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Drug profiles

An evaluation of alirocumab for the treatment of hypercholesterolemia

References

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•• A 78-week randomized, double-blind comparison of alirocumab and placebo providing a long-term evaluation of efficacy and safety in a large population of 2341 patients and an evidence of a possible reduction in cardiovascular events

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•• Two 78-week randomized, double-blind trials evaluating efficacy and safety of alirocumab in large cohorts of patients with heterozygous familial hypercholesterolemia

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• A 52-week trial comparing alirocumab and placebo in high cardiovascular risk patients on maximally tolerated lipid-lowering therapy

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•• A 2-year randomized, double-blind comparison of the efficacy and safety of alirocumab and ezetimibe in high cardiovascular risk patients not controlled on maximally tolerated statin therapy

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• The first trial evaluating the efficacy and safety of a PCSK9 inhibitor, alirocumab, in patients with history of statin intolerance and with a rechallenge to statin therapy

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• The first report of efficacy of a PCSK9 inhibitor in patients with gain-of-function mutations in PCSK9.

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