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Expert Review of Neurotherapeutics Volume 15, 2015 - Issue 12
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Reviews

New understanding of nonconvulsive status epilepticus in adults: treatments and challenges

José L Fernández-TorreDepartment of Physiology and Pharmacology, University of Cantabria (UNICAN), Santander, Cantabria, Spain;Biomedical Research Institute (IDIVAL), Santander, SpainCorrespondence[email protected]
,
Peter W KaplanDepartment of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA
&
Miguel A Hernández-HernándezBiomedical Research Institute (IDIVAL), Santander, Spain;Department of Intensive Medicine, Marqués de Valdecilla University Hospital, Santander, Cantabria, Spain
Pages 1455-1473 | Published online: 23 Nov 2015

References

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•• This article is an excellent review of the physiological and subcellular changes that might play a role in the transition from single seizures to status epilepticus. The authors also reviewed the principles underlying the treatment of status epilepticus

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•• This article is a special report of the ILAE on the definition and classification of status epilepticus. The experts propose a new definition of status epilepticus, with two operational dimensions: the length of the seizure and the time point (t1) beyond which the seizure should be regarded as “continuous seizure activity”; and the second time point (t2) representing the time of ongoing seizure activity associated with a risk of long-term consequences

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