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Review

Improving strategies for the diagnosis of cardiac amyloidosis

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References

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  • APOLLO: the study of an investigational drug, patisiran (ALN-TTR02), for the treatment of transthyretin (TTR)-mediated amyloidosis. Available from: www.clinicaltrials.gov/ct2/show/NCT01960348
  • A extension study to evaluate revusiran (ALN-TTRSC) in patients with transthyretin (TTR) cardiac amyloidosis. Available from: www.clinicaltrials.gov/ct2/show/NCT02292186
  • Efficacy and safety of ISIS-TTR Rx in familial amyloid polyneuropathy. Available from: www.clinicaltrials.gov/ct2/show/NCT01737398
  • Safety and efficacy evaluation of Fx-1006A in subjects with transthyretin amyloidosis. Available from: www.clinicaltrials.gov/ct2/show/NCT00925002
  • Safety and efficacy of tafamidis in patients with transthyretin cardiomyopathy (ATTR-ACT). Available from: www.clinicaltrials.gov/ct2/show/NCT01994889
  • The effect of diflunisal on familial transthyretin amyloidosis (DFNS01). Available from: www.clinicaltrials.gov/ct2/show/NCT01432587
  • Phase I/2, open label, dose escalation study of NEOD001 in subjects with light chain (AL) amyloidosis. Available from: www.clinicaltrials.gov/ct2/show/NCT01707264
  • The vital amyloidosis study, a Phase III, multicenter efficacy and safety study of NEOD001. Available from: www.clinicaltrials.gov/ct2/show/NCT02312206
  • A study to evaluate the safety of GSK2398852 when co-administered with GSK2315698 in patients with systemic amyloidosis. Available from: www.clinicaltrials.gov/ct2/show/NCT01777243
  • Study of chimeric fibril-reactive monoclonal antibody 11-1F4 in patients with AL amyloidosis. Available from: www.clinicaltrials.gov/ct2/show/NCT02245867
  • Oral doxycycline administered as an adjunct to plasma cell directed therapy in light chain amyloidosis. Available from: www.clinicaltrials.gov/ct2/show/NCT02207556
  • Epigallocatechin gallate (EGCG) in cardiac AL amyloidosis (EpiCardiAL). Available from: www.clinicaltrials.gov/ct2/show/NCT01511263
  • A trial for the treatment of cardiac AL-amyloidosis with the green tea compound epigallocatechin-3-gallate (TAME-AL). Available from: www.clinicaltrials.gov/ct2/show/NCT02015312
  • Gertz MA, Dispenzieri A, Sher T. Pathophysiology and treatment of cardiac amyloidosis. Nat Rev Cardiol 2015;12(2):91-102

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