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Expert Review of Vaccines Volume 15, 2016 - Issue 1
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Review

Human papillomavirus vaccination in HIV-infected women: need for increased coverage

Erna Milunka KojicDivision of Infectious Diseases, Warren Alpert School of Medicine, Brown University, Providence, RI, USACorrespondence[email protected]
,
Aadia I. RanaDivision of Infectious Diseases, Warren Alpert School of Medicine, Brown University, Providence, RI, USA
&
Susan Cu-UvinDivision of Infectious Diseases, Warren Alpert School of Medicine, Brown University, Providence, RI, USA
Pages 105-117 | Published online: 24 Nov 2015

References

  • Papers of special note have been highlighted as:
  • * of interest to readers
  • ** of considerable interest to readers
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* This is one of the first studies to publish data on the epidemiology of anal HPV infection in both HIV-infected and HIV-uninfected women

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  • Massad LS, Xie X, Burk RD, et al. Association of cervical precancer with human papillomavirus types other than 16 among HIV co-infected women. Am J Obstet Gynecol. Forthcoming 2015 Sep 30. pii: S0002-9378(15)01200-4. doi:10.1016/j.ajog.2015.09.086.
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** This study has highlighted the fact that HIV-infected women who receive regular care and screening have similar rates of invasive cervical cancer as HIV-uninfected women, adding data to support screening recommendations for women living with HIV

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** A two dose vaccine schedule is as immunogenic as a three dose HPV vaccine. This may have significant public health and policy implications and should also be evaluated in HIV-infected women

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  • Kojic EM, Kang M, Cespedes MS, et al. Immunogenicity and safety of the quadrivalent human papillomavirus vaccine in HIV-1-infected women. Clin Infect Dis. 2014;59(1):127–135.

** This study showed that tha qHPV vaccine is immunogenic in HIV-infected women and stands out as the study also included women with high degree of immunosuppression

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* This study revealed that the HPV vaccine is safe to use even among women with high exposure rates to HPC 16 and 18 as is the fact in South Africa

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* Here, the study found that the vaccine is both safe and immunogenic in HIV-infected children who has provided data to support vaccinating all children living with HIV infection

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** This is a very nice overall review of HPV vaccination in general with a historical perspective and lessons learned. These lessons can also be applied to HIV-infected women although they were not addressed in the review

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