Treating brain metastases: current approaches and future directions

References

• Patchell RA. Brain metastases. In: Cancer of the Nervous System. Black PM, Loeffler JS (Eds). Blackwell Science Inc, MA, USA, 653–663 (1997).
   Google Scholar
• Zimm 5, Wampler GL, Stablein D, Hazra T, Young HE Intracerebral metastases in solid-tumor patients: natural history and results of treatment. Cancer 48,384–394 (1981).
   PubMed Web of Science ®Google Scholar
• Schouten L, Rutten J, Huveneers HAM, Twijnstra A. Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney, lung and melanoma. Cancer 94,2698–2705 (2002).
   PubMed Web of Science ®Google Scholar
• Gaspar L, Scott C, Rotman M et al. Recursive partitioning analysis (RPA) of prognostic factors in three radeiation therapy oncology group (RTOG) brain metastases trials. Int. J Radiat. OncoL Biol. Phys. 37,745–751 (1997).
   PubMed Web of Science ®Google Scholar
• Patchell RA, Tibbs PA, Walsh RV et al. A randomized trial of surgery in the treatment of single metastases to the brain. N EngL J Med. 322,494–500 (1990).
   PubMed Web of Science ®Google Scholar
• •• Establishes aggressive therapy (surgical resection) in addition to whole-brain radiation therapy as standard treatment for a single brain metastasis because it improves survival compared with radiation therapy alone.
   Google Scholar
• Noordijk EM, Vecht CJ, Haaxma-Reiche H et al The choice of treatment of a single brain metastasis should be based on extracranial tumor activity and age. Int. J Radiat. OncoL Biol. Phys. 29,711–717 (1994).
   PubMed Web of Science ®Google Scholar
• ••Demonstrates that surgical resection of asingle brain metastasis only improves survival when other sites of extracranial disease were well controlled.
   Google Scholar
• Mintz AH, Kestle J, Rathbone MP et aL A randomized trial to assess the efficacy of surgery in adddition to radiotherapy in patients with a single cerebral metastasis. Cancer78, 1470–1476 (1996).
   PubMed Web of Science ®Google Scholar
• Bindal AK, Bindal RK, Hess KR et aL Surgery versus radiosurgery in the treatment of brain metastasis. J. Neurosurg. 84,748–754 (1996).
   PubMed Web of Science ®Google Scholar
• Alexander E, Moriarty TM, Davis RB et aL Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. Natl Cancer Inst. 87,34–40 (1995).
   Google Scholar
• Auchter RM, Lamond JP Alexander E etal. A multi-institutional outcome and prognostic factor analysis of radiosurgery for resectable single brain metastasis. Int. J Radiat. OncoL Biol. Phys. 35,27–35 (1996).
   Google Scholar
• Andrews DW, Scott CB, Sperduto PW et al. Whole-brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomized trial. Lancet 363, 1665–1672 (2004).
   PubMed Web of Science ®Google Scholar
• ••Demonstrates that radiosurgery inaddition to whole-brain irradiation improves survival for patients with a single brain metastasis. Shows that patients with one to three brain metastases are more likely to have a stable or improving performance status if they are treated with radiosurgery plus whole-brain irradiation rather than radiation therapy alone.
   Google Scholar
• Sneed PK, Lamborn KR, Forstner JM et aL Radiosurgery for brain metastases: is whole-brain radiotherapy necessary? Int. J Radiat. OncoL Biol. Phys. 43,549–558 (1999).
   PubMed Web of Science ®Google Scholar
• Hasegawa T, Kondziolka D, Flickinger JC, Germanwala A, Lunsford LD. Brain metastases treated with radiosurgery alone: an alternative to whole-brain radiotherapy? Neurosurgery 52,1318–1326 (2003).
   Google Scholar
• Sneed P, Suh J, Goetsch S et al. A multi- institutional review of radiosurgery alone vs. radiosurgery with whole-brain radiotherapy as the initial management of brain metastases. Int. J Radiat. Onto): Biol. Phys. 53,519-526 (2002).
   Google Scholar
• DeAngelis L, Delattre J, Posner J. Radiation-induced dementia in patients cured of brain metastases. Neurology39, 789–796 (1989).
   Google Scholar
• Arriagada R, LeChevalier T, Bode F et aL Prophylactic cranial irradiation for patients with small cell lung cancer in complete remission. J Natl. Cancer Inst. 87,183–190 (1995).
   PubMed Web of Science ®Google Scholar
• •A prospective, randomized controlled trial of prophylactic cranial irradiation demonstrated that after 2 years, cranial irradiation was not associated with a decline in neuropsychologic function compared with patients who did not receive cranial irradiation.
   Google Scholar
• Stuschke M, Eberhardt W, Pottgen C et al. Prophylactic cranial irradiation in locally advanced non-small cell lung cancer after multimodality treatment: long-term follow-up and investigations of late neuropsychologic effects. J. Clin. amyl. 17, 2700–2709 (1999).
   Google Scholar
• Patchell RA, Tibbs PA, Regine WF et aL Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA 280,1485–1489 (1998).
   PubMed Web of Science ®Google Scholar
• •Demonstrates that whole-brain radiation therapy in addition to surgical resection for a single metastasis decreased the risk of another brain metastasis and improved neurologic outcome.
   Google Scholar
• Shehata MK, Young B, Reid B et al Stereotactic radiosurgery of 468 brain metastases 2cm: implications for SRS dose and whole-brain radiation therapy. Int. J Radiat. Oncol Biol. Phys. 59,87-93 (2004).
   Google Scholar
• Regine WE Huhn JL, Patchell RA et al. Risk of symptomatic brain tumor recuuence and neurologic deficit after radiosurgery alone in patients with newly diagnosed brain metastases: results and implications. Int. J. Radiat. OncoL Biol. Phys. 52,333–338 (2002).
   PubMed Web of Science ®Google Scholar
• Sanghavi SN, Miranpuri SS, Chappell R et aL Radiosurgery for patients with brain metastases: a multi-institutional analysis, stratified by the RTOG recursive partitioning analysis method. Int. J. Radiat. OncoL Biol. Phys. 51,426–434 (2001).
   PubMed Web of Science ®Google Scholar
• Kondziolka D, Patel A, Lunsford LD, Kassam A, Flickinger JC. Stereotactic radiosurgery plus whole-brain radiotherapy alone for patients with multiple brain metastases Int. J. Radiat. OncoL Biol. Phys. 45,427–434 (1999).
   Google Scholar
• Varlotto JM, Flickinger JC, Niranjan A, Bhatnagar AK, Kondziolka D, Lunsford LD. Analysis of tumor control and toxicity in patients who have survived at least 1 year after radiosurgery for brain metastases. Int. Radiat. OncoL Biol. Phys. 57,452-464. (2003).
   Google Scholar
• van den Bent MJ. The role of chemotherapy in brain metastases. Eur. Cancer39, 2114–2120 (2003).
   PubMed Web of Science ®Google Scholar
• Abrey LE, Olson JD, Raizer JJ et al. A Phase II trial of temozolomide for patients with recurrent or progressive brain metastases. J Neurooncol. 53,259–265 (2001).
   PubMed Web of Science ®Google Scholar
• Agarwala SS, Kirkwood JM, Gore M et aL Temozolomide for the treatment of brain metastases associated with metastatic melanoma: a Phase II study. J. Clin. Oncol. 22,2101–2107 (2004).
   PubMed Web of Science ®Google Scholar
• Wong ET, Berkenblit A. The role of topotecan in the treatment of brain metastases. The Oncologist 9,68–79 (2004).
   PubMed Web of Science ®Google Scholar
• Korfel A, Oehm C, vonPawel J et al. Response to topotecan of symptomatic brain metastases of small cell lung cancer also after whole-brain irradiation: a multicentre Phase II study. Eur. J. Cancer 38,1724–1729 (2002).
   PubMed Web of Science ®Google Scholar
• Komarnicky L, Phillips T, Martz K, Asbell S, Isaacson S, Urtasun R. A randomized Phase III protocol for the evaluation of misonidazole combined with radiation in the treatment of patients with brain metastases (RTOG-7916). mt. J. Radiat. OncoL Biol. Phys. 20,53-58 (1991).
   Google Scholar
• DeAngelis LM, Currie VE, Kim JH et al. The combined use of radiation therapy and lonidamine in the treatment of brain metastases. J. Neurooncol. 7,241–247 (1989).
   PubMed Web of Science ®Google Scholar
• Phillips TL, Scott CB, Leibel SA, Rotman M, Weigensberg IJ. Results of a randomized comparison of radiotherapy and bromodeoxyuridine with radiotherapy alone for brain metastases: report of RTOG trial 89–05. Int. J. Radiat. OncoL Biol. Phys. 33,339-348 (1995).
   Google Scholar
• Ushio Y, Arita N, Hayakawa T et al. Chemotherapy of brain metastases from lung carcinoma: a controlled randomized study. Neurosurgery28,201–205 (1991).
   PubMed Web of Science ®Google Scholar
• Antonadou D, Paraskevaidis M, Sarris G et al. Phase II randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases. J. Clin. OncoL 20,3644–3650 (2002).
   PubMed Web of Science ®Google Scholar
• Auperin A, Arriagada R, Pignon JP et aL Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl. J. Med. 341,476–484 (1999).
   Google Scholar
• •Meta-analysis which demonstrates a survival advantage to prophylactic cranial irradiation in patients with small cell lung cancer that have achieved a complete remission.
   Google Scholar
• Gregor A, Cull A, Stephens RJ et al. Prophylactic cranial irradiation is indicated following complete response to induction therapy in small cell lung cancer: results of a muticentre randomised trial. Eur. J. Cancer 33,1752–1758 (1997).
   PubMed Web of Science ®Google Scholar
• Tai TH, Yu E, Dickof P et aL Prophylactic cranial irradiation revisted: cost-effectiveness and quality of life in small-cell lung cancer. Int. J. Radiat. OncoL Biol. Phys. 52,68–74 (2002).
   PubMed Web of Science ®Google Scholar
• Meyerson M, Franklin WA, Kelley MJ. Molecular classification and molecular genetics of human lung cancers. Semin. OncoL 31,4–19 (2004).
   Google Scholar
• van de Vijver MJ, He YD, van't Veer LJ et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl. J Med. 347,1999–2009 (2002).
   Google Scholar
• van't Veer LJ, Dai H, van de Vijver MJ. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530–536 (2002).
   Google Scholar
• Bhattacharjee A, Richards WG, Staunton J et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc. Natl Acad. Sci. USA 98, 13790–13795 (2001).
   PubMed Web of Science ®Google Scholar
• Ohshima K, Hamasaki M, Makimoto Y et al. Differential chemokine, chemokine receptor, cytokine and cytokine receptor expression in pulmonary adenocarcinoma: diffuse downregulation is associated with immune evasion and brain metastasis. Int. OncoL 23,965–973 (2003).
   PubMed Web of Science ®Google Scholar