin Crit Care 2011;17(2):94-100
   PubMed Web of Science ®Google Scholar
• Rosenow F, Knake S, Hamer HM. [Non-convulsive status epilepticus: temporary fad or reality in need of treatment?]. Nervenarzt 2012;83(12):1551-8
   PubMed Web of Science ®Google Scholar
• Meierkord H, Boon P, Engelsen B, et al. EFNS guideline on the management of status epilepticus in adults. Eur J Neurol 2010;17(3):348-55
   PubMed Web of Science ®Google Scholar
• Capovilla G, Beccaria F, Beghi E, et al. Treatment of convulsive status epilepticus in childhood: recommendations of the Italian League Against Epilepsy. Epilepsia 2013;54(Suppl 7):23-34
   PubMed Web of Science ®Google Scholar
• Abend NS, Huh JW, Helfaer MA, Dlugos DJ. Anticonvulsant medications in the pediatric emergency room and intensive care unit. Pediatr Emerg Care 2008;24(10):705-18; quiz 19-21
   PubMed Web of Science ®Google Scholar
• Sugaya Y, Maru E, Kudo K, et al. Levetiracetam suppresses development of spontaneous EEG seizures and aberrant neurogenesis following kainate-induced status epilepticus. Brain Res 2010;1352:187-99
   PubMed Web of Science ®Google Scholar
• Zheng Y, Moussally J, Cash SS, et al. Intravenous levetiracetam in the rat pilocarpine-induced status epilepticus model: behavioral, physiological and histological studies. Neuropharmacology 2010;58(4-5):793-8
   PubMed Web of Science ®Google Scholar
• Tripathi M, Vibha D, Choudhary N, et al. Management of refractory status epilepticus at a tertiary care centre in a developing country. Seizure 2010;19(2):109-11
   PubMed Web of Science ®Google Scholar
• Swisher CB, Doreswamy M, Gingrich KJ, et al. Phenytoin, levetiracetam, and pregabalin in the acute management of refractory status epilepticus in patients with brain tumors. Neurocrit Care 2012;16(1):109-13
   PubMed Web of Science ®Google Scholar
• Beyenburg S, Reuber M, Maraite N. Intravenous levetiracetam for epileptic seizure emergencies in older people. Gerontology 2009;55(1):27-31
   PubMed Web of Science ®Google Scholar
• Kim JS, Lee JH, Ryu HW, et al. Effectiveness of intravenous levetiracetam as an adjunctive treatment in pediatric refractory status epilepticus. Pediatr Emerg Care 2014;30(8):525-8
   PubMed Web of Science ®Google Scholar
• Burakgazi E, Bashir S, Doss V, Pellock J. The safety and tolerability of different intravenous administrations of levetiracetam, bolus versus infusion, in intensive care unit patients. Clin EEG Neurosci 2014;45(2):89-91
   PubMed Web of Science ®Google Scholar
• Prasad M, Krishnan PR, Sequeira R, Al-Roomi K. Anticonvulsant therapy for status epilepticus. Cochrane data Sys Rev 2014;9:Cd003723
   PubMed Web of Science ®Google Scholar
• Yasiry Z, Shorvon SD. The relative effectiveness of five antiepileptic drugs in treatment of benzodiazepine-resistant convulsive status epilepticus: a meta-analysis of published studies. Seizure 2014;23(3):167-74
   PubMed Web of Science ®Google Scholar
• Mazarati AM, Baldwin R, Klitgaard H, et al. Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus. Epilepsy Res 2004;58(2-3):167-74
   PubMed Web of Science ®Google Scholar
• Rigo JM, Hans G, Nguyen L, et al. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br J Pharmacol 2002;136(5):659-72
   PubMed Web of Science ®Google Scholar
• Opherk C, Coromilas J, Hirsch LJ. Heart rate and EKG changes in 102 seizures: analysis of influencing factors. Epilepsy Res 2002;52(2):117-27
   PubMed Web of Science ®Google Scholar
• Lee DS, Ryu HJ, Kim JE, et al. The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. Seizure 2013;22(5):368-77
   PubMed Web of Science ®Google Scholar
• Gibbs JE, Walker MC, Cock HR. Levetiracetam: antiepileptic properties and protective effects on mitochondrial dysfunction in experimental status epilepticus. Epilepsia 2006;47(3):469-78
   PubMed Web of Science ®Google Scholar
• Margineanu DG, Matagne A, Kaminski RM, Klitgaard H. Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats. Brain Res Bull 2008;77(5):282-5
   PubMed Web of Science ®Google Scholar
• Brodie MJ, Perucca E, Ryvlin P, et al. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 2007;68(6):402-8
   PubMed Web of Science ®Google Scholar
• Doheny HC, Ratnaraj N, Whittington MA, et al. Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat. Epilepsy Res 1999;34(2-3):161-8
   PubMed Web of Science ®Google Scholar
• Svalheim S, Tauboll E, Surdova K, et al. Long-term levetiracetam treatment affects reproductive endocrine function in female Wistar rats. Seizure 2008;17(2):203-9
   PubMed Web of Science ®Google Scholar
• Patsalos PN. The pharmacokinetic characteristics of levetiracetam. Methods Find Exp Clin Pharmacol 2003;25(2):123-9
   PubMed Web of Science ®Google Scholar
• Perucca E, Johannessen SI. The ideal pharmacokinetic properties of an antiepileptic drug: how close does levetiracetam come? Epileptic Disorders 2003;5(Suppl 1):S17-26
   PubMedGoogle Scholar
• Tong X, Patsalos PN. A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain. Br J Pharmacol 2001;133(6):867-74
   PubMed Web of Science ®Google Scholar
• Radtke RA. Pharmacokinetics of levetiracetam. Epilepsia 2001;42:Suppl 4 24-7
   PubMed Web of Science ®Google Scholar
• Perucca E, Gidal BE, Baltes E. Effects of antiepileptic comedication on levetiracetam pharmacokinetics: a pooled analysis of data from randomized adjunctive therapy trials. Epilepsy Res 2003;53(1-2):47-56
   PubMed Web of Science ®Google Scholar
• Navarro V, Dagron C, Demeret S, et al. A prehospital randomized trial in convulsive status epilepticus. Epilepsia 2011;52(Suppl 8):48-9
   PubMedGoogle Scholar
• Su TF, Xu SQ, Chen L. [Efficacy of levetiracetam combined with short-term clonazepam in treatment of electrical status epilepticus during sleep in children with benign childhood epilepsy with centrotemporal spikes]. Zhongguo Dang Dai Er Ke Za Zhi 2014;16(8):829-33
   PubMedGoogle Scholar
• Brockmoller J, Thomsen T, Wittstock M, et al. Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): characterization by dynamic liver function tests. Clin Pharmacol Ther 2005;77(6):529-41
   PubMed Web of Science ®Google Scholar
• Farooq MU, Naravetla B, Majid A, et al. IV levetiracetam in the management of non-convulsive status epilepticus. Neurocrit Care 2007;7(1):36-9
   PubMed Web of Science ®Google Scholar
• Yamamuro K, Yoshino H, Tamura K, et al. Levetiracetam improves disinhibitory behavior in nonconvulsive status epilepticus. Ann Gen Psychiatry 2014;13(1):32
   PubMedGoogle Scholar
• Berning S, Boesebeck F, van Baalen A, Kellinghaus C. Intravenous levetiracetam as treatment for status epilepticus. J Neurol 2009;256(10):1634-42
   PubMed Web of Science ®Google Scholar
• Falip M, Carreno M, Amaro S, et al. Use of levetiracetam in hospitalized patients. Epilepsia 2006;47(12):2186-8
   PubMed Web of Science ®Google Scholar
• Eckert M, Besser R. Rapid intravenous infusion of levetiracetam. Stuttgart, Allemagne. Thieme 2008;35:211-13
   Google Scholar
• Misra UK, Kalita J, Maurya PK. Levetiracetam versus lorazepam in status epilepticus: a randomized, open labeled pilot study. J Neurol 2012;259(4):645-8
   PubMed Web of Science ®Google Scholar
• McTague A, Kneen R, Kumar R, et al. Intravenous levetiracetam in acute repetitive seizures and status epilepticus in children: experience from a children’s hospital. Seizure 2012;21(7):529-34
   PubMed Web of Science ®Google Scholar
• Khan O, Chang E, Cipriani C, et al. Use of intravenous levetiracetam for management of acute seizures in neonates. Pediatric neurol 2011;44(4):265-9
   PubMed Web of Science ®Google Scholar
• Fattouch J, Di Bonaventura C, Casciato S, et al. Intravenous Levetiracetam as first-line treatment of status epilepticus in the elderly. Acta Neurol Scand 2010;121(6):418-21
   PubMed Web of Science ®Google Scholar
• Haberlandt E, Sigl SB, Scholl-Buergi S, et al. Levetiractam in the treatment of two children with myoclonic status epilepticus. EJPN 2009;13(6):546-9
   PubMed Web of Science ®Google Scholar
• Patel NC, Landan IR, Levin J, et al. The use of levetiracetam in refractory status epilepticus. Seizure 2006;15(3):137-41
   PubMed Web of Science ®Google Scholar
• Knake S, Gruener J, Hattemer K, et al. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol 2008;79(5):588-9
   Web of Science ®Google Scholar
• Moddel G, Bunten S, Dobis C, et al. Intravenous levetiracetam: a new treatment alternative for refractory status epilepticus. J Neurol 2009;80(6):689-92
   Web of Science ®Google Scholar
• Shoemaker MT, Rotenberg JS. Levetiracetam for the treatment of neonatal seizures. J Child Neurol 2007;22(1):95-8
   PubMed Web of Science ®Google Scholar
• Trabacca A, Profice P, Costanza MC, et al. Levetiracetam in nonconvulsive status epilepticus in childhood: a case report. J Child Neurol 2007;22(5):639-41
   PubMed Web of Science ®Google Scholar
• Galanopoulou AS, Bojko A, Lado F, Moshe SL. The spectrum of neuropsychiatric abnormalities associated with electrical status epilepticus in sleep. Brain devel 2000;22(5):279-95
   PubMed Web of Science ®Google Scholar
• Bjornaes H, Bakke KA, Larsson PG, et al. Subclinical epileptiform activity in children with electrical status epilepticus during sleep: effects on cognition and behavior before and after treatment with levetiracetam. Epilepsy behavior 2013;27(1):40-8
   PubMed Web of Science ®Google Scholar
• Chen J, Cai F, Jiang L, et al. Levetiracetam efficacy in children with epilepsy with electrical status epilepticus in sleep. Epilepsy Behav 2015;44c:73-7
   Google Scholar
• Arhan E, Serdaroglu A, Aydin K, et al. Epileptic encephalopathy with electrical status epilepticus: An electroclinical study of 59 patients. Seizure 2015;26:86-93
   PubMed Web of Science ®Google Scholar
• Zelano J, Kumlien E. Levetiracetam as alternative stage two antiepileptic drug in status epilepticus: a systematic review. Seizure 2012;21(4):233-6
   PubMed Web of Science ®Google Scholar
• Khongkhatithum C, Thampratankul L, Wiwattanadittakul N, Visudtibhan A. Intravenous levetiracetam in Thai children and adolescents with status epilepticus and acute repetitive seizures. EJPN 2015
   PubMed Web of Science ®Google Scholar
• Rossetti AO, Bromfield EB. Levetiracetam in the treatment of status epilepticus in adults: a study of 13 episodes. European neurol 2005;54(1):34-8
   Web of Science ®Google Scholar
• Rossetti AO, Bromfield EB. Determinants of success in the use of oral levetiracetam in status epilepticus. Epilepsy Behav 2006;8(3):651-4
   PubMed Web of Science ®Google Scholar
• Chen XQ, Zhang WN, Yang ZX, et al. Efficacy of levetiracetam in electrical status epilepticus during sleep of children: a multicenter experience. Pediatric Neurol 2014;50(3):243-9
   PubMed Web of Science ®Google Scholar
• Betts T, Waegemans T, Crawford P. A multicentre, double-blind, randomized, parallel group study to evaluate the tolerability and efficacy of two oral doses of levetiracetam, 2000 mg daily and 4000 mg daily, without titration in patients with refractory epilepsy. Seizure 2000;9(2):80-7
   PubMed Web of Science ®Google Scholar
• Harden C. Safety profile of levetiracetam. Epilepsia 2001;42(Suppl 4):36-9
   PubMed Web of Science ®Google Scholar
• Weintraub D, Buchsbaum R, Resor SRJr, Hirsch LJ. Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy. Epilepsy behavior 2007;10(1):105-10
   PubMed Web of Science ®Google Scholar
• De Los Reyes EC, Sharp GB, Williams JP, Hale SE. Levetiracetam in the treatment of Lennox-Gastaut syndrome. Pediatr Neurol 2004;30(4):254-6
   PubMed Web of Science ®Google Scholar
• French J. Use of levetiracetam in special populations. Epilepsia 2001;42(Suppl 4):40-3
   PubMedGoogle Scholar
• Rupprecht S, Franke K, Fitzek S, et al. Levetiracetam as a treatment option in non-convulsive status epilepticus. Epilepsy Res 2007;73(3):238-44
   PubMed Web of Science ®Google Scholar
• Uges JW, van Huizen MD, Engelsman J, et al. Safety and pharmacokinetics of intravenous levetiracetam infusion as add-on in status epilepticus. Epilepsia 2009;50(3):415-21
   PubMed Web of Science ®Google Scholar
• Gallentine WB, Hunnicutt AS, Husain AM. Levetiracetam in children with refractory status epilepticus. Epilepsy behavior 2009;14(1):215-18
   PubMed Web of Science ®Google Scholar
• Briggs DE, French JA. Levetiracetam safety profiles and tolerability in epilepsy patients. Expert Opin Drug Saf 2004;3(5):415-24
   PubMedGoogle Scholar
• Yuan GQ, Gao DD, Lin J, et al. Treatment of recurrent epileptic seizures in patients with neurological disorders. Exp Therapeut Med 2013;5(1):267-70
   Web of Science ®Google Scholar
• Bleck T, Cock H, Chamberlain J, et al. The established status epilepticus trial 2013. Epilepsia 2013;54(Suppl 6):89-92
   PubMed Web of Science ®Google Scholar
• Bleck TP. Status epilepticus and the use of continuous EEG monitoring in the intensive care unit. Continuum (Minneapolis, Minn) 2012;18(3):560-78
   PubMedGoogle Scholar
• Rogalski R, Rogalski A. Benzodiazepine selection in the management of status epilepticus: a review. Adv Eme Nur J 2015;37(2):83-94
   PubMedGoogle Scholar
• Alldredge BK, Gelb AM, Isaacs SM, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. New EngJ Med 2001;345(9):631-7
   PubMed Web of Science ®Google Scholar
• Inokuchi R, Ohashi-Fukuda N, Nakamura K, et al. Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study. Medicine 2015;94(7):e555
   PubMedGoogle Scholar
• Parsai S, Hariri I, Taleb M, Yoon Y. A literature review revisiting phenytoin-induced sinus arrest. Am J Therapeut 2014
   PubMedGoogle Scholar
• Pugin D, Foreman B, De Marchis GM, et al. Is pentobarbital safe and efficacious in the treatment of super-refractory status epilepticus: a cohort study. Critical care (London, England) 2014;18(3):R103
   PubMedGoogle Scholar
• Mayer SA, Claassen J, Lokin J, et al. Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch Neurol 2002;59(2):205-10
   PubMed Web of Science ®Google Scholar
• Sutter R, Kaplan PW. Can anesthetic treatment worsen outcome in status epilepticus? Epilepsy behavior 2015
   PubMed Web of Science ®Google Scholar