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Review

Obesity and cardiovascular risk: the new public health problem of worldwide proportions

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Pages 203-212 | Published online: 10 Jan 2014

References

  • World Health Organization. Obesity: preventing and managing the global epidemic—report of a WHO consultation on obesity. World Health Organization, Geneva, Switzerland (1998).
  • Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999–2000.JA/11,4 288(14), 1723–1727 (2002).
  • ••This study clearly indicates the increase inprevalence of obesity and overweight in the USA and that this is a problem of public health importance.
  • Freedman DS, Khan LK, Serdula MK, Galuska DA, Dietz WH. Trends and correlates of class 3 obesity in the United States from 1990 to 2000. JA/11/1 288(14), 1758–1761 (2002).
  • Schoenborn C, Adams P, Barnes P. Body weight status of adults. United States, 1997-1998. Adv. Data 330,1–15 (2002).
  • World Health Organization. Obesity: preventing and managing the global epidemic—report of a WHO consultation. World Health Organ. Tech. Rep. Ser. 894,1–253 (2000).
  • Grundy SM. Multifactorial causation of obesity. Implications for prevention. Am. J. Clin. Nutr. 67 (Suppl. 3), 563S-572S (1998).
  • Najjar MF, Rowland M. Antropometric reference data and prevalence of overweight. United States, 1976–1980. Vital Health Stat. 11(238), 1–73 (1987).
  • National Heart and Blood Institute Clinical guidelines on the identification, evaluation and treatment of overweight and obesity in adults — Executive Summary. National Institute of Health, Bethesda, MD (1998).
  • Mckeigue P, Shah B, Marmot M. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337,382–386 (1991).
  • Lakka HM, Lakka TA, Tuomilehto J, Salonen JT. Abdominal obesity is associated with increased risk of acute coronary events in men. Eur Heart J. 23,706–713 (2002).
  • Bjorntorp P Visceral obesity: a civilization sindrome'. Obes. Res. 1,206–222 (1993).
  • Larsson B, Svardsudd K, Welin L et al Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13-year follow-up of participants in a study of men born in 1913. Br. Med J. 288, 1401–1404 (1984).
  • ••The first large prospective study that clearlyindicates that central fat distribution may be considered one of the most important cardiovascular risk factors.
  • Hubert HB, Feinleib M, McNamara PM et al Obesity as an independent risk factor for cardiovascular disease: a 26 year follow-up of partecipants in the Framingham Heart Study. Circulation 67,968–976 (1983).
  • Manson JE, Colditz GA, Stampfer MJ et al A prospective study of obesity and risk of coronary heart disease in women. N EngL Med 322,882–889 (1990).
  • The first large prospective study thatindicates that obesity is clearly associated With CAD in women.
  • Dorn JM, Schiesterman EF, Wilkelstein W et al Body mass index and mortality in a general population sample of men and women. The Buffalo Health Study. Am. Epidemid 146(11), 919–931 (1997).
  • Schulte H. Obesity, mortality and cardiovascular disease in the Muns (PROCAM). Atherosclerosis 144(1), 199–209 (1999).
  • Licata G, Corrao S, Parrinello G, Scaglione R Obes. Cardiovasc. dis. Excerpta Medica, Almere, The Netherlands (1996).
  • Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW. Body mass index and mortality in a prospective cohort of US adults. N EngL J. Med. 341,1097–1105 (1999).
  • Sowers JR Obesity and cardiovascular disease. Clin. Chem. 44(8), 1821–1825 (1998).
  • National Task Force on the Prevention and Treatment of Obesity. Long-term pharmacotherapy in the management of obesity. JA/I/L4 276,1907-1915 (1996).
  • Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents. N EngL j Med 327, 1350–1355 (1992).
  • •A large prospective study that indicates the importance of obesity in adolescence as a cardiovascular risk factor in the adult.
  • Eckel RH, Krauss RM. American Heart Association call to action: obesity as a major risk factor for coronary artery disease. AHA Nutrition Committee. Circulation 97(21), 2099–2100 (1998).
  • •The first report of the American Heart Association including obesity as a major risk factor for coronary artery disease. In this report weight loss has been included as one of the most important strategies in both primary and secondary cardiovascular disease prevention.
  • Castelli VT Cardiovascular disease and multifactorial risk challenge of the 1980s. Am. Heart J. 106,1191-1200 (1983).
  • Vague J. The degree of masculine differentation of obesesities: a factor determining predisposition to diabetes, atherosclerosis, gout and uric calcolous disease. Am. J. Clin. Nut,: 4,20–34(1956).
  • Licata G, Scaglione R, Capuana G et al Hypertension in obese subjects: distinct hypertensive subgroup. J. Hum. Hypert. 4, 37–41 (1990).
  • •Reports that hypertensive obese subjects were characterized by specific hemodynamic changes indicating these subjects are a particular subset of hypertensives.
  • Grassi G, Seravalle G, Dell'Oro R, Turn i C, Bolla GB, Mancia G. Adrenergic and reflex abnormalities in obesity-related hypertension. Hypertension 36,538–542 (2000).
  • Rocchini AP Insulin resistance and blood pressure regulation in obese and non-obesesubjects. Hypertension 17, 837–842 (1991).
  • Licata G, Volpe M, Scaglione R, Rubattu S. Salting regulating hormones in young normotensive obese subjects. Effects of saline load. Hypertension 23 (Suppl. 1), 20–24 (1994).
  • •The first study indicating that central obese subjects could be characterized by a dysfunction in the hormonal mechanisms that control saline balance.
  • Hall JE, Hildebrandt DA, Kuo J. Obesity hypertension: role of leptin and sympathetic nervous system. Am. J. Hypertens. 14, 103S-115S (2001).
  • Schmieder RD, Messerli FH. Does obesity influence early target organ damage in hypertensive patients? Circulation 87, 1482–1488 (1993).
  • Zemel MB. Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insulin resistance and hypertension. Mal Cell Biochem. 188, 129–136 (1998).
  • Willet WC, Dietz WH, Colditz GA. Guidelines for healthy weight. N Engl J. Med. 341(6), 427–434 (1999).
  • Licata G, Scaglione R, Corrao S et al. Heredity and obesity associated hypertension. Impact of hormonal characteristics and left ventricular mass. J. Hypertension 13, 611–618 (1995).
  • Golden P, Maccagnan TJ, Pardrigde WM. Human blood—brain barrier leptin receptor: binding and endocytosis in isolated human brain microvessels. J. Clin. Invest. 99, 14–18 (1997).
  • Considine RV, Sinha MK, Heiman ML et al. Serum immunoeractive leptin concentrations in normal weight and obese humans. N Engl J. Med. 334, 292–295 (1996).
  • Haynes WG, Morgan DA, Walsh SA et al. Cardiovascular consequences of obesity: role of leptin. Clin. Exp. Pharmacol PhysioL 2565–2569 (1998).
  • Esposito K, Pontillo A, Di Palo C et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women. /AMA 289,14 1799–1804 (2003).
  • Alessi MC, Bastelica D, Morange P et al. Plasminogen activator inhibitor, transforming growth factor-13 and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes 49, 1374–1380 (2000).
  • Porreca E, Di Febbo C, Vitacolonna E et al. Transforming growth factor-131 levels in hypertensive patients: association with body mass index and leptin. Am. J. Hyper. 15, 759–765 (2002).
  • Scaglione R, Argano C, Parrinello G et al. Relationship between transforming growth factor 01 and progression of hypertensive renal disease. J. Hum. Hypert. 16, 641–645 (2002).
  • Scaglione R, Argano C, Di Chiara T et al Central obesity and hypertensive renal disease: Association between higher levels of BMI, circulating transforming growth factor 01 and urinary albumin excretion. Blood Pressure 12, 269–276 (2003).
  • ECAT Angina Pectoris Study Group. Baseline associations of haemostatic factors with extent of coronary arteriosclerosis and other coronary risk factors in 3000 patients with angina pectoris undergoing coronary angiography. Eur Heart J 14, 8–17 (1993).
  • •In this multicenter prospective study, an important relationship between hemostatic factors, coronary atherosclerosis and coronary risk factors are reported in 3000 patients with angina pectoris. This indicates the relevant role of the prothrombotic—hypofibrinolitc profile in the development of cardiovascular events.
  • Licata G, Scaglione R, Avellone G et al Haemostatic function in young subjects with central obesity: relationship with left ventricular function. Metabolism 44(11), 1417–1421 (1995).
  • De Pergola G, De Mitrio V, Giorgino F et al Increase in both prothrombotic and antithrombotic factors in obese premenopausal women: relationship with body fat distribution. Int. J Obes. 21, 527–535 (1997).
  • Parenti M, Babbini AC, Palareti G et al Body Et distribution assessed by CT and Haemorheologic pattern in human obesity. Int. J Obes. 18 (Suppl. 2), 210–215 (1994).
  • Folsom AR Impact of weight loss on plasminogen activator inhibitor (PAT 1), Factor VII and other hemostatic factors in moderately overweight adulats. Arterioscler Thromb. Vasc. Biol 13, 162–169 (1993).
  • Luscher TF, Seo BG, Buhler FR. Potential role of endothelin in hypertension. Hypertension 21, 752–757 (1993).
  • Levin ER Endothelins. N Engl J Med 333, 356–363 (1995).
  • Parrinello G, Scaglione R, Pinto A et al Central obesity and hypertension: role of plasma endothelin. Am. J Hypert. 9, 1186–1191 (1996).
  • Cines DB, Pollak ES, Buck CA. Endothelial cells in physiology and in pathophysiology of vascular disorders. Blood 91, 3527–3561 (1998).
  • Dong ZM, Chapman SM, Brown AA et al The combined role of P-and E-selectins in atherosclerosis. J Clin. Invest. 102, 145–152 (1998).
  • Blankenberg S, Rupprecht HJ, Bickel C et al Circulating cell adhesion molecules and death in patients with coronary artery disease. Circulation 104, 1336–1342 (2001).
  • Ferri C, Desideri G, Valenti M et al. Early upregulation of endothelial adhesion molecules in obese hypertensive men. Hypertension 34, 568–573 (1999).
  • Hwang S. Circulation adhesion molecules VCAM-1, ICAM-1 and E-selectin in carotid atherosclerosis and incident coronary heart disease case: the Atherosclerosis Risk in Communities (ARIC) Study. Circulation 96, 4219–4225 (1997).
  • Malik I, Danesh J, Whincup P et al Soluble adhesion molecules and prediction of coronary heart disease: a prospective study and meta-analysis. Lancet 358, 971–976 (2001).
  • Suwadi JAL, Higano TS, Holmes DR, Lerman A. Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries. J Am. Coll Cardiol 37, 1523–1528 (2001).
  • •Endothelial dysfunction is investigated in obese subjects by a technique able to detect coronary endothelial dependent or independent vasodilation.
  • Rea TD, Heckbert RS, Kaplan RC et al Body mass index and the risk of recurrent coronary events following acute myocardial infarction. Am. J Cardiol 88 (5), 467–472 (2001).
  • Cambien F, Poirier 0, LecerfL et al Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 359, 641–644 (1992).
  • Lidpainter K, Pfeffer MA, Kreutz R et al A prospective evaluation of an angiotensin-converting enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J. Med. 332, 706–711 (1995).
  • Licata G, Di Chiara T, Licata A et al Relationship between circulating E-selectin, DD genotype of angiotensin-converting-enzyme and cardiovascualr damage in central obese subjects. Metabolism 52, 999–1004 (2003).
  • •The first study indicating that obese subjects with endothelial dysfunction and DD genotype of ACE are a particular subset of subjects at higher risk for cardiovascular damage.
  • Alexander JK, Pettigrove JR Obesity and congestive heart failure. Geriatrics 22, 101–108 (1967).
  • American Heart Association. 2002 Heart and Stroke Statistical Update. American Heart Association, Dallas, TX USA (2001).
  • Kenchaiah S, Evans JC, Levy D etaL Obesity and the risk of heart failure. N EngL j Med 347,305–313 (2002).
  • ••This elaboration of Framingham datademonstrated for the first time that not only severe obesity but also overweight may be characterized by a higher risk of heart failure.
  • Horwich TB, Fonarow GC, Hamilton MA et al The relationship between obesity and mortality in patients with heart failure. J. Am. CoIL CardioL 38,789–795 (2001).
  • Mosterd A, Cost B, Hoes AW et al The prognosis of heart failure in the general population: The Rotterdam Study. Eur Heart J. 22,1318–1327 (2001).
  • Davos CH, Doehner W Rachlaus M et al Obesity and survival in chronic heart failure (abstract). Circulation 102 (Suppl. 2), 876 (2000).
  • Anker SD, Rachlaus M. Insight into pathogenesis of chronic heart failure: immune activation and cachexia. Curr Opin. CardioL 14,211–216(1999).
  • Anker SD, Swan JW, Volterrani M et al The influence of muscle mass, strenght, fatigability and blood flow on excersise capacity in cachectic and non-cachectic patients with chronic heart failure. Eur Heart J. 18,259–269 (1997).
  • Anker SD, AL Clark, Kemp M et al Tumor necrosis factor and steroid metabolism in chronic heart failure: possible relation to muscle wasting. J. Am. ColL CardioL 30, 997–1001 (1997).
  • Anker SD, Ponikowski P, Varney S et al. Wasting as independent risk factor for mortality in chronic heart failure. Lancet 349, 1050–1053 (1997).
  • Lavie CJ, Osman AF, Milani RV, Mehera MR Body composition and prognosis in chronic systolic heart failure: the obesity paradox. Am. J. CardioL 91,891–894 (2003).
  • •Emphasizes some questions on the relationship between obesity and heart failure. Even if obesity has been characterized by an higher risk of heart failure, the prognosis in these subjects is better than lean subjects with heart failure.
  • Messerli FH, Sundgaard—Riise K, Reisen ED et al Dimorphic cardiac adaptation to obesity and arterial hypertension. Ann. Intern. Med. 99,757–761 (1983).
  • •An important study that clearly indicates that association between hypertension and obesity is characterized by specific alterations in left ventricular structure and function.
  • Alpert MA, Terry BE, Kelly DL. Effect of weight loss on cardiac chamber size, wall thickness and left ventricular function in morbid obesity. Am. J. Cordial 55, 783–786 (1985).
  • Alexander JK. The cardiomyopathy of obesity. Prog Cardiovasc. Dis. 27,325–333 (1985).
  • ••Cardiovascular alterations in severe obesityare well documented and untilized for the classification of cardiomyopathy of obesity
  • Frohlich ED, Epstein C, Chobanian AV et al. The heart in hypertension. N EngL J. Med. 327,998–1008 (1992).
  • Nakajima T, Fujioka S, Tokunaga K et al. Correlation of intrabdominal fat accumulation and left ventricular performance in obesity. Am. J. CardioL 64, 235–239 (1989).
  • Licata G, Scaglione R, Paterna S et al. Left ventricular function response to excercise in normotensive obese subjects: influence of degree and duration of obesity. Int. J. CardioL 27,223–230 (1992).
  • The first study that indicates that it is also possible to detect a left ventricular dysfunction early in overweight subjects. This alteration is primarily related to the degree and duration of obesity.
  • Scaglione R, Di Chiara MA, Indovina A et al. Left ventricular diastolic and systolic function in normotensive obese subjects: influence of degree and duration of obesity. Eur. Heart J. 13,738–742 (1992).
  • Stoddard MF, Tseuda K, Thomas M et al. The influence of obesity on left ventricular filling in eccentric left ventricular hypertrophy of obesity. Am. J. CardioL 68, 694–699 (1991).
  • Zarich SW Kowalchuk GJ, McGuire MP et al. Left ventricular filling abnormalities in asymptomatic morbid obesity. Am. J. CardioL 68,377–381 (1991).
  • Chakko S, Mayor M, Allison MD et al. Abnormal left ventricular diastolic filling in eccentric left ventricular hypertrophy of obesity. Am. J. CardioL 68,95–98 (1991).
  • De Simone G, Devereux RB, Roman MJ et al. Relation of obesity and gender to left ventricular hypertrophy in normotensive and hypertensive adults. Hypertension 23, 600–604 (1994).
  • Duflou J, Virmani R, Rabin J et al. Sudden death as a result of heart disease in morbid obesity. Am. Heart. J. 130,306–313 (1995).
  • Bharati S, Lev M. Cardiac conduction system involvement in sudden death of obese young people. Am. Heart. J. 129, 273–281 (1995).
  • Lip GYH, Gammage MD, Beevers DG. Hypertension and the heart. Br Med BuIL 18,193–197 (1994).
  • Anderson JW, Konz EC. Obesity and disease management: effects of weight loss on comorbid conditions. Obesity Res. 9(Suppl. 4), 326S-334S (2001).
  • Denke M. Connections between obesity and dyslipidaemia. Curr Opin. LipidoL 12, 626–628 (2001).
  • Yanovsky SZ, Yanovsky JA. Obesity. N EngL J. Med. 346 (8), 591–602 (2002).
  • Wannamethee G, Shaper AG. Weight change in middle-aged British men: implications for health. Eur J. Clin. Nutr 44,133–142 (1990).
  • Singh R, Rastogi SS, Verni R et al Randomized controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow-up. Br Med J. 304, 1015–1019 (1992).
  • •One of the few prospective studies designed to analyze the cardioprotective beneficial effects of weight loss in patients with recent myocardial infarction.
  • Ornish D, Brown SE, Scherwitz LW et al Can life style change reverse coronary heart disease? Lancet 336,129–133 (1990).

Website

  • International Association for the Study of Obesity www.iotforg Accessed February 2004

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