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Review

Pain management in neonates

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Pages 491-505 | Published online: 10 Jan 2014

References

  • Hatch DJ. Analgesia in the neonate. BE Med. (Clin. Res. Ed) 294(6577), 920 (1987).
  • Anand KJ, Hickey PR. Pain and its effects in the human neonate and fetus. N Engl. j Med. 317(21), 1321–1329 (1987).
  • Purcell-Jones G,Dormon F, Sumner E. Paediatric anaesthetists' perceptions of neonatal and infant pain. Pain 33(2), 181–187 (1988).
  • Melzack R, Will PD. Pain mechanisms: a new theory. Science 150(699), 971–979 (1965).
  • Pain terms: a list with definitions and notes on usage. Recommended by the IASP Subcommittee on Taxonomy. Pain 6(3), 249 (1979).
  • Anand KJ, Craig KD. New perspectives on the definition of pain. Pain 67(1), 3–6 (Discussion 209–211) (1996).
  • Menon G, Anand KL, McIntosh N. Practical approach to analgesia and sedation in the neonatal intensive care unit. Semin. Perinatal 22(5), 417–424 (1998).
  • •Important description of available drugs for neonatal pain treatment.
  • Stevens B, Anand KJ. An overview of neonatal pain. In: Pain In Neonates. Anand KJ, Stevens B, McGrath P (Eds). Elsevier Science BV, Amsterdam, Holland, 1–7 (2000).
  • Fitzgerald M. Development of the peripheral and spinal pain system. In: Pain In Neonates. Anand KJ, Stevens B, McGrath P (Eds). Elsevier Science BV, Amsterdam, Holland, 9–21 (2000).
  • Fitzgerald M, Jennings E. The postnatal development of spinal sensory processing. Proc. Natl Acad. Sci. USA 96(14), 7719–7722 (1999).
  • Bhutta AT, Anand IKA. Vulnerability of the developing brain. Neuronal mechanisms. Clin. Perinatal 29(3), 357–372 (2002).
  • •Complete review of current evidence concerning the effects of pain in the brain of the premature neonate.
  • Coskum V, Anand KJ. Development of supraspinal pain processing. In: Pain In Neonates. Anand KJ, Stevens B, McGrath P (Eds). Elsevier Science BV, Amsterdam, Holland, 23–54 (2000).
  • Rahman W, Fitzgerald M, Aynsley-Green A, Dickenson A. The effects of neonatal exposure to inflammation and/or morphine on neuronal responses and morphine analgesia in adult rats. In: Progress in Pain Research and Management. Proceedings of the 8th World Congress on Pain. Jensen T, Turner J, Wiesenfeld-Hallin Z (Eds). IASP Press,WA, USA, 783–794 (1997).
  • Andrews K, Fitzgerald M. The cutaneous withdrawal reflex in human neonates: sensitization, receptive fields and the effects of contralateral stimulation. Pain 56(1), 95–101 (1994).
  • •Includes the most important pain scales validated in the neonate.
  • Fitzgerald M, Andrews K. Flexion reflex properties in the human infant: a measure of spinal sensory processing in the newborn. In: Measurement of Pain in Infants., and Children. Progress in Pain Research and Management. Finley GA, McGrath PJ (Eds). IASP Press, WA, USA, 47–57 (1998).
  • Falcon M, Guendelman D, Stolberg A. Development of thermal nociception in rats. Pain 67,203–208 (1996).
  • Fitzgerald M. Development of pain mechanisms. BE Med. Bull. 47(3), 667–675 (1991).
  • Fitzgerald M, Millard C, Macintosh N. Hyperalgesia in premature infants. Lancet 1(8580), 292 (1988).
  • Fitzgerald M, Millard C, McIntosh N. Cutaneous hypersensitivity following peripheral tissue damage in newborn infants and its reversal with topical anaesthesia. Pain 39(1), 31–36 (1989).
  • Fiselier T, Monnens L, Moerman E, Van Munster P, Jansen M, Peer P. Influence of the stress of venepuncture on basal levels of plasma renin activity in infants and children. Int. J. Pediatr. Nephrol 4(3), 181–185 (1983).
  • Greisen G, Frederiksen PS, Hertel J, Christensen NJ. Catecholamine response to chest physiotherapy and endotracheal suctioning in pre term infants. Acta Paedtr: Land. 74(4), 525–529 (1985).
  • I agercrantz H, Nilsson E, Redham I, Hjemdahl P Plasma catecholamines following nursing procedures in a neonatal ward. Early Hum. Dev. 14(1), 61–65 (1986).
  • Pokela ML. Pain relief can reduce hypoxemia in distressed neonates during routine treatment procedures. Pediatrics 93(3), 379–383 (1994).
  • Friesen RII, Honda AT, Thieme RE. Changes in anterior fontanel pressure in pre term neonates during tracheal intubation. Aneseth. Analg. 66(9), 874–878 (1987).
  • Greenough A, Nicolaides KH, Lagercrantz H. Human fetal sympathoadrenal responsiveness. Early Hum. Dev. 23(1), 9–13 (1990).
  • Stang HJ, Gunnar MR, Snellman L, Condon LM, Kestenbaum R. Local anesthesia for neonatal circumcision. Effects on distress and cortisol response. JAIVIA 259(10), 1507–1511 (1988).
  • Owens ME, Todt EH. Pain in infancy: neonatal reaction to a heel lance. Pain 20(1), 77–86 (1984).
  • Williamson PS, Williamson ML. Physiologic stress reduction by a local anesthetic during newborn circumcision. Pediatrics71 (1), 36–40 (1983).
  • Maxwell LG, Yaster M, Wetzel RC, Niebyl JR. Penile nerve block for newborn circumcision. Obstet. Cynecol 70 (3Pt 1), 415–419 (1987).
  • Hickey PR, Hansen DD, Wessel DL, Lang P, Jonas RA, Elixson EM. Blunting of stress responses in the pulmonary circulation of infants by fentanyl. Anesth. Analg. 64(12), 1137–1142 (1985).
  • Anand KJ, Hickey PR. Halothane- morphine compared with high-dose sufentanyl for anaesthesia and postoperative analgesia in neonatal cardiac surgery. N Engl. Med. 326,1–9 (1992).
  • Grunau R. Early pain in pre term infants. A model of long-term effects. Clin. Perinatal 29(3), 373–394 (2002)
  • Grunau R. Long-term consequences of pain in human neonates. In: Pain in Neonates. Anand KJ, Stevens B, McGrath P (Eds). Elsevier Science BV, Amsterdam, Holland, 55–76 (2000).
  • Taddio A, Katz J, Ilersich AL, Koren G. Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet 349 (9052), 599–603 (1997).
  • Taddio A, Shah V, Gilbert-MacLeod C, Katz J. Conditioning and hyperalgesia in newborns exposed to repeated heel lances. JAIVIA 288(7), 857–861 (2002).
  • Johnston CC, Stevens BJ. Experience in a neonatal intensive care unit affects pain response. Pediatrics 98(5), 925–930 (1996).
  • Grunau RE, Oberlander TF, Whitfield ME, Fitzgerald C, Lee SK. Demographic and therapeutic determinants of pain reactivity in very low birth weight neonates at 32 weeks postconceptional age. Pediatrics 107(1), 105–112 (2001).
  • Barker DP, Rutter N. Exposure to invasive procedures in neonatal intensive care unit admissions. Awl?. Dis. Child. Fetal Neonatal Ed 72(1), F47—F48 (1995).
  • Johnston CC, Collinge JM, Henderson SJ, Anand KJ. A cross-sectional survey of pain and pharmacological analgesia in Canadian neonatal intensive care units. Clin. J. Pain 13(4), 308–312 (1997).
  • Southall DP, Cronin BC, Hartmann H, Harrison-Sewell C, Samuels MP. Invasive procedures in children receiving intensive care. BE Med J. 306(6891), 1512–1513 (1993).
  • Porter FL, Wolf CM, Gold J, Lotsoff D, Miller JR Pain and pain management in newborn infants: a survey of physicians and nurses. Pediatrics 100(4), 626–632 (1997).
  • Abu-Saad HH, Bouts GJ, Stevens B, Hamers JR Assessment of pain in the neonate. Semin. Per/natal. 22(5), 402–416 (1998).
  • Oberlander TF, Grunau RE, Fitzgerald C, Whitfield ME Does parenchymal brain injury affect biobehavioral pain responses in very low birth weight infants at 32 weeks postconceptional age? Pediatrics 110(3), 570–576 (2002).
  • Debillon T, Zupan V, Ravault N, Magny JF, Dehan M. Development and initial validation of the EDIN scale, a new tool for assessing prolonged pain in pre term infants. Arrh. Dis. Child Fetal Neonatal Ed. 85(1), F36—F41 (2001).
  • Stevens B, Johnston C, Gibbins S. Pain assessment in neonates. In: Pain In Neonates. Second Edition Revised and Enlarged Anand KJ, Stevens B, McGrath PJ. (Eds). Elsevier, Amsterdam, Holland, 101–134 (2000).
  • •Includes the most important pain scales validated in the neonate.
  • Stevens B, Gibbins S, Franck LS. Treatment of pain in the neonatal intensive care unit. Pediatr. Clin. North Am. 47(3), 633–650 (2000).
  • Harpin VA, Rutter N. Making heel pricks less painful. Arch. Dis. Child 58(3), 226–228 (1983).
  • McIntosh N, van Veen L, Brameyer H. Alleviation of the pain of heel prick in pre term infants. Arch. Dis. Child Fetal Neonatal Ed 70(3), F177—F181 (1994).
  • Barker D, Latty B, Rutter T Heel blood sampling in pre term infants: Which technique? Arch. Dis. Child Fetal Neonatal Ed. 71, F206—F208 (1994).
  • Paes B, Janes M, Vegh P, LaDuca F, Andrew M. A comparative study of heel-stick devices for infant blood collection. Am. J. Dis. Child. 147(3), 346–348 (1993).
  • Barker DP, Willetts B, Cappendijk VC, Rutter N. Capillary blood sampling: should the heel be warmed7krh. Dis. Child Fetal Neonatal Ed 74(2), F139—F140 (1996).
  • Larsson BA, Tannfeldt G, Lagercrantz H, Olsson GL. Venipuncture is more effective and less painful than heel lancing for blood tests in neonates. Pediatrics 101(5), 882–886 (1998).
  • Shah VS, Taddio A, Bennett S, Speidel BD. Neonatal pain response to heel stick vs. venepuncture for routine blood sampling. Arch. Dis. Child. Fetal Neonatal Ed. 77(2), F143—F144 (1997).
  • Blackburn S, Patteson D. Effects of cycled light on activity state and cardiorespiratory function in pre term infants. j Perinat. Neonatal. NUTS. 4(4), 47–54 (1991).
  • Mann NP, Haddow R, Stokes L, Goodley S, Rutter N. Effect of night and day on pre term infants in a newborn nursery: randomised trial. BE Med J. (Clin. Res. Ed) 293(6557), 1265–1267 (1986).
  • Stevens B, Petryshen P, Hawkins J, Smith B, Taylor P. Developmental versus conventional care: a comparison of clinical outcomes for very low birth weight infants. Can.j NUTS. Res. 28(4), 97–113 (1996).
  • Campos RG. Soothing pain-elicited distress in infants with swaddling and pacifiers. Child. Dev. 60(4), 781–792 (1989).
  • Field T, Goldson E. Pacifying effects of nonnutritive sucking on term and pre term neonates during heelstick procedures. Pediatrics74(6), 1012–1015 (1984).
  • Blass EM, Watt LB. Suckling- and sucrose- induced analgesia in human newborns. Pain 83(3), 611–623 (1999).
  • •Important description of available evidence concerning the underlying mechanisms of suckling and sucrose induced analgesia.
  • Carbajal R, Chauvet X, Couderc S, Olivier- Martin M. Randomised trial of analgesic effects of sucrose, glucose and pacifiers in term neonates. BE Med 1319(7222), 1393–1397 (1999).
  • Blass EM, Hoffmeyer LB. Sucrose as an analgesic for newborn infants. Pediatrics 87(2), 215–218 (1991).
  • Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev (4), CD001069 (2001).
  • •Important meta-analysis of sucrose trials in neonates.
  • Skogsdal Y, Eriksson M, Schollin J. Analgesia in newborns given oral glucose. Acta. Paerliatr 86(2), 217–220 (1997).
  • Carbajal R, Lenclen R, Gajdos V, Jugie M, Paupe A. Crossover trial of analgesic efficacy of glucose and pacifier in very pre term neonates during subcutaneous injections. Pediatrics110(2 Pt 1), 389–393 (2002).
  • Prevention and management of pain and stress in the neonate. American Academy of Pediatrics. Committee on Fetus and Newborn. Committee on Drug. Section on Anesthesiology. Section on Surgery. Canadian Paediatric Society. Fetus and Newborn Committee. Pediatrics105(2), 454–461 (2000).
  • Johnston CC, Filion F, Snider L et al Routine sucrose analgesia during the first week of life in neonates younger than 31 weeks postconceptional age. Pediatrics 110(3), 523–528 (2002).
  • Bellieni CV, Bagnoli F, Perrone S et al. Effect of multisensory stimulation on analgesia in term neonates: a randomized controlled trial. Pediatr. Res. 51(4), 460–463 (2002).
  • Gray L, Watt L, Blass EM. Skin-to-skin contact is analgesic in healthy newborns. Pediatrics 105(1), E14 (2002).
  • Gray L, Miller LW Philipp BL, Blass EM. Breastfeeding is analgesic in healthy newborns. Pediatrics109(4), 590–593 (2002).
  • Carbajal R, Veerapen S, Couderc S, Jugie M, Ville Y. Analgesic effect of breast feeding in term neonates: randomised controlled trial. Br. Med 326(7379), 13 (2003).
  • •First randomized trial showing the analgesic effects of breastfeeding during venepunctures in neonates.
  • Blass EM, Fitzgerald E. Milk-induced analgesia and comforting in 10-day-old rats: opioid mediation. Pharmacol. Biochem. Behar/. 29(1), 9–13 (1988).
  • Blass EM, Shide DJ, Zaw-Mon C, Sorrentino J. Mother as shield: differential effects of contact and nursing on pain responsivity in infant rats-evidence for nonopioid mediation. Behar/. Neurosci. 109(2), 342–353 (1995).
  • Anand KJ. Systemic analgesic therapy. In: Pain in Neonates. Anand KJ, Stevens B, McGrath P (Eds). Elsevier Science BV, Amsterdam, Holland, 159–188 (2000).
  • •Important review of systemic analgesics used in the neonatal intensive care unit.
  • Gauntlett IS, Fisher DM, Hertzka RE, Kuhls E, Spellman MJ, Rudolph C. Pharmacokinetics of fentanyl in neonatal humans and lambs: effects of age. Anesthesiology69(5), 683–687 (1988).
  • Greeley WJ, de Bruijn NP, Davis DR Sufentanil pharmacokinetics in pediatric cardiovascular patients. Anesth. Analg. 66(11), 1067–1072 (1987).
  • Rosow CE, Moss J, Philbin DM, Savarese JJ. Histamine release during morphine and fentanyl anesthesia. Anesthesiology56 (2), 93–96 (1982).
  • Wells S, Williamson M, Hooker D. Fentanyl-induced chest wall rigidity in a neonate: a case report. Heart Lung23 (3), 196–198 (1994).
  • Lindemann R. Respiratory muscle rigidity in a pre term infant after use of fentanyl during Caesarean section. Eur j PecBab: 157(12), 1012–1013 (1998).
  • American Academy of Pediatrics. Neonatal drug withdrawal. American Academy of Pediatrics Committee on Drugs. Pediatrics 101(6), 1079–1088 (1998).
  • Suresh S, Anand AJ. Opioid tolerance in neonates: mechanisms, diagnosis, assessment and management. Semin. Perinatal 22(5), 425–433 (1998).
  • Bhat R, Abu-Harb M, Chari G, Gulati A. Morphine metabolism in acutely ill pre term newborn infants. J. Pecliatr 120(5), 795–799 (1992).
  • Bhat R, Chari G, Gulati A, Aldana 0, Velamati R, Bhargava H. Pharmacokinetics of a single dose of morphine in pre term infants during the first week of life. J. Pecliatr 117(3), 477–481 (1990).
  • Saarenmaa E, Huttunen P, Leppaluoto J, Meretoja 0, Fellman V. Advantages of fentanyl over morphine in analgesia for ventilated newborn infants after birth: a randomized trial. J. Pecliatr 134(2), 144–150 (1999).
  • Anand KJ, Barton BA, McIntosh N et al Analgesia and sedation in pre term neonates who require ventilatory support: results from the NOPAIN trial. Neonatal Outcome and Prolonged Analgesia in Neonates. Arrh. Pecliatr Adolesc. Med. 153(4), 331–338 (1999).
  • MacGregor R, Evans D, Sugden D, Gaussen T, Levene M. Outcome at 5–6 years of prematurely born children who received morphine as neonates. Arch. Dis. Child Fetal Neonatal Ed 79(1), F40—F43 (1998).
  • Vacanti JP, Crone RK, Murphy JD et al The pulmonary hemodynamic response to perioperative anesthesia in the treatment of high-risk infants with congenital diaphragmatic hernia. J. Pecliatr Surg. 19(6), 672–679 (1984).
  • Koehntop DE, Rodman JH, Brundage DM, Hegland MG, Buckley JJ. Pharmacokinetics of fentanyl in neonates. Anesth. Analg. 65(3), 227–232 (1986).
  • Yaster M, Krane EJ, Kaplan RE Pediatric Pain Management and Sedadion Handbook. Mosby, MO, USA (1997).
  • Arnold JH, Truog RD, Scavone JM, Fenton T Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion. J. Pediah: 119(4), 639–643 (1991).
  • Franck LS, Vilardi J, Durand D, Powers R. Opioid withdrawal in neonates after continuous infusions of morphine or fentanyl during extracorporeal membrane oxygenation. Am. J. Grit. Care 7(5), 364–369 (1998).
  • Olkkola KT, Hamunen K. Pharmacokinetics and pharmacodynamics of analgesic drugs. In: Pain in Neonates. Anand KJ, Stevens B, McGrath P. (Eds). Elsevier Science BV, Amsterdam, Holland, 135–158 (2000).
  • Jacqz-Aigrain E, Burtin P. Clinical pharmacokinetics of sedatives in neonates. Clin. Pharmacokinet. 31(6), 423–443 (1996).
  • Seguin JH, Erenberg A, Leff RD. Safety and efficacy of sufentanil therapy in the ventilated infant. Neonatal Netw 13(4), 37–40 (1994).
  • Wilson AS, Stiller RL, Davis PJ et al Fentanyl and alfentanil plasma protein binding in pre term and term neonates. Anesth. Analg. 84(2), 315–318 (1997).
  • Marlow N, Weindling AM, Van Peer A, Heykants J. Alfentanil pharmacokinetics in pre term infants. Arch. Dis. Child 65(4Spec. No.), 349–351 (1990).
  • Saarenmaa E, Huttunen P, Leppaluoto J, Fellman V. Alfentanil as procedural pain relief in newborn infants. Arch. Dis. Child Fetal Neonatal Ed. 75(2), F103—F107 (1996).
  • Autret E, Dutertre JP, Breteau M, Jonville AP, Furet Y, Laugier J. Pharmacokinetics of paracetamol in the neonate and infant after administration of propacetamol chlorhydrate. Dev Pharmacol Ther. 20(3-4), 129–134 (1993).
  • Birmingham PK, Tobin MJ, Henthorn TK et al Twenty-four-hour pharmacokinetics of rectal acetaminophen in children: an old drug with new recommendations. Anesthesiology87 (2), 244–252 (1997).
  • van Lingen RA, Deinum JT, Quak JM et al Pharmacokinetics and metabolism of rectally administered paracetamol in pre term neonates. Arch. Dis. Child Fetal Neonatal Ed. 80(1), F59—F63 (1999).
  • Shah V, Taddio A, Ohlsson A. Randomised controlled trial of paracetamol for heel prick pain in neonates. Arch. as. Child. Fetal Neonatal Ed. 79(3), F209—F211 (1998).
  • Tashiro C, Matsui Y, Nakano S, Ueyama H, Nishimura M, Oka N. Respiratory outcome in extremely premature infants following ketamine anaesthesia. Can. J. Anaesth. 38(3), 287–291 (1991).
  • Louon A, Lithander J, Reddy VG, Gupta A. Sedation with nasal ketamine and midazolam for cryotherapy in retinopathy of prematurity. BE J. Ophthalmol 77(8), 529–530 (1993).
  • Betremieux P, Cane P, Pladys P, Roze 0, Lefrancois C, Malledant Y. Doppler ultrasound assessment of the effects of ketamine on neonatal cerebral circulation. Dev. Pharmacol firer 20(1–2), 9–13 (1993).
  • Ng E, Taddio A, Ohlsson A. Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit. Cochrane Database Syst. Rev. (1), CD002052 (2003).
  • Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics 101 (2), El (1998) .
  • •Important review of EMLATm cream trials for procedural pain in neonates.
  • Abad F, Diaz-Gomez NM, Domenech E, Gonzalez D, Robayna M, Feria M. Oral sucrose compares favourably with lidocaine-prilocaine cream for pain relief during venepuncture in neonates. Acta. Paecliatr 90(2), 160–165 (2001).
  • Gradin M, Eriksson M, Holmqvist G, Holstein A, Schollin J. Pain reduction at venipuncture in newborns: oral glucose compared with local anesthetic cream. Pediatrics 110(6), 1053–1057 (2002).
  • Jain A, Rutter N. Does topical amethocaine gel reduce the pain of venepuncture in newborn infants? A randomised double-blind controlled trial. Arch. Dis. Child. Fetal Neonatal Ed 83(3), F207—F210 (2000).
  • Jain A, Rutter N, Ratnayaka M. Topical amethocaine gel for pain relief of heel prick blood sampling: a randomised double-blind controlled trial. krli. Dis. Child Fetal Neonatal Ed 84, F56 (2001).
  • Arland KJ. Consensus statement for the prevention and management of pain in the newborn. Arrh. Pecliatr Adolesc. Med. 155(2), 173–180 (2001).
  • Marshall RE. Neonatal pain associated with caregiving procedures. Pecliatr Clin. North Am. 36(4), 885–903 (1989).
  • Marshall TA, Deeder R, Pai S, Berkowitz GP, Austin TL. Physiologic changes associated with endotracheal intubation in pre term infants. Grit. Care Med. 12(6), 501–503 (1984).
  • Esuri M, Kurlak LO, Stephenson TJ. The effect of endotracheal suction on plasma levels of atrial natriuretic peptide (ANP) in pre term infants. Early Hum. Dev. 47,212 (1997).
  • Haxhija EQ, Rosegger H, Prechtl HF. Vagal response to feeding tube insertion in pre term infants: has the key been found? Early Hum. Dev. 41,15–25 (1995).
  • Halperin BA, Halperin SA, McGrath P, Smith B, Houston T Use of lidocaine—prilocaine patch to decrease intramuscular injection pain does not adversely affect the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-haemophilus influenzae type b conjugate and hepatitis B vaccines in infants from birth to 6 months of age. Pediatr. Infect. Dis. 21(5), 399–405 (2002).
  • Duncan HP, Zurick NJ, Wolf AR. Should we reconsider awake neonatal intubation? A review of the evidence and treatment strategies. Paediatc Anaesth. 11(2), 135–145 (2001).
  • •Important review of available data concerning the efficacy of premedication for intubation in neonates.
  • Shah V, Ohlsson A. The effectiveness of premedication for endotracheal intubation in mechanically ventilated neonates. A systematic review. Clin. Perinatal. 29(3), 535–554 (2002).
  • •Important review of available data concerning the efficacy of premedication for intubation in neonates.

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