A new tr(i)p to sense pain: TRPA1 channel as a target for novel analgesics

References

• National Center for Health Statistics. Health, United States, with chartbook on trends in the health of Americans. Hyattsville, MD, USA, 68–71 (2006).
   Google Scholar
• Stucky CL, Gold MS, Zhang X. Mechanisms of pain. Proc. Natl Acad. Sci. USA98(21), 11845–11846 (2001).
   PubMed Web of Science ®Google Scholar
• Sherrington CS. The Integrative Action of the Nervous System. Yale University Press, New Haven, CN, USA (1906).
   Google Scholar
• Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature413(6852), 203–210 (2001).
   PubMed Web of Science ®Google Scholar
• Dhaka A, Viswanath V, Patapoutian A. Trp ion channels and temperature sensation. Annu. Rev. Neurosci.29, 135–161 (2006).
   PubMed Web of Science ®Google Scholar
• Patapoutian A, Peier AM, Story GM, Viswanath V. ThermoTRP channels and beyond: mechanisms of temperature sensation. Nat. Rev. Neurosci.4(7), 529–539 (2003).
   PubMed Web of Science ®Google Scholar
• Hille B. Ionic Channels of Excitable Membranes. Sinauer Associates Inc., Sunderland, MA, USA (2001).
   Google Scholar
• Cai X. Subunit stoichiometry and channel pore structure of ion channels: all for one, or one for one? J. Physiol.586(4), 925–926 (2008).
   Google Scholar
• Woolf CJ, Ma Q. Nociceptors – noxious stimulus detectors. Neuron55(3), 353–364 (2007).
   PubMed Web of Science ®Google Scholar
• Dib-Hajj SD, Cummins TR, Black JA, Waxman SG. From genes to pain: Na v 1.7 and human pain disorders. Trends Neurosci.30(11), 555–563 (2007).
   PubMed Web of Science ®Google Scholar
• Cummins TR, Sheets PL, Waxman SG. The roles of sodium channels in nociception: implications for mechanisms of pain. Pain131(3), 243–257 (2007).
   PubMed Web of Science ®Google Scholar
• Jarvis MF, Honore P, Shieh CC et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc. Natl Acad. Sci. USA104(20), 8520–8525 (2007).
   PubMed Web of Science ®Google Scholar
• Altier C, Zamponi GW. Targeting Ca2+ channels to treat pain: T-type versus N-type. Trends Pharmacol. Sci.25(9), 465–470 (2004).
   PubMed Web of Science ®Google Scholar
• Swayne LA, Bourinet E. Voltage-gated calcium channels in chronic pain: emerging role of alternative splicing. Pflugers Arch.456(3), 459–466 (2008).
   PubMed Web of Science ®Google Scholar
• Schroeder CI, Doering CJ, Zamponi GW, Lewis RJ. N-type calcium channel blockers: novel therapeutics for the treatment of pain. Med. Chem.2(5), 535–543 (2006).
   PubMedGoogle Scholar
• Donnelly-Roberts D, McGaraughty S, Shieh CC, Honore P, Jarvis MF. Painful purinergic receptors. J. Pharmacol. Exp. Ther.324(2), 409–415 (2008).
   Web of Science ®Google Scholar
• Cockayne DA, Hamilton SG, Zhu QM et al. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature407(6807), 1011–1015 (2000).
   PubMed Web of Science ®Google Scholar
• Wemmie JA, Price MP, Welsh MJ. Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci.29(10), 578–586 (2006).
   PubMed Web of Science ®Google Scholar
• Lingueglia E. Acid-sensing ion channels in sensory perception. J. Biol. Chem.282(24), 17325–17329 (2007).
   PubMed Web of Science ®Google Scholar
• Sutherland SP, Benson CJ, Adelman JP, McCleskey EW. Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc. Natl. Acad. Sci. USA98(2), 711–716 (2001).
   PubMed Web of Science ®Google Scholar
• Maingret F, Lauritzen I, Patel AJ et al. TREK-1 is a heat-activated background K+ channel. EMBO J.19(11), 2483–2491 (2000).
   PubMed Web of Science ®Google Scholar
• Belmonte C, Viana F. Molecular and cellular limits to somatosensory specificity. Mol. Pain.4, 14 (2008).
   PubMed Web of Science ®Google Scholar
• Alloui A, Zimmermann K, Mamet J et al. TREK-1, a K+ channel involved in polymodal pain perception. EMBO J.25(11), 2368–2376 (2006).
   PubMed Web of Science ®Google Scholar
• Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol. Rev.87(1), 165–217 (2007).
   PubMed Web of Science ®Google Scholar
• Cai X. Unicellular Ca2+ signaling ‘toolkit’ at the origin of Metazoa. Mol. Biol. Evol.25(7), 1357–1361 (2008).
   PubMedGoogle Scholar
• Levine JD, Alessandri-Haber N. TRP channels: targets for the relief of pain. Biochem. Biophys. Acta1772(8), 989–1003 (2007).
   PubMed Web of Science ®Google Scholar
• Caterina MJ, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci.24, 487–517 (2001).
   PubMed Web of Science ®Google Scholar
• Mezey E, Toth ZE, Cortright DN et al. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc. Natl Acad. Sci. USA97(7), 3655–3660 (2000).
   PubMed Web of Science ®Google Scholar
• Gibson HE, Edwards JG, Page RS, Van Hook MJ, Kauer JA. TRPV1 channels mediate long-term depression at synapses on hippocampal interneurons. Neuron57(5), 746–759 (2008).
   PubMed Web of Science ®Google Scholar
• Shimosato G, Amaya F, Ueda M, Tanaka Y, Decosterd I, Tanaka M. Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG. Pain119(1–3), 225–232 (2005).
   PubMed Web of Science ®Google Scholar
• Alessandri-Haber N, Dina OA, Joseph EK, Reichling D, Levine JD. A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J. Neurosci.26(14), 3864–3874 (2006).
   PubMed Web of Science ®Google Scholar
• Peier AM, Moqrich A, Hergarden AC et al. A TRP channel that senses cold stimuli and menthol. Cell108(5), 705–715 (2002).
   PubMed Web of Science ®Google Scholar
• Suh BC, Hille B. PIP2 is a necessary cofactor for ion channel function: how and why? Annu. Rev. Biophys.37, 175–195 (2008).
   PubMed Web of Science ®Google Scholar
• Kim D, Cavanaugh EJ. Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates. J. Neurosci.27(24), 6500–6509 (2007).
   PubMed Web of Science ®Google Scholar
• Rohacs T, Nilius B. Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Arch.455(1), 157–168 (2007).
   PubMed Web of Science ®Google Scholar
• Rohacs T. Regulation of TRP channels by PIP(2). Pflugers Arch.453(6), 753–762 (2007).
   Google Scholar
• Karashima Y, Prenen J, Meseguer V, Owsianik G, Voets T, Nilius B. Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch.457(1), 77–89 (2008).
   PubMed Web of Science ®Google Scholar
• Kim D, Cavanaugh EJ, Simkin D. Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate. Am. J. Physiol. Cell. Physiol.295(1), C92–C99 (2008).
   PubMed Web of Science ®Google Scholar
• Tai C, Zhu S, Zhou N. TRPA1: the central molecule for chemical sensing in pain pathway? J. Neurosci.28(5), 1019–1021 (2008).
   PubMed Web of Science ®Google Scholar
• Ramsey IS, Delling M, Clapham DE. An introduction to TRP channels. Annu. Rev. Physiol.68, 619–647 (2006).
   PubMed Web of Science ®Google Scholar
• Venkatachalam K, Montell C. TRP channels. Annu. Rev. Biochem.76, 387–417 (2007).
   PubMed Web of Science ®Google Scholar
• Christensen AP, Corey DP. TRP channels in mechanosensation: direct or indirect activation? Nat. Rev. Neurosci.8(7), 510–521 (2007).
   PubMedGoogle Scholar
• Stokes A, Wakano C, Koblan-Huberson M, Adra CN, Fleig A, Turner H. TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD. Cell Signal.18(10), 1584–1594 (2006).
   PubMed Web of Science ®Google Scholar
• Hinman A, Chuang HH, Bautista DM, Julius D. TRP channel activation by reversible covalent modification. Proc. Natl Acad. Sci. USA103(51), 19564–19568 (2006).
   PubMed Web of Science ®Google Scholar
• Macpherson LJ, Dubin AE, Evans MJ et al. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature445(7127), 541–545 (2007).
   PubMed Web of Science ®Google Scholar
• Salazar H, Llorente I, Jara-Oseguera A et al. A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat. Neurosci.11(3), 255–261 (2008).
   PubMed Web of Science ®Google Scholar
• Karashima Y, Damann N, Prenen J et al. Bimodal action of menthol on the transient receptor potential channel TRPA1. J. Neurosci.27(37), 9874–9884 (2007).
   PubMed Web of Science ®Google Scholar
• Zurborg S, Yurgionas B, Jira JA, Caspani O, Heppenstall PA. Direct activation of the ion channel TRPA1 by Ca2+. Nat. Neurosci.10(3), 277–279 (2007).
   PubMed Web of Science ®Google Scholar
• Matta JA, Cornett PM, Miyares RL, Abe K, Sahibzada N, Ahern GP. General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc. Natl Acad. Sci. USA105(25), 8784–8789 (2008).
   PubMed Web of Science ®Google Scholar
• Macpherson LJ, Xiao B, Kwan KY et al. An ion channel essential for sensing chemical damage. J. Neurosci.27(42), 11412–11415 (2007).
   PubMed Web of Science ®Google Scholar
• McNamara CR, Mandel-Brehm J, Bautista DM et al. TRPA1 mediates formalin-induced pain. Proc. Natl Acad. Sci. USA104(33), 13525–13530 (2007).
   PubMed Web of Science ®Google Scholar
• Trevisani M, Siemens J, Materazzi S et al. 4-hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc. Natl. Acad. Sci. USA104(33), 13519–13524 (2007).
   PubMed Web of Science ®Google Scholar
• Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain51(1), 5–17 (1992).
   PubMed Web of Science ®Google Scholar
• Lee G, Abdi K, Jiang Y, Michaely P, Bennett V, Marszalek PE. Nanospring behaviour of ankyrin repeats. Nature440(7081), 246–249 (2006).
   PubMed Web of Science ®Google Scholar
• Andersson DA, Gentry C, Moss S, Bevan S. Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J. Neurosci.28(10), 2485–2494 (2008).
   PubMed Web of Science ®Google Scholar
• Taylor-Clark TE, McAlexander MA, Nassenstein C et al. Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J. Physiol.586(14), 3447–3459 (2008).
   Google Scholar
• Bessac BF, Sivula M, von Hehn CA, Escalera J, Cohn L, Jordt SE. TRPA1 is a major oxidant sensor in murine airway sensory neurons. J. Clin. Invest.118(5), 1899–1910 (2008).
   PubMed Web of Science ®Google Scholar
• Woolf CJ. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann. Intern. Med.140(6), 441–451 (2004).
   PubMed Web of Science ®Google Scholar
• Dykxhoorn DM, Lieberman J. Knocking down disease with siRNAs. Cell126(2), 231–235 (2006).
   PubMed Web of Science ®Google Scholar