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Implantable cardioverter defibrillators in diabetics: efficacy and safety in patients at risk of sudden cardiac death

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References

  • Preis SR, Hwang SJ, Coady S, et al. Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005. Circulation 2009;119(13):1728-35
  • Balkau B, Jouven X, Ducimetière P, Eschwège E. Diabetes as a risk factor for sudden death. Lancet 1999;354(9194):1968-9
  • Jouven X, Lemaître RN, Rea TD, et al. Diabetes, glucose level, and risk of sudden cardiac death. Eur Heart J 2005;26(20):2142-7
  • Zaccardi F, Khan H, Laukkanen JA. Diabetes mellitus and risk of sudden cardiac death: a systematic review and meta-analysis. Int J Cardiol 2014;177(2):535-7
  • Lee DS, Green LD, Liu PP, et al. Effectiveness of implantable defibrillators for preventing arrhythmic events and death: a meta-analysis. J Am Coll Cardiol 2003;41(9):1573-82
  • Tung R, Zimetbaum P, Josephson ME. A critical appraisal of implantable cardioverter-defibrillator therapy for the prevention of sudden cardiac death. J Am Coll Cardiol 2008;52(14):1111-21
  • Jahangir A, Bradley DJ, Shen WK. ICDs for secondary prevention of sudden death in the older-elderly. Eur Heart J 2007;28(14):1665-7
  • Healey JS, Hallstrom AP, Kuck KH, et al. Role of the implantable defibrillator among elderly patients with a history of life-threatening ventricular arrhythmias. Eur Heart J 2007;28(14):1746-9
  • Hess PL, Hellkamp AS, Peterson ED, et al. Survival after primary prevention implantable cardioverter-defibrillator placement among patients with chronic kidney disease. Circ Arrhythm Electrophysiol 2014;7(5):793-9
  • Hlatky MA, Mark DB. The high cost of implantable defibrillators. Eur Heart J 2007;28(4):388-91
  • American Diabetes Association. National Diabetes Statistics Report. 2014. Available from: http://www.diabetes.org/diabetes-basics/statistics/ [Last accessed 15 April 2015]
  • Rathmann W, Giani G. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27(10):2568-9
  • Center for Disease Control’s Division of Diabetes Translation. National Diabetes Surveillance System. Available from: http://www.cdc.gov/diabetes/statistics [Last accessed 15 May 2015]
  • American Diabetes Association. The Cost of Diabetes. 2013. Available from: http://www.diabetes.org/advocacy/news-events/cost-of-diabetes.html [Last accessed 15 April 2015]
  • Secrest AM, Becker DJ, Kelsey SF, et al. All-cause mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes: the Allegheny County type 1 diabetes registry. Diabetes Care 2010;33(12):2573-9
  • Secrest AM, Becker DJ, Kelsey SF, et al. Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes. Diabetes 2010;59(12):3216-22
  • Nasir S, Aguilar D. Congestive heart failure and diabetes mellitus: balancing glycemic control with heart failure improvement. Am J Cardiol 2012;110(9 Suppl):50B-7B
  • Casis O, Echevarria E. Diabetic cardiomyopathy: electromechanical cellular alterations. Curr Vasc Pharmacol 2004;2(3):237-48
  • Kosiborod M, Rathore SS, Inzucchi SE, et al. Admission glucose and mortality in elderly patients hospitalized with acute myocardial infarction: implications for patients with and without recognized diabetes. Circulation 2005;111(23):3078-86
  • Curb JD, Rodriguez BL, Burchfiel CM, et al. Sudden death, impaired glucose tolerance, and diabetes in Japanese American men. Circulation 1995;91(10):2591-5
  • Jouven X, Desnos M, Guerot C, Ducimetière P. Predicting sudden death in the population: the Paris Prospective Study I. Circulation 1999;99(15):1978-83
  • Nordin C. The proarrhythmic effect of hypoglycemia: evidence for increased risk from ischemia and bradycardia. Acta Diabetol 2014;51(1):5-14
  • Nordin C. The case for hypoglycaemia as a proarrhythmic event: basic and clinical evidence. Diabetologia 2010;53(8):1552-61
  • Nakou ES, Mavrakis H, Vardas PE. Are diabetic patients at increased risk of arrhythmias? Hellenic J Cardiol 2012;53(5):335-9
  • Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med 2004;350(10):1013-22
  • Xu Z, Patel KP, Rozanski GJ. Metabolic basis of decreased transient outward K+ current in ventricular myocytes from diabetic rats. Am J Physiol 1996;271(5 Pt 2):H2190-6
  • Tsuchida K, Watajima H. Potassium currents in ventricular myocytes from genetically diabetic rats. Am J Physiol 1997;273(4 Pt 1):E695-700
  • Roden DM. Taking the “idio” out of “idiosyncratic”: predicting torsades de pointes. Pacing Clin Electrophysiol 1998;21(15):1029-34
  • Zhang Y, Han H, Wang J, et al. Impairment of human ether-à-go-go-related gene (HERG) K+ channel function by hypoglycemia and hyperglycemia. Similar phenotypes but different mechanisms. J Biol Chem 2003;278(12):10417-26
  • Vassalle M, Lin CI. Calcium overload and cardiac function. J Biomed Sci 2004;11(5):542-65
  • Shao CH, Rozanski GJ, Patel KP, Bidasee KR. Dyssynchronous (non-uniform) Ca2+ release in myocytes from streptozotocin-induced diabetic rats. J Mol Cell Cardiol 2007;42(1):234-46
  • Clark RJ, McDonough PM, Swanson E, et al. Diabetes and the accompanying hyperglycemia impairs cardiomyocyte calcium cycling through increased nuclear O-GlcNAcylation. J Biol Chem 2003;278(45):44230-7
  • Yaras N, Ugur M, Ozdemir S, et al. Effects of diabetes on ryanodine receptor Ca release channel (RyR2) and Ca2+ homeostasis in rat heart. Diabetes 2005;54(11):3082-8
  • Nordin C, Gilat E, Aronson RS. Delayed afterdepolarizations and triggered activity in ventricular muscle from rats with streptozotocin-induced diabetes. Circ Res 1985;57(1):28-34
  • Erickson JR, Pereira L, Wang L, et al. Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature 2013;502(7471):372-6
  • Anderson ME, Brown JH, Bers DM. CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol 2011;51(4):468-73
  • Barth AS, Tomaselli GF. Cardiac metabolism and arrhythmias. Arrhythm Electrophysiol 2009;2(3):327-35
  • Choi BR, Burton F, Salama G. Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome. J Physiol 2002;543(Pt 2):615-31
  • Boudina S, Abel ED. Diabetic cardiomyopathy revisited. Circulation 2007;115(25):3213-23
  • Siscovick DS, Sotoodehnia N, Rea TD, et al. Type 2 diabetes mellitus and the risk of sudden cardiac arrest in the community. Rev Endocr Metab Disord 2010;11(1):53-9
  • Spallone V, Ziegler D, Freeman R, et al. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev 2011;27(7):639-53
  • Duckworth W, Abraira C, Moritz T, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med 2009;360(2):129-39
  • Wang Y, Xuan YL, Hu HS, et al. Risk of ventricular arrhythmias after myocardial infarction with diabetes associated with sympathetic neural remodeling in rabbits. Cardiology 2012;121(1):1-9
  • ADVANCE Collaborative Group. Patel A, MacMahon S, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008;358:2560-72
  • Action to Control Cardiovascular Risk in Diabetes Study Group. Gerstein HC, Miller ME, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008;358(24):2545-59
  • Chow E, Bernjak A, Williams S, et al. Risk of cardiac arrhythmias during hypoglycemia in patients with type 2 diabetes and cardiovascular risk. Diabetes 2014;63(5):1738-47
  • Stahn A, Pistrosch F, Ganz X, et al. Relationship between hypoglycemic episodes and ventricular arrhythmias in patients with type 2 diabetes and cardiovascular diseases: silent hypoglycemias and silent arrhythmias. Diabetes Care 2014;37(2):516-20
  • Tattersall RB, Gill GV. Unexplained deaths of type 1 diabetic patients. Diabet Med 1991;8(1):49-58
  • Thordarson H, Søvik O. Dead in bed syndrome in young diabetic patients in Norway. Diabet Med 1995;12(9):782-7
  • Heller SR. Abnormalities of the electrocardiogram during hypoglycaemia: the cause of the dead in bed syndrome? Int J Clin Pract Suppl 2002(129):27-32
  • Robinson RT, Harris ND, Ireland RH, et al. Mechanisms of abnormal cardiac repolarization during insulin-induced hypoglycemia. Diabetes 2003;52(6):1469-74
  • Robinson RT, Harris ND, Ireland RH, et al. Changes in cardiac repolarization during clinical episodes of nocturnal hypoglycaemia in adults with Type 1 diabetes. Diabetologia 2004;47(2):312-15
  • Eckert B, Agardh CD. Hypoglycaemia leads to an increased QT interval in normal men. Clin Physiol 1998;18(6):570-5
  • Landstedt-Hallin L, Englund A, Adamson U, Lins PE. Increased QT dispersion during hypoglycaemia in patients with type 2 diabetes mellitus. J Intern Med 1999;246(3):299-307
  • Hoffman RP. Sympathetic mechanisms of hypoglycemic counterregulation. Curr Diabetes Rev 2007;3(3):185-93
  • Lee S, Harris ND, Robinson RT, et al. Effects of adrenaline and potassium on QTc interval and QT dispersion in man. Eur J Clin Invest 2003;33(2):93-8
  • Okazaki O, Suda N, Hongo K, et al. Modulation of Ca2+ transients and contractile properties by beta-adrenoceptor stimulation in ferret ventricular muscles. J Physiol 1990;423:221-40
  • Aronson RS, Nordin C. Arrhythmogenic interaction between low potassium and ouabain in isolated guinea-pig ventricular myocytes. J Physiol 1988;400:113-34
  • Yakubovich N, Gerstein HC. Serious cardiovascular outcomes in diabetes: the role of hypoglycemia. Circulation 2011;123(3):342-8
  • Zoungas S, Patel A, Chalmers J, et al. Severe hypoglycemia and risks of vascular events and death. N Engl J Med 2010;363(15):1410-18
  • ORIGIN Trial Investigators. Mellbin LG, Rydén L, et al. Does hypoglycaemia increase the risk of cardiovascular events? A report from the ORIGIN trial. Eur Heart J 2013;34(40):3137-44
  • Skyler JS, Bergenstal R, Bonow RO, et al. Intensive glycemic control and the prevention of cardiovascular events: implications of the ACCORD, ADVANCE, and VA diabetes trials: a position statement of the American Diabetes Association and a scientific statement of the American College of Cardiology Foundation and the American Heart Association. Diabetes Care 2009;32(1):187-92
  • Wittenberg SM, Cook JR, Hall WJ, et al. Comparison of efficacy of implanted cardioverter-defibrillator in patients with versus without diabetes mellitus. Am J Cardiol 2005;96(3):417-19
  • Cygankiewicz I, Gillespie J, Zareba W, et al. Predictors of long-term mortality in Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) patients with implantable cardioverter-defibrillators. Heart Rhythm 2009;6(4):468-73
  • Parkash R, Stevenson WG, Epstein LM, Maisel WH. Predicting early mortality after implantable defibrillator implantation: a clinical risk score for optimal patient selection. Am Heart J 2006;151(2):397-403
  • Lee DS, Tu JV, Austin PC, et al. Effect of cardiac and noncardiac conditions on survival after defibrillator implantation. J Am Coll Cardiol 2007;49(25):2408-15
  • Goldenberg I, Vyas AK, Hall WJ, et al. Risk stratification for primary implantation of a cardioverter-defibrillator in patients with ischemic left ventricular dysfunction. J Am Coll Cardiol 2008;51(3):288-96
  • Stein KM, Mittal S, Gilliam FR, et al. Predictors of early mortality in implantable cardioverter-defibrillator recipients. Europace 2009;11(6):734-40
  • Kramer DB, Friedman PA, Kallinen LM, et al. Development and validation of a risk score to predict early mortality in recipients of implantable cardioverter-defibrillators. Heart Rhythm 2012;9(1):42-6
  • van Rees JB, Borleffs CJ, van Welsenes GH, et al. Clinical prediction model for death prior to appropriate therapy in primary prevention implantable cardioverter defibrillator patients with ischaemic heart disease: the FADES risk score. Heart 2012;98(11):872-7
  • Bilchick KC, Stukenborg GJ, Kamath S, Cheng A. Prediction of mortality in clinical practice for medicare patients undergoing defibrillator implantation for primary prevention of sudden cardiac death. J Am Coll Cardiol 2012;60(17):1647-55
  • Soliman OI, van Dalen BM, Theuns DA, et al. The ischemic etiology of heart failure in diabetics limits reverse left ventricular remodeling after cardiac resynchronization therapy. J Diabetes Complications 2009;23(5):365-70
  • Mangiavacchi M, Gasparini M, Genovese S, et al. Insulin-treated type 2 diabetes is associated with a decreased survival in heart failure patients after cardiac resynchronization therapy. Pacing Clin Electrophysiol 2008;31(11):1425-32
  • Moss AJ, Zareba W, Hall WJ, et al. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med 2002;346(12):877-83
  • Ruwald MH, Zareba W, Jons C, et al. Influence of diabetes mellitus on inappropriate and appropriate implantable cardioverter-defibrillator therapy and mortality in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT) Trial. Circulation 2013;128(7):694-701
  • Sandesara CM, Sullivan RM, Russo AM, et al. Older persons with diabetes receive fewer inappropriate ICD shocks: results from the INTRINSIC RV trial. J Cardiovasc Transl Res 2011;4(1):27-34
  • Moss AJ, Hall WJ, Cannom DS, et al. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 2009;361(14):1329-38
  • Ghali JK, Boehmer J, Feldman AM, et al. Influence of diabetes on cardiac resynchronization therapy with or without defibrillator in patients with advanced heart failure. J Card Fail 2007;13(9):769-73
  • Martin DT, McNitt S, Nesto RW, et al. Cardiac resynchronization therapy reduces the risk of cardiac events in patients with diabetes enrolled in the multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy (MADIT-CRT). Circ Heart Fail 2011;4(3):332-8
  • van Rees JB, Borleffs CJ, de Bie MK, et al. Inappropriate implantable cardioverter-defibrillator shocks: incidence, predictors, and impact on mortality. J Am Coll Cardiol 2011;57(5):556-62
  • Poole JE, Johnson GW, Hellkamp AS, et al. Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med 2008;359(10):1009-17
  • Ruwald AC, Schuger C, Moss AJ, et al. Mortality reduction in relation to implantable cardioverter defibrillator programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). Circ Arrhythm Electrophysiol 2014;7(5):785-92
  • Proietti R, Labos C, Davis M, et al. A systematic review and meta-analysis of the association between implantable cardioverter-defibrillator shocks and long-term mortality. Can J Cardiol 2015;31(3):270-7
  • Kleemann T, Strauss M, Kouraki K, Zahn R. Clinical course and prognostic relevance of antitachycardia pacing-terminated ventricular tachyarrhythmias in implantable cardioverter-defibrillator patients. Europace 2015; published online 16 February 2015; pii: euv007
  • Saxon LA, Bristow MR, Boehmer J, et al. Predictors of sudden cardiac death and appropriate shock in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial. Circulation 2006;114(25):2766-72
  • Singh JP, Hall WJ, McNitt S, et al. Factors influencing appropriate firing of the implanted defibrillator for ventricular tachycardia/fibrillation: findings from the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II). J Am Coll Cardiol 2005;46(9):1712-20
  • van Rees JB, de Bie MK, Thijssen J, et al. Implantation-related complications of implantable cardioverter-defibrillators and cardiac resynchronization therapy devices: a systematic review of randomized clinical trials. J Am Coll Cardiol 2011;58(10):995-1000
  • Bloom H, Heeke B, Leon A, et al. Renal insufficiency and the risk of infection from pacemaker or defibrillator surgery. Pacing Clin Electrophysiol 2006;29(2):142-5
  • Lekkerkerker JC, van Nieuwkoop C, Trines SA, et al. Risk factors and time delay associated with cardiac device infections: Leiden device registry. Heart 2009;95(9):715-20
  • Klug D, Balde M, Pavin D, et al. Risk factors related to infections of implanted pacemakers and cardioverter-defibrillators: results of a large prospective study. Circulation 2007;116(12):1349-55
  • Prutkin JM, Reynolds MR, Bao H, et al. Rates of and factors associated with infection in 200 909 Medicare implantable cardioverter-defibrillator implants: results from the National Cardiovascular Data Registry. Circulation 2014;130(13):1037-43
  • Mittal S, Shaw RE, Michel K, et al. Cardiac implantable electronic device infections: incidence, risk factors, and the effect of the AigisRx antibacterial envelope. Heart Rhythm 2014;11(4):595-601
  • Hercé B, Nazeyrollas P, Lesaffre F, et al. Risk factors for infection of implantable cardiac devices: data from a registry of 2496 patients. Europace 2013;15(1):66-70
  • Polyzos KA, Konstantelias AA, Falagas ME. Risk factors for cardiac implantable electronic device infection: a systematic review and meta-analysis. Europace 2015;17(5):767-77
  • García-Bolao I, Teijeira R, Díaz-Dorronsoro I. Late fatal right ventricular perforation as complication of permanent pacing leads. Pacing Clin Electrophysiol 2001;24(6):1036-7
  • Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015;518(7538):197-206
  • Fumagalli S, Gasparini M, Landolina M, et al. Determinants of all-cause mortality in different age groups in patients with severe systolic left ventricular dysfunction receiving an implantable cardioverter defibrillator (from the Italian ClinicalService Multicenter Observational Project). Am J Cardiol 2014;113(10):1691-6
  • Alba AC, Braga J, Gewarges M, et al. Predictors of mortality in patients with an implantable cardiac defibrillator: a systematic review and meta-analysis. Can J Cardiol 2013;29(12):1729-40

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