Pharmacotherapy of post-traumatic stress disorder: a family practitioner’s guide to management of the disease

References

• Kessler R, Sonnega A, Bromet E, Hughes M, Nelson C. Posttraumatic stress disorder in the national comorbidity survey. Arch. Gen. Psych.52(12), 1048–1060 (1995).
   PubMed Web of Science ®Google Scholar
• Kaplan H, Sadock B. Kaplan and Sadock’s Synopsis of Psychiatry: Behavioural Sciences, Clinical Psychiatry. Eighth Edition. Williams & Williams, MD, USA (1998).
   Google Scholar
• Pincus H, Davis W, McQueen L. ‘Subthreshold’ mental disorders. A review and synthesis of studies on minor depression and other ‘brand names’. Br. J. Psychiatry174, 288–296 (1999).
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-I). First Edition. American Psychiatric Association, Washington DC, USA (1952).
   Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-II). Second Edition. American Psychiatric Association, Washington, DC, USA (1968).
   Google Scholar
• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Fourth Edition. Text Revision, American Psychiatric Association, Washington DC, USA (2000).
   Google Scholar
• Ungar T, Bursztain H, Joshi P, Sutherland S, Tomb D. Recognizing post-traumatic stress. Patient Care Canada11(6), 53–65 (2000).
   Google Scholar
• Buydens-Branchey L, Noumair D, Branchey M. Duration and intensity of combat exposure and posttraumatic stress disorder in vietnam veterans. J. Nerv. Ment. Dis.178(9), 582–587 (1990).
   PubMed Web of Science ®Google Scholar
• Dean E. Shook Over Hell: Post-traumatic Stress, Vietnam, and the Civil War. Harvard University Press, MA, USA (1997).
   Google Scholar
• Butler D, Moffic H, Turkal N. Post-traumatic stress reactions following motor vehicle accidents. Am. Fam. Physician60(2), 524–531 (1999).
   PubMed Web of Science ®Google Scholar
• Rothbaum B, Ninan P, Thomas L. Sertraline in the treatment of rape victims with posttraumatic stress disorder. J. Trauma Stress9(4), 865–871 (1996).
   PubMed Web of Science ®Google Scholar
• Bryant R, Harvey A. Delayed-onset posttraumatic stress disorder: a prospective evaluation. Aust. NZ J. Psychiatry.36(2), 205–209 (2002).
   PubMed Web of Science ®Google Scholar
• Kessler R, Borges G, Walters E. Prevalence of and risk factors for lifetime suicide attempts in the national comorbidity survey. Arch. Gen. Psych.56(7), 617–626 (1999).
   PubMed Web of Science ®Google Scholar
• Marshall R, Olfson M, Hellman F, Blanco C, Guardino M, Struening E. Comorbidity, impairment, and suicidality in subthreshold PTSD. Am. J. Psychiatry158(9), 1467–1473 (2001).
   PubMed Web of Science ®Google Scholar
• Yehuda R. Risk and resilience in posttraumatic stress disorder. J. Clin. Psychiatry65(Suppl. 1), 29–36 (2004).
   PubMed Web of Science ®Google Scholar
• Corneil W, Beaton R, Murphy S, Johnson C, Pike K. Exposure to traumatic incidents and prevalence of posttraumatic stress symptomatology in urban firefighters in two countries. J. Occup. Health Psychol.4(2), 131–141 (1999).
   PubMedGoogle Scholar
• Hodgetts G, Broers T, Godwin M, Bowering E, Hasanovic M. Post-traumatic stress disorder among family physicians in bosnia and herzegovina. Fam. Pract.20(4), 489–491 (2003).
   PubMed Web of Science ®Google Scholar
• Ursano R, Fullerton C, Vance K, Kao T. Posttraumatic stress disorder and identification in disaster workers. Am. J. Psychiatry156(3), 353–359 (1999).
   PubMed Web of Science ®Google Scholar
• Murphy S, Braun T, Tillery L, Cain K, Johnson L, Beaton R. PTSD among bereaved parents following the violent deaths of their 12- to 28-year-old children: a longitudinal prospective analysis. J. Trauma Stress12(2), 273–291 (1999).
   PubMed Web of Science ®Google Scholar
• Murphy S, Johnson L, Chung I, Beaton R. The prevalence of PTSD following the violent death of a child and predictors of change 5 years later. J. Trauma Stress16(1), 17–25 (2003).
   PubMed Web of Science ®Google Scholar
• Breslau N, Kessler R, Chilcoat H, Schultz L, Davis G, Andreski P. Trauma and posttraumatic stress disorder in the community: the 1996 Detroit area survey of trauma. Arch. Gen. Psych.55(7), 626–632 (1998).
   PubMed Web of Science ®Google Scholar
• Lecrubier Y. Posttraumatic stress disorder in primary care: a hidden diagnosis. J. Clin. Psychiatry65(Suppl. 1), 49–54 (2004).
   PubMedGoogle Scholar
• Udwin O, Boyle S, Yule W, Bolton D, O’Ryan D. Risk factors for long-term psychological effects of a disaster experienced in adolescence: Predictors of post traumatic stress disorder. J. Child. Psychol. Psychiatry41(8), 969–979 (2000).
   PubMed Web of Science ®Google Scholar
• Foa E, Meadows E. Psychosocial treatments for posttraumatic stress disorder. In: Psychological Trauma: Review of Psychiatry Series. Yehuda R (Ed.). American Psychiatric Association Press, Washington DC, USA, 179–204 (1998).
   Google Scholar
• Marshall R, Pierce D. Implications of recent findings in posttraumatic stress disorder and the role of pharmacotherapy. Harv. Rev. Psychiatry7(5), 247–256 (2000).
   PubMedGoogle Scholar
• Foa E, Tolin D. Comparison of the PTSD symptom scale-interview version and the clinician-administered PTSD scale. J. Trauma Stress13(2), 181–191 (2000).
   PubMed Web of Science ®Google Scholar
• Davidson J, Rothbaum B, van der Kolk B, Sikes C, Farfel G. Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Arch. Gen. Psych.58(5), 485–492 (2001).
   PubMed Web of Science ®Google Scholar
• Brady K, Pearlstein T, Asnis G et al. Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial. JAMA283(14), 1837–1844 (2000).
   PubMed Web of Science ®Google Scholar
• Zohar J, Amital D, Miodownik C et al. Double-blind placebo-controlled pilot study of sertraline in military veterans with posttraumatic stress disorder. J. Clin. Psychopharmacol.22(2), 190–195 (2002).
   PubMed Web of Science ®Google Scholar
• Davidson J, Lipschitz A, Musgnung J. Venlafaxine XR and sertraline in PTSD: A placebo-controlled study. J. Eur. Coll. Neuropsychopharmacol.13(Suppl. 4), S380 (2003).
   Google Scholar
• Rapaport M, Endicott J, Clary C. Posttraumatic stress disorder and quality of life: results across 64 weeks of sertraline treatment. J. Clin. Psychiatry63(1), 59–65 (2002).
   PubMedGoogle Scholar
• Londborg P, Hegel M, Goldstein S et al. Sertraline treatment of posttraumatic stress disorder: results of 24 weeks of open-label continuation treatment. J. Clin. Psychiatry62(5), 325–331 (2001).
   PubMed Web of Science ®Google Scholar
• Davidson J, Pearlstein T, Londborg P et al. Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study. Am. J. Psychiatry158(12), 1974–1981 (2001).
   PubMed Web of Science ®Google Scholar
• Tucker P, Zaninelli R, Yehuda R, Ruggiero L, Dillingham K, Pitts C. Paroxetine in the treatment of chronic posttraumatic stress disorder: results of a placebo-controlled, flexible-dosage trial. J. Clin. Psychiatry62(11), 860–868 (2001).
   PubMed Web of Science ®Google Scholar
• Marshall R, Beebe K, Oldham M, Zaninelli R. Efficacy and safety of paroxetine treatment for chronic PTSD: a fixed-dose, placebo-controlled study. Am. J. Psychiatry158(12), 1982–1988 (2001).
   PubMed Web of Science ®Google Scholar
• Hertzberg MA, Feldman ME, Beckham JC, Kudler HS, Davidson JR. Lack of efficacy for fluoxetine in PTSD: A placebo-controlled trial in combat veterans. Ann. Clin. Psychiatry12(2), 101–105 (2000).
   PubMedGoogle Scholar
• van der Kolk B, Dreyfuss D, Michaels M et al. Fluoxetine in posttraumatic stress disorder. J. Clin. Psychiatry55(12), 517–522 (1994).
   PubMed Web of Science ®Google Scholar
• Connor K, Sutherland S, Tupler L, Malik M, Davidson J. Fluoxetine in post-traumatic stress disorder. Randomised, double-blind study. Br. J. Psychiatry175, 17–22 (1999).
   PubMed Web of Science ®Google Scholar
• Meltzer Brody S, Connor KM, Churchill E, Davidson JR. Symptom-specific effects of fluoxetine in post-traumatic stress disorder. Int. Clin. Psychopharmacol.15(4), 227–231 (2000).
   Google Scholar
• Martenyi F, Brown E, Zhang H, Prakash A, Koke S. Fluoxetine versus placebo in posttraumatic stress disorder. J. Clin. Psychiatry63(3), 199–206 (2002).
   PubMed Web of Science ®Google Scholar
• Barnett SD, Tharwani HM, Hertzberg MA, Sutherland SM, Connor KM, Davidson JR. Tolerability of fluoxetine in posttraumatic stress disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry26(2), 363–367 (2002).
   Google Scholar
• Martenyi F, Brown E, Zhang H, Koke S, Prakash A. Fluoxetine vs. placebo in prevention of relapse in post-traumatic stress disorder. Br. J. Psychiatry181, 315–320 (2002).
   PubMed Web of Science ®Google Scholar
• Seedat S, Lockhat R, Kaminer D, Zungu-Dirwayi N, Stein D. An open trial of citalopram in adolescents with post-traumatic stress disorder. Int. Clin. Psychopharmacol.16(1), 21–25 (2001).
   PubMed Web of Science ®Google Scholar
• Seedat S, Stein D, Emsley R. Open trial of citalopram in adults with post-traumatic stress disorder. Int. J. Neuropsychopharmacol.3(2), 135–140 (2000).
   PubMedGoogle Scholar
• Seedat S, Stein D, Ziervogel C et al. Comparison of response to a selective serotonin re-uptake inhibitor in children, adolescents, and adults with posttraumatic stress disorder. J. Child. Adolesc. Psychopharmacol.12(1), 37–46 (2002).
   PubMed Web of Science ®Google Scholar
• Tucker P, Potter-Kimball R, Wyatt D et al. Can physiologic assessment and side effects tease out differences in PTSD trials? A double-blind comparison of citalopram, sertraline, and placebo. Psychopharmacol. Bull.37(3), 135–149 (2003).
   PubMedGoogle Scholar
• Davidson J, Weisler R, Malik M, Tupler L. Fluvoxamine in civilians with posttraumatic stress disorder. J. Clin. Psychopharmacol.18(1), 93–95 (1998).
   Google Scholar
• Marmar C, Schoenfeld F, Weiss D et al. Open trial of fluvoxamine treatment for combat-related posttraumatic stress disorder. J. Clin. Psychiatry57(Suppl. 8), 66–70 (1996).
   PubMed Web of Science ®Google Scholar
• Escalona R, Canive J, Calais L, Davidson J. Fluvoxamine treatment in veterans with combat-related post-traumatic stress disorder. Depress. Anxiety15(1), 29–33 (2002).
   PubMed Web of Science ®Google Scholar
• Tucker P, Smith K, Marx B, Jones D, Miranda R, Lensgraf J. Fluvoxamine reduces physiologic reactivity to trauma scripts in posttraumatic stress disorder. J. Clin. Psychopharmacol.20(3), 367–372 (2000).
   Google Scholar
• Neylan T, Metzler T, Schoenfeld F et al. Fluvoxamine and sleep disturbances in posttraumatic stress disorder. J. Trauma Stress14(3), 461–467 (2001).
   Web of Science ®Google Scholar
• DeBoer M, Op den Velde W, Falger P, Hovens J, De Groen J, Van Duijn H. Fluvoxamine treatment for chronic PTSD: a pilot study. Psychother. Psychosom.57(4), 158–163 (1992).
   Google Scholar
• Bahk W, Pae C, Tsoh J et al. Effects of mirtazapine in patients with post-traumatic stress disorder in korea: a pilot study. Hum. Psychopharmacol.17(7), 341–344 (2002).
   PubMed Web of Science ®Google Scholar
• Connor K, Davidson J, Weisler R, Ahearn E. A pilot study of mirtazapine in post-traumatic stress disorder. Int. Clin. Psychopharmacol.14(1), 29–31 (1999).
   PubMed Web of Science ®Google Scholar
• Connor K, Davidson J, Weisler R, Butterfield M, Casat C. Mirtazapine in posttraumatic stress disorder: Results of a placebo-controlled trial. J. Eur. Coll. Neuropsychopharmacol.12(Suppl. 3), S334 (2002).
   Google Scholar
• Burstein A. Treatment of post-traumatic stress disorder with imipramine. Psychosomatics25(9), 681–687 (1984).
   PubMed Web of Science ®Google Scholar
• Falcon S, Ryan C, Chamberlain K, Curtis G. Tricyclics: Possible treatment for posttraumatic stress disorder. J. Clin. Psychiatry46(9), 385–388 (1985).
   Web of Science ®Google Scholar
• Bleich A, Siegel B, Garb R, Lerer B. Post-traumatic stress disorder following combat exposure: clinical features and psychopharmacological treatment. Br. J. Psychiatry149, 365–369 (1986).
   PubMed Web of Science ®Google Scholar
• Blake D. Treatment of acute posttraumatic stress disorder with tricyclic antidepressants. South Med. J.79(2), 201–204 (1986).
   Web of Science ®Google Scholar
• Cheung P. Somatisation as a presentation in depression and post-traumatic stress disorder among cambodian refugees. Aust. NZ J. Psychiatry27(3), 422–428 (1993).
   PubMed Web of Science ®Google Scholar
• Chen C. The obsessive quality and clomipramine treatment in PTSD. Am. J. Psychiatry148(8), 1087–1088 (1991).
   PubMedGoogle Scholar
• Dow B, Kline N. Antidepressant treatment of posttraumatic stress disorder and major depression in veterans. Ann. Clin. Psychiatry9(1), 1–5 (1997).
   PubMedGoogle Scholar
• Frank J, Kosten T, Giller E, Dan E. A randomized clinical trial of phenelzine and imipramine for posttraumatic stress disorder. Am. J. Psychiatry145(10), 1289–1291 (1988).
   PubMed Web of Science ®Google Scholar
• Kosten T, Frank J, Dan E, McDougle C, Giller E. Pharmacotherapy for posttraumatic stress disorder using phenelzine or imipramine. J. Nerv. Ment. Dis.179(6), 366–370 (1991).
   PubMed Web of Science ®Google Scholar
• Davidson J, Kudler H, Smith R et al. Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch. Gen. Psych.47(3), 259–266 (1990).
   PubMed Web of Science ®Google Scholar
• Davidson J, Kudler H, Saunders W et al. Predicting response to amitriptyline in posttraumatic stress disorder. Am. J. Psychiatry150(7), 1024–1029 (1993).
   PubMed Web of Science ®Google Scholar
• Reist C, Kauffmann C, Haier R et al. A controlled trial of desipramine in 18 men with posttraumatic stress disorder. Am. J. Psychiatry146(4), 513–516 (1989).
   PubMed Web of Science ®Google Scholar
• Hogben G, Cornfield R. Treatment of traumatic war neurosis with phenelzine. Arch. Gen. Psych.38(4), 440–445 (1981).
   PubMed Web of Science ®Google Scholar
• Shestatzky M, Greenberg D, Lerer B. A controlled trial of phenelzine in posttraumatic stress disorder. Psychiatry Res.24(2), 149–155 (1988).
   PubMed Web of Science ®Google Scholar
• Lerer B, Bleich A, Kotler M, Garb R, Hertzberg M, Levin B. Posttraumatic stress disorder in Israeli combat veterans. Effect of phenelzine treatment. Arch. Gen. Psych.44(11), 976–981 (1987).
   Google Scholar
• Sutherland S, Davidson J. Pharmacological treatment of posttraumatic stress disorder. In: Post-traumatic Stress Disorder. Saigh P, Bremner J (Eds). Allyn & Bacon, MA, USA, 335–348 (1999).
   Google Scholar
• Neal L, Shapland W, Fox C. An open trial of moclobemide in the treatment of post-traumatic stress disorder. Int. Clin. Psychopharmacol.12(4), 231–237 (1997).
   PubMed Web of Science ®Google Scholar
• Baker D, Diamond B, Gillette G et al. A double-blind, randomized, placebo-controlled, multi-center study of brofaromine in the treatment of post-traumatic stress disorder. Psychopharmacology122(4), 386–389 (1995).
   PubMed Web of Science ®Google Scholar
• Hidalgo R, Hertzberg M, Mellman T et al. Nefazodone in post-traumatic stress disorder: results from six open-label trials. Int. Clin. Psychopharmacol.14(2), 61–68 (1999).
   Web of Science ®Google Scholar
• Hertzberg M, Feldman M, Beckham J, Moore S, Davidson J. Open trial of nefazodone for combat-related posttraumatic stress disorder. J. Clin. Psychiatry59(9), 460–464 (1998).
   PubMedGoogle Scholar
• Garfield D, Fichtner C, Leveroni C, Mahableshwarkar A. Open trial of nefazodone for combat veterans with posttraumatic stress disorder. J. Trauma Stress.14(3), 453–460 (2001).
   Google Scholar
• Davidson J, Weisler R, Malik M, Connor K. Treatment of posttraumatic stress disorder with nefazodone. Int. Clin. Psychopharmacol.13(3), 111–113 (1998).
   PubMed Web of Science ®Google Scholar
• Neylan T, Lenoci M, Maglione M et al. The effect of nefazodone on subjective and objective sleep quality in posttraumatic stress disorder. J. Clin. Psychiatry64(4), 445–450 (2003).
   PubMedGoogle Scholar
• Canive J, Clark R, Calais L, Qualls C, Tuason V. Bupropion treatment in veterans with posttraumatic stress disorder: an open study. J. Clin. Psychopharmacol.18(5), 379–383 (1998).
   PubMedGoogle Scholar
• Lipper S, Davidson J, Grady T et al. Preliminary study of carbamazepine in post-traumatic stress disorder. Psychosomatics27(12), 849–854 (1986).
   PubMed Web of Science ®Google Scholar
• Wolf M, Alavi A, Mosnaim A. Posttraumatic stress disorder in vietnam veterans clinical and EEG findings; possible therapeutic effects of carbamazepine. Biol. Psychiatry23(6), 642–644 (1988).
   PubMed Web of Science ®Google Scholar
• Fesler F. Valproate in combat-related posttraumatic stress disorder. J. Clin. Psychiatry52(9), 361–364 (1991).
   PubMed Web of Science ®Google Scholar
• Clark R, Canive J, Calais L, Qualls C, Tuason V. Divalproex in posttraumatic stress disorder: an open-label clinical trial. J. Trauma Stress12(2), 395–401 (1999).
   PubMed Web of Science ®Google Scholar
• Ford N. The use of anticonvulsants in posttraumatic stress disorder: case study and overview. J. Trauma Stress9(4), 857–863 (1996).
   PubMed Web of Science ®Google Scholar
• Kitchner I, Greenstein R. Low dose lithium carbonate in the treatment of post traumatic stress disorder: brief communication. Mil. Med.150(7), 378–381 (1985).
   PubMedGoogle Scholar
• Forster P, Schoenfeld F, Marmar C, Lang A. Lithium for irritability in post-traumatic stress disorder. J. Trauma Stress8(1), 143–149 (1995).
   PubMed Web of Science ®Google Scholar
• Hamner M, Brodrick P, Labbate L. Gabapentin in PTSD: a retrospective, clinical series of adjunctive therapy. Ann. Clin. Psychiatry13(3), 141–146 (2001).
   PubMedGoogle Scholar
• Taylor F. Tiagabine for posttraumatic stress disorder: a case series of 7 women. J. Clin. Psychiatry64(12), 1421–1425 (2003).
   PubMed Web of Science ®Google Scholar
• Malek-Ahmadi P. Gabapentin and posttraumatic stress disorder. Ann. Pharmacother.37(5), 664–666 (2003).
   Google Scholar
• Hertzberg M, Butterfield M, Feldman M et al. A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder. Biol. Psychiatry45(9), 1226–1229 (1999).
   PubMed Web of Science ®Google Scholar
• Braun P, Greenberg D, Dasberg H, Lerer B. Core symptoms of posttraumatic stress disorder unimproved by alprazolam treatment. J. Clin. Psychiatry51(6), 236–238 (1990).
   PubMed Web of Science ®Google Scholar
• Shalev A, Rogel-Fuchs Y. Auditory startle reflex in post-traumatic stress disorder patients treated with clonazepam. Isr. J. Psychiatry Relat. Sci.29(1), 1–6 (1992).
   Google Scholar
• Risse S, Whitters A, Burke J, Chen S, Scurfield R, Raskind M. Severe withdrawal symptoms after discontinuation of alprazolam in eight patients with combat-induced posttraumatic stress disorder. J. Clin. Psychiatry51(5), 206–209 (1990).
   PubMedGoogle Scholar
• Patterson J. Withdrawal from alprazolam dependency using clonazepam: clinical observations. J. Clin. Psychiatry51(Suppl.), 47–49 (1990).
   Google Scholar
• Gelpin E, Bonne O, Peri T, Brandes D, Shalev A. Treatment of recent trauma survivors with benzodiazepines:a prospective study. J. Clin. Psychiatry57(9), 390–394 (1996).
   PubMed Web of Science ®Google Scholar
• Hamner M, Frueh B, Ulmer H, Arana G. Psychotic features and illness severity in combat veterans with chronic posttraumatic stress disorder. Biol. Psychiatry.45(7), 846–852 (1999).
   PubMed Web of Science ®Google Scholar
• Ivezic S, Oruc L, Bell P. Psychotic symptoms in post-traumatic stress disorder. Mil. Med.164(1), 73–75 (1999).
   PubMedGoogle Scholar
• Hamner M, Deitsch S, Brodrick P, Ulmer H, Lorberbaum J. Quetiapine treatment in patients with posttraumatic stress disorder: an open trial of adjunctive therapy. J. Clin. Psychopharmacol.23(1), 15–20 (2003).
   PubMed Web of Science ®Google Scholar
• Hamner M, Faldowski R, Ulmer H, Frueh B, Huber M, Arana G. Adjunctive risperidone treatment in post-traumatic stress disorder: a preliminary controlled trial of effects on comorbid psychotic symptoms. Int. Clin. Psychopharmacol.18(1), 1–8 (2003).
   PubMed Web of Science ®Google Scholar
• Stein M, Kline N, Matloff J. Adjunctive olanzapine for SSRI-resistant combat-related PTSD: a double-blind, placebo-controlled study. Am. J. Psychiatry159(10), 1777–1779 (2002).
   PubMed Web of Science ®Google Scholar
• Bartzokis G, Freeman T, Roca V. Risperidone in the treatment of chronic combat-related post traumatic stress disorder. NT. J. Neuropsychopharmacology5(Suppl. 1), 130 (2002).
   Google Scholar
• Monnelly E, Ciraulo D, Knapp C, Keane T. Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder. J. Clin. Psychopharmacol.23(2), 193–196 (2003).
   PubMed Web of Science ®Google Scholar
• Butterfield MI, Becker ME, Connor KM, Sutherland S, Churchill LE, Davidson JR. Olanzapine in the treatment of post-traumatic stress disorder: a pilot study. Int. Clin. Psychopharmacol.16(4), 197–203 (2001).
   PubMed Web of Science ®Google Scholar
• Sokolski K, Denson T, Lee R, Reist C. Quetiapine for treatment of refractory symptoms of combat-related post-traumatic stress disorder. Mil. Med.168(6), 486–489 (2003).
   PubMedGoogle Scholar
• Sattar S, Ucci B, Grant K, Bhatia S, Petty F. Quetiapine therapy for posttraumatic stress disorder. Ann. Pharmacother.36(12), 1875–1878 (2002).
   PubMed Web of Science ®Google Scholar
• Kinzie J, Leung P. Clonidine in cambodian patients with posttraumatic stress disorder. J. Nerv. Ment. Dis.177(9), 546–550 (1989).
   PubMed Web of Science ®Google Scholar
• Harmon R, Riggs P. Clonidine for posttraumatic stress disorder in preschool children. J. Am. Acad. Child. Adolesc. Psychiatry35(9), 1247–1249 (1996).
   PubMed Web of Science ®Google Scholar
• Hertzberg M, Feldman M, Beckham J, Davidson J. Trial of trazodone for posttraumatic stress disorder using a multiple baseline group design. J. Clin. Psychopharmacol.16(4), 294–298 (1996).
   PubMed Web of Science ®Google Scholar
• Duffy J, Malloy P. Efficacy of buspirone in the treatment of posttraumatic stress disorder: An open trial. Ann. Clin. Psychiatry6(1), 33–37 (1994).
   PubMedGoogle Scholar
• Wells B, Chu C, Johnson R et al. Buspirone in the treatment of posttraumatic stress disorder. Pharmacotherapy11(4), 340–343 (1991).
   PubMed Web of Science ®Google Scholar
• Peskind E, Bonner L, Hoff D, Raskind M. Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder. J. Geriatr. Psychiatry Neurol.16(3), 165–171 (2003).
   PubMed Web of Science ®Google Scholar
• Raskind M, Dobie D, Kanter E, Petrie E, Thompson C, Peskind E. The α1-adrenergic antagonist prazosin ameliorates combat trauma nightmares in veterans with posttraumatic stress disorder: a report of 4 cases. J. Clin. Psychiatry61(2), 129–133 (2000).
   Google Scholar
• Raskind M, Thompson C, Petrie E et al. Prazosin reduces nightmares in combat veterans with posttraumatic stress disorder. J. Clin. Psychiatry63(7), 565–568 (2002).
   PubMed Web of Science ®Google Scholar
• Taylor F, Raskind M. The α1-adrenergic antagonist prazosin improves sleep and nightmares in civilian trauma posttraumatic stress disorder. J. Clin. Psychopharmacol.22(1), 82–85 (2002).
   PubMed Web of Science ®Google Scholar
• Raskind M, Peskind E, Kanter E et al. Reduction of nightmares and other PTSD symptoms in combat veterans by prazosin: a placebo-controlled study. Am. J. Psychiatry160(2), 371–373 (2003).
   PubMed Web of Science ®Google Scholar
• Taylor F, Cahill L. Propranolol for reemergent posttraumatic stress disorder following an event of retraumatization: a case study. J. Trauma Stress15(5), 433–437 (2002).
   PubMedGoogle Scholar
• Vaiva G, Ducrocq F, Jezequel K et al. Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma. Biol. Psychiatry54(9), 947–949 (2003).
   PubMed Web of Science ®Google Scholar
• Pitman R, Sanders K, Zusman R et al. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol. Psychiatry51(2), 189–192 (2002).
   PubMed Web of Science ®Google Scholar