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Review

Age-related decline in immunity: implications for vaccine responsiveness

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Pages 467-479 | Published online: 09 Jan 2014

References

  • Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology120(4), 435–446 (2007).
  • Pawelec G. Immunity and ageing in man. Exp. Gerontol.41(12), 1239–1242 (2006).
  • Herndler-Brandstetter D, Cioca DP, Grubeck-Loebenstein B. Immunizations in the elderly: do they live up to their promise? Wien. Med. Wochenschr.156(5–6), 130–141 (2006).
  • Kovaiou RD, Herndler-Brandstetter D, Grubeck-Loebenstein B. Age-related changes in immunity: implications for vaccination in the elderly. Expert. Rev. Mol. Med.9(3), 1–17 (2007).
  • Gruver AL, Hudson LL, Sempowski GD. Immunosenescence of ageing. J. Pathol.211(2), 144–156 (2007).
  • Plowden J, Renshaw-Hoelscher M, Engleman C, Katz J, Sambhara S. Innate immunity in aging: impact on macrophage function. Aging Cell3(4), 161–167 (2004).
  • Burns EA. Effects of aging on immune function. J. Nutr. Health Aging8(1), 9–18 (2004).
  • Kondo M, Wagers AJ, Manz MG et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu. Rev. Immunol.21, 759–806 (2003).
  • Kamminga LM, de Haan G. Cellular memory and hematopoietic stem cell aging. Stem Cells24(5), 1143–1149 (2006).
  • Henckaerts E, Langer JC, Snoeck HW. Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice. Blood104(2), 374–379 (2004).
  • Yuan R, Astle CM, Chen J, Harrison DE. Genetic regulation of hematopoietic stem cell exhaustion during development and growth. Exp. Hematol.33(2), 243–250 (2005).
  • Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature411(6835), 366–374 (2001).
  • Aspinall R, Andrew D. Thymic involution in aging. J. Clin. Immunol.20(4), 250–256 (2000).
  • Prelog M. Aging of the immune system: a risk factor for autoimmunity? Autoimmun. Rev.5(2), 136–139 (2006).
  • Varas A, Sacedon R, Hernandez-Lopez C et al. Age-dependent changes in thymic macrophages and dendritic cells. Microsc. Res. Tech.62(6), 501–507 (2003).
  • Aspinall R. T cell development, ageing and interleukin-7. Mech. Ageing Dev.127(6), 572–578 (2006).
  • Andrew D, Aspinall R. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp. Gerontol.37(2–3), 455–463 (2002).
  • Ginaldi L, De MM, D’Ostilio A et al. Immunological changes in the elderly. Aging (Milano)11(5), 281–286 (1999).
  • Schindowski K, Frohlich L, Maurer K, Muller WE, Eckert A. Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets. Mech. Ageing Dev.123(4), 375–390 (2002).
  • Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat. Immunol.5(2), 133–139 (2004).
  • Hakim FT, Flomerfelt FA, Boyiadzis M, Gress RE. Aging, immunity and cancer. Curr. Opin. Immunol.16(2), 151–156 (2004).
  • Romanyukha AA, Yashin AI. Age related changes in population of peripheral T cells: towards a model of immunosenescence. Mech. Ageing Dev.124(4), 433–443 (2003).
  • Davenport RJ. Immunity challenge. Sci. Aging Knowledge Environ.2003(23), OA1 (2003).
  • Effros RB. Replicative senescence of CD8 T cells: effect on human ageing. Exp. Gerontol.39(4), 517–524 (2004).
  • Effros RB, Dagarag M, Valenzuela HF. in vitro senescence of immune cells. Exp. Gerontol.38(11–12), 1243–1249 (2003).
  • Goronzy JJ, Fulbright JW, Crowson CS et al. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J. Virol.75(24), 12182–12187 (2001).
  • Pourgheysari B, Khan N, Best D et al. The CMV-specific CD4+ T cell response expands with age and markedly alters the CD4+ T cell repertoire. J. Virol.81(14), 7759–7765 (2007).
  • Trzonkowski P, Mysliwska J, Szmit E et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination – an impact of immunosenescence. Vaccine21(25–26), 3826–3836 (2003).
  • Rink L, Cakman I, Kirchner H. Altered cytokine production in the elderly. Mech. Ageing Dev.102(2–3), 199–209 (1998).
  • Fischer MB, Hauber I, Eggenbauer H et al. A defect in the early phase of T-cell receptor-mediated T-cell activation in patients with common variable immunodeficiency. Blood84(12), 4234–4241 (1994).
  • Ginaldi L, De MM, D’Ostilio A et al. The immune system in the elderly: II. Specific cellular immunity. Immunol. Res.20(2), 109–115 (1999).
  • Haynes L, Eaton SM, Burns EM, Rincon M, Swain SL. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo.J. Immunol.172(9), 5194–5199 (2004).
  • Toda A, Piccirillo CA. Development and function of naturally occurring CD4+CD25+ regulatory T cells. J. Leukoc. Biol.80(3), 458–470 (2006).
  • Rouse BT, Sarangi PP, Suvas S. Regulatory T cells in virus infections. Immunol. Rev.212, 272–286 (2006).
  • Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat. Immunol.6(4), 353–360 (2005).
  • Chatila TA. Role of regulatory T cells in human diseases. J. Allergy Clin. Immunol.116(5), 949–959 (2005).
  • Nishioka T, Shimizu J, Iida R, Yamazaki S, Sakaguchi S. CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice. J. Immunol.176(11), 6586–6593 (2006).
  • Tsaknaridis L, Spencer L, Culbertson N et al. Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity. J. Neurosci. Res.74(2), 296–308 (2003).
  • Johnson KM, Owen K, Witte PL. Aging and developmental transitions in the B cell lineage. Int. Immunol.14(11), 1313–1323 (2002).
  • Min H, Montecino-Rodriguez E, Dorshkind K. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J. Immunol.176(2), 1007–1012 (2006).
  • Tsuboi I, Morimoto K, Hirabayashi Y et al. Senescent B lymphopoiesis is balanced in suppressive homeostasis: decrease in interleukin-7 and transforming growth factor-β levels in stromal cells of senescence-accelerated mice. Exp. Biol. Med. (Maywood)229(6), 494–502 (2004).
  • Stephan RP, Lill-Elghanian DA, Witte PL. Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J. Immunol.158(4), 1598–1609 (1997).
  • Chung JB, Silverman M, Monroe JG. Transitional B cells: step by step towards immune competence. Trends Immunol.24(6), 343–349 (2003).
  • Souvannavong V, Lemaire C, Andreau K, Brown S, Adam A. Age-associated modulation of apoptosis and activation in murine B lymphocytes. Mech. Ageing Dev.103(3), 285–299 (1998).
  • Zharhary D, Segev Y, Gershon H. The affinity and spectrum of cross reactivity of antibody production in senescent mice: the IgM response. Mech. Ageing Dev.6(5), 385–392 (1977).
  • Johnson SA, Cambier JC. Ageing, autoimmunity and arthritis: senescence of the B cell compartment – implications for humoral immunity. Arthritis Res. Ther.6(4), 131–139 (2004).
  • Zheng B, Han S, Takahashi Y, Kelsoe G. Immunosenescence and germinal center reaction. Immunol. Rev.160, 63–77 (1997).
  • Han S, Zheng B, Takahashi Y, Kelsoe G. Distinctive characteristics of germinal center B cells. Semin. Immunol.9(4), 255–260 (1997).
  • Yang X, Stedra J, Cerny J. Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J. Exp. Med.183(3), 959–970 (1996).
  • Lazuardi L, Jenewein B, Wolf AM et al. Age-related loss of naive T cells and dysregulation of T-cell/B-cell interactions in human lymph nodes. Immunology114(1), 37–43 (2005).
  • Ginaldi L, De MM, D’Ostilio A et al. The immune system in the elderly: III. Innate immunity. Immunol. Res.20(2), 117–126 (1999).
  • Stout RD, Suttles J. Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changes. Immunol. Rev.205, 60–71 (2005).
  • Andrade CF, Waddell TK, Keshavjee S, Liu M. Innate immunity and organ transplantation: the potential role of Toll-like receptors. Am. J. Transplant.5(5), 969–975 (2005).
  • Renshaw M, Rockwell J, Engleman C et al. Cutting edge: impaired Toll-like receptor expression and function in aging. J. Immunol.169(9), 4697–4701 (2002).
  • Garg M, Luo W, Kaplan AM, Bondada S. Cellular basis of decreased immune responses to pneumococcal vaccines in aged mice. Infect. Immun.64(11), 4456–4462 (1996).
  • Zissel G, Schlaak M, Muller-Quernheim J. Age-related decrease in accessory cell function of human alveolar macrophages. J. Investig. Med.47(1), 51–56 (1999).
  • Herrero C, Sebastian C, Marques L et al. Immunosenescence of macrophages: reduced MHC class II gene expression. Exp. Gerontol.37(2–3), 389–394 (2002).
  • de la Fuente M, Hernanz A, Guayerbas N, Alvarez P, Alvarado C. Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell Mol. Biol. (Noisy-le-grand)50, OL683–OL690 (2004).
  • Kalinski P, Schuitemaker JH, Hilkens CM, Kapsenberg ML. Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J. Immunol.161(6), 2804–2809 (1998).
  • Wick G, Grubeck-Loebenstein B. Primary and secondary alterations of immune reactivity in the elderly: impact of dietary factors and disease. Immunol. Rev.160, 171–184 (1997).
  • Sato H, Dobashi M. The distribution, immune complex trapping ability and morphology of follicular dendritic cells in popliteal lymph nodes of aged rats. Histol. Histopathol.13(1), 99–108 (1998).
  • Chidrawar SM, Khan N, Chan YL, Nayak L, Moss PA. Ageing is associated with a decline in peripheral blood CD56bright NK cells. Immun. Ageing3, 10 (2006).
  • Mariani E, Sgobbi S, Meneghetti A et al. Perforins in human cytolytic cells: the effect of age. Mech. Ageing Dev.92(2–3), 195–209 (1996).
  • Steele TA, Brahmi Z. Inhibition of human natural killer cell activity by the protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpiperazine is an early but post-binding event. J. Immunol.141(9), 3164–3169 (1988).
  • Solana R, Mariani E. NK and NK/T cells in human senescence. Vaccine18(16), 1613–1620 (2000).
  • Heron MP, Smith BL. Deaths: leading causes for 2003. Natl Vital Stat. Rep.55(10), 1–92 (2007).
  • Hamilton BE, Minino AM, Martin JA et al. Annual summary of vital statistics: 2005. Pediatrics119(2), 345–360 (2007).
  • Bridges CB, Harper SA, Fukuda K et al. Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep.52(RR-8), 1–34 (2003).
  • Thompson WW, Shay DK, Weintraub E et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA289(2), 179–186 (2003).
  • Jefferson T, Rivetti D, Rivetti A et al. Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet366(9492), 1165–1174 (2005).
  • Hak E, Nordin J, Wei F et al. Influence of high-risk medical conditions on the effectiveness of influenza vaccination among elderly members of 3 large managed-care organizations. Clin. Infect. Dis.35(4), 370–377 (2002).
  • Bellei NC, Carraro E, Castelo A, Granato CF. Risk factors for poor immune response to influenza vaccination in elderly people. Braz. J. Infect. Dis.10(4), 269–273 (2006).
  • Smith NM, Bresee JS, Shay DK et al. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep.55(RR-10), 1–42 (2006).
  • Govaert TM, Thijs CT, Masurel N et al. The efficacy of influenza vaccination in elderly individuals. A randomized double-blind placebo-controlled trial. JAMA272(21), 1661–1665 (1994).
  • Nichol KL, Wuorenma J, von Sternberg T. Benefits of influenza vaccination for low-, intermediate-, and high-risk senior citizens. Arch. Intern. Med.158(16), 1769–1776 (1998).
  • Mullooly JP, Bennett MD, Hornbrook MC et al. Influenza vaccination programs for elderly persons: cost–effectiveness in a health maintenance organization. Ann. Intern. Med.121(12), 947–952 (1994).
  • Bouree P. Immunity and immunization in elderly. Pathol. Biol. (Paris)51(10), 581–585 (2003).
  • Shugarman LR, Hales C, Setodji CM, Bardenheier B, Lynn J. The influence of staff and resident immunization rates on influenza-like illness outbreaks in nursing homes. J. Am. Med. Dir. Assoc.7(9), 562–567 (2006).
  • Almanzar G, Herndler-Brandstetter D, Chaparro SV et al. Immunodominant peptides from conserved influenza proteins – a tool for more efficient vaccination in the elderly? Wien. Med. Wochenschr.157(5–6), 116–121 (2007).
  • Butcher SK, Lord JM. Stress responses and innate immunity: aging as a contributory factor. Aging Cell3(4), 151–160 (2004).
  • Danenberg HD, Ben-Yehuda A, Zakay-Rones Z, Friedman G. Dehydroepiandrosterone (DHEA) treatment reverses the impaired immune response of old mice to influenza vaccination and protects from influenza infection. Vaccine13(15), 1445–1448 (1995).
  • Ben-Yehuda A, Danenberg HD, Zakay-Rones Z, Gross DJ, Friedman G. The influence of sequential annual vaccination and of DHEA administration on the efficacy of the immune response to influenza vaccine in the elderly. Mech. Ageing Dev.102(2–3), 299–306 (1998).
  • Danenberg HD, Ben-Yehuda A, Zakay-Rones Z, Gross DJ, Friedman G. Dehydroepiandrosterone treatment is not beneficial to the immune response to influenza in elderly subjects. J. Clin. Endocrinol. Metab82(9), 2911–2914 (1997).
  • Evans TG, Judd ME, Dowell T et al. The use of oral dehydroepiandrosterone sulfate as an adjuvant in tetanus and influenza vaccination of the elderly. Vaccine14(16), 1531–1537 (1996).
  • Negrotto S, Malaver E, Alvarez ME et al. Aspirin and salicylate suppress polymorphonuclear apoptosis delay mediated by proinflammatory stimuli. J. Pharmacol. Exp. Ther.319(2), 972–979 (2006).
  • Mazur I, Wurzer WJ, Ehrhardt C et al. Acetylsalicylic acid (ASA) blocks influenza virus propagation via its NF-κB-inhibiting activity. Cell Microbiol.9(7), 1683–1994 (2007).
  • Pneumococcal and influenza vaccination levels among adults aged > or = 65 years – United States, 1995. MMWR Morb. Mortal. Wkly Rep.46(39), 913–919 (1997).
  • Robinson KA, Baughman W, Rothrock G et al. Epidemiology of invasive Streptococcus pneumoniae infections in the United States, 1995–1998: opportunities for prevention in the conjugate vaccine era. JAMA285(13), 1729–1735 (2001).
  • Musher DM, Luchi MJ, Watson DA, Hamilton R, Baughn RE. Pneumococcal polysaccharide vaccine in young adults and older bronchitics: determination of IgG responses by ELISA and the effect of adsorption of serum with non-type-specific cell wall polysaccharide. J. Infect. Dis.161(4), 728–735 (1990).
  • Fedson DS. Influenza and pneumococcal vaccination of the elderly: newer vaccines and prospects for clinical benefits at the margin. Prev. Med.23(5), 751–755 (1994).
  • Mufson MA, Hughey DF, Turner CE, Schiffman G. Revaccination with pneumococcal vaccine of elderly persons 6 years after primary vaccination. Vaccine9(6), 403–407 (1991).
  • Shapiro ED, Berg AT, Austrian R et al. The protective efficacy of polyvalent pneumococcal polysaccharide vaccine. N. Engl. J. Med.325(21), 1453–1460 (1991).
  • Prevention of pneumococcal disease: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep.46(RR-8), 1–24 (1997).
  • Robbins JB, Schneerson R. Polysaccharide–protein conjugates: a new generation of vaccines. J. Infect. Dis.161(5), 821–832 (1990).
  • Baltimore RS. New challenges in the development of a conjugate pneumococcal vaccine. JAMA268(23), 3366–3367 (1992).
  • Weller TH. Varicella and herpes zoster. Changing concepts of the natural history, control, and importance of a not-so-benign virus. N. Engl. J. Med.309(23), 1434–1440 (1983).
  • Gnann JW Jr, Whitley RJ. Clinical practice. Herpes zoster. N. Engl. J. Med.347(5), 340–346 (2002).
  • Brisson M, Edmunds WJ, Law B et al. Epidemiology of varicella zoster virus infection in Canada and the United Kingdom. Epidemiol. Infect.127(2), 305–314 (2001).
  • Marin M, Guris D, Chaves SS, Schmid S, Seward JF. Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep.56(RR-4), 1–40 (2007).
  • Donahue JG, Choo PW, Manson JE, Platt R. The incidence of herpes zoster. Arch. Intern. Med.155(15), 1605–1609 (1995).
  • Kost RG, Straus SE. Postherpetic neuralgia – pathogenesis, treatment, and prevention. N. Engl. J. Med.335(1), 32–42 (1996).
  • Dworkin RH, Portenoy RK. Pain and its persistence in herpes zoster. Pain67(2–3), 241–251 (1996).
  • Galil K, Choo PW, Donahue JG, Platt R. The sequelae of herpes zoster. Arch. Intern. Med.157(11), 1209–1213 (1997).
  • Oxman MN. Immunization to reduce the frequency and severity of herpes zoster and its complications. Neurology45(12 Suppl. 8), S41–S46 (1995).
  • Sederholm B, Peterson D. Zoster vaccine to prevent postherpetic neuralgia. J. Pain Palliat. Care Pharmacother.20(4), 41–42 (2006).
  • Holcomb K, Weinberg JM. A novel vaccine (Zostavax) to prevent herpes zoster and postherpetic neuralgia. J. Drugs Dermatol.5(9), 863–866 (2006).
  • Robinson DM, Perry CM. Zoster vaccine live (Oka/Merck). Drugs Aging23(6), 525–531 (2006).
  • Caple J. Varicella-zoster virus vaccine: a review of its use in the prevention of herpes zoster in older adults. Drugs Today (Barc.)42(4), 249–254 (2006).
  • Kimberlin DW, Whitley RJ. Varicella-zoster vaccine for the prevention of herpes zoster. N. Engl. J. Med.356(13), 1338–1343 (2007).
  • Oxman MN, Levin MJ, Johnson GR et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N. Engl. J. Med.352(22), 2271–2284 (2005).
  • Irwin MR, Olmstead R, Oxman MN. Augmenting immune responses to varicella zoster virus in older adults: a randomized, controlled trial of Tai Chi. J. Am. Geriatr. Soc.55(4), 511–517 (2007).
  • Smith TP, Kennedy SL, Fleshner M. Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in men. J. Appl. Physiol97(2), 491–498 (2004).
  • Kroger AT, Atkinson WL, Marcuse EK, Pickering LK. General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep.55(RR-15), 1–48 (2006).
  • Kretsinger K, Broder KR, Cortese MM et al. Preventing tetanus, diphtheria, and pertussis among adults: use of tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine recommendations of the Advisory Committee on Immunization Practices (ACIP) and recommendation of ACIP, supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC), for use of Tdap among health-care personnel. MMWR Recomm. Rep.55(RR-17), 1–37 (2006).
  • Gergen PJ, McQuillan GM, Kiely M et al. A population-based serologic survey of immunity to tetanus in the United States. N. Engl. J. Med.332(12), 761–766 (1995).
  • Balestra DJ, Littenberg B. Should adult tetanus immunization be given as a single vaccination at age 65? A cost–effectiveness analysis. J. Gen. Intern. Med.8(8), 405–412 (1993).
  • Bell BP, Kruszon-Moran D, Shapiro CN et al. Hepatitis A virus infection in the United States: serologic results from the Third National Health and Nutrition Examination Survey. Vaccine23(50), 5798–5806 (2005).
  • Fiore AE, Wasley A, Bell BP. Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep.55(RR-7), 1–23 (2006).
  • Genton B, D’Acremont V, Furrer HJ, Hatz C, Louis L. Hepatitis A vaccines and the elderly. Travel. Med. Infect. Dis.4(6), 303–312 (2006).
  • Palena C, Abrams SI, Schlom J, Hodge JW. Cancer vaccines: preclinical studies and novel strategies. Adv. Cancer Res.95, 115–145 (2006).
  • Johansson J, Hellman L. Modifications increasing the efficacy of recombinant vaccines; marked increase in antibody titers with moderately repetitive variants of a therapeutic allergy vaccine. Vaccine25(9), 1676–1682 (2007).
  • Lavelle EC, O’Hagan DT. Delivery systems and adjuvants for oral vaccines. Expert. Opin. Drug Deliv.3(6), 747–762 (2006).
  • Pascual DM, Morales RD, Gil ED et al. Adjuvants: present regulatory challenges. Vaccine24(Suppl. 2), S2–S9 (2006).
  • Ahluwalia N. Aging, nutrition and immune function. J. Nutr. Health Aging8(1), 2–6 (2004).
  • Mahalanabis D, Basak M, Paul D et al. Antioxidant vitamins E and C as adjunct therapy of severe acute lower-respiratory infection in infants and young children: a randomized controlled trial. Eur. J. Clin. Nutr.60(5), 673–680 (2006).
  • Ciocoiu M, Lupusoru EC, Colev V, Badescu M, Paduraru I. [The involvement of vitamins C and E in changing the immune response]. Rev. Med. Chir. Soc. Med. Nat. Iasi102(1–2), 93–96 (1998).
  • Adolfsson O, Meydani SN. Nutrition and the aging immune response. Nestle Nutr. Workshop Ser. Clin. Perform. Programme6, 207–220 (2002).
  • Saker KE. Nutrition and immune function. Vet. Clin. North Am. Small Anim. Pract.36(6), 1199–224, v (2006).
  • Kelley KW. The role of growth hormone in modulation of the immune response. Ann. NY Acad. Sci.594, 95–103 (1990).
  • Ribeiro F, Lopes RP, Nunes CP et al. Dehydroepiandrosterone sulphate enhances IgG and interferon-γ production during immunization to tuberculosis in young but not aged mice. Biogerontology8(2), 209–220 (2007).
  • Pagani S, Meazza C, Travaglino P, Moretta A, Bozzola M. Effect of growth hormone therapy on the proinflammatory cytokine profile in growth hormone-deficient children. Eur. Cytokine Netw.16(1), 65–69 (2005).
  • Toogood AA. The somatopause: an indication for growth hormone therapy? Treat. Endocrinol.3(4), 201–209 (2004).
  • Tentori L, Graziani G. Doping with growth hormone/IGF-1, anabolic steroids or erythropoietin: is there a cancer risk? Pharmacol. Res.55(5), 359–369 (2007).
  • Roberson ED, Mucke L. 100 years and counting: prospects for defeating Alzheimer’s disease. Science314(5800), 781–784 (2006).
  • Levites Y, Smithson LA, Price RW et al. Insights into the mechanisms of action of anti-Aβ antibodies in Alzheimer’s disease mouse models. FASEB J.20(14), 2576–2578 (2006).
  • Nikolic WV, Bai Y, Obregon D et al. Transcutaneous β-amyloid immunization reduces cerebral β-amyloid deposits without T cell infiltration and microhemorrhage. Proc. Natl Acad. Sci. USA104(7), 2507–2512 (2007).
  • Every AL, Kramer DR, Mannering SI, Lew AM, Harrison LC. Intranasal vaccination with proinsulin DNA induces regulatory CD4+ T cells that prevent experimental autoimmune diabetes. J. Immunol.176(8), 4608–4615 (2006).
  • Li A, Ojogho O, Franco E et al. Pro-apoptotic DNA vaccination ameliorates new onset of autoimmune diabetes in NOD mice and induces Foxp3+ regulatory T cells in vitro. Vaccine24(23), 5036–5046 (2006).
  • Rapoport AP. Immunity for tumors and microbes after autotransplantation: if you build it, they will (not) come. Bone Marrow Transplant.37(3), 239–247 (2006).

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