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Editorial

Are plant sterols and plant stanols a viable future treatment for dyslipidemia?

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Pages 549-551 | Received 08 Feb 2016, Accepted 14 Mar 2016, Published online: 30 Mar 2016

References

  • Ostlund RE Jr, McGill JB, Zeng C-M, et al. Gastrointestinal absorption and plasma kinetics of soy Δ5-phytosterols and phytostanols in humans. Am J Physiol Endocrinol Metab. 2002;282:E911–E916.
  • Gylling H, Plat J, Turley S, et al. for the European atherosclerosis society consensus panel on phytosterols. Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease. Atherosclerosis. 2014;232:346–360.
  • Ikeda I, Tanaka K, Sugano M, et al. Inhibition of cholesterol absorption in rats by plant sterols. J Lipid Res. 1988;29:1573–1582.
  • Nissinen M, Gylling H, Vuoristo M, et al. Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. Am J Physiol Gastrointest Liver Physiol. 2002;282:G1009–G1015.
  • Ras RT, van der Schouw YT, Trautwein EA, et al. Intake of phytosterols from natural sources and risk of cardiovascular disease in the European prospective investigation into cancer and nutrition- the Netherlands (EPIC-NL) population. Eur J Prev Cardiol. 2015;22:1067–1075.
  • Valsta LM, Lemström A, Ovaskainen M-L, et al. Estimation of plant sterol and cholesterol intake in Finland: quality of new values and their effect on intake. Br J Nutr. 2004;92:671–678.
  • Lin X, Racette SB, Lefevre M, et al. The effects of phytosterols present in natural food matrices on cholesterol metabolism and LDL-cholesterol: a controlled feeding trial. Eur J Clin Nutr. 2010;64:1481–1487.
  • The Myocardial Infarction Genetics Consortium Investigators. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014;371:2072–2082.
  • Klingberg S, Ellegård L, Johansson I, et al. Dietary intake of naturally occurring plant sterols is related to a lower risk of a first myocardial infarction in men but not in women in northern Sweden. J Nutr. 2013;143:1630–1635.
  • Demonty I, Ras RT, van der Knaap HC, et al. Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake. J Nutr. 2009;139:271–284.
  • Musa-Veloso K, Poon TH, Elliot JA, et al. A comparison of the LDL-cholesterol lowering efficacy of plant stanols and plant sterols over a continuous dose range: results of a meta-analysis of randomized, placebo-controlled trials. Prostaglandins Leukot Essent Fatty Acids. 2011;85:9–28.
  • Ras RT, Geleijnse JM, Trautwein EA. LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies. Br J Nutr. 2014;112:214–219.
  • Simonen P, Stenman U-H, Gylling H. Serum proprotein convertase subtilisin/kexin type 9 concentration is not increased by plant stanol ester consumption in normo- to moderately hypercholesterolaemic non-obese subjects. The BLOOD FLOW intervention study. Clin Sci (London). 2015;129:439–446.
  • Hansel B, Carrié A, Brun-Druc N, et al. Premature atherosclerosis is not systematic in phytosterolemic patients: severe hypercholesterolemia as a confounding factor in five subjects. Atherosclerosis. 2014;234:162–168.
  • Ras RT, Hiemstra H, Lin Y, et al. Consumption of plant sterol-enriched foods and effects on plasma plant sterol concentrations- meta-analysis of randomized controlled studies. Atherosclerosis. 2013;230:336–346.
  • Gylling H, Halonen J, Lindholm H, et al. The effects of plant stanol ester consumption on arterial stiffness and endothelial function in adults: a randomised controlled clinical trial. BMC Cardiovasc Disord. 2013;13:50. Available from: http://www.biomedcentral.com/1471-2261/13/50
  • Ras RT, Fuchs D, Koppenol WP, et al. The effect of a low-fat spread with added plant sterols on vascular function markers: results of the investigating vascular function effects of plant sterols (INVEST) study. Am J Clin Nutr. 2015;101:733–741.
  • Cannon CP, Blazing MA, Giugliano RP, et al. for the IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372:2387–2397.
  • Plat J, Hendrikx T, Bieghs V, et al. Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans. PLoS ONE. 2014;9(10):e110758. doi:10.1371/journal.pone.0110758.
  • Loomba R, Sirlin CB, Ang B, et al. for the San Diego Integrated NAFLD Research Consortium (SINC). Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART Trial). Hepatology. 2015;61:1239–1250.

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