107
Views
12
CrossRef citations to date
0
Altmetric
Perspective

Model for product development of vaccines against neglected tropical diseases: a vaccine against human hookworm

&
Pages 1481-1492 | Published online: 09 Jan 2014

References

  • Hotez PJ, Brindley PJ, Bethony JM, King CH, Pearce EJ, Jacobson J. Helminth infections: the great neglected tropical diseases. J. Clin. Invest.118(4), 1311–1321 (2008).
  • Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Diemert D, Loukas A. New technologies for the control of human hookworm infection. Trends Parasitol.22, 327–331 (2006).
  • Goud GN, Bottazzi ME, Zhan B et al. Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine23(39), 4754–4764 (2005).
  • Loukas A, Bethony JM, Mendez S et al. Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs. PLoS Med.2(10), e295 (2005).
  • Loukas A, Bethony J, Brooker S, Hotez P. Hookworm vaccines: past, present, and future. Lancet Infect. Dis.6(11), 733–741 (2006).
  • Xiao S, Zhan B, Xue J et al. The evaluation of recombinant hookworm antigens as vaccines in hamsters (Mesocricetus auratus) challenged with human hookworm, necator americanus. Exp. Parasitol.118(1), 32–40 (2008).
  • Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Roses-Periago M. The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination PLoS Negl. Trop. Dis.2 (9), e300, 1–10 (2008).
  • Hotez PJ. The giant anteater in the room: Brazil’s neglected tropical diseases problem. PLoS Negl. Trop. Dis.2(1), e177 (2008).
  • Morel CM, Acharya T, Broun D et al. Health innovation networks to help developing countries address neglected diseases. Science309(5733), 401–404 (2005).
  • Morel CM, Broun D, Dangi A et al. Health innovation in developing countries to address diseases of the poor. Innovation Strategy Today1, 1–15 (2005).
  • Thorsteinsdottir H, Quach U, Martin DK, Daar AS, Singer PA. Introduction: promoting global health through biotechnology. Nat. Biotechnol.22(Suppl.), DC3–DC7 (2004).
  • Guimaraes R. Health research in Brazil: context and challenges. Rev. Saude Publica40, 3–10 (2006).
  • Hotez PJ, Ferris MT. The antipoverty vaccines. Vaccine24(31–32), 5787–5799 (2006).
  • Marques MB. An overview of health-related industrial biotechnology in latin america and the caribbean. Bull. Pan. Am. Health Organ.30(2), 95–105 (1996).
  • Salicrup LA, Fedorkova L. Challenges and opportunities for enhancing biotechnology and technology transfer in developing countries. Biotechnol. Adv.24(1), 69–79 (2006).
  • Gardner CA, Acharya T, Yach D. Technological and social innovation: a unifying new paradigm for global health. Health. Aff. (Millwood)26(4), 1052–1061 (2007).
  • Wheeler C, Berkley S. Initial lessons from public–private partnerships in drug and vaccine development. Bull. World Health Organ.79(8), 728–734 (2001).
  • Bottazzi ME, Miles AP, Diemert D, Hotez PJ. An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseases. Expert Rev. Vaccines5(2), 189–198 (2006).
  • Jadhav S, Datla M, Kreeftenberg H, Hendriks J. The developing countries vaccine manufacturers’ network (DCVMN) is a critical constituency to ensure access to vaccines in developing countries. Vaccine26(13), 1611–1615 (2008).
  • Henriks J, Poeloengan T, Raw I, Martinez LH, El-Abbadi M. Developing country vaccine manufacturers network (DCVMN), 26–27 April 2001, Baudung, Indonesia. Vaccine20, 285–287 (2002).
  • Milstien JB, Gaule P, Kaddar M. Access to vaccine technologies in developing countries: Brazil and India. Vaccine25(44), 7610–7619 (2007).
  • Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Buss P. Hookworm: “the great infection of mankind”. PLoS Med.2(3), e67 (2005).
  • Hotez PJ, Zhan B, Bethony JM et al. Progress in the development of a recombinant vaccine for human hookworm disease: the human hookworm vaccine initiative. Int. J. Parasitol.33(11), 1245–1258 (2003).
  • Roberts L. Infectious disease. An ill wind, bringing meningitis. Science320(5884), 1710–1715 (2008).
  • Brooke S, Harner-Jay CM, Lasher H, Jacoby E. How public–private partnerships handle intellectual property: the PATH experience. In: In Intellectual Property Management in Health and Agricultural Innovation: A Handbook of Best Practices. Krattiger A, Mahoney RT, Nelsen L (Eds). MIHR, Oxford, UK and PIPRA, CA USA 1755 (2007).
  • Kane MA, Sherris J, Coursaget P, Aguado T, Cutts F. Chapter 15: HPV vaccine use in the developing world. Vaccine24(Suppl. 3), S132–S139 (2006).
  • Andrus JK, de Quadros CA. Global access to vaccines. In: AIDS Vaccine Development: Challenges and Opportunities. Koff WC, Kahn P, Gust D (Eds). Horizon Press, Norwich, UK 125–132 (2007).
  • Oehler J. The role of milestones in licensing deals to assure access to health products in developing countries. IP Strategy Today10, 59–70 (2004).
  • Martins RM, Bensabath G, Arraes LC et al. Multicenter study on the immunogenicity and safety of two recombinant vaccines against hepatitis B. Mem. Inst. Oswaldo Cruz99(8), 865–871 (2004).
  • Rodrigues DG, Kesselring G. Clinical trials in Brazil, facing the challenges. Monitor75–78 (2008).
  • Serdobova I, Kieny MP. Assembling a global vaccine development pipeline for infectious diseases in the developing world. Am. J. Public Health96(9), 1554–1559 (2006).
  • de Silva NR, Brooker S, Hotez PJ, Montresor A, Engels D, Savioli L. Soil-transmitted helminth infections: updating the global picture. Trends Parasitol.19(12), 547–551 (2003).
  • Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect. Dis.6, 411–425 (2006).

Patent

  • Hotez P, Ashcom J, Bdamchian M et al. Hookworm Vaccine. US7303752 4 December 2007.

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.